Search Results - "Stojkov, Natasa J"

Repeated immobilization stress disturbed steroidogenic machinery and stimulated the expression of cAMP signaling elements and adrenergic receptors in Leydig cells by Stojkov, Natasa J, Janjic, Marija M, Bjelic, Maja M, Mihajlovic, Aleksandar I, Kostic, Tatjana S, Andric, Silvana A

“…This study was designed to evaluate the effect of acute (2 h daily) and repeated (2 h daily for 2 or 10 consecutive days) immobilization stress (IMO) on: 1)…”
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Anabolic–androgenic steroids induce apoptosis and NOS2 (nitric-oxide synthase 2) in adult rat Leydig cells following in vivo exposure by Janjic, Marija M., Stojkov, Natasa J., Andric, Silvana A., Kostic, Tatjana S.

“…Different effects of 2 and 10 weeks in vivo testosterone enanthate (TE) treatment on NO signaling and apoptosis in Leydig cell of adult rat. Two and ten weeks…”
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Protein kinase G-mediated stimulation of basal Leydig cell steroidogenesis by Andric, Silvana A, Janjic, Marija M, Stojkov, Natasa J, Kostic, Tatjana S

“…The androgen-secreting Leydig cells produce cGMP, but the pathways responsible for generation and actions of this intracellular messenger have been…”
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The opposite roles of glucocorticoid and α1-adrenergic receptors in stress triggered apoptosis of rat Leydig cells by Andric, Silvana A, Kojic, Zvezdana, Bjelic, Maja M, Mihajlovic, Aleksandar I, Baburski, Aleksandar Z, Sokanovic, Srdjan J, Janjic, Marija M, Stojkov, Natasa J, Stojilkovic, Stanko S, Kostic, Tatjana S

“…The stress-induced initiation of proapoptotic signaling in Leydig cells is relatively well defined, but the duration of this signaling and the mechanism(s)…”
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Testosterone-Induced Modulation of Nitric Oxide-cGMP Signaling Pathway and Androgenesis in the Rat Leydig Cells1 by Andric, Silvana A, Janjic, Marija M, Stojkov, Natasa J, Kostic, Tatjana S

“…Testosterone, acting as a systemic and local factor, is one of the major regulatory molecules that initiate and maintain testicular function. In the present…”
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Sildenafil treatment in vivo stimulates Leydig cell steroidogenesis via the cAMP/cGMP signaling pathway by Andric, Silvana A, Janjic, Marija M, Stojkov, Natasa J, Kostic, Tatjana S

“…Sildenafil citrate (Viagra), a cGMP-selective phosphodiesterase (PDE) inhibitor, is widely used to treat erectile dysfunction and pulmonary arterial…”
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Testosterone-Induced Modulation of Nitric Oxide-cGMP Signaling Pathway and Androgenesis in the Rat Leydig Cells by ANDRIC, Silvana A, JANJIC, Marija M, STOJKOV, Natasa J, KOSTIC, Tatjana S

“…Testosterone, acting as a systemic and local factor, is one of the major regulatory molecules that initiate and maintain testicular function. In the present…”
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The Opposing Roles of Nitric Oxide and cGMP in the Age-Associated Decline in Rat Testicular Steroidogenesis by Sokanovic, Srdjan J, Baburski, Aleksandar Z, Janjic, Marija M, Stojkov, Natasa J, Bjelic, Maja M, Lalosevic, Dusan, Andric, Silvana A, Stojilkovic, Stanko S, Kostic, Tatjana S

“…The molecular mechanism of the aging-associated dysfunction of Leydig cells (LCs) is complex and poorly understood. In this study, we analyzed the contribution…”
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Pharmacological doses of testosterone upregulated androgen receptor and 3-Beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase and impaired leydig cells steroidogenesis in adult rats by Kostic, Tatjana S, Stojkov, Natasa J, Bjelic, Maja M, Mihajlovic, Aleksandar I, Janjic, Marija M, Andric, Silvana A

“…Anabolic androgenic steroids (AAS) are testosterone derivatives originally designed to enhance muscular mass and used for the treatment of many clinical…”
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Prolonged in vivo administration of testosterone-enanthate, the widely used and abused anabolic androgenic steroid, disturbs prolactin and cAMP signaling in Leydig cells of adult rats by Bjelic, Maja M., Stojkov, Natasa J., Radovic, Sava M., Baburski, Aleksandar Z., Janjic, Marija M., Kostic, Tatjana S., Andric, Silvana A.

“…[Display omitted] •Administration of testosterone-enanthate for 10-weeks increased prolactin in pituitary.•Prolactin and increased Jak2/Jak3 could account for…”
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Molecular adaptations of testosterone-producing Leydig cells during systemic in vivo blockade of the androgen receptor by Bjelic, Maja M., Stojkov, Natasa J., Baburski, Aleksandar Z., Sokanovic, Srdjan J., Mihajlovic, Aleksandar I., Janjic, Marija M., Kostic, Tatjana S., Andric, Silvana A.

“…•Androcur prevented testosterone-reduced Leydig cells steroidogenic capacity/activity.•Androcur completely abolished testosterone-reduced expression of…”
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Transient Rise of Serum Testosterone Level after Single Sildenafil Treatment of Adult Male Rats by Janjic, Marija M., Stojkov, Natasa J., Bjelic, Maja M., Mihajlovic, Aleksandar I., Andric, Silvana A., Kostic, Tatjana S.

“…Phosphodiesterase type 5 (PDE5) inhibitors have been established in therapy for a variety of physiological disorders including erectile dysfunction. Despite…”
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Sustained in vivo blockade of α₁-adrenergic receptors prevented some of stress-triggered effects on steroidogenic machinery in Leydig cells by Stojkov, Natasa J, Janjic, Marija M, Baburski, Aleksandar Z, Mihajlovic, Aleksandar I, Drljaca, Dragana M, Sokanovic, Srdjan J, Bjelic, Maja M, Kostic, Tatjana S, Andric, Silvana A

“…This study was designed to systematically analyze and evaluate the effects of in vivo blockade of α₁-adrenergic receptors (α₁-ADRs) on the stress-induced…”
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In vivo blockade of α1-adrenergic receptors mitigates stress-disturbed cAMP and cGMP signaling in Leydig cells by Stojkov, Natasa J, Baburski, Aleksandar Z, Bjelic, Maja M, Sokanovic, Srdjan J, Mihajlovic, Aleksandar I, Drljaca, Dragana M, Janjic, Marija M, Kostic, Tatjana S, Andric, Silvana A

“…The molecular mechanism of stress-associated reproductive dysfunction is complex and largely unknown. This study was designed to systematically analyze…”
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Melatonin replacement restores the circadian behavior in adult rat Leydig cells after pinealectomy by Baburski, Aleksandar Z., Sokanovic, Srdjan J., Janjic, Marija M., Stojkov-Mimic, Natasa J., Bjelic, Maja M., Andric, Silvana A., Kostic, Tatjana S.

“…Melatonin actions on oscillators in reproductive organs are poorly understood. Here we analyzed melatonin effects on rhythmic expression of clock and…”
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Stress triggers mitochondrial biogenesis to preserve steroidogenesis in Leydig cells by Gak, Igor A., Radovic, Sava M., Dukic, Aleksandra R., Janjic, Marija M., Stojkov-Mimic, Natasa J., Kostic, Tatjana S., Andric, Silvana A.

“…Adaptability to stress is a fundamental prerequisite for survival. Mitochondria are a key component of the stress response in all cells. For…”
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Intratesticular alpha1-adrenergic receptors mediate stress-disturbed transcription of steroidogenic stimulator NUR77 as well as steroidogenic repressors DAX1 and ARR19 in Leydig cells of adult rats by Stojkov-Mimic, Natasa J., Bjelic, Maja M., Radovic, Sava M., Mihajlovic, Aleksandar I., Sokanovic, Srdjan J., Baburski, Aleksandar Z., Janjic, Marija M., Kostic, Tatjana S., Andric, Silvana A.

“…•In vivo blockade of testicular α1-ADRs reduces circulating androgen level.•α1-ADR blockade abolished stress-induced partial recovery of androgen…”
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In vivo blockade of  1-adrenergic receptors mitigates stress-disturbed cAMP and cGMP signaling in Leydig cells by Stojkov, N. J., Baburski, A. Z., Bjelic, M. M., Sokanovic, S. J., Mihajlovic, A. I., Drljaca, D. M., Janjic, M. M., Kostic, T. S., Andric, S. A.

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Protein kinase G‐dependent stimulation of Leydig cell steroidogenesis by Kostic, Tatjana S, Janjic, Marija M, Stojkov, Natasa J, Stojilkovic, Stanko S, Andric, Silvana A

“…The androgen‐secreting Leydig cells produce cGMP, but the pathways responsible for generation, degradation, and actions of this intracellular messenger have…”
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Involvement of nitric oxide‐cGMP signaling in Leyding cell stress response by Andric, Silvana A, Stojkov, Natasa J, Janjic, Marija M, Stojilkovic, Stanko S, Kostic, Tatjana S

“…The ability of stress to interfere with the Leydig cell steroidogenesis has been shown previously, but the intracellular signaling pathways involved in this…”
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