Search Results - "Stokvis, E."

A simple and sensitive assay for the quantitative analysis of paclitaxel in human and mouse plasma and brain tumor tissue using coupled liquid chromatography and tandem mass spectrometry by Stokvis, E., Ouwehand, M., Nan, L. G. A. H., Kemper, E. M., van Tellingen, O., Rosing, H., Beijnen, J. H.

“…The development and validation of an assay for the determination of paclitaxel in human plasma, human brain tumor tissue, mouse plasma and mouse brain tumor…”
Get full text

Quantitative analysis of the novel depsipeptide anticancer drug Kahalalide F in human plasma by high-performance liquid chromatography under basic conditions coupled to electrospray ionization tandem mass spectrometry by Stokvis, E., Rosing, H., López-Lázaro, L., Rodriguez, I., Jimeno, J. M., Supko, J. G., Schellens, J. H. M., Beijnen, J. H.

“…Kahalalide F (KF) is a novel cyclic depsipeptide anticancer drug, which has shown anticancer activity both in vitro and in vivo especially against human…”
Get full text

Simple and sensitive liquid chromatographic quantitative analysis of the novel marine anticancer drug Yondelis™ (ET-743, trabectedin) in human plasma using column switching and tandem mass spectrometric detection by Stokvis, E., Rosing, H., López-Lázaro, L., Beijnen, J. H.

“…The development of a simple and sensitive assay for the quantitative analysis of the marine anticancer agent Yondelis (ET‐743, trabectedin) in human plasma…”
Get full text

Switching from an analogous to a stable isotopically labeled internal standard for the LC-MS/MS quantitation of the novel anticancer drug Kahalalide F significantly improves assay performance by Stokvis, E., Rosing, H., López-Lázaro, L., Schellens, J. H. M., Beijnen, J. H.

“…The importance of a stable isotopically labeled (SIL) internal standard for the quantitative LC‐MS/MS assay for Kahalalide F in human plasma is highlighted…”
Get full text

Quantitative analysis of the novel anticancer drug ABT-518, a matrix metalloproteinase inhibitor, plus the screening of six metabolites in human plasma using high-performance liquid chromatography coupled with electrospray tandem mass spectrometry by Stokvis, E., Rosing, H., Crul, M., Rieser, M. J., Heck, A. J. R., Schellens, J. H. M., Beijnen, J. H.

“…A liquid chromatographic/tandem mass spectrometric (LC/MS/MS) assay for the quantitative analysis of the novel anticancer drug ABT‐518 and the screening of six…”
Get full text

Stable isotopically labeled internal standards in quantitative bioanalysis using liquid chromatography/mass spectrometry: necessity or not? by Stokvis, Ellen, Rosing, Hilde, Beijnen, Jos H.

“…It appears to be a general belief that stable isotopically labeled (SIL) internal standards yield better assay performance results for quantitative…”
Get full text

Quantitative analysis of ES-285, an investigational marine anticancer drug, in human, mouse, rat, and dog plasma using coupled liquid chromatography and tandem mass spectrometry by Stokvis, E., Nan-Offeringa, L., Rosing, H., López-Lázaro, L., Aceña, J. L., Miranda, E., Lyubimov, A., Levine, B. S., D'Aleo, C., Schellens, J. H. M., Beijnen, J. H.

“…A method was developed for the quantitative analysis of the novel anticancer agent ES‐285 (spisulosine; free base) in human, mouse, rat, and dog plasma using…”
Get full text

Bioanalysis of the novel peptide anticancer drug kahalalide F in human plasma by h.p.l.c. under basic conditions coupled with positive turbo‐ionspray tandem mass spectrometry by Stokvis, E., Rosing, H., López‐Lázaro, L., Jimeno, J. M., Supko, J. G., Schellens, J. H. M., Beijnen, J. H.

“…Kahalalide F (KF) is a cyclic depsipeptide derived from the marine mollusc Elysia rufescens. Anti‐cancer activity of KF was observed both in vitro and in vivo…”
Get full text

DEVELOPMENT OF AN HPLC METHOD WITH UV DETECTION FOR THE PHARMACEUTICAL QUALITY CONTROL OF THE NOVEL MARINE ANTICANCER AGENT KAHALALIDE F by Nuijen, B., Bouma, M., Floriano, P., Manada, C., Rosing, H., Stokvis, E., Kettenes-van den Bosch, J. J., Bult, A., Beijnen, J. H.

“…Kahalalide F is a cyclic depsipeptide derived from the marine mollusc Elysia rufescens, an organism living in the seas near Hawaii. On the basis of its in…”
Get full text

Liquid chromatography-mass spectrometry for the quantitative bioanalysis of anticancer drugs by Stokvis, Ellen, Rosing, Hilde, Beijnen, Jos H.

“…The monitoring of anticancer drugs in biological fluids and tissues is important during both pre‐clinical and clinical development and often in routine…”
Get full text

Phase I Clinical and Pharmacokinetic Study of Kahalalide F in Patients with Advanced Androgen Refractory Prostate Cancer by RADEMAKER-LAKHAI, Jeany M, HORENBLAS, Simon, MEINHARDT, Willem, STOKVIS, Ellen, DE REIJKE, Theo M, JIMENO, José M, LOPEZ-LAZARO, Luis, LOPEZ MARTIN, José A, BEIJNEN, Jos H, SCHELLENS, Jan H. M

“…Purpose: The purpose is to determine the maximum tolerated dose, profile of adverse events, and dose-limiting toxicity of Kahalalide F (KF) in patients with…”
Get full text

A simple and sensitive assay for the quantitative analysis of paclitaxel and metabolites in human plasma using liquid chromatography/tandem mass spectrometry by Vainchtein, Liia D., Thijssen, Bas, Stokvis, Ellen, Rosing, Hilde, Schellens, Jan H.M., Beijnen, Jos H.

“…A sensitive and specific LC‐MS/MS assay for the determination of paclitaxel and its 3′p‐ and 6‐α‐hydroxy metabolites is presented. A 200 µL plasma aliquot was…”
Get full text

Simple and sensitive liquid chromatographic quantitative analysis of the novel marine anticancer drug Yondelis super(TM) (ET-743, trabectedin) in human plasma using column switching and tandem mass spectrometric detection by Stokvis, E, Rosing, H, Lopez-Lazaro, L, Beijnen, J H

“…The development of a simple and sensitive assay for the quantitative analysis of the marine anticancer agent Yondelis (ET-743, trabectedin) in human plasma…”
Get full text

Metastable ion formation and disparate charge separation in the gas-phase dissection of protein assemblies studied by orthogonal time-of-flight mass spectrometry by Versluis, Cees, van der Staaij, Arlette, Stokvis, Ellen, Heck, Albert J.R, de Craene, Bart

“…The dissection of specific and nonspecific protein complexes in the gas phase is studied by collisionally activated decomposition. In particular, the gas phase…”
Get full text

Quantitative analysis of the P-glycoprotein inhibitor Elacridar (GF120918) in human and dog plasma using liquid chromatography with tandem mass spectrometric detection by Stokvis, Ellen, Rosing, Hilde, Causon, Roger C., Schellens, Jan H.M., Beijnen, Jos H.

“…A liquid chromatographic/tandem mass spectrometric (LC/MS/MS) method for the determination of the P‐glycoprotein and breast cancer resistance protein inhibitor…”
Get full text

Phase I and pharmacokinetic study of Kahalalide F in patients with advanced androgen refractory prostate cancer by Beijnen, J. H., Rademaker-Lakhai, J. M., Horenblas, S., Meinhardt, W., Stokvis, E., De Rijke, T. M., Jimeno, J. M., Lopez Lazaro, L., Lopez Martin, J. A., Schellens, J.

“…Abstract only…”
Get full text

Phase I and pharmacokinetic study of Kahalalide F in patients with advanced androgen refractory prostate cancer by Beijnen, J. H., Rademaker-Lakhai, J. M., Horenblas, S., Meinhardt, W., Stokvis, E., De Rijke, T. M., Jimeno, J. M., Lopez Lazaro, L., Lopez Martin, J. A., Schellens, J.

“…Abstract only…”
Get full text

Chemical and enzymatic stability of a cyclic depsipeptide, the novel, marine-derived, anti-cancer agent kahalalide F by Sparidans, Rolf W, Stokvis, Ellen, Jimeno, José M, López-Lázaro, Luis, Schellens, Jan HM, Beijnen, Jos H

“…Kahalalide F is a cyclic depsipeptide isolated from the Hawaiian mollusk Elysia rufescens. This compound is under present phase I clinical investigations as an…”
Get full text

Quantitative analysis of D-24851, a novel anticancer agent, in human plasma and urine by liquid chromatography coupled with tandem mass spectrometry by Stokvis, Ellen, Nan-Offeringa, Lianda G. A. H., Ouwehand, Mariët, Tibben, Matthijs M., Rosing, Hilde, Schnaars, Yvonne, Grigat, Martina, Romeis, Peter, Schellens, Jan H. M., Beijnen, Jos H.

“…The development of a liquid chromatography/tandem mass spectrometric assay for the quantitative analysis of the novel tubulin inhibitor D‐24851 in human plasma…”
Get full text

Growth temperature regulation of host-specific modifications of rhizobial lipo-chitin oligosaccharides : The function of nodX is temperature regulated by OISTHOORN, M. M. A, STOKVIS, E, HAVERKAMP, J, SPAINK, H. P, THOMAS-OATES, J. E

“…Lipo-chitin oligosaccharides (LCOs) are usually produced and isolated for structural analysis from bacteria cultured under laboratory rather than field…”
Get full text