Search Results - "Stockley, T L"

The role of molecular microsatellite identity testing to detect sampling errors in prenatal diagnosis by Winsor, E. J. T., Akoury, H., Chitayat, D., Steele, L., Stockley, T. L.

“…Objective The objective was to determine the risk of sampling error in amniocentesis and chorionic villus sampling (CVS) in singleton and multiple pregnancies…”
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Data resources for the identification and interpretation of actionable mutations by clinicians by Prawira, A., Pugh, T.J., Stockley, T.L., Siu, L.L.

“…Following initial characterization of the reference human genome, initiatives have evolved worldwide to identify genomic aberrations in cancer with the aim of…”
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A phase I study of binimetinib (MEK 162), a MEK inhibitor, plus carboplatin and pemetrexed chemotherapy in non-squamous non-small cell lung cancer by Fung, A.S., Graham, D.M., Chen, E.X., Stockley, T.L., Zhang, T., Le, L.W., Albaba, H., Pisters, K.M., Bradbury, P.A., Trinkaus, M., Chan, M., Arif, S., Zurawska, U., Rothenstein, J., Zawisza, D., Effendi, S., Gill, S., Sawczak, M., Law, J.H., Leighl, N.B.

“…•Recommended phase II dose is binimetinib 30 mg BID with carboplatin/pemetrexed in non-squamous NSCLC.•Manageable toxicities observed with the combination of…”
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The Somatic Curation and Interpretation Across Laboratories (SOCIAL) project-current state of solid-tumour variant interpretation for molecular pathology in Canada by Spence, T, Sukhai, M A, Kamel-Reid, S, Stockley, T L

“…Practices in somatic variant interpretation and classification vary between Canadian clinical molecular diagnostic laboratories, and understanding of current…”
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Inter-laboratory proficiency testing scheme for tumour next-generation sequencing in Ontario: a pilot study by Spence, T, Stickle, N, Yu, C, Chow, H, Feilotter, H, Lo, B, McCready, E, Sadikovic, B, Siu, L L, Bedard, P L, Stockley, T L

“…A pilot inter-laboratory proficiency scheme for 5 Ontario clinical laboratories testing tumour samples for the Ontario-wide Cancer Targeted Nucleic Acid…”
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Crizotinib inhibition of ROS1- positive tumours in advanced non-small-cell lung cancer: a Canadian perspective by Bebb, D G, Agulnik, J, Albadine, R, Banerji, S, Bigras, G, Butts, C, Couture, C, Cutz, J C, Desmeules, P, Ionescu, D N, Leighl, N B, Melosky, B, Morzycki, W, Rashid-Kolvear, F, Lab, Clin, Sekhon, H S, Smith, A C, Stockley, T L, Torlakovic, E, Xu, Z, Tsao, M S

“…The ros1 kinase is an oncogenic driver in non-small-cell lung cancer (nsclc). Fusion events involving the gene are found in 1%-2% of nsclc patients and lead to…”
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OCTANE (Ontario-wide Cancer Targeted Nucleic Acid Evaluation): a platform for intraprovincial, national, and international clinical data-sharing by Malone, E R, Saleh, R R, Yu, C, Ahmed, L, Pugh, T, Torchia, J, Bartlett, J, Virtanen, C, Hotte, S J, Hilton, J, Welch, S, Robinson, A, McCready, E, Lo, B, Sadikovic, B, Feilotter, H, Hanna, T P, Kamel-Reid, S, Stockley, T L, Siu, L L, Bedard, P L

“…Cancer is a genetic disease resulting from germline or somatic genetic aberrations. Rapid progress in the field of genomics in recent years is allowing for…”
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The in vivo delivery of heterologous proteins by microencapsulated recombinant cells by Chang, Patricia L, Van Raamsdonk, Jeremy M, Hortelano, Gonzalo, Barsoum, Susan C, MacDonald, Nicole C, Stockley, Tracy L

“…The microencapsulation of recombinant cells is a novel and potentially cost-effective method of heterologous protein delivery. A ‘universal’ cell line,…”
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Discordant KCNQ1OT1 imprinting in sets of monozygotic twins discordant for Beckwith–Wiedemann syndrome by Weksberg, Rosanna, Shuman, Cheryl, Caluseriu, Oana, Smith, Adam C., Fei, Yan-Ling, Nishikawa, Joy, Stockley, Tracy L., Best, Lyle, Chitayat, David, Olney, Ann, Ives, Elizabeth, Schneider, Adele, Bestor, Timothy H., Li, Madeline, Sadowski, Paul, Squire, Jeremy

“…Beckwith–Wiedemann syndrome (BWS) presents with visceromegaly, macroglossia, tumor predisposition and other congenital abnormalities, and is usually associated…”
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Canavan disease: Carrier-frequency determination in the Ashkenazi Jewish population and development of a novel molecular diagnostic assay by Feigenbaum, Annette, Moore, Robert, Clarke, Joe, Hewson, Stacy, Chitayat, David, Ray, Peter N., Stockley, Tracy L.

“…Canavan disease (CD) is an autosomal recessive progressive neurodegenerative disorder prevalent in the Ashkenazi Jewish (AJ) population. The carrier rate for…”
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Delivery of recombinant product from subcutaneous implants of encapsulated recombinant cells in canines by Stockley, Tracy L., Robinson, Kelly E., Delaney, Kathy, Ofosu, Frederick A., Chang, Patricia L.

“…Delivering recombinant therapeutic proteins from a universal microencapsulated cell line is an alternate method for gene therapy. It has proved effective in…”
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Prospective Next-Generation Sequencing Molecular Profiling of Myeloid Malignancies: Assessment of Information Benefit and Impact on Patient Care by Kamel-Reid, Suzanne, Thomas, Mariam, Sukhai, Mahadeo A., Barber, Dwayne L., Garg, Swati, Misyura, Maksym, Dolatshahi, Roozbeh, Harbi, Djamel, Zhang, Tong, Porwit, Anna, Delabie, Jan M.A., Ibrahimova, Narmin, Shanavas, Mohamed, Yee, Karen W.L., Pugh, Trevor J., Bedard, Philippe, Schimmer, Aaron D., Stockley, Tracy L., Gupta, Vikas, Minden, Mark D., Schuh, Andre C

“…Introduction. Recent genome profiling studies have increased our understanding of the mutation landscapes of myeloid malignancies. Molecular testing of AMLs…”
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Auditory Responses in Cochlear Implant Users With and Without GJB2 Deafness by Propst, Evan Jon, Papsin, Blake C., Stockley, Tracy L., Harrison, Robert V., Gordon, Karen A.

“…Objective/Hypothesis: It is reasonable to suppose that the pattern of sensorineural damage along the length of the cochlea depends on the etiology of a hearing…”
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Non-Autologous Transplantation with Immuno-isolation in Large Animals-A Review by STOCKLEY, TRACY L., CHANG, PATRICIA L.

“…Transplantation has become a successful method for the management of functional failure of a variety of tissues or organs. However, the majority of clinical…”
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Ethnicity and mutations in GJB2 (connexin 26) and GJB6 (connexin 30) in a multi-cultural Canadian paediatric Cochlear Implant Program by Propst, Evan Jon, Stockley, Tracy L, Gordon, Karen A, Harrison, Robert V, Papsin, Blake Croll

“…To determine the relationship between ethnicity and mutations in the GJB2 and GJB6 genes in multi-cultural patients enrolled in a Canadian paediatric Cochlear…”
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Parents of children with spinal muscular atrophy are not obligate carriers: Carrier testing is important for reproductive decision-making by Zeesman, Susan, Whelan, Donald T., Carson, Nancy, McGowan-Jordan, Jean, Stockley, Tracy L., Ray, Peter N., Prior, Thomas W.

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