Search Results - "Stoika, R."

Systems biology: essential principles and OMICS approaches by Stoika, R.

“…The systems biology is a new branch of modern biology aimed at studying various systems existing in nature on the level of their biological components such as…”
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Selected 5-amino-1-aryl-1H-1,2,3-triazole scaffolds as promising antiproliferative agents by Pokhodylo, N., Shyyka, O., Finiuk, N., Stoika, R.

“…Development of a new effective drugs with low side effects and definite chemical characteristics needs indentification of bioactive scaffolds for further…”
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Application of C60 Fullerene-Doxorubicin Complex for Tumor Cell Treatment In Vitro and In Vivo by Panchuk, R R, Prylutska, S V, Chumakl, V V, Skorokhyd, N R, Lehka, L V, Evstigneev, M P, Prylutskyy, Yu I, Berger, W, Heffeter, P, Scharff, P, Ritter, U, Stoika, R S

“…Development of nanocarriers for effective drug delivery to molecular targets in tumor cells is a real problem in modern pharmaceutical chemistry. In the…”
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Enhanced Proapoptotic Effects of Water Dispersed Complexes of 4-Thiazolidinone-Based Chemotherapeutics with a PEG-Containing Polymeric Nanocarrier by Kobylinska, L., Ivasechko, I., Skorokhyd, N., Panchuk, R., Riabtseva, A., Mitina, N., Zaichenko, A., Lesyk, R., Zimenkovsky, B., Stoika, R., Vari, S. G.

“…Aim To study whether water formulation of the complex of 4-thiazolidinone derivatives with a PEG-containing polymeric nanocarrier enhances their pro-apoptotic…”
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Targeting of the pro-oxidant-antioxidant balance in vitro and in vivo by 4-thiazolidinone-based chemotherapeutics with anticancer potential by Kobylinska, L., Klyuchivska, O., Lesyk, R., Stoika, R.

“…Oxidative stress is one of the main mechanisms by which anticancer chemotherapeutics damage normal tissues and organs. At the same time, it is an important…”
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Novel putative ligands of cannabinoid receptors: synthesis and effects on cell signaling and neuronal functions by Senkiv, J., Kryshchyshyn-Dylevych, A., Khylyuk, D., Wujec, M., Stoika, R., Irving, A. J., Lesyk, R.

“…Cannabinoid ligands are known to possess neuroprotective actions and may have utility in the treatment of neurodegeneration. The major targets for cannabinoids…”
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Multifunctional chitosan-based hydrogels: characterization and evaluation of biocompatibility and biodegradability in vitro by Manko, N., Lootsik, M., Antonyuk, V., Ivasechko, I., Skorokhyd, N., Kosiakova, H., Mehed’, O., Horid’ko, T., Hula, N., Klyuchivska, O., Panchuk, R., Pokhodylo, N., Barabash, О., Dumych, T., Stoika, R.

“…Creation of novel remedies efficient in supporting wound healing remains an actual task in pharmacology. Hydrogels showed high efficiency in wound healing and…”
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Honeybee chitosan-melanin complex: isolation and investigation of antimicrobial activity by Lootsik, M., Manko, N., Gromyko, O., Tistechok, S., Lutsyk (Jr.), M., Stoika, R.

“…Antimicrobial activity of marine crustaceans chitosans is well studied and is widely used in medicine, while chitosans of insects are poorly investigated in…”
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Evaluation of Phytotoxicity and Mutagenicity of Novel DMAEMA-Containing Gene Carriers by Finiuk, N., Romanyuk, N., Mitina, N., Lobachevska, O., Zaichenko, A., Terek, O., Stoika, R.

“…—The use of novel carriers for gene delivery has been rapidly growing; thus, investigation of potential phytotoxic and mutagenic action of gene delivery…”
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Identification of cortactin molecular forms in human urine and their possible diagnostic value by Starykovych, M., Souchelnytskyi, S., Fayura, O., Abrahamovych, O., Abrahamovych, M., Lukavetskyy, N., Stoika, R., Kit, Y.

“…The protein composition of human urine reflects changes in the biochemical and physiological status of an individual and has an essential diagnostic value…”
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Desialylation of dying cells with catalytically active antibodies possessing sialidase activity facilitate their clearance by human macrophages by Tomin, A., Dumych, T., Tolstyak, Y., Kril, I., Mahorivska, I., Bila, E., Stoika, R., Herrmann, M., Kit, Y., Bilyy, R.

“…Summary Recently we reported the first known incidence of antibodies possessing catalytic sialidase activity (sialidase abzymes) in the serum of patients with…”
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Water-soluble pristine fullerenes C60 increase the specific conductivity and capacity of lipid model membrane and form the channels in cellular plasma membrane by Prylutska, S, Bilyy, R, Overchuk, M, Bychko, A, Andreichenko, K, Stoika, R, Rybalchenko, V, Prylutskyy, Y, Tsierkezos, N G, Ritter, U

“…The aim of the present work was the investigation of the interaction of water-soluble pristine fullerenes C60 with bimolecular lipid model membrane (BLM) and…”
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Antineoplastic Activity In Vitro of 2-amino-5-benzylthiasol Derivative in the Complex with Nanoscale Polymeric Carriers by Finiuk, N. S., Popovych, M. V., Shalai, Ya. R., Mandzynets’, S. M., Hreniuh, V. P., Ostapiuk, Yu. V., Obushak, M. D., Mitina, N. E., Zaichenko, O. S., Stoika, R. S., Babsky, A. M.

“…The main problems of contemporary chemotherapy are the insufficient efficacy of antitumor drugs and low selectivity of their action, development of multidrug…”
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Anti-histone H1 IgGs possess proliferative activity towards human T-leukaemia CEM cells by Kit, Y, Magorivska, I, Bilyi, R, Myronovskij, S, Stoika, R

“…The aim of this study was to characterize the proliferative activity of the anti-histone H1 IgGs towards human T-leukaemia CEM cells. Anti-histone H1 IgGs were…”
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Effect of Thermodiffusion Nitriding on Cytocompatibility of Ti-6Al-4V Titanium Alloy by Pohrelyuk, I. M., Tkachuk, O. V., Proskurnyak, R. V., Boiko, N. M., Kluchivska, O. Yu, Stoika, R. S.

“…The nitrided layer was formed on the surface of Ti-6Al-4V titanium alloy by the thermodiffusion saturation in nitrogen at the atmospheric pressure. The study…”
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Chemistry and biology of landomycins, an expanding family of polyketide natural products by Ostash, B, Korynevska, A, Stoika, R, Fedorenko, V

“…This review covers existing literature (from 1990 to 2008) on landomycins (LS), a family of glycosylated angucyclines, with an emphasis on the bioactivity…”
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Cytotoxic proteins of Amanita virosa Secr. mushroom: Purification, characteristics and action towards mammalian cells by Antonyuk, V.O., Yu Klyuchivska, O., Stoika, R.S.

“…A new hemolytic lectin was purified from the fruit bodies of Amanita virosa Secr. mushroom by the affinity chromatography on the cross-linked ovomucin. This…”
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THE ROLE OF REACTIVE OXYGEN SPECIES IN TUMOR CELLS APOPTOSIS INDUCED BY LANDOMYCIN A by Lehka, L V, Panchuk, R R, Berger, W, Rohr, Ju, Stoika, R S

“…Landomycin A (LA) is a new antitumor antibiotic of angucycline group, possessing high antitumor activity against cancer cells of different origin, which…”
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Use of lectins as vector molecules for delivery of drugs to cells and tissues. Report 2 by Antonyuk, V. O., Skorohyd, N. R., Lozynskyi, A. V., Antonyuk, R. V., Lesyk, R. B., Stoika, R. S.

“…Aim.To determine cytotoxic effects towards a tumor cells culture of the heterocyclic derivative conjugated with lectins of different carbohydrate specificity…”
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Nanoformulation improves activity of the (pre)clinical anticancer ruthenium complex KP1019 by Heffeter, P, Riabtseva, A, Senkiv, Y, Kowol, C R, Körner, W, Jungwith, U, Mitina, N, Keppler, B K, Konstantinova, T, Yanchuk, I, Stoika, R, Zaichenko, A, Berger, W

“…Ruthenium anticancer drugs belong to the most promising non-platinum anticancer metal compounds in clinical evaluation. However, although the clinical results…”
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