Search Results - "Stocker, Sean"

Altered Neuronal Discharge in the Organum Vasculosum of the Lamina Terminalis Contributes to Dahl Salt-Sensitive Hypertension by Stocker, Sean D.

“…Salt-sensitive hypertension in humans and experimental models is associated with higher plasma and cerebrospinal fluid sodium chloride (NaCl) concentrations…”
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Deletion of the Transient Receptor Potential Vanilloid 1 Channel Attenuates Sympathoexcitation and Hypertension and Improves Glomerular Filtration Rate in 2-Kidney-1-Clip Rats by Stocker, Sean D., Sullivan, Jacob B.

“…Renal denervation lowers arterial blood pressure in both clinical populations and multiple experimental models of hypertension. This therapeutic effect is…”
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Sympathetic Nervous System Contributions to Hypertension: Updates and Therapeutic Relevance by DeLalio, Leon J., Sved, Alan F., Stocker, Sean D.

“…The sympathetic nervous system plays a pivotal role in the long-term regulation of arterial blood pressure through the ability of the central nervous system to…”
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Impact of anesthesia and sex on sympathetic efferent and hemodynamic responses to renal chemo- and mechanosensitive stimuli by DeLalio, Leon J, Stocker, Sean D

“…Activation of renal sensory nerves by chemo- and mechanosensitive stimuli produces changes in efferent sympathetic nerve activity (SNA) and arterial blood…”
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NaCl and osmolarity produce different responses in organum vasculosum of the lamina terminalis neurons, sympathetic nerve activity and blood pressure by Kinsman, Brian J., Browning, Kirsteen N., Stocker, Sean D.

“…Key points Changes in extracellular osmolarity stimulate thirst and vasopressin secretion through a central osmoreceptor; however, central infusion of…”
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Dietary Salt Intake Exaggerates Sympathetic Reflexes and Increases Blood Pressure Variability in Normotensive Rats by SIMMONDS, Sarah S, LAY, Jennifer, STOCKER, Sean D

“…Previous studies have reported that chronic increases in dietary salt intake enhance sympathetic nerve activity and arterial blood pressure (ABP) responses…”
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Missing pieces of the Piezo1/Piezo2 baroreceptor hypothesis: an autonomic perspective by Stocker, Sean D, Sved, Alan F, Andresen, Michael C

“…Baroreceptors play a pivotal role in the regulation of blood pressure through moment to moment sensing of arterial blood pressure and providing information to…”
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Renal sensory nerves increase sympathetic nerve activity and blood pressure in 2-kidney 1-clip hypertensive mice by Ong, Jason, Kinsman, Brian J, Sved, Alan F, Rush, Brittney M, Tan, Roderick J, Carattino, Marcelo D, Stocker, Sean D

“…Renal denervation lowers arterial blood pressure (ABP) in multiple clinical trials and some experimental models of hypertension. These antihypertensive effects…”
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Impact of anesthesia, sex, and circadian cycle on renal afferent nerve sensitivity by DeLalio, Leon J, Stocker, Sean D

“…Elevated renal afferent nerve (ARNA) activity or dysfunctional reno-renal reflexes via altered ARNA sensitivity contribute to hypertension and chronic kidney…”
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Hypernatremia-induced vasopressin secretion is not altered in TRPV1-/- rats by Tucker, Andrew Blake, Stocker, Sean D

“…Changes in osmolality or extracellular NaCl concentrations are detected by specialized neurons in the hypothalamus to increase vasopressin (VP) and stimulate…”
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Organum Vasculosum of the Lamina Terminalis Detects NaCl to Elevate Sympathetic Nerve Activity and Blood Pressure by Kinsman, Brian J, Simmonds, Sarah S, Browning, Kirsteen N, Stocker, Sean D

“…High-salt diet elevates NaCl concentrations in the cerebrospinal fluid to increase sympathetic nerve activity (SNA) in salt-sensitive hypertension. The organum…”
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Genetic or pharmacologic Nrf2 activation increases proteinuria in chronic kidney disease in mice by Rush, Brittney M, Bondi, Corry D, Stocker, Sean D, Barry, Kacie M, Small, Sarah A, Ong, Jason, Jobbagy, Soma, Stolz, Donna B, Bastacky, Sheldon I, Chartoumpekis, Dionysios V, Kensler, Thomas W, Tan, Roderick J

“…The nuclear factor erythroid 2-related factor 2 (Nrf2) pathway upregulates key cellular defenses. Clinical trials are utilizing pharmacologic Nrf2 inducers…”
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DREADD-induced activation of subfornical organ neurons stimulates thirst and salt appetite by Nation, Haley L, Nicoleau, Marvin, Kinsman, Brian J, Browning, Kirsteen N, Stocker, Sean D

“…The subfornical organ (SFO) plays a pivotal role in body fluid homeostasis through its ability to integrate neurohumoral signals and subsequently alter…”
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Activation of the Organum Vasculosum of the Lamina Terminalis Produces a Sympathetically Mediated Hypertension by Stocker, Sean D., Wenner, Megan M., Farquhar, William B., Browning, Kirsteen N.

“…Neurons in the organum vasculosum of the lamina terminalis (OVLT) sense extracellular NaCl and angiotensin II concentrations to regulate body fluid homeostasis…”
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Recording sympathetic nerve activity chronically in rats: surgery techniques, assessment of nerve activity, and quantification by Stocker, Sean D, Muntzel, Martin S

“…The sympathetic nervous system plays a pivotal role in homeostasis through its direct innervation and functional impact on a variety of end organs. In rats, a…”
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Physiological Mechanisms of Dietary Salt Sensing in the Brain, Kidney, and Gastrointestinal Tract by Stocker, Sean D, Kinsman, Brian J, Farquhar, William B, Gyarmati, Georgina, Peti-Peterdi, Janos, Sved, Alan F

“…Excess dietary salt (NaCl) intake is strongly correlated with cardiovascular disease and is a major contributing factor to the pathogenesis of hypertension…”
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Recent Advances in Neurogenic Hypertension: Dietary Salt, Obesity, and Inflammation by Stocker, Sean D, Kinsman, Brian J, Sved, Alan F

“…Neurally-mediated hypertension results from a dysregulation of sympathetic and/or neuroendocrine mechanisms to increase ABP. Multiple factors may exert…”
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Glutamate receptors in the hypothalamic paraventricular nucleus contribute to insulin-induced sympathoexcitation by Stocker, Sean D, Gordon, Kathryn W

“…The sympathoexcitatory response to insulin is mediated by neurons in the arcuate nucleus (ARC) and hypothalamic paraventricular nucleus (PVH). Previous studies…”
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Brain Pathways in Blood Pressure Regulation by Stocker, Sean D, Ferreira, Caroline B, Souza, George M P R, Abbott, Stephen B G

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Functional knockout of the TRPV1 channel has no effect on the exercise pressor reflex in rats by Anselmi, Laura, Ducrocq, Guillaume P., Ruiz‐Velasco, Victor, Stocker, Sean D., Higgins, Shannon P., Kaufman, Marc P.

“…The role played by the transient receptor potential vanilloid 1 (TRPV1) channel on the thin fibre afferents evoking the exercise pressor reflex is…”
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