Search Results - "Stohs, S J"

Oxidative mechanisms in the toxicity of metal ions by Stohs, S.J., Bagchi, D.

“…The role of reactive oxygen species, with the subsequent oxidative deterioration of biological macromolecules in the toxicities associated with transition…”
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In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticides by Bagchi, D., Bagchi, M., Hassoun, E.A., Stohs, S.J.

“…Reactive oxygen species may be involved in the toxicity of various pesticides and we have, therefore, examined the in vivo effects of structurally dissimilar…”
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Multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women: a randomized controlled trial by Hackman, R.M, Havel, P.J, Schwartz, H.J, Rutledge, J.C, Watnik, M.R, Noceti, E.M, Stohs, S.J, Stern, S, Keen, C.L

“…Objective: To determine the safety and efficacy of a dietary supplement with a low dose of ephedra and caffeine in overweight/obese premenopausal female…”
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Chromium (VI)-induced oxidative stress, apoptotic cell death and modulation of p53 tumor suppressor gene by Bagchi, D, Bagchi, M, Stohs, S J

“…Chromium (VI) is a widely used industrial chemical, extensively used in paints, metal finishes, steel including stainless steel manufacturing, alloy cast…”
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Safety assessment of (−)-hydroxycitric acid and Super CitriMax ®, a novel calcium/potassium salt by Soni, M.G., Burdock, G.A., Preuss, H.G., Stohs, S.J., Ohia, S.E., Bagchi, D.

“…(−)-Hydroxycitric acid (HCA) is a principle constituent (10–30%) of the dried fruit rind of Garcinia cambogia, a plant native to Southeastern Asia. The dried…”
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The glutathione defense system in the pathogenesis of rheumatoid arthritis by Hassan, M. Q., Hadi, R. A., Al-Rawi, Z. S., Padron, V. A., Stohs, S. J.

“…In order to assess a possible role of the natural glutathione defense system in the pathogenesis of rheumatoid arthritis (RA), serum reduced glutathione levels…”
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Cadmium-induced excretion of urinary lipid metabolites, DNA damage, glutathione depletion, and hepatic lipid peroxidation in Sprague-Dawley rats by Bagchi, D, Bagchi, M, Hassoun, E A, Stohs, S J

“…Recent studies have described lipid peroxidation to be an early and sensitive consequence of cadmium exposure, and free radical scavengers and antioxidants…”
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cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cells by Ye, X, Krohn, R.L, Liu, W, Joshi, S.S, Kuszynski, C.A, McGinn, T.R, Bagchi, M, Preuss, H.G, Stohs, S.J, Bagchi, D

“…Grape seed proanthocyanidins are natural antioxidants which possess a broad spectrum of chemoprotective properties against free radicals and oxidative stress…”
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Cadmium-induced production of superoxide anion and nitric oxide, DNA single strand breaks and lactate dehydrogenase leakage in J774A.1 cell cultures by Hassoun, Ezdihar A., Stohs, Sidney J.

“…The involvement of reactive oxygen species in the toxicity of cadmium (Cd) has been proposed. We have, therefore, examined the effects of this cation on the…”
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Citrus aurantium (bitter orange) extract: Safety assessment by acute and 14-day oral toxicity studies in rats and the Ames Test for mutagenicity by Deshmukh, N.S., Stohs, S.J., Magar, C.C., Kadam, S.B.

“…The primary active constituent in bitter orange extract (BOE) is p-synephrine. This study assessed the safety of a BOE standardized to 50% p-synephrine…”
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Cadmium- and chromium-induced oxidative stress, DNA damage, and apoptotic cell death in cultured human chronic myelogenous leukemic K562 cells, promyelocytic leukemic HL-60 cells, and normal human peripheral blood mononuclear cells by Bagchi, D., Joshi, S. S., Bagchi, M., Balmoori, J., Benner, E. J., Kuszynski, C. A., Stohs, S. J.

“…Sodium dichromate [Cr(VI)] and cadmium chloride [Cd(II)] are both cytotoxic and mutagenic. This study examined the toxic and apoptotic potentials of these two…”
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In vitro and in vivo induction of heat shock (stress) protein (Hsp) gene expression by selected pesticides by Bagchi, D., Bhattacharya, G., Stohs, S.J.

“…The chloroacetamide insecticide alachlor, polyhalogenated cyclic hydrocarbons endrin and chlordane and the organophosphate pesticides chlorpyrifos and fenthion…”
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Induction of Oxidative Stress by Chronic Administration of Sodium Dichromate [Chromium VI] and Cadmium Chloride [Cadmium II] to Rats by Bagchi, D, Vuchetich, P.J, Bagchi, M, Hassoun, E.A, Tran, M.X, Tang, L, Stohs, S.J

“…Recent studies have demonstrated that both chromium (VI) and cadmium (II) induce an oxidative stress, as determined by increased hepatic lipid peroxidation,…”
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Production of reactive oxygen species by gastric cells in association with Helicobacter pylori by Bagchi, D, Bhattacharya, G, Stohs, S J

“…Reactive oxygen species (ROS) and Helicobacter pylori have been identified as pathogenic factors in several gastrointestinal disorders. Since little…”
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Stress, diet and alcohol-induced oxidative gastrointestinal mucosal injury in rats and protection by bismuth subsalicylate by Bagchi, D., Carryl, O. R., Tran, M. X., Krohn, R. L., Bagchi, D. J., Garg, A., Bagchi, M., Mitra, S., Stohs, S. J.

“…Oxygen free radicals are implicated in the pathogenesis of stress and food/alcohol‐induced gastrointestinal injury. We have investigated the effects of…”
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The relative abilities of TCDD and its congeners to induce oxidative stress in the hepatic and brain tissues of rats after subchronic exposure by Hassoun, Ezdihar A., Li, Feng, Abushaban, Ahmed, Stohs, Sidney J.

“…The abilities of single doses of 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) to induce oxidative stress in hepatic and some extra-hepatic tissues of animals,…”
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Comparative in vitro and in vivo protein kinase C activation by selected pesticides and transition metal salts by Bagchi, D., Bagchi, M., Tang, L., Stohs, S.J.

“…Various pesticides and transition metals induce oxidative deterioration of biological macromolecules. Protein kinase C (PKC) may mediate' these effects…”
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In vitro induction of reactive oxygen species by 2,3,7,8-tetrachlorodibenzo-p-dioxin, endrin, and lindane in rat peritoneal macrophages, and hepatic mitochondria and microsomes by Bagchi, M, Stohs, S J

“…Hepatic mitochondria and microsomes as well as peritoneal macrophages from female Sprague-Dawley rats were incubated for up to 30 min at 37 degrees C in the…”
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Modulation of TCDD-induced fetotoxicity and oxidative stress in embryonic and placental tissues of C57BL/6J mice by vitamin E succinate and ellagic acid by Hassoun, E.A, Walter, A.C, Alsharif, N.Z, Stohs, S.J

“…The ability of vitamin E succinate and ellagic acid to modulate 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD)-induced developmental toxicity and oxidative damage…”
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Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro by Bagchi, D, Garg, A, Krohn, R L, Bagchi, M, Tran, M X, Stohs, S J

“…Proanthocyanidins, a group of polyphenolic bioflavonoids, have been reported to exhibit a wide range of biological, pharmacological and chemoprotective…”
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