Search Results - "Stockmeier, Craig"

Astrocyte pathology in major depressive disorder: insights from human postmortem brain tissue by Rajkowska, Grazyna, Stockmeier, Craig A

“…The present paper reviews astrocyte pathology in major depressive disorder (MDD) and proposes that reductions in astrocytes and related markers are key…”
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Decreased expression of synapse-related genes and loss of synapses in major depressive disorder by Kang, Hyo Jung, Voleti, Bhavya, Hajszan, Tibor, Rajkowska, Grazyna, Stockmeier, Craig A, Licznerski, Pawel, Lepack, Ashley, Majik, Mahesh S, Jeong, Lak Shin, Banasr, Mounira, Son, Hyeon, Duman, Ronald S

“…Ronald Duman and colleagues report that synapse number is reduced in subjects with major depressive disorder. This is associated with decreased expression of…”
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Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression by Feyissa, Anteneh M., Chandran, Agata, Stockmeier, Craig A., Karolewicz, Beata

“…Recent neuroimaging and postmortem studies have demonstrated abnormalities in glutamatergic transmission in major depression. Glutamate NMDA (N-methyl-…”
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Venlafaxine Stimulates an MMP-9-Dependent Increase in Excitatory/Inhibitory Balance in a Stress Model of Depression by Alaiyed, Seham, McCann, Mondona, Mahajan, Gouri, Rajkowska, Grazyna, Stockmeier, Craig A, Kellar, Kenneth J, Wu, Jian Young, Conant, Katherine

“…Emerging evidence suggests that there is a reduction in overall cortical excitatory to inhibitory balance in major depressive disorder (MDD), which afflicts…”
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GABAergic Neurons Immunoreactive for Calcium Binding Proteins are Reduced in the Prefrontal Cortex in Major Depression by Rajkowska, Grazyna, O'Dwyer, Gillian, Teleki, Zsofia, Stockmeier, Craig A, Miguel-Hidalgo, Jose Javier

“…Post-mortem morphometric studies report reductions in the average density and size of cortical neurons in the dorsolateral prefrontal cortex (dlPFC) and…”
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A negative regulator of MAP kinase causes depressive behavior by Stockmeier, Craig A, Licznerski, Pawel, Duric, Vanja, Duman, Ronald S, Simen, Arthur A, Newton, Samuel S, Schmidt, Heath D, Banasr, Mounira

“…The lifetime prevalence (∼16%) and the economic burden ($100 billion annually) associated with major depressive disorder (MDD) make it one of the most common…”
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Risk-taking behaviors and stressors differentially predict suicidal preparation, non-fatal suicide attempts, and suicide deaths by Athey, Alison, Overholser, James, Bagge, Courtney, Dieter, Lesa, Vallender, Eric, Stockmeier, Craig A.

“…•Risk-taking is elevated among suicide decedents.•Risk-taking is associated with non-fatal suicide attempts in decedents.•Suicide decedents who did not prepare…”
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Coverage of Blood Vessels by Astrocytic Endfeet Is Reduced in Major Depressive Disorder by Rajkowska, Grazyna, Hughes, Jonathan, Stockmeier, Craig A, Javier Miguel-Hidalgo, Jose, Maciag, Dorota

“…Background Depression and cerebrovascular disease influence each other, according to clinical studies. Despite this evidence, no studies have investigated the…”
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The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder by Jernigan, Courtney S., Goswami, Dharmendra B., Austin, Mark C., Iyo, Abiye H., Chandran, Agata, Stockmeier, Craig A., Karolewicz, Beata

“…Recent studies demonstrate that rapid antidepressant response to ketamine is mediated by activation of the mammalian target of rapamycin (mTOR) signaling…”
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Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects by Duric, Vanja, Banasr, Mounira, Stockmeier, Craig A., Simen, Arthur A., Newton, Samuel S., Overholser, James C., Jurjus, George J., Dieter, Lesa, Duman, Ronald S.

“…Major depressive disorder (MDD) has been linked to changes in function and activity of the hippocampus, one of the central limbic regions involved in…”
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REDD1 is essential for stress-induced synaptic loss and depressive behavior by Ota, Kristie T, Liu, Rong-Jian, Voleti, Bhavya, Maldonado-Aviles, Jaime G, Duric, Vanja, Iwata, Masaaki, Dutheil, Sophie, Duman, Catharine, Boikess, Steve, Lewis, David A, Stockmeier, Craig A, DiLeone, Ralph J, Rex, Christopher, Aghajanian, George K, Duman, Ronald S

“…Chronic stress can lead to depression. Ronald Duman and his colleagues show that REDD1 expression is increased in the brain of patients with major depressive…”
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Evaluation of chromatin accessibility in prefrontal cortex of individuals with schizophrenia by Bryois, Julien, Garrett, Melanie E., Song, Lingyun, Safi, Alexias, Giusti-Rodriguez, Paola, Johnson, Graham D., Shieh, Annie W., Buil, Alfonso, Fullard, John F., Roussos, Panos, Sklar, Pamela, Akbarian, Schahram, Haroutunian, Vahram, Stockmeier, Craig A., Wray, Gregory A., White, Kevin P., Liu, Chunyu, Reddy, Timothy E., Ashley-Koch, Allison, Sullivan, Patrick F., Crawford, Gregory E.

“…Schizophrenia genome-wide association studies have identified >150 regions of the genome associated with disease risk, yet there is little evidence that coding…”
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The role of premeditation in suicide: Identifying factors associated with increased planning among suicide decedents by Gomez, Stephanie H, Overholser, James, McGovern, Christopher, Silva, Christiana, Stockmeier, Craig A

“…Suicide premeditation is a critical factor to consider when assessing suicide risk. Understanding which individuals are more or less likely to plan their…”
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Apples to oranges?: A direct comparison between suicide attempters and suicide completers by DeJong, Timothy M, Overholser, James C, Stockmeier, Craig A

“…Abstract Background Suicide attempters and completers may represent different but overlapping groups of distressed individuals. Although depression is related…”
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Reduced Metabotropic Glutamate Receptor 5 Density in Major Depression Determined by [11C]ABP688 PET and Postmortem Study by DESCHWANDEN, Alexandra, KAROLEWICZ, Beata, BUCK, Alfred, HASLER, Gregor, FEYISSA, Anteneh M, TREYER, Valerie, AMETAMEY, Simon M, JOHAYEM, Anass, BURGER, Cyrill, AUBERSON, Yves P, SOVAGO, Judit, STOCKMEIER, Craig A

“…Clinical and preclinical evidence suggests a hyperactive glutamatergic system in clinical depression. Recently, the metabotropic glutamate receptor 5 (mGluR5)…”
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Astrocyte pathology in the ventral prefrontal white matter in depression by Rajkowska, Grazyna, Legutko, Beata, Moulana, Mohadetheh, Syed, Maryam, Romero, Damian G., Stockmeier, Craig A., Miguel-Hidalgo, Jose Javier

“…Astrocyte functions in white matter are less well understood than in gray matter. Our recent study of white matter in ventral prefrontal cortex (vPFC) revealed…”
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Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder by Mahajan, Gouri J., Vallender, Eric J., Garrett, Michael R., Challagundla, Lavanya, Overholser, James C., Jurjus, George, Dieter, Lesa, Syed, Maryam, Romero, Damian G., Benghuzzi, Hamed, Stockmeier, Craig A.

“…Major Depressive Disorder (MDD) is a common psychiatric disorder for which available medications are often not effective. The high prevalence of MDD and modest…”
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Reduced connexin 43 immunolabeling in the orbitofrontal cortex in alcohol dependence and depression by Miguel-Hidalgo, José Javier, Wilson, Barbara A, Hussain, Syed, Meshram, Ashish, Rajkowska, Grazyna, Stockmeier, Craig A

“…Abstract Reduced density of glial cells and low levels of some astrocyte proteins have been described in the orbitofrontal cortex (OFC) in depression and…”
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Involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter by Stockmeier, Craig A.

“…Definitive conclusions on the role of serotonin receptors and transporter in suicide and depression have been elusive in studies of postmortem brain tissue. A…”
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The path not taken: Distinguishing individuals who die by suicide from those who die by natural causes despite a shared history of suicide attempt by Beale, Eleanor E., Overholser, James, Gomez, Stephanie, Brannam, Sidney, Stockmeier, Craig A.

“…Objectives This study aimed to identify variables that distinguish suicide risk among individuals with previous suicide attempts. Method Using psychological…”
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