Search Results - "Stockis, Julie"

Cutting Edge: Active TGF-β1 Released from GARP/TGF-β1 Complexes on the Surface of Stimulated Human B Lymphocytes Increases Class-Switch Recombination and Production of IgA by Dedobbeleer, Olivier, Stockis, Julie, van der Woning, Bas, Coulie, Pierre G, Lucas, Sophie

“…Production of active TGF-β is regulated at a posttranslational level and implies release of the mature cytokine dimer from the inactive, latent TGF-β…”
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Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors by Bach, Karsten, Pensa, Sara, Zarocsinceva, Marija, Kania, Katarzyna, Stockis, Julie, Pinaud, Silvain, Lazarus, Kyren A., Shehata, Mona, Simões, Bruno M., Greenhalgh, Alice R., Howell, Sacha J., Clarke, Robert B., Caldas, Carlos, Halim, Timotheus Y. F., Marioni, John C., Khaled, Walid T.

“…It is unclear how genetic aberrations impact the state of nascent tumour cells and their microenvironment. BRCA1 driven triple negative breast cancer (TNBC)…”
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Role of GARP in the activation of latent TGF-β1 by Stockis, Julie, Dedobbeleer, Olivier, Lucas, Sophie

“…TGF-β1, 2 and 3 cytokines are involved in many cellular processes including cell proliferation, differentiation, migration and survival. Whereas TGF-β2 and 3…”
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Arsenic Trioxide Treatment Decreases the Oxygen Consumption Rate of Tumor Cells and Radiosensitizes Solid Tumors by DIEPART, Caroline, KARROUM, Oussama, JORDAN, Bénédicte F, GALLEZ, Bernard, MAGAT, Julie, FERON, Olivier, VERRAX, Julien, BUC CALDERON, Pedro, GREGOIRE, Vincent, LEVEQUE, Philippe, STOCKIS, Julie, DAUGUET, Nicolas

“…Arsenic trioxide (As(2)O(3)) is an effective therapeutic against acute promyelocytic leukemia and certain solid tumors. Because As(2)O(3) inhibits…”
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GARP is regulated by miRNAs and controls latent TGF-β1 production by human regulatory T cells by Gauthy, Emilie, Cuende, Julia, Stockis, Julie, Huygens, Caroline, Lethé, Bernard, Collet, Jean-François, Bommer, Guido, Coulie, Pierre G, Lucas, Sophie

“…GARP is a transmembrane protein present on stimulated human regulatory T lymphocytes (Tregs), but not on other T lymphocytes (Th cells). It presents the latent…”
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Comparison of stable human Treg and Th clones by transcriptional profiling by Stockis, Julie, Fink, Wolfram, François, Violaine, Connerotte, Thierry, de Smet, Charles, Knoops, Laurent, van der Bruggen, Pierre, Boon, Thierry, Coulie, Pierre G, Lucas, Sophie

“…From cancerous and non-cancerous patients, we derived stable clones of CD4⁺ Treg, defined as clones that expressed high CD25 at rest, were anergic in vitro,…”
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PDGF-D expression is down-regulated by TGFβ in fibroblasts by Charni Chaabane, Saima, Coomans de Brachène, Alexandra, Essaghir, Ahmed, Velghe, Amélie, Lo Re, Sandra, Stockis, Julie, Lucas, Sophie, Khachigian, Levon M, Huaux, François, Demoulin, Jean-Baptiste

“…Transforming growth factor-β (TGFβ) is a key mediator of fibrogenesis. TGFβ is overexpressed and activated in fibrotic diseases, regulates fibroblast…”
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Role of glycolysis inhibition and poly(ADP‐ribose) polymerase activation in necrotic‐like cell death caused by ascorbate/menadione‐induced oxidative stress in K562 human chronic myelogenous leukemic cells by Verrax, Julien, Vanbever, Stéphanie, Stockis, Julie, Taper, Henryk, Calderon, Pedro Buc

“…Among different features of cancer cells, two of them have retained our interest: their nearly universal glycolytic phenotype and their sensitivity towards an…”
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Regulation of regulatory T cells in cancer by Stockis, Julie, Roychoudhuri, Rahul, Halim, Timotheus Y. F.

“…Summary The inflammatory response to transformed cells forms the cornerstone of natural or therapeutically induced protective immunity to cancer. Regulatory T…”
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Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8 by Stockis, Julie, Liénart, Stéphanie, Colau, Didier, Collignon, Amandine, Nishimura, Stephen L., Sheppard, Dean, Coulie, Pierre G., Lucas, Sophie

“…Human regulatory T cells (Tregs) suppress other T cells by converting the latent, inactive form of TGF-β1 into active TGF-β1. In Tregs, TGF-β1 activation…”
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Membrane protein GARP is a receptor for latent TGF-β on the surface of activated human Treg by Stockis, Julie, Colau, Didier, Coulie, Pierre G, Lucas, Sophie

“…Human Treg and Th clones secrete the latent form of TGF-β, in which the mature TGF-β protein is bound to the latency-associated peptide (LAP), and is thereby…”
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Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells by Liénart, Stéphanie, Merceron, Romain, Vanderaa, Christophe, Lambert, Fanny, Colau, Didier, Stockis, Julie, van der Woning, Bas, De Haard, Hans, Saunders, Michael, Coulie, Pierre G, Savvides, Savvas N, Lucas, Sophie

“…Transforming growth factor-β1 (TGF-β1) is one of very few cytokines produced in a latent form, requiring activation to exert any of its vastly diverse effects…”
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ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung by Schuijs, Martijn J., Png, Shaun, Richard, Arianne C., Tsyben, Anastasia, Hamm, Gregory, Stockis, Julie, Garcia, Celine, Pinaud, Silvain, Nicholls, Ashley, Ros, Xavier Romero, Su, Jing, Eldridge, Matthew D., Riedel, Angela, Serrao, Eva M., Rodewald, Hans-Reimer, Mack, Matthias, Shields, Jacqueline D., Cohen, E. Suzanne, McKenzie, Andrew N. J., Goodwin, Richard J. A., Brindle, Kevin M., Marioni, John C., Halim, Timotheus Y. F.

“…Metastasis constitutes the primary cause of cancer-related deaths, with the lung being a commonly affected organ. We found that activation of lung-resident…”
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Characterising the role of tissue-resident immune cells in PanIN to PDAC progression by Simpson, Charlotte, Yip, Thomas, Stockis, Julie, Lee, Sheng, Garcia, Celine, Halim, Timotheus

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Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo by Cuende, Julia, Liénart, Stéphanie, Dedobbeleer, Olivier, van der Woning, Bas, De Boeck, Gitte, Stockis, Julie, Huygens, Caroline, Colau, Didier, Somja, Joan, Delvenne, Philippe, Hannon, Muriel, Baron, Frédéric, Dumoutier, Laure, Renauld, Jean-Christophe, De Haard, Hans, Saunders, Michael, Coulie, Pierre G, Lucas, Sophie

“…Regulatory T cells (Tregs) are essential to prevent autoimmunity, but excessive Treg function contributes to cancer progression by inhibiting antitumor immune…”
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Blocking GARP-mediated activation of TGF-β1 did not alter innate or adaptive immune responses to bacterial infection or protein immunization in mice by Gaignage, Mélanie, Zhang, Xuhao, Stockis, Julie, Dedobbeleer, Olivier, Michiels, Camille, Cochez, Perrine, Dumoutier, Laure, Coulie, Pierre G., Lucas, Sophie

“…Transmembrane protein GARP binds latent TGF-β1 to form GARP:(latent)TGF-β1 complexes on the surface of several cell types including Tregs, B-cells, and…”
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Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor β1 (TGF-β1) Production in Human Regulatory T Cells by Huygens, Caroline, Liénart, Stéphanie, Dedobbeleer, Olivier, Stockis, Julie, Gauthy, Emilie, Coulie, Pierre G., Lucas, Sophie

“…Production of active TGF-β1 is one mechanism by which human regulatory T cells (Tregs) suppress immune responses. This production is regulated by glycoprotein…”
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Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin aVß8 by Stockis, Julie, Liénart, Stéphanie, Colau, Didier, Collignon, Amandine, Nishimura, Stephen L, Sheppard, Dean, Coulie, Pierre G, Lucas, Sophie

“…Human regulatory T cells (Tregs) suppress other T cells by converting the latent, inactive form of TGF-β1 into active TGF-β1. In Tregs, TGF-β1 activation…”
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ILC2-driven innate immune checkpoint mechanism antagonizes NK cell anti-metastatic function in the lung by Halim, Timotheus You Fu, Schuijs, Martijn, Png, Shaun, Richard, Arianne, Tsyben, Anastasia, Hamm, Gregory, Stockis, Julie, Garcia, Celine, Pinaud, Silvain, Nichols, Ashley, Romero-Ros, Xavier, Shields, Jacqueline, Cohen, E. Suzanne, McKenzie, Andrew, Goodwin, Richard, Su, Jing, Eldridge, Matthew, Riedel, Angela, Serrao, Eva, Brindle, Kevin, Marioni, John

“…Abstract Metastasis constitutes the primary cause of cancer-related deaths, with the lung being a commonly affected organ. We found that activation of…”
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Abstract 2341: Group 2 innate lymphoid cells influence pancreatic stromal cell composition in homeostasis and pancreatic cancer by Yip, Thomas, Lee, Sheng, Stockis, Julie, Garcia, Celine, Raghunathan, Shwetha, Lim, Bram, Pinaud, Silvain, Png, Shaun, Halim, Timotheus

“…Abstract Background: Group 2 Innate Lymphoid Cells (ILC2s) are tissue-resident innate immune cells critical in orchestrating type-2 immune responses…”
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