Search Results - "Stocco, Douglas M."

The changing landscape in translocator protein (TSPO) function by Selvaraj, Vimal, Stocco, Douglas M

“…Highlights • Recent data question the role of TSPO in steroidogenesis and the MPT and suggest that TSPO is not involved. • Exploiting TSPO upregulation in…”
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Current knowledge on the acute regulation of steroidogenesis by Selvaraj, Vimal, Stocco, Douglas M, Clark, Barbara J

“…How rapid induction of steroid hormone biosynthesis occurs in response to trophic hormone stimulation of steroidogenic cells has been a subject of intensive…”
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Translocator Protein (TSPO) Affects Mitochondrial Fatty Acid Oxidation in Steroidogenic Cells by Tu, Lan N, Zhao, Amy H, Hussein, Mahmoud, Stocco, Douglas M, Selvaraj, Vimal

“…Translocator protein (TSPO), also known as the peripheral benzodiazepine receptor, is a highly conserved outer mitochondrial membrane protein present in…”
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Minireview: Translocator Protein (TSPO) and Steroidogenesis: A Reappraisal by Selvaraj, Vimal, Stocco, Douglas M, Tu, Lan N

“…The 18-kDa translocator protein (TSPO), also known as the peripheral benzodiazepine receptor, is a transmembrane protein in the outer mitochondrial membrane…”
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A brief history of the search for the protein(s) involved in the acute regulation of steroidogenesis by Stocco, Douglas M., Zhao, Amy H., Tu, Lan N., Morohaku, Kanako, Selvaraj, Vimal

“…The synthesis of steroid hormones occurs in specific cells and tissues in the body in response to trophic hormones and other signals. In order to synthesize…”
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Multiple Signaling Pathways Regulating Steroidogenesis and Steroidogenic Acute Regulatory Protein Expression: More Complicated than We Thought by Stocco, Douglas M, Wang, XingJia, Jo, Youngah, Manna, Pulak R

“…Steroid hormone biosynthesis in steroidogenic cells is regulated through trophic hormone activation of protein kinase A (PKA) signaling pathways. However, many…”
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Expression and roles of steroidogenic acute regulatory (StAR) protein in ‘non-classical’, extra-adrenal and extra-gonadal cells and tissues by Anuka, Eli, Gal, Michael, Stocco, Douglas M., Orly, Joseph

“…► ‘Non-classical’ StAR facilitates steroidogenesis or other mitochondrial activities. ► Steroidogenic StAR affects development and protects against cytotoxic…”
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Tracking the Role of a StAR in the Sky of the New Millennium by Stocco, Douglas M

“…The steroidogenic acute regulatory protein is indispensable for the biosynthesis of steroid hormones. Steroidogenic acute regulatory protein mediates the…”
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Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy by Jo Ann Janovick, Stewart, M. David, Jacob, Darla, Martin, L. D., Deng, Jian Min, Stewart, C. Allison, Wang, Ying, Cornea, Anda, Chavali, Lakshmi, Lopez, Suhujey, Mitalipov, Shoukhrat, Kang, Eunju, Lee, Hyo-Sang, Manna, Pulak R., Stocco, Douglas M., Behringer, Richard R., Conn, P. Michael

“…Mutations in receptors, ion channels, and enzymes are frequently recognized by the cellular quality control system as misfolded and retained in the endoplasmic…”
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Synergistic Activation of Steroidogenic Acute Regulatory Protein Expression and Steroid Biosynthesis by Retinoids: Involvement of cAMP/PKA Signaling by Manna, Pulak R, Slominski, Andrzej T, King, Steven R, Stetson, Cloyce L, Stocco, Douglas M

“…Both retinoic acid receptors (RARs) and retinoid X receptors (RXRs) mediate the action of retinoids that play important roles in reproductive development and…”
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Mechanisms of Protein Kinase C Signaling in the Modulation of 3′,5′-Cyclic Adenosine Monophosphate-Mediated Steroidogenesis in Mouse Gonadal Cells by Manna, Pulak R, Huhtaniemi, Ilpo T, Stocco, Douglas M

“…The protein kinase C (PKC) signaling pathway plays integral roles in the expression of the steroidogenic acute regulatory (StAR) protein that regulates steroid…”
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Crucial Role Reported for TSPO in Viability and Steroidogenesis is a Misconception. Commentary: Conditional Steroidogenic Cell-Targeted Deletion of TSPO Unveils a Crucial Role in Viability and Hormone-Dependent Steroid Formation by Selvaraj, Vimal, Tu, Lan N, Stocco, Douglas M

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Commentary: Amhr2 -Cre-Mediated Global Tspo Knockout by Selvaraj, Vimal, Morohaku, Kanako, Koganti, Prasanthi P, Zhang, Jianmin, He, Wei, Quirk, Susan M, Stocco, Douglas M

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Crosstalk of CREB and Fos/Jun on a single cis-element: transcriptional repression of the steroidogenic acute regulatory protein gene by Manna, Pulak R, Stocco, Douglas M

“…AbstractTranscriptional regulation of the steroidogenic acute regulatory (StAR) protein gene by cAMP-dependent mechanisms occurs in the absence of a consensus…”
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Regulation of Leydig cell steroidogenesis by extracellular signal-regulated kinase 1/2: role of protein kinase A and protein kinase C signaling by Manna, Pulak R, Jo, Youngah, Stocco, Douglas M

“…The steroidogenic acute regulatory (StAR) protein plays a central role in the regulation of steroid biosynthesis. While steroidogenesis is influenced by many…”
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Role of basic leucine zipper proteins in transcriptional regulation of the steroidogenic acute regulatory protein gene by Manna, Pulak R., Dyson, Matthew T., Stocco, Douglas M.

“…The regulation of steroidogenic acute regulatory protein (StAR) gene transcription by cAMP-dependent mechanisms occurs in the absence of a consensus cAMP…”
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cAMP-independent signaling regulates steroidogenesis in mouse Leydig cells in the absence of StAR phosphorylation by Manna, Pulak R, Chandrala, Syam P, Jo, Youngah, Stocco, Douglas M

“…In the regulation of steroid biosynthesis, a process mediated by the steroidogenic acute regulatory (StAR) protein, both cAMP-dependent and -independent…”
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The differential regulation of steroidogenic acute regulatory protein-mediated steroidogenesis by type I and type II PKA in MA-10 cells by Dyson, Matthew T., Kowalewski, Mariusz P., Manna, Pulak R., Stocco, Douglas M.

“…Following tropic hormone challenge, steroidogenic tissues utilize PKA to phosphorylate unique subsets of proteins necessary to facilitate steroidogenesis. This…”
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Molecular Mechanisms of Insulin-like Growth Factor-I Mediated Regulation of the Steroidogenic Acute Regulatory Protein in Mouse Leydig Cells by Manna, Pulak R, Chandrala, Syam P, King, Steven R, Jo, Youngah, Counis, Raymond, Huhtaniemi, Ilpo T, Stocco, Douglas M

“…Growth factors are known to play diverse roles in steroidogenesis, a process regulated by the mitochondrial steroidogenic acute regulatory (StAR) protein. The…”
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Mitochondrial A-Kinase Anchoring Protein 121 Binds Type II Protein Kinase A and Enhances Steroidogenic Acute Regulatory Protein-Mediated Steroidogenesis in MA-10 Mouse Leydig Tumor Cells by Dyson, Matthew T, Jones, Jeffrey K, Kowalewski, Mariusz P, Manna, Pulak R, Alonso, Manuela, Gottesman, Max E, Stocco, Douglas M

“…The expression of the steroidogenic acute regulatory protein (STAR) is regulated by PKA in response to trophic hormone stimulation through the second messenger…”
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