Search Results - "Stockbridge, Randy"

The application of Poisson distribution statistics in ion channel reconstitution to determine oligomeric architecture by Stockbridge, Randy B

“…During reconstitution, membrane proteins are randomly inserted into liposomes according to Poisson distribution statistics. When the protein to lipid ratios in…”
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The link between ancient microbial fluoride resistance mechanisms and bioengineering organofluorine degradation or synthesis by Stockbridge, Randy B., Wackett, Lawrence P.

“…Fluorinated organic chemicals, such as per- and polyfluorinated alkyl substances (PFAS) and fluorinated pesticides, are both broadly useful and unusually…”
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Bacterial fluoride resistance, Fluc channels, and the weak acid accumulation effect by Ji, Chunhui, Stockbridge, Randy B, Miller, Christopher

“…Fluoride ion (F(-)) is a ubiquitous environmental threat to microorganisms, which have evolved a family of highly selective "Fluc" F(-) channels that export…”
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Widespread Genetic Switches and Toxicity Resistance Proteins for Fluoride by Baker, Jenny L., Sudarsan, Narasimhan, Weinberg, Zasha, Roth, Adam, Stockbridge, Randy B., Breaker, Ronald R.

“…Most riboswitches are metabolite-binding RNA structures located in bacterial messenger RNAs where they control gene expression. We have discovered a riboswitch…”
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Membrane Exporters of Fluoride Ion by McIlwain, Benjamin C, Ruprecht, Michal T, Stockbridge, Randy B

“…Microorganisms contend with numerous and unusual chemical threats and have evolved a catalog of resistance mechanisms in response. One particularly ancient,…”
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Crystal structures of a double-barrelled fluoride ion channel by Stockbridge, Randy B., Kolmakova-Partensky, Ludmila, Shane, Tania, Koide, Akiko, Koide, Shohei, Miller, Christopher, Newstead, Simon

“…Microorganisms can export toxic fluoride ions through highly selective channels of the Fluc family; here, the crystal structures of two bacterial Fluc…”
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Molecular Mechanisms for Bacterial Potassium Homeostasis by Stautz, Janina, Hellmich, Yvonne, Fuss, Michael F., Silberberg, Jakob M., Devlin, Jason R., Stockbridge, Randy B., Hänelt, Inga

“…[Display omitted] •Principles of bacterial membrane physiology.•Molecular determinants of bacterial K+ channels and transporters.•Molecular physiology of…”
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Guanidinium export is the primal function of SMR family transporters by Kermani, Ali A., Macdonald, Christian B., Gundepudi, Roja, Stockbridge, Randy B.

“…The small multidrug resistance (SMR) family of membrane proteins is prominent because of its rare dual topology architecture, simplicity, and small size. Its…”
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A clearer image of the structure and regulation of bestrophin by Stockbridge, Randy B

“…Stockbridge highlights new work revealing an allosteric inactivation mechanism for the bestrophin channel…”
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Metabolism of Free Guanidine in Bacteria Is Regulated by a Widespread Riboswitch Class by Nelson, James W., Atilho, Ruben M., Sherlock, Madeline E., Stockbridge, Randy B., Breaker, Ronald R.

“…The guanidyl moiety is a component of fundamental metabolites, including the amino acid arginine, the energy carrier creatine, and the nucleobase guanine…”
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Transport of metformin metabolites by guanidinium exporters of the small multidrug resistance family by Lucero, Rachael M, Demirer, Kemal, Yeh, Trevor Justin, Stockbridge, Randy B

“…Proteins from the small multidrug resistance (SMR) family are frequently associated with horizontally transferred multidrug resistance gene arrays found in…”
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Still rocking in the structural era: A molecular overview of the small multidrug resistance (SMR) transporter family by Burata, Olive E., Yeh, Trevor Justin, Macdonald, Christian B., Stockbridge, Randy B.

“…The small multidrug resistance (SMR) family is composed of widespread microbial membrane proteins that fulfill different transport functions. Four functional…”
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Elucidating the Physiological Role of Guanidinium (Gdm+) in Bacteria by Lucero, Rachael M., Stockbridge, Randy B.

“…Until recently, guanidinium (Gdm+) was not known to be physiologically relevant in bacteria. Gdm+ is most commonly known for industrials purposes in production…”
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The structural basis of promiscuity in small multidrug resistance transporters by Kermani, Ali A., Macdonald, Christian B., Burata, Olive E., Ben Koff, B., Koide, Akiko, Denbaum, Eric, Koide, Shohei, Stockbridge, Randy B.

“…By providing broad resistance to environmental biocides, transporters from the small multidrug resistance (SMR) family drive the spread of multidrug resistance…”
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Fluoride resistance and transport by riboswitch-controlled CLC antiporters by Stockbridge, Randy B, Lim, Hyun-Ho, Otten, Renee, Williams, Carole, Shane, Tania, Weinberg, Zasha, Miller, Christopher

“…A subclass of bacterial CLC anion-transporting proteins, phylogenetically distant from long-studied CLCs, was recently shown to be specifically up-regulated by…”
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Lysosomal membrane transporter purification and reconstitution for functional studies by Arines, Felichi Mae, Wielenga, Aleksander, Henn, Danielle, Burata, Olive E, Garcia, Francisco Narro, Stockbridge, Randy B, Li, Ming

“…Lysosomes achieve their function through numerous transporters that import or export nutrients across their membrane. However, technical challenges in membrane…”
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Proof of dual-topology architecture of Fluc F− channels with monobody blockers by Stockbridge, Randy B., Koide, Akiko, Miller, Christopher, Koide, Shohei

“…Fluc-type F − channels—used by microorganisms for resisting fluoride toxicity—are unusual in their quaternary architecture: they are thought to associate as…”
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Inroads into Membrane Physiology through Transport Nanomachines by Stockbridge, Randy B., Gaudet, Rachelle, Grabe, Michael, Minor, Daniel L.

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A topologically diverse family of fluoride channels by Macdonald, Christian B, Stockbridge, Randy B

“…[Display omitted] •Flucs are highly selective fluoride channels that protect microbes against cytoplasmic accumulation of toxic fluoride ion.•Flucs are found…”
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Dimerization mechanism of an inverted-topology ion channel in membranes by Ernst, Melanie, Orabi, Esam A, Stockbridge, Randy B, Faraldo-Gómez, José D, Robertson, Janice L

“…Many ion channels are multisubunit complexes where oligomerization is an obligatory requirement for function as the binding axis forms the charged permeation…”
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