Search Results - "Stokes, Alan"

Performance Comparison of the Digital Neuromorphic Hardware SpiNNaker and the Neural Network Simulation Software NEST for a Full-Scale Cortical Microcircuit Model by van Albada, Sacha J, Rowley, Andrew G, Senk, Johanna, Hopkins, Michael, Schmidt, Maximilian, Stokes, Alan B, Lester, David R, Diesmann, Markus, Furber, Steve B

“…The digital neuromorphic hardware SpiNNaker has been developed with the aim of enabling large-scale neural network simulations in real time and with low power…”
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sPyNNaker: A Software Package for Running PyNN Simulations on SpiNNaker by Rhodes, Oliver, Bogdan, Petruţ A, Brenninkmeijer, Christian, Davidson, Simon, Fellows, Donal, Gait, Andrew, Lester, David R, Mikaitis, Mantas, Plana, Luis A, Rowley, Andrew G D, Stokes, Alan B, Furber, Steve B

“…This work presents sPyNNaker 4.0.0, the latest version of the software package for simulating PyNN-defined spiking neural networks (SNNs) on the SpiNNaker…”
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A self-amplifying mRNA SARS-CoV-2 vaccine candidate induces safe and robust protective immunity in preclinical models by Maruggi, Giulietta, Mallett, Corey P., Westerbeck, Jason W., Chen, Tiffany, Lofano, Giuseppe, Friedrich, Kristian, Qu, Lin, Sun, Jennifer Tong, McAuliffe, Josie, Kanitkar, Amey, Arrildt, Kathryn T., Wang, Kai-Fen, McBee, Ian, McCoy, Deborah, Terry, Rebecca, Rowles, Alison, Abrahim, Maia Araujo, Ringenberg, Michael A., Gains, Malcolm J., Spickler, Catherine, Xie, Xuping, Zou, Jing, Shi, Pei-Yong, Dutt, Taru, Henao-Tamayo, Marcela, Ragan, Izabela, Bowen, Richard A., Johnson, Russell, Nuti, Sandra, Luisi, Kate, Ulmer, Jeffrey B., Steff, Ann-Muriel, Jalah, Rashmi, Bertholet, Sylvie, Stokes, Alan H., Yu, Dong

“…RNA vaccines have demonstrated efficacy against SARS-CoV-2 in humans, and the technology is being leveraged for rapid emergency response. In this report, we…”
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SpiNNTools: The Execution Engine for the SpiNNaker Platform by Rowley, Andrew G D, Brenninkmeijer, Christian, Davidson, Simon, Fellows, Donal, Gait, Andrew, Lester, David R, Plana, Luis A, Rhodes, Oliver, Stokes, Alan B, Furber, Steve B

“…SpiNNaker is a massively parallel distributed architecture primarily focused on real time simulation of spiking neural networks. The largest realization of the…”
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Nonclinical Safety Assessment of Lipid Nanoparticle-and Emulsion-Based Self-Amplifying mRNA Vaccines in Rats by Donahue, Douglas A., Ballesteros, Cristina, Maruggi, Giulietta, Glover, Christiana, Ringenberg, Michael A., Marquis, Miriam, Ben Abdeljelil, Nawel, Ashraf, Asma, Rodriguez, Luis-Alexander, Stokes, Alan H.

“…Vaccines containing mRNA with the capacity to self-amplify represent an alternative to the mRNA vaccines that came to prominence during the COVID-19 pandemic…”
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Recovery Animals in Toxicology Studies: An Innovation and Quality Consortium Perspective on Best Practices With Case Study Examples by Salian-Mehta, Smita, Smith, James D., Flandre, Thierry D., Lambert, Amy L., Lane, Joan H., Stokes, Alan H., Orsted, Kathy, Bratcher-Petersen, Natalie A., Janardhan, Kyathanahalli S., Tonkin, Elizabeth G.

“…The inclusion of recovery animals in nonclinical safety studies that support clinical trials is undertaken with a wide diversity of approaches even while…”
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MRI/PET multimodal imaging of the innate immune response in skeletal muscle and draining lymph node post vaccination in rats by Madi, Saaussan, Xie, Fang, Farhangi, Kamyar, Hsu, Chih-Yang, Cheng, Shih-Hsun, Aweda, Tolulope, Radaram, Bhasker, Slania, Stephanie, Lambert, Tammy, Rambo, Mary, Skedzielewski, Tina, Cole, Austin, Sherina, Valeriia, McKearnan, Shannon, Tran, Hoang, Alsaid, Hasan, Doan, Minh, Stokes, Alan H, O'Hagan, Derek T, Maruggi, Giulietta, Bertholet, Sylvie, Temmerman, Stéphane T, Johnson, Russell, Jucker, Beat M

“…The goal of this study was to utilize a multimodal magnetic resonance imaging (MRI) and positron emission tomography (PET) imaging approach to assess the local…”
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Building a Spiking Neural Network Model of the Basal Ganglia on SpiNNaker by Sen-Bhattacharya, Basabdatta, James, Sebastian, Rhodes, Oliver, Sugiarto, Indar, Rowley, Andrew, Stokes, Alan B., Gurney, Kevin, Furber, Steve B.

“…We present a biologically inspired and scalable model of the basal ganglia (BG) simulated on the spiking neural network architecture (SpiNNaker) machine, a…”
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A Spiking Neural Network Model of the Lateral Geniculate Nucleus on the SpiNNaker Machine by Sen-Bhattacharya, Basabdatta, Serrano-Gotarredona, Teresa, Balassa, Lorinc, Bhattacharya, Akash, Stokes, Alan B, Rowley, Andrew, Sugiarto, Indar, Furber, Steve

“…We present a spiking neural network model of the thalamic Lateral Geniculate Nucleus (LGN) developed on SpiNNaker, which is a state-of-the-art digital…”
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Repeated-Dose Toxicity, Biodistribution, and Shedding Assessments With a ChAd155 Respiratory Syncytial Virus Vaccine Candidate Evaluated in Rabbits and Rats by Stokes, Alan H., Planty, Camille, Pion, Johanne, Ancian, Philippe, Rogue, Alexandra, Bansard, Carine, Silvano, Jérémy, Papineau, Dominique, Ben Abdeljelil, Nawel, Maruggi, Giulietta, Song, Haifeng, Spickler, Catherine, Blouin, Karine, Dubois, Guillaume, Rodriguez, Luis-Alexander, Baumeister, Judith, Steff, Ann-Muriel, Destexhe, Eric

“…Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections (LRTI) in infants, and toddlers and vaccines are not yet…”
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Repeated Dose Toxicity Study and Developmental and Reproductive Toxicology Studies of a Respiratory Syncytial Virus Candidate Vaccine in Rabbits and Rats by Stokes, Alan H., Franklin, Kelle, Fisher, Daniel E., Posobiec, Lorraine M., Binazon, Ornella, Tripathi, Niraj, Ringenberg, Michael Alan, Charlap, Jeffrey, Ziejewski, Mary K., Vemireddi, Vimala, Khanna Weiss, Payal, Majumdar, Ritankar, Bouzya, Badiaa, Donner, Marie-Noëlle, Rodriguez, Luis-Alexander, Baumeister, Judith

“…Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections, and vaccines are needed to treat young children and older…”
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Dermal Toxicity Studies: Factors Impacting Study Interpretation and Outcome by Chandra, Sundeep A., Stokes, Alan H., Hailey, Rick, Merrill, Christine L., Melich, David H., DeSmet, Kristina, Furst, Sylvia M., Peterson, Richard A., Mellon-Kusibab, Katherine, Adler, Rick R.

“…The field of dermal toxicity continues to evolve in order to accurately predict dermal (and systemic) responses in humans to topically applied chemicals…”
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An initial characterization of N-terminal-proatrial natriuretic peptide in serum of Sprague Dawley rats by Colton, Heidi M, Stokes, Alan H, Yoon, Lawrence W, Quaile, Michael P, Novak, Paul J, Falls, James Greg, Kimbrough, Carie L, Cariello, Neal F, Jordan, Holly L, Berridge, Brian R

“…In the clinical setting, natriuretic peptides (NPs) have proven to be reliable noninvasive markers for diagnostic, prognostic, and therapeutic monitoring of…”
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Migration to the coast: The Australian sea change phenomenon by Stokes, Alan

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Integrated Approach to Early Detection of Cardiovascular Toxicity Induced by a Ghrelin Receptor Agonist by Stokes, Alan H., Falls, J. Greg, Yoon, Lawrence, Cariello, Neal, Faiola, Brenda, Colton, Heidi M., Jordan, Holly L., Berridge, Brian R.

“…Cardiovascular (CV) safety concerns are among the leading causes of compound attrition in drug development. This work describes a strategy of applying novel…”
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Effects of Solutol (Kolliphor) and Cremophor in Polyethylene Glycol 400 Vehicle Formulations in Sprague-Dawley Rats and Beagle Dogs by Stokes, Alan H., Kemp, Daniel C., Faiola, Brenda, Jordan, Holly L., Merrill, Christine L., Hailey, James R., Brown, Randy E., Bailey, David W.

“…When conventional vehicles (eg, methylcellulose and water) impart inadequate physical, chemical, and/or biological properties for proper toxicological…”
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Code Generation in Computational Neuroscience: A Review of Tools and Techniques by Blundell, Inga, Brette, Romain, Cleland, Thomas A, Close, Thomas G, Coca, Daniel, Davison, Andrew P, Diaz-Pier, Sandra, Fernandez Musoles, Carlos, Gleeson, Padraig, Goodman, Dan F M, Hines, Michael, Hopkins, Michael W, Kumbhar, Pramod, Lester, David R, Marin, Bóris, Morrison, Abigail, Müller, Eric, Nowotny, Thomas, Peyser, Alexander, Plotnikov, Dimitri, Richmond, Paul, Rowley, Andrew, Rumpe, Bernhard, Stimberg, Marcel, Stokes, Alan B, Tomkins, Adam, Trensch, Guido, Woodman, Marmaduke, Eppler, Jochen Martin

“…Advances in experimental techniques and computational power allowing researchers to gather anatomical and electrophysiological data at unprecedented levels of…”
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Manganese-Induced Cytotoxicity in Dopamine-Producing Cells by Stredrick, Denise L., Stokes, Alan H., Worst, Travis J., Freeman, Willard M., Johnson, Elizabeth A., Lash, Lawrence H., Aschner, Michael, Vrana, Kent E.

“…Manganese (Mn) is an essential metal that, at excessive levels in the brain, produces extrapyramidal symptoms similar to those in patients with Parkinson’s…”
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Cytotoxic and genotoxic potential of dopamine by Stokes, Alan H., Hastings, Teresa G., Vrana, Kent E.

“…A variety of in vitro and in vivo studies demonstrate that dopamine is a toxic molecule that may contribute to neurodegenerative disorders such as Parkinson's…”
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In vivo assessment of mitochondrial toxicity by Hamilton, Bradley F., Stokes, Alan H., Lyon, Jon, Adler, Rick R.

“…Drug effects on mitochondrial function are frequently characterized in vitro. Whether these findings are relevant pharmacologically or toxicologically is…”
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