Search Results - "Stoleriu, Gabriel Mircea"

Predicting the effectiveness of high-flow oxygen therapy in COVID-19 patients: a single-centre observational study by Schmidt, Felicitas, Nowak, Lorenz, Obereisenbuchler, Florian, Hetrodt, Justin, Heiß-Neumann, Marion, Schönlebe, Anna, Heinig-Menhard, Katharina, Gesierich, Wolfgang, Behr, Jürgen, Hatz, Rudolf, Dinkel, Julien, Stoleriu, Mircea-Gabriel

“…High-flow nasal cannula (HFNC) therapy is a helpful tool in the treatment of hypoxaemic respiratory failure. However, the clinical parameters predicting the…”
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Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread by Ambike, Shubhankar, Cheng, Cho-Chin, Feuerherd, Martin, Velkov, Stoyan, Baldassi, Domizia, Afridi, Suliman Qadir, Porras-Gonzalez, Diana, Wei, Xin, Hagen, Philipp, Kneidinger, Nikolaus, Stoleriu, Mircea Gabriel, Grass, Vincent, Burgstaller, Gerald, Pichlmair, Andreas, Merkel, Olivia M, Ko, Chunkyu, Michler, Thomas

“…Abstract A promising approach to tackle the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) could be small interfering (si)RNAs. So far it is…”
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Preoperative risk factors predict perioperative allogenic blood transfusion in patients undergoing primary lung cancer resections: a retrospective cohort study from a high-volume thoracic surgery center by Stoleriu, Mircea Gabriel, Gerckens, Michael, Zimmermann, Julia, Schön, Johannes, Damirov, Fuad, Samm, Nicole, Kovács, Julia, Stacher-Priehse, Elvira, Kellerer, Christina, Jörres, Rudolf A, Kauke, Teresa, Ketscher, Christian, Grützner, Uwe, Hatz, Rudolf

“…Our study aimed to identify preoperative predictors for perioperative allogenic blood transfusion (ABT) in patients undergoing major lung cancer resections in…”
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Histology of the Primary Tumor Correlates with False Positivity of Integrated 18F-FDG-PET/CT Lymph Node Staging in Resectable Lung Cancer Patients by Damirov, Fuad, Stoleriu, Mircea Gabriel, Manapov, Farkhad, Büsing, Karen, Michels, Julia Dorothea, Preissler, Gerhard, Hatz, Rudolf A, Hohenberger, Peter, Roessner, Eric D

“…This study aimed to evaluate the diagnostic accuracy and false positivity rate of lymph node (LN) staging assessed by integrated 18F-fluorodeoxyglucose…”
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Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score by Rubio, Karla, Müller, Jason M., Mehta, Aditi, Watermann, Iris, Olchers, Till, Koch, Ina, Wessels, Sabine, Schneider, Marc A., Araujo-Ramos, Tania, Singh, Indrabahadur, Kugler, Christian, Stoleriu, Mircea Gabriel, Kriegsmann, Mark, Eichhorn, Martin, Muley, Thomas, Merkel, Olivia M., Braun, Thomas, Ammerpohl, Ole, Reck, Martin, Tresch, Achim, Barreto, Guillermo

“…Background Lung cancer (LC) causes more deaths worldwide than any other cancer type. Despite advances in therapeutic strategies, the fatality rate of LC cases…”
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Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery by Zimmermann, Christoph M., Baldassi, Domizia, Chan, Karen, Adams, Nathan B.P., Neumann, Alina, Porras-Gonzalez, Diana Leidy, Wei, Xin, Kneidinger, Nikolaus, Stoleriu, Mircea Gabriel, Burgstaller, Gerald, Witzigmann, Dominik, Luciani, Paola, Merkel, Olivia M.

“…While all the siRNA drugs on the market target the liver, the lungs offer a variety of currently undruggable targets which could potentially be treated with…”
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Inhibition of SARS-CoV-2 replication in the lung with siRNA/VIPER polyplexes by Baldassi, Domizia, Ambike, Shubhankar, Feuerherd, Martin, Cheng, Cho-Chin, Peeler, David J., Feldmann, Daniel P., Porras-Gonzalez, Diana Leidy, Wei, Xin, Keller, Lea-Adriana, Kneidinger, Nikolaus, Stoleriu, Mircea Gabriel, Popp, Andreas, Burgstaller, Gerald, Pun, Suzie H., Michler, Thomas, Merkel, Olivia M.

“…SARS-CoV-2 has been the cause of a global pandemic since 2019 and remains a medical urgency. siRNA-based therapies are a promising strategy to fight viral…”
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Perioperative Predictive Factors for Tumor Regression and Survival in Non-Small Cell Lung Cancer Patients Undergoing Neoadjuvant Treatment and Lung Resection by Damirov, Fuad, Stoleriu, Mircea Gabriel, Manapov, Farkhad, Boedeker, Enole, Dreher, Sascha, Gerz, Sibylle, Hehr, Thomas, Sandner, Evelin, Ott, German, Hatz, Rudolf Alexander, Preissler, Gerhard

“…Our study aimed to identify predictors for the effectiveness of tumor regression in lung cancer patients undergoing neoadjuvant treatment and cancer…”
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COPD basal cells are primed towards secretory to multiciliated cell imbalance driving increased resilience to environmental stressors by Stoleriu, Mircea Gabriel, Ansari, Meshal, Strunz, Maximilian, Schamberger, Andrea, Heydarian, Motaharehsadat, Ding, Yaobo, Voss, Carola, Schneider, Juliane Josephine, Gerckens, Michael, Burgstaller, Gerald, Castelblanco, Alejandra, Kauke, Teresa, Fertmann, Jan, Schneider, Christian, Behr, Juergen, Lindner, Michael, Stacher-Priehse, Elvira, Irmler, Martin, Beckers, Johannes, Eickelberg, Oliver, Schubert, Benjamin, Hauck, Stefanie M, Schmid, Otmar, Hatz, Rudolf A, Stoeger, Tobias, Schiller, Herbert B, Hilgendorff, Anne

“…Environmental pollutants injure the mucociliary elevator, thereby provoking disease progression in chronic obstructive pulmonary disease (COPD). Epithelial…”
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Antiviral CD8 + T-cell immune responses are impaired by cigarette smoke and in COPD by Chen, Jie, Wang, Xinyuan, Schmalen, Adrian, Haines, Sophia, Wolff, Martin, Ma, Huan, Zhang, Huabin, Stoleriu, Mircea Gabriel, Nowak, Johannes, Nakayama, Misako, Bueno, Marta, Brands, Judith, Mora, Ana L, Lee, Janet S, Krauss-Etschmann, Susanne, Dmitrieva, Anna, Frankenberger, Marion, Hofer, Thomas P, Noessner, Elfriede, Moosmann, Andreas, Behr, Jürgen, Milger, Katrin, Deeg, Cornelia A, Staab-Weijnitz, Claudia A, Hauck, Stefanie M, Adler, Heiko, Goldmann, Torsten, Gaede, Karoline I, Behrends, Jochen, Kammerl, Ilona E, Meiners, Silke

“…Virus infections drive COPD exacerbations and progression. Antiviral immunity centres on the activation of virus-specific CD8 T-cells by viral epitopes…”
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Sfrp1 inhibits lung fibroblast invasion during transition to injury-induced myofibroblasts by Mayr, Christoph H, Sengupta, Arunima, Asgharpour, Sara, Ansari, Meshal, Pestoni, Jeanine C, Ogar, Paulina, Angelidis, Ilias, Liontos, Andreas, Rodriguez-Castillo, José Alberto, Lang, Niklas J, Strunz, Maximilian, Porras-Gonzalez, Diana, Gerckens, Michael, De Sadeleer, Laurens J, Oehrle, Bettina, Viteri-Alvarez, Valeria, Fernandez, Isis E, Tallquist, Michelle, Irmler, Martin, Beckers, Johannes, Eickelberg, Oliver, Stoleriu, Gabriel Mircea, Behr, Jürgen, Kneidinger, Nikolaus, Wuyts, Wim A, Wasnick, Roxana Maria, Yildirim, Ali Önder, Ahlbrecht, Katrin, Morty, Rory E, Samakovlis, Christos, Theis, Fabian J, Burgstaller, Gerald, Schiller, Herbert B

“…Fibroblast-to-myofibroblast conversion is a major driver of tissue remodelling in organ fibrosis. Distinct lineages of fibroblasts support homeostatic tissue…”
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Clinical Course of Three Postoperative Symptomatic COVID-19 Cases in Patients After Lung Lobectomy by Stoleriu, Mircea Gabriel, Gerckens, Michael, Hetrodt, Justin, Heiß-Neumann, Marion, Koch, Ina, Stacher-Priehse, Elvira, Dinkel, Julien, Behr, Jürgen, Grützner, Uwe, Hatz, Rudolf

“…The novel coronavirus disease 2019 is a highly contagious viral infection caused by the severe acute respiratory syndrome coronavirus 2 virus. Its rapid spread…”
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Ex vivo tissue perturbations coupled to single-cell RNA-seq reveal multilineage cell circuit dynamics in human lung fibrogenesis by Lang, Niklas J, Gote-Schniering, Janine, Porras-Gonzalez, Diana, Yang, Lin, De Sadeleer, Laurens J, Jentzsch, R Christoph, Shitov, Vladimir A, Zhou, Shuhong, Ansari, Meshal, Agami, Ahmed, Mayr, Christoph H, Hooshiar Kashani, Baharak, Chen, Yuexin, Heumos, Lukas, Pestoni, Jeanine C, Molnar, Eszter Sarolta, Geeraerts, Emiel, Anquetil, Vincent, Saniere, Laurent, Wögrath, Melanie, Gerckens, Michael, Lehmann, Mareike, Yildirim, Ali Önder, Hatz, Rudolf, Kneidinger, Nikolaus, Behr, Jürgen, Wuyts, Wim A, Stoleriu, Mircea-Gabriel, Luecken, Malte D, Theis, Fabian J, Burgstaller, Gerald, Schiller, Herbert B

“…Pulmonary fibrosis develops as a consequence of failed regeneration after injury. Analyzing mechanisms of regeneration and fibrogenesis directly in human…”
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Predicting Long-term Survival After Lung Metastasectomy in Patients With Malignant Germ-cell Tumors by STOLERIU, MIRCEA GABRIEL, STATHOPOULOS, GEORGIOS, STACHER-PRIEHSE, ELVIRA, KETSCHER, CHRISTIAN, GRÜTZNER, UWE, FERTMANN, JAN, SCHNEIDER, CHRISTIAN, HATZ, RUDOLF, STROBL, NICOLE, PREISSLER, GERHARD

“…Background/Aim: The aim of the study was to identify predictors of long-term survival and propose an improved risk stratification in patients with pulmonary…”
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Expiratory Venous Volume and Arterial Tortuosity are Associated with Disease Severity and Mortality Risk in Patients with COPD: Results from COSYCONET by Stoleriu, Mircea Gabriel, Pienn, Michael, Joerres, Rudolf A, Alter, Peter, Fero, Tamas, Urschler, Martin, Kovacs, Gabor, Olschewski, Horst, Kauczor, Hans-Ulrich, Wielpütz, Mark, Jobst, Bertram, Welte, Tobias, Behr, Jürgen, Trudzinski, Franziska C, Bals, Robert, Watz, Henrik, Vogelmeier, Claus F, Biederer, Jürgen, Kahnert, Kathrin

“…The aim of this study was to evaluate the association between computed tomography (CT) quantitative pulmonary vessel morphology and lung function, disease…”
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A new strategy in the treatment of chemoresistant lung adenocarcinoma via specific siRNA transfection of SRF, E2F1, Survivin, HIF and STAT3 by Stoleriu, Mircea Gabriel, Steger, Volker, Mustafi, Migdat, Michaelis, Martin, Cinatl, Jindrich, Schneider, Wilke, Nolte, Andrea, Kurz, Julia, Wendel, Hans Peter, Schlensak, Christian, Walker, Tobias

“…OBJECTIVES According to the actual treatment strategies of lung cancer, the current therapeutic regimen is an individualized, multidisciplinary concept. The…”
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Prevention of COVID-19 in Thoracic Surgery Patients: Lessons Learned during the First Pandemic Wave by Stoleriu, Mircea Gabriel, Gerckens, Michael, Ströh, Katja, Kovács, Julia, Samm, Nicole, Obereisenbuchner, Florian, Hetrodt, Justin, Schmidt, Felicitas Maria, Reinmuth, Niels, Heiß-Neumann, Marion, Stacher-Priehse, Elvira, Koch, Ina, Behr, Jürgen, Ketscher, Christian, Grützner, Uwe, Hatz, Rudolf

“…The aim of this retrospective study was to investigate the implementation of measures to prevent perioperative COVID-19 in thoracic surgery during the first…”
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Automated quantitative thin slice volumetric low dose CT analysis predicts disease severity in COVID-19 patients by Stoleriu, Mircea Gabriel, Gerckens, Michael, Obereisenbuchner, Florian, Zaimova, Iva, Hetrodt, Justin, Mavi, Sarah-Christin, Schmidt, Felicitas, Schoenlebe, Anna Auguste, Heinig-Menhard, Katharina, Koch, Ina, Jörres, Rudolf A, Spiro, Judith, Nowak, Lorenz, Hatz, Rudolf, Behr, Jürgen, Gesierich, Wolfgang, Heiß-Neumann, Marion, Dinkel, Julien

“…This study aimed to identify predictive (bio-)markers for COVID-19 severity derived from automated quantitative thin slice low dose volumetric CT analysis,…”
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Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics by Gerckens, Michael, Schorpp, Kenji, Pelizza, Francesco, Wögrath, Melanie, Reichau, Kora, Ma, Huilong, Dworsky, Armando-Marco, Sengupta, Arunima, Stoleriu, Mircea Gabriel, Heinzelmann, Katharina, Merl-Pham, Juliane, Irmler, Martin, Alsafadi, Hani N, Trenkenschuh, Eduard, Sarnova, Lenka, Jirouskova, Marketa, Frieß, Wolfgang, Hauck, Stefanie M, Beckers, Johannes, Kneidinger, Nikolaus, Behr, Jürgen, Hilgendorff, Anne, Hadian, Kamyar, Lindner, Michael, Königshoff, Melanie, Eickelberg, Oliver, Gregor, Martin, Plettenburg, Oliver, Yildirim, Ali Önder, Burgstaller, Gerald

“…Fibrogenic processes instigate fatal chronic diseases leading to organ failure and death. Underlying biological processes involve induced massive deposition of…”
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