Search Results - "Stoddart, Angela"

Inhibition of WNT signaling in the bone marrow niche prevents the development of MDS in the Apcdel/+ MDS mouse model by Stoddart, Angela, Wang, Jianghong, Hu, Chunmei, Fernald, Anthony A., Davis, Elizabeth M., Cheng, Jason X., Le Beau, Michelle M.

“…There is accumulating evidence that functional alteration(s) of the bone marrow (BM) microenvironment contribute to the development of some myeloid disorders,…”
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CUX1 regulates human hematopoietic stem cell chromatin accessibility via the BAF complex by Liu, Weihan, Kurkewich, Jeffrey L., Stoddart, Angela, Khan, Saira, Anandan, Dhivyaa, Gaubil, Alexandre N., Wolfgeher, Donald J., Jueng, Lia, Kron, Stephen J., McNerney, Megan E.

“…CUX1 is a homeodomain-containing transcription factor that is essential for the development and differentiation of multiple tissues. CUX1 is recurrently…”
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Cytogenetic and genetic pathways in therapy-related acute myeloid leukemia by Qian, Zhijian, Joslin, John M., Tennant, Thelma R., Reshmi, Shalini C., Young, David J., Stoddart, Angela, Larson, Richard A., Le Beau, Michelle M.

“…Therapy-related myelodysplastic syndrome and acute myeloid leukemia (t-MDS/t-AML) are late complications of cytotoxic therapy used in the treatment of…”
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Plasticity of B cell receptor internalization upon conditional depletion of clathrin by Stoddart, Angela, Jackson, Antony P, Brodsky, Frances M

“…B cell antigen receptor (BCR) association with lipid rafts, the actin cytoskeleton, and clathrin-coated pits influences B cell signaling and antigen…”
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The B Lymphocyte Adaptor Molecule of 32 Kilodaltons (Bam32) Regulates B Cell Antigen Receptor Internalization by Niiro, Hiroaki, Allam, Atef, Stoddart, Angela, Brodsky, Frances M, Marshall, Aaron J, Clark, Edward A

“…The B lymphocyte adaptor molecule of 32 kDa (Bam32) is an adaptor that plays an indispensable role in BCR signaling. In this study, we found that upon BCR…”
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Knockdown of Hnrnpa0, a del(5q) gene, alters myeloid cell fate in murine cells through regulation of AU-rich transcripts by Young, David J, Stoddart, Angela, Nakitandwe, Joy, Chen, Shann-Ching, Qian, Zhijian, Downing, James R, Le Beau, Michelle M

“…The control of mRNA stability plays a central role in orchestrating gene-regulatory networks in hematopoietic cell growth, differentiation and tumorigenesis…”
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Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms by Stoddart, Angela, Qian, Zhijian, Fernald, Anthony A, Bergerson, Rachel J, Wang, Jianghong, Karrison, Theodore, Anastasi, John, Bartom, Elizabeth T, Sarver, Aaron L, McNerney, Megan E, Largaespada, David A, Le Beau, Michelle M

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Genetic pathways leading to therapy-related myeloid neoplasms by Stoddart, Angela, McNerney, Megan E, Bartom, Elizabeth, Bergerson, Rachel, Young, David J, Qian, Zhijian, Wang, Jianghong, Fernald, Anthony A, Davis, Elizabeth M, Larson, Richard A, White, Kevin P, Le Beau, Michelle M

“…Therapy-related myeloid neoplasm (t-MN) is a distinctive clinical syndrome occurring after exposure to chemotherapy or radiotherapy. t-MN arises in most cases…”
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Chromosome 7 Myeloid Tumor Suppressor Genes Cooperate in Chemotherapy Resistance by Jotte, Matthew R.M., Nam, Henna S., Hu, Bonnie, Martinez, Tanner C., Khan, Saira, An, Ningfei, Stoddart, Angela, McNerney, Megan E.

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Lysosomal and Cytosolic Sialic Acid 9-O-Acetylesterase Activities Can Be Encoded by One Gene via Differential Usage of a Signal Peptide-encoding Exon at the N Terminus by Takematsu, Hiromu, Diaz, Sandra, Stoddart, Angela, Zhang, Yu, Varki, Ajit

“…9-O-Acetylation is one of the most common modifications of sialic acids, and it can affect several sialic acid-mediated recognition phenomena. We previously…”
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Combined Deficiency of Chromosome 7 Myeloid Tumor Suppressors Enhances Chemotherapy Resistance by Jotte, Matthew R. M., Martinez, Tanner C., Stoddart, Angela, Imgruet, Molly K., Nam, Henna S., Hu, Bonnie, Khan, Saira, An, Ningfei, McNerney, Megan E.

“…Monosomy 7 and del(7q) [-7/del(7q)] are recurrent in myeloid neoplasms and associated with chemoresistance. -7/del(7q) is identified in up to half of…”
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3009 – COMBINED DEFICIENCY OF CHROMOSOME 7 MYELOID TUMOR SUPPRESSORS ENHANCES CHEMOTHERAPY RESISTANCE by Jotte, Matthew, Martinez, Tanner, Stoddart, Angela, Imgruet, Molly, Nam, Henna, Hu, Bonnie, Khan, Saira, An, Ningfei, McNerney, Megan

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Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice by Stoddart, Angela, Fernald, Anthony A., Wang, Jianghong, Davis, Elizabeth M., Karrison, Theodore, Anastasi, John, Le Beau, Michelle M.

“…An interstitial deletion of chromosome 5, del(5q), is the most common structural abnormality in primary myelodysplastic syndromes (MDS) and therapy-related…”
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EGR1 Haploinsufficiency Confers a Fitness Advantage to Hematopoietic Stem Cells Following Chemotherapy by Stoddart, Angela, Fernald, Anthony A., Davis, Elizabeth M., McNerney, Megan E., Le Beau, Michelle M.

“…•Loss of del(5q) gene, EGR1, imparts a clonal advantage to stem cells under stress.•Complete loss of EGR1 function is incompatible with malignant…”
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Abstract 5598: Combined loss of the chromosome 7 genes CUX1 and EZH2 promotes chemotherapy resistance by Jotte, Matthew R., Stoddart, Angela, Martinez, Tanner C., Xue, Yuqing, Imgruet, Molly K., McNerney, Megan E.

“…Abstract Monosomy 7 (-7) or del(7q) are recurrent in high-risk myeloid neoplasms, including up to 50% of myeloid neoplasms arising after prior exposure to…”
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Cytotoxic Therapy–Induced Effects on Both Hematopoietic and Marrow Stromal Cells Promotes Therapy-Related Myeloid Neoplasms by Stoddart, Angela, Wang, Jianghong, Fernald, Anthony A., Davis, Elizabeth M., Johnson, Camille R., Hu, Chunmei, Cheng, Jason X., McNerney, Megan E., Le Beau, Michelle M.

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Inhibition of Canonical WNT Signaling in the Bone Marrow Niche Prevents the Development of Disease in a Mouse MDS Model with Apc Haploinsufficiency by Stoddart, Angela, Wang, Jianghong, Hu, Chunmei, Fernald, Anthony A., Davis, Elizabeth M., Cheng, Jason X., Le Beau, Michelle M.

“…The myelodysplastic syndromes (MDS) include a spectrum of clonal hematopoietic stem cell (HSC) disorders that are characterized by ineffective hematopoiesis,…”
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Haploinsufficient loss of multiple 5q genes may fine-tune Wnt signaling in del(5q) therapy-related myeloid neoplasms by Stoddart, Angela, Nakitandwe, Joy, Chen, Shann-Ching, Downing, James R., Le Beau, Michelle M.

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Cytotoxic Exposure to Both Hematopoietic Stem and Progenitor Cells and the Bone Marrow Niche Cooperate to Promote Leukemogenesis in a Mouse Model of Therapy-Related Myeloid Neoplasms with a Del(5q) by Stoddart, Angela, Wang, Jianghong, Hu, Chunmei, Fernald, Anthony A., Davis, Elizabeth M., Cheng, Jason X., Le Beau, Michelle M.

“…A del(5q) is frequently noted in MDS, AML, and therapy-related myeloid neoplasms (t-MN) following alkylating agent therapy. Mutation/loss of the TP53 is gene…”
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Egr1 and Apc Haploinsufficiency Cooperate in the Pathogenesis of Myeloid Neoplasia: A Mouse Model for Therapy-Related Myeloid Neoplasms with a Del(5q) by Stoddart, Angela, Wang, Jianghong, Fernald, Anthony, Anastasi, John, Lebeau, Michelle

“…Abstract 117 Heterozygous deletions of the long arm of chromosome 5 are among the most common abnormalities in de novo (∼15% of patients) and therapy-related…”
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