Search Results - "Stolpe, Anja Van De"

Enabling precision medicine by unravelling disease pathophysiology: quantifying signal transduction pathway activity across cell and tissue types by van de Stolpe, Anja, Holtzer, Laurent, van Ooijen, Henk, Inda, Marcia Alves de, Verhaegh, Wim

“…Signal transduction pathways are important in physiology and pathophysiology. Targeted drugs aim at modifying pathogenic pathway activity, e.g., in cancer…”
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Measurement of activity of developmental signal transduction pathways to quantify stem cell pluripotency and phenotypically characterize differentiated cells by Holtzer, Laurent, Wesseling-Rozendaal, Yvonne, Verhaegh, Wim, van de Stolpe, Anja

“…•Novel technology to quantitatively measure activity of signal transduction pathways (STP) in individual stem cell samples.•Pluripotency STP activity profile…”
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Androgen Receptor Pathway Activity Assay for Sepsis Diagnosis and Prediction of Favorable Prognosis by Bouwman, Wilbert, Verhaegh, Wim, van de Stolpe, Anja

“…Sepsis is a life-threatening complication of a bacterial infection. It is hard to predict which patients with a bacterial infection will develop sepsis, and…”
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Cytostretch, an Organ-on-Chip Platform by Gaio, Nikolas, van Meer, Berend, Quirós Solano, William, Bergers, Lambert, van de Stolpe, Anja, Mummery, Christine, Sarro, Pasqualina M, Dekker, Ronald

“…Organ-on-Chips (OOCs) are micro-fabricated devices which are used to culture cells in order to mimic functional units of human organs. The devices are designed…”
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Quantitative Measurement of Functional Activity of the PI3K Signaling Pathway in Cancer by van de Stolpe, Anja

“…The phosphoinositide 3-kinase (PI3K) growth factor signaling pathway plays an important role in embryonic development and in many physiological processes, for…”
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Wnt signaling in multiple myeloma: a central player in disease with therapeutic potential by Spaan, Ingrid, Raymakers, Reinier A, van de Stolpe, Anja, Peperzak, Victor

“…Multiple myeloma is the second most frequent hematological malignancy in the western world and remains incurable, predominantly due to acquired drug resistance…”
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Improved diagnosis of inflammatory bowel disease and prediction and monitoring of response to anti-TNF alpha treatment based on measurement of signal transduction pathway activity by Bouwman, Wilbert, Verhaegh, Wim, van de Stolpe, Anja

“…Ulcerative colitis (UC) and Crohn's disease (CD) are two subtypes of chronic inflammatory bowel disease (IBD). Differential diagnosis remains a challenge…”
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Circulating tumor cell isolation and diagnostics: toward routine clinical use by van de Stolpe, Anja, Pantel, Klaus, Sleijfer, Stefan, Terstappen, Leon W, den Toonder, Jaap M J

“…From February 7-11, 2011, the multidisciplinary Lorentz Workshop Circulating Tumor Cell (CTC) Isolation and Diagnostics: Toward Routine Clinical Use was held…”
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Corrigendum: Improved diagnosis of inflammatory bowel disease and prediction and monitoring of response to anti-TNF alpha treatment based on measurement of signal transduction pathway activity by Bouwman, Wilbert, Verhaegh, Wim, van de Stolpe, Anja

“…[This corrects the article DOI: 10.3389/fphar.2022.1008976.]…”
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Measurement of Cellular Immune Response to Viral Infection and Vaccination by Bouwman, Wilbert, Verhaegh, Wim, Holtzer, Laurent, van de Stolpe, Anja

“…Combined cellular and humoral host immune response determine the clinical course of a viral infection and effectiveness of vaccination, but currently the…”
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Quantitative characterization of immune cells by measuring cellular signal transduction pathway activity by Bouwman, Wilbert, Verhaegh, Wim, van Doorn, Arie, Raymakers, Reinier, van der Poll, Tom, van de Stolpe, Anja

“…For many diseases, including cancer, infections, and auto-immune diseases, the immune response is a major determinant of disease progression, response to…”
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Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes by Braam, Stefan R, Tertoolen, Leon, van de Stolpe, Anja, Meyer, Thomas, Passier, Robert, Mummery, Christine L

“…Recent withdrawals of prescription drugs from clinical use because of unexpected side effects on the heart have highlighted the need for more reliable cardiac…”
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Assessment of Functional Phosphatidylinositol 3-Kinase Pathway Activity in Cancer Tissue Using Forkhead Box-O Target Gene Expression in a Knowledge-Based Computational Model by van Ooijen, Henk, Hornsveld, Marten, Dam-de Veen, Christa, Velter, Rick, Dou, Meng, Verhaegh, Wim, Burgering, Boudewijn, van de Stolpe, Anja

“…The phosphatidylinositol 3-kinase (PI3K) pathway is commonly activated in cancer. Tumors are potentially sensitive to PI3K pathway inhibitors, but reliable…”
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Towards a 21st-century roadmap for biomedical research and drug discovery: consensus report and recommendations by Langley, Gillian R., Adcock, Ian M., Busquet, François, Crofton, Kevin M., Csernok, Elena, Giese, Christoph, Heinonen, Tuula, Herrmann, Kathrin, Hofmann-Apitius, Martin, Landesmann, Brigitte, Marshall, Lindsay J., McIvor, Emily, Muotri, Alysson R., Noor, Fozia, Schutte, Katrin, Seidle, Troy, van de Stolpe, Anja, Van Esch, Hilde, Willett, Catherine, Woszczek, Grzegorz

“…•Innovative 21st-century roadmaps need to be devised for biomedical research.•Advanced human biology-based models and tools hold the key to progress.•Human…”
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Prediction of clinical benefit from androgen deprivation therapy in salivary duct carcinoma patients by Boxtel, Wim, Verhaegh, Gerald W., Engen‐van Grunsven, Ilse A., Strijp, Dianne, Kroeze, Leonie I., Ligtenberg, Marjolein J., Zon, Hans B., Hendriksen, Yara, Keizer, Diederick, Stolpe, Anja, Schalken, Jack A., Herpen, Carla M.

“…Androgen deprivation therapy (ADT) is first‐line palliative treatment in androgen receptor‐positive (AR+) salivary duct carcinoma (SDC), and response rates are…”
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Impact of hormonal biomarkers on response to hormonal therapy in advanced and recurrent endometrial cancer by van Weelden, Willem Jan, Lalisang, Roy I., Bulten, Johan, Lindemann, Kristina, van Beekhuizen, Heleen J., Trum, Hans, Boll, Dorry, Werner, Henrica M.J., van Lonkhuijzen, Luc R.C.W., Yigit, Refika, Forsse, David, Witteveen, Petronella O., Galaal, Khadra, van Ginkel, Alexandra, Bignotti, Eliana, Weinberger, Vit, Sweegers, Sanne, Kroep, Judith R., Cabrera, Silvia, Snijders, Marc P.L.M., Inda, Márcia A., Eriksson, Ane Gerda Z., Krakstad, Camilla, Romano, Andrea, van de Stolpe, Anja, Pijnenborg, Johanna M.A.

“…Approximately 20% of women with endometrial cancer have advanced-stage disease or suffer from a recurrence. For these women, prognosis is poor, and palliative…”
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Oestrogen receptor pathway activity is associated with outcome in endometrial cancer by van Weelden, Willem Jan, van der Putten, Louis J. M., Inda, Márcia A., van Brussel, Anne, Snijders, Marc P. L. M., Schriever, Lisanne M. M., Bulten, Johan, Massuger, Leon F. A. G., van de Stolpe, Anja, Pijnenborg, Johanna M. A.

“…Background Oestrogen receptor (ER) expression is a prognostic biomarker in endometrial cancer (EC). However, expression does not provide information about the…”
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Stem Cells: Scientific Facts and Fiction by Mummery, Christine L, van de Stolpe, Anja, Roelen, Bernard, Clevers, Hans

“…Recent advances in the fields of medicine and technology have led to the development of stem cell therapy. A stem cell is a cell that has the potential to…”
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Publisher Correction: Enabling precision medicine by unravelling disease pathophysiology: quantifying signal transduction pathway activity across cell and tissue types by van de Stolpe, Anja, Holtzer, Laurent, van Ooijen, Henk, Inda, Marcia Alves de, Verhaegh, Wim

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Estrogen Receptor Pathway Activity Score to Predict Clinical Response or Resistance to Neoadjuvant Endocrine Therapy in Primary Breast Cancer by Inda, Márcia A, Blok, Erik J, Kuppen, Peter J K, Charehbili, Ayoub, den Biezen-Timmermans, Eveline C, van Brussel, Anne, Fruytier, Sevgi E, Meershoek-Klein Kranenbarg, Elma, Kloet, Susan, van der Burg, Bart, Martens, John W M, Sims, Andrew H, Turnbull, Arran K, Dixon, J Michael, Verhaegh, Wim, Kroep, Judith R, van de Velde, Cornelis J H, van de Stolpe, Anja

“…Endocrine therapy is important for management of patients with estrogen receptor (ER)-positive breast cancer; however, positive ER staining does not reliably…”
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