Search Results - "Stocker, Jonathan W"

Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease by Ataga, Kenneth I, Kutlar, Abdullah, Kanter, Julie, Liles, Darla, Cancado, Rodolfo, Friedrisch, João, Guthrie, Troy H, Knight-Madden, Jennifer, Alvarez, Ofelia A, Gordeuk, Victor R, Gualandro, Sandra, Colella, Marina P, Smith, Wally R, Rollins, Scott A, Stocker, Jonathan W, Rother, Russell P

“…In this yearlong trial involving patients with sickle cell disease, crizanlizumab, an antibody to P-selectin, was associated with a 45% lower rate of pain…”
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ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice by Stocker, Jonathan W., De Franceschi, Lucia, McNaughton-Smith, Grant A., Corrocher, Roberto, Beuzard, Yves, Brugnara, Carlo

“…A prominent feature of sickle cell anemia is the presence of dehydrated red blood cells (RBCs) in circulation. Loss of potassium (K+), chloride (Cl−), and…”
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Haemoglobin response to senicapoc in patients with sickle cell disease: a re‐analysis of the Phase III trial by Ataga, Kenneth I., Staffa, Steven J., Brugnara, Carlo, Stocker, Jonathan W.

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Improvements in haemolysis and indicators of erythrocyte survival do not correlate with acute vaso‐occlusive crises in patients with sickle cell disease: a phase III randomized, placebo‐controlled, double‐blind study of the gardos channel blocker senicapoc (ICA‐17043) by Ataga, Kenneth I., Reid, Marvin, Ballas, Samir K., Yasin, Zahida, Bigelow, Carolyn, James, Luther St, Smith, Wally R., Galacteros, Frederic, Kutlar, Abdullah, Hull, James H., Stocker, Jonathan W.

“…Summary Red blood cell (RBC) hydration is regulated in part by the Ca2+‐activated K+ efflux (Gardos) channel. Senicapoc selectively blocks potassium efflux…”
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Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia by Ataga, Kenneth I., Smith, Wally R., De Castro, Laura M., Swerdlow, Paul, Saunthararajah, Yogen, Castro, Oswaldo, Vichinsky, Elliot, Kutlar, Abdullah, Orringer, Eugene P., Rigdon, Greg C., Stocker, Jonathan W.

“…Senicapoc, a novel Gardos channel inhibitor, limits solute and water loss, thereby preserving sickle red blood cell (RBC) hydration. Because hemoglobin S…”
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Novel Inhibitors of the Gardos Channel for the Treatment of Sickle Cell Disease by McNaughton-Smith, Grant A, Burns, J. Ford, Stocker, Jonathan W, Rigdon, Gregory C, Creech, Christopher, Arrington, Susan, Shelton, Tara, de Franceschi, Lucia

“…Sickle cell disease (SCD) is a hereditary condition characterized by deformation of red blood cells (RBCs). This phenomenon is due to the presence of abnormal…”
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Anti‐haemolytic effect of senicapoc and decrease in NT‐proBNP in adults with sickle cell anaemia by Minniti, Caterina P., Wilson, Jonathan, Mendelsohn, Laurel, Rigdon, Greg C., Stocker, Jonathan W., Remaley, Alan T., Kato, Gregory J.

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Dose-Escalation Study of ICA-17043 in Patients with Sickle Cell Disease by Ataga, Kenneth I., Orringer, Eugene P., Styles, Lori, Vichinsky, Elliott P., Swerdlow, Paul, Davis, George A., DeSimone, Philip A., Stocker, Jonathan W.

“…Study Objective. To determine the dose tolerance, safety, and pharmacokinetics of a single oral dose of ICA‐17043 in patients with sickle cell disease. Design…”
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GABA-Mediated Inhibition Between Amacrine Cells in the Goldfish Retina by Watanabe, Shu-Ichi, Koizumi, Amane, Matsunaga, Shinya, Stocker, Jonathan W, Kaneko, Akimichi

“…Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan Watanabe, Shu-Ichi, Amane Koizumi, Shinya Matsunaga, Jonathan W. Stocker,…”
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Preferential Interaction of omega -Conotoxins with Inactivated N-type Ca2+ Channels by Stocker, Jonathan W, Nadasdi, Laszlo, Aldrich, Richard W, Tsien, Richard W

“…The selective block of N-type Ca2+ channels by omega-conotoxins has been a hallmark of these channels, critical in delineating their biological roles and…”
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Biochemical characterization and electron-transfer reactions of sym1, a Rhodobacter capsulatus reaction center symmetry mutant which affects the initial electron donor by Taguchi, Aileen K. W, Stocker, Jonathan W, Alden, Rhett G, Causgrove, Timothy P, Peloquin, Jeffrey M, Boxer, Steven G, Woodbury, Neal W

“…A 51 bp section of the Rhodobacter capsulatus photosynthetic reaction center M subunit gene (nucleotides M562-M612 of the pufM structural sequence) encoding…”
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Placebo-Controlled, Double-Blind, First-In-Human, Ascending Single Dose and Multiple Dose, Healthy Subject Study Of Intravenous-Administered SelG1, a Humanized Anti-P-Selectin Antibody In Development For Sickle Cell Disease by Stocker, Jonathan W., Mandarino, Debra, Kawar, Ziad, Alvarez, Richard, Falconer, David, Rollins, Scott A., Rother, Russell P.

“…SelG1 is a humanized anti-P-selectin monoclonal antibody being developed as a treatment for sickle cell disease (SCD). Extensive data have been published that…”
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Spectroscopic and redox properties of sym1 and (M)F195H: Rhodobacter capsulatus reaction center symmetry mutants which affect the initial electron donor by Stocker, Jonathan W, Taguchi, Aileen K. W, Murchison, Heather A, Woodbury, Neal W, Boxer, Steven G

“…The redox properties, absorption, electroabsorption, CD, EPR, and P+QA- recombination kinetics have been measured for the special pairs of two mutants of…”
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SUSTAIN: A Multicenter, Randomized, Placebo-Controlled, Double-Blind, 12-Month Study to Assess Safety and Efficacy of SelG1 with or without Hydroxyurea Therapy in Sickle Cell Disease Patients with Sickle Cell-Related Pain Crises by Ataga, Kenneth I., Kutlar, Abdullah, Kanter, Julie, Liles, Darla, Cancado, Rodolfo, Friedrisch, João, Guthrie, Troy H., Knight-Madden, Jennifer, Alvarez, Ofelia A., Gordeuk, Victor R., Gualandro, Sandra, Collela, Marina Pereira, Smith, Wally R., Rollins, Scott A., Stocker, Jonathan W., Rother, Russell P.

“…Introduction: Acute painful episodes, frequently called sickle cell-related pain crises (SCPC), are a substantial cause of morbidity in sickle cell disease…”
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A 48-Week Open-Label Study of Senicapoc (ICA-17043), a Gardos Channel Blocker, in Patients with Sickle Cell Disease by Swerdlow, Paul, Ataga, Kenneth, Smith, Wally, Saunthararajah, Yogen, Stocker, Jonathan W.

“…The Gardos channel, a calcium-activated potassium channel that spans the membrane of red blood cells (RBCs), is a key pathway in RBC dehydration affecting the…”
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Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia. Commentary by JOINER, Clinton H, ATAGA, Kenneth I, RIGDON, Greg C, STOCKER, Jonathan W, SMITH, Wally R, DE CASTRO, Laura M, SWERDLOW, Paul, SAUNTHARARAJAH, Yogen, CASTRO, Oswaldo, VICHINSKY, Elliot, KUTLAR, Abdullah, ORRINGER, Eugene P

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Preferential Interaction of ω-Conotoxins with Inactivated N-type Ca 2+ Channels by Stocker, Jonathan W., Nadasdi, Laszlo, Aldrich, Richard W., Tsien, Richard W.

“…The selective block of N-type Ca 2+ channels by ω-conotoxins has been a hallmark of these channels, critical in delineating their biological roles and…”
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Photosynthetic reaction center mutagenesis via chimeric rescue of a non-functional Rhodobacter capsulatus puf operon with sequences from Rhodobacter sphaeroides by TAGUCHI, A. K. W, STOCKER, J. W, BOXER, S. G, WOODBURY, N. W

“…Photosynthetically active chimeric reaction centers which utilize genetic information from both Rhodobacter capsulatus and Rb. sphaeroides puf operons were…”
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