Search Results - "Stokes, Barbara"

Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda by Uwimana, Aline, Legrand, Eric, Stokes, Barbara H., Ndikumana, Jean-Louis Mangala, Warsame, Marian, Umulisa, Noella, Ngamije, Daniel, Munyaneza, Tharcisse, Mazarati, Jean-Baptiste, Munguti, Kaendi, Campagne, Pascal, Criscuolo, Alexis, Ariey, Frédéric, Murindahabi, Monique, Ringwald, Pascal, Fidock, David A., Mbituyumuremyi, Aimable, Menard, Didier

“…Artemisinin resistance (delayed P. falciparum clearance following artemisinin-based combination therapy), is widespread across Southeast Asia but to date has…”
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Increasing Prevalence of Artemisinin-Resistant HRP2-Negative Malaria in Eritrea by Mihreteab, Selam, Platon, Lucien, Berhane, Araia, Stokes, Barbara H., Warsame, Marian, Campagne, Pascal, Criscuolo, Alexis, Ma, Laurence, Petiot, Nathalie, Doderer-Lang, Cécile, Legrand, Eric, Ward, Kurt E., Zehaie Kassahun, Assefash, Ringwald, Pascal, Fidock, David A., Ménard, Didier

“…This study shows the emergence and spread of artemisinin resistance, along with the loss of hrp2 required for malaria rapid diagnostic tests, in P. falciparum…”
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Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents by Stokes, Barbara H, Yoo, Euna, Murithi, James M, Luth, Madeline R, Afanasyev, Pavel, da Fonseca, Paula C A, Winzeler, Elizabeth A, Ng, Caroline L, Bogyo, Matthew, Fidock, David A

“…Therapeutics with novel modes of action and a low risk of generating resistance are urgently needed to combat drug-resistant Plasmodium falciparum malaria…”
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Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13 by Gnädig, Nina F, Stokes, Barbara H, Edwards, Rachel L, Kalantarov, Gavreel F, Heimsch, Kim C, Kuderjavy, Michal, Crane, Audrey, Lee, Marcus C S, Straimer, Judith, Becker, Katja, Trakht, Ilya N, Odom John, Audrey R, Mok, Sachel, Fidock, David A

“…The emergence of artemisinin (ART) resistance in Plasmodium falciparum intra-erythrocytic parasites has led to increasing treatment failure rates with…”
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Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival by Mok, Sachel, Stokes, Barbara H., Gnädig, Nina F., Ross, Leila S., Yeo, Tomas, Amaratunga, Chanaki, Allman, Erik, Solyakov, Lev, Bottrill, Andrew R., Tripathi, Jaishree, Fairhurst, Rick M., Llinás, Manuel, Bozdech, Zbynek, Tobin, Andrew B., Fidock, David A.

“…The emergence and spread of artemisinin resistance, driven by mutations in Plasmodium falciparum K13, has compromised antimalarial efficacy and threatens the…”
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Evidence of Artemisinin-Resistant Malaria in Africa by Stokes, Barbara H, Ward, Kurt E, Fidock, David A, Mita, Toshihiro, Fukuda, Naoyuki, Balikagala, Betty

“…To the Editor: Balikagala et al. (Sept. 23 issue) 1 report evidence that Plasmodium falciparum malaria parasite resistance to first-line artemisinin…”
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Mutation in the Plasmodium falciparum BTB/POZ Domain of K13 Protein Confers Artemisinin Resistance by Paloque, Lucie, Coppée, Romain, Stokes, Barbara H, Gnädig, Nina F, Niaré, Karamoko, Augereau, Jean-Michel, Fidock, David A, Clain, Jérôme, Benoit-Vical, Françoise

“…Partial artemisinin resistance, defined in patients as a delayed parasite clearance following artemisinin-based treatment, is conferred by non-synonymous…”
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Plasmodium falciparum K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness In Vitro by Straimer, Judith, Gnädig, Nina F, Stokes, Barbara H, Ehrenberger, Michelle, Crane, Audrey A, Fidock, David A

“…The emergence and spread in Southeast Asia of resistance to artemisinin (ART) derivatives, the cornerstone of first-line artemisinin-based combination…”
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Defining the Determinants of Specificity of Plasmodium Proteasome Inhibitors by Yoo, Euna, Stokes, Barbara H, de Jong, Hanna, Vanaerschot, Manu, Kumar, TRS, Lawrence, Nina, Njoroge, Mathew, Garcia, Arnold, Van der Westhuyzen, Renier, Momper, Jeremiah D, Ng, Caroline L, Fidock, David A, Bogyo, Matthew

“…The Plasmodium proteasome is an emerging antimalarial target due to its essential role in all the major life cycle stages of the parasite and its contribution…”
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The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites by Yoo, Euna, Schulze, Christopher J, Stokes, Barbara H, Onguka, Ouma, Yeo, Tomas, Mok, Sachel, Gnädig, Nina F, Zhou, Yani, Kurita, Kenji, Foe, Ian T, Terrell, Stephanie M, Boucher, Michael J, Cieplak, Piotr, Kumpornsin, Krittikorn, Lee, Marcus C S, Linington, Roger G, Long, Jonathan Z, Uhlemann, Anne-Catrin, Weerapana, Eranthie, Fidock, David A, Bogyo, Matthew

“…Salinipostin A (Sal A) is a potent antiplasmodial marine natural product with an undefined mechanism of action. Using a Sal A-derived activity-based probe, we…”
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Author Correction: Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda by Uwimana, Aline, Legrand, Eric, Stokes, Barbara H., Ndikumana, Jean-Louis Mangala, Warsame, Marian, Umulisa, Noella, Ngamije, Daniel, Munyaneza, Tharcisse, Mazarati, Jean-Baptiste, Munguti, Kaendi, Campagne, Pascal, Criscuolo, Alexis, Ariey, Frédéric, Murindahabi, Monique, Ringwald, Pascal, Fidock, David A., Mbituyumuremyi, Aimable, Menard, Didier

“…In the version of this article initially published, affiliation 2 (Malaria Genetics and Resistance Unit, Institut Pasteur, Paris, France) was incorrect. The…”
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Plasmodium berghei K13 Mutations Mediate In Vivo Artemisinin Resistance That Is Reversed by Proteasome Inhibition by Simwela, Nelson V, Stokes, Barbara H, Aghabi, Dana, Bogyo, Matt, Fidock, David A, Waters, Andrew P

“…The recent emergence of parasite resistance to the first line antimalarial drug artemisinin is of particular concern. Artemisinin resistance is primarily…”
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Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome by Deni, Ioanna, Stokes, Barbara H, Ward, Kurt E, Fairhurst, Kate J, Pasaje, Charisse Flerida A, Yeo, Tomas, Akbar, Shirin, Park, Heekuk, Muir, Ryan, Bick, Daniella S, Zhan, Wenhu, Zhang, Hao, Liu, Yi Jing, Ng, Caroline L, Kirkman, Laura A, Almaliti, Jehad, Gould, Alexandra E, Duffey, Maëlle, O'Donoghue, Anthony J, Uhlemann, Anne-Catrin, Niles, Jacquin C, da Fonseca, Paula C A, Gerwick, William H, Lin, Gang, Bogyo, Matthew, Fidock, David A

“…The Plasmodium falciparum proteasome constitutes a promising antimalarial target, with multiple chemotypes potently and selectively inhibiting parasite…”
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A conserved metabolic signature associated with response to fast-acting anti-malarial agents by Simwela, Nelson V, Guiguemde, W Armand, Straimer, Judith, Regnault, Clement, Stokes, Barbara H, Tavernelli, Luis E, Yokokawa, Fumiaki, Taft, Benjamin, Diagana, Thierry T, Barrett, Michael P, Waters, Andrew P

“…In malaria drug discovery, understanding the mode of action of lead compounds is important as it helps in predicting the potential emergence of drug resistance…”
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Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness by Stokes, Barbara H, Dhingra, Satish K, Rubiano, Kelly, Mok, Sachel, Straimer, Judith, Gnädig, Nina F, Deni, Ioanna, Schindler, Kyra A, Bath, Jade R, Ward, Kurt E, Striepen, Josefine, Yeo, Tomas, Ross, Leila S, Legrand, Eric, Ariey, Frédéric, Cunningham, Clark H, Souleymane, Issa M, Gansané, Adama, Nzoumbou-Boko, Romaric, Ndayikunda, Claudette, Kabanywanyi, Abdunoor M, Uwimana, Aline, Smith, Samuel J, Kolley, Olimatou, Ndounga, Mathieu, Warsame, Marian, Leang, Rithea, Nosten, François, Anderson, Timothy Jc, Rosenthal, Philip J, Ménard, Didier, Fidock, David A

“…The emergence of mutant K13-mediated artemisinin (ART) resistance in malaria parasites has led to widespread treatment failures across Southeast Asia. In…”
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A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin by Qiu, Deyun, Pei, Jinxin V., Rosling, James E. O., Thathy, Vandana, Li, Dongdi, Xue, Yi, Tanner, John D., Penington, Jocelyn Sietsma, Aw, Yi Tong Vincent, Aw, Jessica Yi Han, Xu, Guoyue, Tripathi, Abhai K., Gnadig, Nina F., Yeo, Tomas, Fairhurst, Kate J., Stokes, Barbara H., Murithi, James M., Kümpornsin, Krittikorn, Hasemer, Heath, Dennis, Adelaide S. M., Ridgway, Melanie C., Schmitt, Esther K., Straimer, Judith, Papenfuss, Anthony T., Lee, Marcus C. S., Corry, Ben, Sinnis, Photini, Fidock, David A., van Dooren, Giel G., Kirk, Kiaran, Lehane, Adele M.

“…Diverse compounds target the Plasmodium falciparum Na + pump PfATP4, with cipargamin and (+)-SJ733 the most clinically-advanced. In a recent clinical trial for…”
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Randomized controlled trial on low level laser therapy (LLLT) in the treatment of osteoarthritis (OA) of the hand by Brosseau, Lucie, Wells, George, Marchand, Serge, Gaboury, Isabelle, Stokes, Barbara, Morin, Michelle, Casimiro, Lynn, Yonge, Katharine, Tugwell, Peter

“…Background and Objectives Low level laser therapy (LLLT) offers promising symptomatic relief of osteoarthritic (OA) pain. We examined efficacy of active LLLT…”
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Emergence and clonal expansion of in vitro artemisinin-resistantPlasmodium falciparum kelch13R561H mutant parasites in Rwanda by Uwimana, A., Legrand, E., Stokes, B. H., Ndikumana, J. L. M., Warsame, Marian, Umulisa, N., Ngamije, D., Munyaneza, T., Mazarati, J. B., Munguti, K., Campagne, P., Criscuolo, A., Ariey, F., Murindahabi, M., Ringwald, P., Fidock, D. A., Mbituyumuremyi, A., Menard, D.

“…Artemisinin resistance (delayedP. falciparumclearance following artemisinin-based combination therapy), is widespread across Southeast Asia but to date has not…”
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Increasing Artemisinin-Resistant HRP2-Negative Malaria in Eritrea by Mihreteab, Selam, Platon, Lucien, Berhane, Araia, Stokes, Barbara H., Warsame, Marian, Campagne, Pascal, Criscuolo, Alexis, Ma, Laurence, Petiot, Nathalie, Doderer-Lang, Cécile, Legrand, Eric, Ward, Kurt E., Kassahun, Assefash Zehaie, Ringwald, Pascal, Fidock, David A., Ménard, Didier

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Examining the Role of K13 in Artemisinin-Resistant Plasmodium falciparum Malaria by Stokes, Barbara Hoyt Squeff

“…Despite the concerted efforts of researchers, policy makers and public health workers worldwide, malaria persists as a significant disease threat for nearly…”
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