Search Results - "Stojkov, Darko"

In vivo evidence for extracellular DNA trap formation by Yousefi, Shida, Simon, Dagmar, Stojkov, Darko, Karsonova, Antonina, Karaulov, Alexander, Simon, Hans-Uwe

“…Extracellular DNA trap formation is a cellular function of neutrophils, eosinophils, and basophils that facilitates the immobilization and killing of invading…”
Get full text

Untangling “NETosis” from NETs by Yousefi, Shida, Stojkov, Darko, Germic, Nina, Simon, Dagmar, Wang, Xiaoliang, Benarafa, Charaf, Simon, Hans‐Uwe

“…Neutrophil extracellular trap (NET) formation is a cellular function of neutrophils that facilitates the immobilization and killing of invading microorganisms…”
Get full text

ROS and glutathionylation balance cytoskeletal dynamics in neutrophil extracellular trap formation by Stojkov, Darko, Amini, Poorya, Oberson, Kevin, Sokollik, Christiane, Duppenthaler, Andrea, Simon, Hans-Uwe, Yousefi, Shida

“…The antimicrobial defense activity of neutrophils partly depends on their ability to form neutrophil extracellular traps (NETs), but the underlying mechanism…”
Get full text

To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps by Boeltz, Sebastian, Amini, Poorya, Anders, Hans-Joachim, Andrade, Felipe, Bilyy, Rostyslav, Chatfield, Simon, Cichon, Iwona, Clancy, Danielle M., Desai, Jyaysi, Dumych, Tetiana, Dwivedi, Nishant, Gordon, Rachael Ann, Hahn, Jonas, Hidalgo, Andrés, Hoffmann, Markus H., Kaplan, Mariana J., Knight, Jason S., Kolaczkowska, Elzbieta, Kubes, Paul, Leppkes, Moritz, Manfredi, Angelo A., Martin, Seamus J., Maueröder, Christian, Maugeri, Norma, Mitroulis, Ioannis, Munoz, Luis E., Nakazawa, Daigo, Neeli, Indira, Nizet, Victor, Pieterse, Elmar, Radic, Marko Z, Reinwald, Christiane, Ritis, Konstantinos, Rovere-Querini, Patrizia, Santocki, Michal, Schauer, Christine, Schett, Georg, Shlomchik, Mark Jay, Simon, Hans-Uwe, Skendros, Panagiotis, Stojkov, Darko, Vandenabeele, Peter, Berghe, Tom Vanden, van der Vlag, Johan, Vitkov, Ljubomir, von Köckritz-Blickwede, Maren, Yousefi, Shida, Zarbock, Alexander, Herrmann, Martin

“…Since the discovery and definition of neutrophil extracellular traps (NETs) 14 years ago, numerous characteristics and physiological functions of NETs have…”
Get full text

Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production by Amini, Poorya, Stojkov, Darko, Felser, Andrea, Jackson, Christopher B., Courage, Carolina, Schaller, André, Gelman, Laurent, Soriano, Maria Eugenia, Nuoffer, Jean-Marc, Scorrano, Luca, Benarafa, Charaf, Yousefi, Shida, Simon, Hans-Uwe

“…Optic atrophy 1 (OPA1) is a mitochondrial inner membrane protein that has an important role in mitochondrial fusion and structural integrity. Dysfunctional…”
Get full text

Editorial: Neutrophil extracellular traps: mechanistic and functional insight by Manda-Handzlik, Aneta, Stojkov, Darko, Wachowska, Malgorzata, Surmiak, Marcin

Get full text

Transcriptional Insights of Oxidative Stress and Extracellular Traps in Lung Tissues of Fatal COVID-19 Cases by Hosseini, Aref, Stojkov, Darko, Fettrelet, Timothée, Bilyy, Rostyslav, Yousefi, Shida, Simon, Hans-Uwe

“…Neutrophil extracellular traps (NETs) and oxidative stress are considered to be beneficial in the innate immune defense against pathogens. However, defective…”
Get full text

NET formation can occur independently of RIPK3 and MLKL signaling by Amini, Poorya, Stojkov, Darko, Wang, Xiaoliang, Wicki, Simone, Kaufmann, Thomas, Wong, Wendy Wei‐Lynn, Simon, Hans‐Uwe, Yousefi, Shida

“…The importance of neutrophil extracellular traps (NETs) in innate immunity is well established but the molecular mechanisms responsible for their formation are…”
Get full text

LTB4 and 5-oxo-ETE from extracellular vesicles stimulate neutrophils in granulomatosis with polyangiitis by Surmiak, Marcin, Gielicz, Anna, Stojkov, Darko, Szatanek, Rafał, Wawrzycka-Adamczyk, Katarzyna, Yousefi, Shida, Simon, Hans-Uwe, Sanak, Marek

“…Activation of neutrophils is an important mechanism in the pathology of granulomatosis with polyangiitis (GPA). In this study, we evaluated whether…”
Get full text

Nascent RHOH acts as a molecular brake on actomyosin-mediated effector functions of inflammatory neutrophils by Peng, Shuang, Stojkov, Darko, Gao, Jian, Oberson, Kevin, Latzin, Philipp, Casaulta, Carmen, Yousefi, Shida, Simon, Hans-Uwe

“…In contrast to molecular changes associated with increased inflammatory responses, little is known about intracellular counter-regulatory mechanisms that…”
Get full text

The regulatory role of eosinophils in adipose tissue depends on autophagy by Hosseini, Aref, Germic, Nina, Markov, Nikita, Stojkov, Darko, Oberson, Kevin, Yousefi, Shida, Simon, Hans-Uwe

“…Obesity is a metabolic condition that elevates the risk of all-cause mortality. Brown and beige adipose tissues, known for their thermogenic properties, offer…”
Get full text

Physiological and Pathophysiological Roles of Metabolic Pathways for NET Formation and Other Neutrophil Functions by Stojkov, Darko, Gigon, Lea, Peng, Shuang, Lukowski, Robert, Ruth, Peter, Karaulov, Alexander, Rizvanov, Albert, Barlev, Nickolai A, Yousefi, Shida, Simon, Hans-Uwe

“…Neutrophils are the most numerous cells in the leukocyte population and essential for innate immunity. To limit their effector functions, neutrophils are able…”
Get full text

Syntaxin-4 and SNAP23 are involved in neutrophil degranulation, but not in the release of mitochondrial DNA during NET formation by Gigon, Lea, Fettrelet, Timothée, Miholic, Marta, McLeish, Kenneth R., Yousefi, Shida, Stojkov, Darko, Simon, Hans-Uwe

“…Neutrophils are a specialized subset of white blood cells, which have the ability to store pre-formed mediators in their cytoplasmic granules. Neutrophils are…”
Get full text

BIF-1 inhibits both mitochondrial and glycolytic ATP production: its downregulation promotes melanoma growth by Frangež, Živa, Fernández-Marrero, Yuniel, Stojkov, Darko, Seyed Jafari, S. Morteza, Hunger, Robert E., Djonov, Valentin, Riether, Carsten, Simon, Hans-Uwe

“…Endophilin B1, also known as BAX-interacting protein 1 (BIF-1), is part of the endophilin B protein family, and is a multifunctional protein involved in the…”
Get full text

The BK Channel Limits the Pro-Inflammatory Activity of Macrophages by Chen, Yihe, Markov, Nikita, Gigon, Lea, Hosseini, Aref, Yousefi, Shida, Stojkov, Darko, Simon, Hans-Uwe

“…Macrophages play a crucial role in the innate immune response, serving as key effector cells in the defense against pathogens. Although the role of the…”
Get full text

The Release Kinetics of Eosinophil Peroxidase and Mitochondrial DNA Is Different in Association with Eosinophil Extracellular Trap Formation by Germic, Nina, Fettrelet, Timothée, Stojkov, Darko, Hosseini, Aref, Horn, Michael P, Karaulov, Alexander, Simon, Dagmar, Yousefi, Shida, Simon, Hans-Uwe

“…Eosinophils are a subset of granulocytes characterized by a high abundance of specific granules in their cytoplasm. To act as effector cells, eosinophils…”
Get full text

NETs: Important players in asthma? by Stojkov, Darko, Yousefi, Shida, Simon, Hans-Uwe

Get full text

Neither eosinophils nor neutrophils require ATG5‐dependent autophagy for extracellular DNA trap formation by Germic, Nina, Stojkov, Darko, Oberson, Kevin, Yousefi, Shida, Simon, Hans‐Uwe

“…Summary The importance of extracellular traps (ETs) in innate immunity is well established, but the molecular mechanisms responsible for their formation remain…”
Get full text

Established and emerging roles for mitochondria in neutrophils by Peng, Shuang, Gao, Jian, Stojkov, Darko, Yousefi, Shida, Simon, Hans‐Uwe

“…Summary Neutrophils are the most abundant innate immune cells in human blood, emerging as important players in a variety of diseases. Mitochondria are…”
Get full text

NET formation is independent of gasdermin D and pyroptotic cell death by Stojkov, Darko, Claus, Meike J, Kozlowski, Evelyne, Oberson, Kevin, Schären, Olivier P, Benarafa, Charaf, Yousefi, Shida, Simon, Hans-Uwe

“…Neutrophil extracellular traps (NETs) are DNA scaffolds coated with granule proteins that are released by neutrophils to ensnare and kill bacteria. NET…”
Get more information