Search Results - "Stokes, Philippa H"

GATA2 is required for lymphatic vessel valve development and maintenance by Kazenwadel, Jan, Betterman, Kelly L, Chong, Chan-Eng, Stokes, Philippa H, Lee, Young K, Secker, Genevieve A, Agalarov, Yan, Demir, Cansaran Saygili, Lawrence, David M, Sutton, Drew L, Tabruyn, Sebastien P, Miura, Naoyuki, Salminen, Marjo, Petrova, Tatiana V, Matthews, Jacqueline M, Hahn, Christopher N, Scott, Hamish S, Harvey, Natasha L

“…Heterozygous germline mutations in the zinc finger transcription factor GATA2 have recently been shown to underlie a range of clinical phenotypes, including…”
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Mechanism of allosteric regulation of transglutaminase 2 by GTP by Begg, Gillian E, Carrington, Lyle, Stokes, Philippa H, Matthews, Jacqueline M, Wouters, Merridee A, Husain, Ahsan, Lorand, Laszlo, Iismaa, Siiri E, Graham, Robert M

“…Allosteric regulation is a fundamental mechanism of biological control. Here, we investigated the allosteric mechanism by which GTP inhibits cross-linking…”
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Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1 by Wilkinson-White, Lorna, Gamsjaeger, Roland, Dastmalchi, Siavoush, Wienert, Beeke, Stokes, Philippa H, Crossley, Merlin, Mackay, Joel P, Matthews, Jacqueline M

“…The control of red blood cell and megakaryocyte development by the regulatory protein GATA1 is a paradigm for transcriptional regulation of gene expression in…”
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The structure of an LIM-only protein 4 (LMO4) and Deformed epidermal autoregulatory factor-1 (DEAF1) complex reveals a common mode of binding to LMO4 by Joseph, Soumya, Kwan, Ann H, Stokes, Philippa H, Mackay, Joel P, Cubeddu, Liza, Matthews, Jacqueline M

“…LIM-domain only protein 4 (LMO4) is a widely expressed protein with important roles in embryonic development and breast cancer. It has been reported to bind…”
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Mutation of a Critical Arginine in the GTP-binding Site of Transglutaminase 2 Disinhibits Intracellular Cross-linking Activity by Begg, Gillian E., Holman, Sara R., Stokes, Philippa H., Matthews, Jacqueline M., Graham, Robert M., Iismaa, Siiri E.

“…Transglutaminase type 2 (TG2; also known as Gh) is a multifunctional protein involved in diverse cellular processes. It has two well characterized enzyme…”
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Dimerization of CtIP, a BRCA1- and CtBP-interacting Protein, Is Mediated by an N-terminal Coiled-coil Motif by Dubin, Manu J., Stokes, Philippa H., Sum, Eleanor Y.M., Williams, R. Scott, Valova, Valentina A., Robinson, Phillip J., Lindeman, Geoffrey J., Glover, J. N. Mark, Visvader, Jane E., Matthews, Jacqueline M.

“…CtIP is a transcriptional co-regulator that binds a number of proteins involved in cell cycle control and cell development, such as CtBP (Cterminus-binding…”
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Insight into the architecture of the NuRD complex: structure of the RbAp48-MTA1 subcomplex by Alqarni, Saad S M, Murthy, Andal, Zhang, Wei, Przewloka, Marcin R, Silva, Ana P G, Watson, Aleksandra A, Lejon, Sara, Pei, Xue Y, Smits, Arne H, Kloet, Susan L, Wang, Hongxin, Shepherd, Nicholas E, Stokes, Philippa H, Blobel, Gerd A, Vermeulen, Michiel, Glover, David M, Mackay, Joel P, Laue, Ernest D

“…The nucleosome remodeling and deacetylase (NuRD) complex is a widely conserved transcriptional co-regulator that harbors both nucleosome remodeling and histone…”
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Mutation in a flexible linker modulates binding affinity for modular complexes by Stokes, Philippa H., Robertson, Neil O., Silva, Ana P. G., Estephan, Tanya, Trewhella, Jill, Guss, J. Mitchell, Matthews, Jacqueline M.

“…Tandem beta zippers are modular complexes formed between repeated linear motifs and tandemly arrayed domains of partner proteins in which β‐strands form upon…”
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Stabilization of a binary protein complex by intein‐mediated cyclization by Jeffries, Cy M., Graham, Stephen C., Stokes, Philippa H., Collyer, Charles A., Guss, J. Mitchell, Matthews, Jacqueline M.

“…The study of protein–protein interactions can be hampered by the instability of one or more of the protein complex components. In this study, we showed that…”
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Dimerization of CtIP may stabilize in vivo interactions with the Retinoblastoma-pocket domain by Stokes, Philippa H., Thompson, Lyndal S., Marianayagam, Neelan J., Matthews, Jacqueline M.

“…CtIP is a tumor suppressor that interacts with Retinoblastoma protein (Rb) to regulate the G1/S-phase transition of the cell cycle. Despite its large size (897…”
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The Structure of an LIM-Only Protein 4 Complex Reveals a Common Mode of Binding to LMO4 by Joseph, Soumya, Kwan, Ann H, Stokes, Philippa H, Mackay, Joel P, Cubeddu, Liza, Matthews, Jacqueline M

“…LIM-domain only protein 4 (LMO4) is a widely expressed protein with important roles in embryonic development and breast cancer. It has been reported to bind…”
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The Structure of an LIM-Only Protein 4 by Joseph, Soumya, Kwan, Ann H, Stokes, Philippa H, Mackay, Joel P, Cubeddu, Liza, Matthews, Jacqueline M

“…LIM-domain only protein 4 (LMO4) is a widely expressed protein with important roles in embryonic development and breast cancer. It has been reported to bind…”
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GATA2 is required for lymphatic vessel valve development and maintenance by Kazenwadel, Jan, Betterman, Kelly L, Chong, Chan-Eng, Stokes, Philippa H, Lee, Young K, Secker, Genevieve A, Agalarov, Yan, Demir, Cansaran Saygili, Lawrence, David M, Sutton, Drew L, Tabruyn, Sebastien P, Miura, Naoyuki, Salminen, Marjo, Petrova, Tatiana V, Matthews, Jacqueline M, Hahn, Christopher N, Scott, Hamish S, Harvey, Natasha L

“…Heterozygous germline mutations in the zinc finger transcription factor GATA2 have recently been shown to underlie a range of clinical phenotypes, including…”
Get full text

Insight into the Architecture of the NuRD Complex by Alqarni, Saad S.M., Murthy, Andal, Zhang, Wei, Przewloka, Marcin R., Silva, Ana P.G., Watson, Aleksandra A., Lejon, Sara, Pei, Xue Y., Smits, Arne H., Kloet, Susan L., Wang, Hongxin, Shepherd, Nicholas E., Stokes, Philippa H., Blobel, Gerd A., Vermeulen, Michiel, Glover, David M., Mackay, Joel P., Laue, Ernest D.

“…The nucleosome remodeling and deacetylase (NuRD) complex is a widely conserved transcriptional co-regulator that harbors both nucleosome remodeling and histone…”
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1H, 15N and 13C assignments of an intramolecular LMO4-LIM1/CtIP complex by Liew, Chu Wai, Kwan, Ann H., Stokes, Philippa H., Mackay, Joel P., Matthews, Jacqueline M.

“…LMO4 is a broadly expressed LIM-only protein that is involved in neural tube development and implicated in breast cancer. Here we report backbone and side…”
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sup 1^H, ^sup 15^N and ^sup 13^C assignments of an intramolecular LMO4-LIM1/CtIP complex by Liew, Chu Wai, Kwan, Ann H, Stokes, Philippa H, Mackay, Joel P, Matthews, Jacqueline M

“…LMO4 is a broadly expressed LIM-only protein that is involved in neural tube development and implicated in breast cancer. Here we report backbone and side…”
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H, ¹⁵N and ¹³C assignments of an intramolecular LMO4-LIM1/CtIP complex by Liew, Chu Wai, Kwan, Ann H, Stokes, Philippa H, Mackay, Joel P, Matthews, Jacqueline M

“…LMO4 is a broadly expressed LIM-only protein that is involved in neural tube development and implicated in breast cancer. Here we report backbone and side…”
Get full text