Prevention of ischemic myocardial damage by reducing the intracellular free carnitine level

3-(2, 2, 2-trimethylhydrazinium) propionate (THP) inhibits gamma-butyrobetaine hydroxylase, which is accompanied by a drop in myocardial free carnitin content. In rabbits, 200 mg/kg THP, administered intraperitoneally for 10 days, decreases free carnitin and long-chain acylcarnitin by 59.8 and 59.2%...

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Bibliographic Details
Published in:	Kardiologiia Vol. 27; no. 7; p. 85
Main Authors:	Simkhovich, B Z, Vitolinia, R O, Stivrinia, M I, Shutenko, Zh V, Meĭrena, D V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-07-1987
Subjects:	Animals Carnitine - metabolism Cell Membrane - metabolism Coronary Disease - metabolism Coronary Disease - prevention & control gamma-Butyrobetaine Dioxygenase Male Methylhydrazines - pharmacology Mixed Function Oxygenases - antagonists & inhibitors Myocardium - metabolism Rabbits Rats
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Summary:	3-(2, 2, 2-trimethylhydrazinium) propionate (THP) inhibits gamma-butyrobetaine hydroxylase, which is accompanied by a drop in myocardial free carnitin content. In rabbits, 200 mg/kg THP, administered intraperitoneally for 10 days, decreases free carnitin and long-chain acylcarnitin by 59.8 and 59.2%, respectively. In a carnitin-depressing dose, THP helps to recover contractility of isolated atria after hypoxic exposure. THP prevents isoproterenol-induced accumulation of long-chain acylcarnitin and ATR fall in the rat myocardium. The protective effect of THP is realized in the presence of considerably reduced (by an average of 77.8%) myocardial free carnitin levels. Inhibition of carnitin-dependent fatty acids metabolism by reducing intracellular carnitin concentration is a pathogenetically justified method of myocardial protection against ischemic damage.
ISSN:	0022-9040