Search Results - "Stojan, Jure"

Rapid Mechanistic Evaluation and Parameter Estimation of Putative Inhibitors in a Single-Step Progress-Curve Analysis: The Case of Horse Butyrylcholinesterase by Stojan, Jure

“…Highly efficient and rapid lead compound evaluation for estimation of inhibition parameters and type of inhibition is proposed. This is based on a single…”
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Discovery, Biological Evaluation, and Crystal Structure of a Novel Nanomolar Selective Butyrylcholinesterase Inhibitor by Brus, Boris, Košak, Urban, Turk, Samo, Pišlar, Anja, Coquelle, Nicolas, Kos, Janko, Stojan, Jure, Colletier, Jacques-Philippe, Gobec, Stanislav

“…Butyrylcholinesterase (BChE) is regarded as a promising drug target as its levels and activity significantly increase in the late stages of Alzheimer’s…”
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Development of an in-vivo active reversible butyrylcholinesterase inhibitor by Košak, Urban, Brus, Boris, Knez, Damijan, Šink, Roman, Žakelj, Simon, Trontelj, Jurij, Pišlar, Anja, Šlenc, Jasna, Gobec, Martina, Živin, Marko, Tratnjek, Larisa, Perše, Martina, Sałat, Kinga, Podkowa, Adrian, Filipek, Barbara, Nachon, Florian, Brazzolotto, Xavier, Więckowska, Anna, Malawska, Barbara, Stojan, Jure, Raščan, Irena Mlinarič, Kos, Janko, Coquelle, Nicolas, Colletier, Jacques-Philippe, Gobec, Stanislav

“…Alzheimer’s disease (AD) is characterized by severe basal forebrain cholinergic deficit, which results in progressive and chronic deterioration of memory and…”
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Cytochrome P450 monooxygenase CYP53 family in fungi: comparative structural and evolutionary analysis and its role as a common alternative anti-fungal drug target by Jawallapersand, Poojah, Mashele, Samson Sitheni, Kovačič, Lidija, Stojan, Jure, Komel, Radovan, Pakala, Suresh Babu, Kraševec, Nada, Syed, Khajamohiddin

“…Cytochrome P450 monooxygenases (CYPs/P450s) are heme-thiolate proteins whose role as a drug target against pathogenic microbes has been explored because of…”
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Ruthenium complexes show potent inhibition of AKR1C1, AKR1C2, and AKR1C3 enzymes and anti-proliferative action against chemoresistant ovarian cancer cell line by Kljun, Jakob, Pavlič, Renata, Hafner, Eva, Lipec, Tanja, Moreno-Da Silva, Sara, Tič, Primož, Turel, Iztok, Büdefeld, Tomaž, Stojan, Jure, Rižner, Tea Lanišnik

“…In this study, we present the synthesis, kinetic studies of inhibitory activity toward aldo-keto reductase 1C (AKR1C) enzymes, and anticancer potential toward…”
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ENZO: a web tool for derivation and evaluation of kinetic models of enzyme catalyzed reactions by Bevc, Staš, Konc, Janez, Stojan, Jure, Hodošček, Milan, Penca, Matej, Praprotnik, Matej, Janežič, Dušanka

“…We describe a web tool ENZO (Enzyme Kinetics), a graphical interface for building kinetic models of enzyme catalyzed reactions. ENZO automatically generates…”
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Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes by Pajk, Stane, Knez, Damijan, Košak, Urban, Zorović, Maja, Brazzolotto, Xavier, Coquelle, Nicolas, Nachon, Florian, Colletier, Jacques-Philippe, Živin, Marko, Stojan, Jure, Gobec, Stanislav

“…Brain butyrylcholinesterase (BChE) is an attractive target for drugs designed for the treatment of Alzheimer's disease (AD) in its advanced stages. It also…”
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Evidence for inhibition of cholinesterases in insect and mammalian nervous systems by the insect repellent deet by Corbel, Vincent, Stankiewicz, Maria, Pennetier, Cédric, Fournier, Didier, Stojan, Jure, Girard, Emmanuelle, Dimitrov, Mitko, Molgó, Jordi, Hougard, Jean-Marc, Lapied, Bruno

“…N,N-Diethyl-3-methylbenzamide (deet) remains the gold standard for insect repellents. About 200 million people use it every year and over 8 billion doses have…”
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Oleic acid metabolism via a conserved cytochrome P450 system-mediated ω-hydroxylation in the bark beetle-associated fungus Grosmannia clavigera by Novak, Metka, Lah, Ljerka, Šala, Martin, Stojan, Jure, Bohlmann, Joerg, Komel, Radovan

“…The bark beetle-associated fungus Grosmannia clavigera participates in the large-scale destruction of pine forests. In the tree, it must tolerate saturating…”
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Glioblastoma-specific anti-TUFM nanobody for in-vitro immunoimaging and cancer stem cell targeting by Samec, Neja, Jovcevska, Ivana, Stojan, Jure, Zottel, Alja, Liovic, Mirjana, Myers, Michael P, Muyldermans, Serge, Šribar, Jernej, Križaj, Igor, Komel, Radovan

“…Glioblastoma multiforme (GBM) is the most common and lethal form of brain tumor. The prognosis for patients remains poor, despite the combination of new…”
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Intestinal cell barrier function in vitro is severely compromised by keratin 8 and 18 mutations identified in patients with inflammatory bowel disease by Zupancic, Tina, Stojan, Jure, Lane, Ellen Birgitte, Komel, Radovan, Bedina-Zavec, Apolonija, Liovic, Mirjana

“…Keratin 8 and 18 (K8/K18) mutations have been implicated in the aetiology of certain pathogenic processes of the liver and pancreas. While some K8 mutations…”
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8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases by Knez, Damijan, Diez-Iriepa, Daniel, Chioua, Mourad, Gottinger, Andrea, Denic, Milica, Chantegreil, Fabien, Nachon, Florian, Brazzolotto, Xavier, Skrzypczak-Wiercioch, Anna, Meden, Anže, Pišlar, Anja, Kos, Janko, Žakelj, Simon, Stojan, Jure, Sałat, Kinga, Serrano, Julia, Fernández, Ana Patricia, Sánchez-García, Aitana, Martínez-Murillo, Ricardo, Binda, Claudia, López-Muñoz, Francisco, Gobec, Stanislav, Marco-Contelles, José

“…We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and…”
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CYP53A15 of Cochliobolus lunatus, a Target for Natural Antifungal Compounds by Podobnik, Barbara, Stojan, Jure, Lah, Ljerka, Kras̆evec, Nada, Selis̆kar, Matej, Riz̆ner, Tea Lanis̆nik, Rozman, Damjana, Komel, Radovan

“…A novel cytochrome P450, CYP53A15, was identified in the pathogenic filamentous ascomycete Cochliobolus lunatus. The protein, classified into the CYP53 family,…”
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The mechanism and benefit of human butyrylcholinesterase activation by what would otherwise be inhibitors by Stojan, Jure

“…Activation of human butyrylcholinesterase by small quaternary ammonium ions is known. Here, additional ligands in this series are presented: edrophonium and…”
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Lost archives and found voices: reconstructing the marketing history of medical marijuana in Austria-Hungary by Stojan, Jure

“…Purpose The purpose of this paper is to reconstruct the marketing history of medical marijuana cigarettes in the past three decades of Austria-Hungary…”
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Acetylcholinesterase alterations reveal the fitness cost of mutations conferring insecticide resistance by Shi, Ming An, Lougarre, Andrée, Alies, Carole, Frémaux, Isabelle, Tang, Zhen Hua, Stojan, Jure, Fournier, Didier

“…Insecticide resistance is now common in insects due to the frequent use of chemicals to control them, which provides a useful tool to study the adaptation of…”
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Conformational rigidity of cholinesterases allows for the prediction of combined effects in a particular double mutant by Stojan, Jure

“…The conformational rigidity of Drosophila melanogaster AChE, was checked by kinetic means on recombinant enzyme with the substitutions of two important amino…”
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Correction: Evidence for inhibition of cholinesterases in insect and mammalian nervous systems by the insect repellent deet by Corbel, Vincent, Stankiewicz, Maria, Pennetier, Cédric, Fournier, Didier, Stojan, Jure, Girard, Emmanuelle, Dimitrov, Mitko, Molgó, Jordi, Hougard, Jean-Marc, Lapied, Bruno

“…Doc number: 86…”
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Disentangling the formation, mechanism, and evolvement of the covalent methanesulfonyl fluoride acetylcholinesterase adduct: Insights into an aged‐like inactive complex susceptible to reactivation by a combination of nucleophiles by Stojan, Jure, Pesaresi, Alessandro, Meden, Anže, Lamba, Doriano

“…Chemical warfare nerve agents and pesticides, known as organophosphorus compounds inactivate cholinesterases (ChEs) by phosphorylating the serine hydroxyl…”
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The significance of low substrate concentration measurements for mechanistic interpretation in cholinesterases by Stojan, Jure

“…► A procedure to obtain high relevance initial rate data in kinetics is described. ► We derive equations to simplify reaction mechanism at low substrate…”
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