Combating inflammaging through a Mediterranean whole diet approach: The NU-AGE project's conceptual framework and design

•Inflammaging is critical for ageing and age-related chronic diseases.•NU-AGE targets the Mediterranean whole diet as a major modulator of inflammaging.•NU-AGE consortium includes research centres, SMEs and food industries and federations.•NU-AGE will identify molecular targets responsible for the e...

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Published in:	Mechanisms of ageing and development Vol. 136-137; pp. 3 - 13
Main Authors:	Santoro, Aurelia, Pini, Elisa, Scurti, Maria, Palmas, Giustina, Berendsen, Agnes, Brzozowska, Anna, Pietruszka, Barbara, Szczecinska, Anna, Cano, Noël, Meunier, Nathalie, de Groot, C.P.G.M., Feskens, Edith, Fairweather-Tait, Susan, Salvioli, Stefano, Capri, Miriam, Brigidi, Patrizia, Franceschi, Claudio, Fabbri, Cristina, Bertarelli, Claudia, Izzi, Massimo, Mazzocchi, Mario, Chardigny, Jean Michel, Morio, Beatrice, Rossi, Daniele, Notarfonso, Maurizio, O’Toole, Paul W., Cashman, Kevin, Carding, Simon R., Nicoletti, Claudio, Jacobs, Dirk, Xipsiti, Maria, Fernandez, Laura, Wills, Josephine, Irz, Xavier, Kuosmanen, Natalia, Gonos, Efstathios S., Voutetakis, Konstantinos, Salmon, Michael, Toussaint, Olivier, Traill, Bruce W., Nocella, Giuseppe, Caracciolo, Barbara, Xu, Weili, Mikko Ikonen, Tuure, Tuula, Brummer, Robert, Kadi, Fawzi, Breton, Sylvie, Triomphe, Marie, Magario, Guido, Villani, Filippo, Pancrazio, Annibale, Teufner, Brigitte, Stocker, Josef, Echevarría, Francisco Javier, Iglesias, Jose Ramón, Smrž, František, Krejcirova, Lucie, Koytsomitropoulou, Efthimia, Georgakidis, Konstantinos, Yornuk, Rezan, Ucar, Cihan, Van Ommen, Ben, Bouwman, Jildau, Collino, Sebastiano, Jankovics, Clara, Losó, Adrienn, de Vos, Willem, Fuentes, Susana, Commelin, Eric
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 01-03-2014 Elsevier
Subjects:	Aged Ageing Aging cd8(+) t-cells cellular senescence Chemical and Process Engineering Diet Diet, Mediterranean Elderly-tailored foods Engineering Sciences Europe Feeding Behavior Female Food Food engineering Food Industry Food, Fortified frailty gut micobiota Gut microbiota Health Status Humans immunosenescence Inflammaging Inflammation - physiopathology Intestines - microbiology Life Sciences longevity Male Medicin och hälsovetenskap Mediterranean diet Mitochondria - physiology Multicenter Studies as Topic muscle older-adults phenotype Randomized Controlled Trials as Topic Research Design style diet system Systems Biology Gut microbiota Inflammaging Mediterranean diet Elderly-tailored foods Ageing
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Summary:	•Inflammaging is critical for ageing and age-related chronic diseases.•NU-AGE targets the Mediterranean whole diet as a major modulator of inflammaging.•NU-AGE consortium includes research centres, SMEs and food industries and federations.•NU-AGE will identify molecular targets responsible for the effect of NU-AGE diet.•NU-AGE will design industrially driven fortified foods for elderly. The development of a chronic, low grade, inflammatory status named “inflammaging” is a major characteristic of ageing, which plays a critical role in the pathogenesis of age-related diseases. Inflammaging is both local and systemic, and a variety of organs and systems contribute inflammatory stimuli that accumulate lifelong. The NU-AGE rationale is that a one year Mediterranean whole diet (considered by UNESCO a heritage of humanity), newly designed to meet the nutritional needs of the elderly, will reduce inflammaging in fully characterized subjects aged 65–79 years of age, and will have systemic beneficial effects on health status (physical and cognitive). Before and after the dietary intervention a comprehensive set of analyses, including omics (transcriptomics, epigenetics, metabolomics and metagenomics) will be performed to identify the underpinning molecular mechanisms. NU-AGE will set up a comprehensive database as a tool for a systems biology approach to inflammaging and nutrition. NU-AGE is highly interdisciplinary, includes leading research centres in Europe on nutrition and ageing, and is complemented by EU multinational food industries and SMEs, interested in the production of functional and enriched/advanced traditional food tailored for the elderly market, and European Federations targeting policy makers and major stakeholders, from consumers to EU Food & Drink Industries.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0047-6374 1872-6216 1872-6216 0047-6374
DOI:	10.1016/j.mad.2013.12.001