Search Results - "Stivala, Simona"

Dual targeting of JAK2 and ERK interferes with the myeloproliferative neoplasm clone and enhances therapeutic efficacy by Brkic, Sime, Stivala, Simona, Santopolo, Alice, Szybinski, Jakub, Jungius, Sarah, Passweg, Jakob R., Tsakiris, Dimitrios, Dirnhofer, Stefan, Hutter, Gregor, Leonards, Katharina, Lischer, Heidi E. L., Dettmer, Matthias S., Neel, Benjamin G., Levine, Ross L., Meyer, Sara C.

“…Myeloproliferative neoplasms (MPN) show dysregulated JAK2 signaling. JAK2 inhibitors provide clinical benefits, but compensatory activation of MAPK pathway…”
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Amotosalen/ultraviolet A pathogen inactivation technology reduces platelet activatability, induces apoptosis and accelerates clearance by Stivala, Simona, Gobbato, Sara, Infanti, Laura, Reiner, Martin F, Bonetti, Nicole, Meyer, Sara C, Camici, Giovanni G, Lüscher, Thomas F, Buser, Andreas, Beer, Jürg H

“…Amotosalen and ultraviolet A (UVA) photochemical-based pathogen reduction using the Intercept™ Blood System (IBS) is an effective and established technology…”
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Glycoprotein Ib clustering in platelets can be inhibited by α-linolenic acid as revealed by cryo-electron tomography by Stivala, Simona, Sorrentino, Simona, Gobbato, Sara, Bonetti, Nicole R, Camici, Giovanni G, Lüscher, Thomas F, Medalia, Ohad, Beer, Jürg H

“…Platelet adhesion to the sub-endothelial matrix and damaged endothelium occurs through a multi-step process mediated in the initial phase by glycoprotein Ib…”
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Elevated HbA1c is not associated with recurrent venous thromboembolism in the elderly, but with all-cause mortality– the SWEETCO 65+ study by Mathis, Alexandra, Villiger, Lukas, Reiner, Martin F., Egloff, Michael, Schmid, Hans Ruedi, Stivala, Simona, Limacher, Andreas, Mean, Marie, Aujesky, Drahomir, Rodondi, Nicolas, Angelillo-Scherrer, Anna, Righini, Marc, Staub, Daniel, Aschwanden, Markus, Frauchiger, Beat, Osterwalder, Joseph, Kucher, Nils, Matter, Christian M., Banyai, Martin, Hugli, Oliver, Beer, Juerg H.

“…The association of glycated hemoglobin (HbA1c) with venous thromboembolism (VTE) and death in the elderly is unknown. In the SWEETCO 65+ study we analyzed…”
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Endothelial LOX-1 activation differentially regulates arterial thrombus formation depending on oxLDL levels: role of the Oct-1/SIRT1 and ERK1/2 pathways by Akhmedov, Alexander, Camici, Giovanni G, Reiner, Martin F, Bonetti, Nicole R, Costantino, Sarah, Holy, Erik W, Spescha, Remo D, Stivala, Simona, Schaub Clerigué, Ariane, Speer, Thimoteus, Breitenstein, Alexander, Manz, Jasmin, Lohmann, Christine, Paneni, Francesco, Beer, Juerg-Hans, Lüscher, Thomas F

“…The lectin-like oxLDL receptor-1 (LOX-1) promotes endothelial uptake of oxidized low-density lipoprotein (oxLDL) and plays an important role in atherosclerosis…”
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S209: TARGETING THE SRC HOMOLOGY 2 DOMAIN‐CONTAINING PHOSPHATASE SHP2 ENHANCES THE THERAPEUTIC EFFICACY OF JAK INHIBITION IN MYELOPROLIFERATIVE NEOPLASMS by Jungius, Sarah, Mattei, Sara, Stivala, Simona, Szybinski, Jakub, Vokalova, Lenka, Rovó, Alicia, Angelillo‐Scherrer, Anne, Dirnhofer, Stefan, Meyer, Sara

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In response to the comment by Hechler et al .: Amotosalen/UVA pathogen inactivation technology reduces platelet activatability, induces apoptosis and accelerates clearance by Stivala, Simona, Gobbato, Sara, Infanti, Laura, Reiner, Martin F, Bonetti, Nicole, Meyer, Sara C, Camici, Giovanni G, Lüscher, Thomas F, Buser, Andreas, Beer, Juerg H

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Cell-cycle inhibition by Helicobacter pylori L-asparaginase by Scotti, Claudia, Sommi, Patrizia, Pasquetto, Maria Valentina, Cappelletti, Donata, Stivala, Simona, Mignosi, Paola, Savio, Monica, Chiarelli, Laurent Roberto, Valentini, Giovanna, Bolanos-Garcia, Victor M, Merrell, Douglas Scott, Franchini, Silvia, Verona, Maria Luisa, Bolis, Cristina, Solcia, Enrico, Manca, Rachele, Franciotta, Diego, Casasco, Andrea, Filipazzi, Paola, Zardini, Elisabetta, Vannini, Vanio

“…Helicobacter pylori (H. pylori) is a major human pathogen causing chronic gastritis, peptic ulcer, gastric cancer, and mucosa-associated lymphoid tissue…”
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Inhibition of Vascular c‐Jun N‐Terminal Kinase 2 Improves Obesity‐Induced Endothelial Dysfunction After Roux‐en‐Y Gastric Bypass by Doytcheva, Petia, Bächler, Thomas, Tarasco, Erika, Marzolla, Vincenzo, Engeli, Michael, Pellegrini, Giovanni, Stivala, Simona, Rohrer, Lucia, Tona, Francesco, Camici, Giovanni G., Vanhoutte, Paul M., Matter, Christian M., Lutz, Thomas A., Lüscher, Thomas F., Osto, Elena

“…Background Roux‐en‐Y gastric bypass (RYGB) reduces obesity‐associated comorbidities and cardiovascular mortality. RYGB improves endothelial dysfunction,…”
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Engineering the NK1 Fragment of Hepatocyte Growth Factor/Scatter Factor as a MET Receptor Antagonist by Youles, Mark, Holmes, Oliver, Petoukhov, Maxim V., Nessen, Merel A., Stivala, Simona, Svergun, Dmitri I., Gherardi, Ermanno

“…The growth and motility factor hepatocyte growth factor/scatter factor (HGF/SF) and its receptor MET, the tyrosine kinase encoded by the c-MET proto-oncogene,…”
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Helicobacter pyloril-asparaginase: A promising chemotherapeutic agent by Cappelletti, Donata, Chiarelli, Laurent R., Pasquetto, Maria Valentina, Stivala, Simona, Valentini, Giovanna, Scotti, Claudia

“…Bacterial l-asparaginases are amidohydrolases that catalyse the conversion of l-asparagine to l-aspartate and ammonia and are used as anti-cancer drugs. The…”
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Establishment of an Innovative Preclinical Mouse Model for Advanced Systemic Mastocytosis by Konantz, Martina, Makeeva, Alina, Ratti, Elena, Clauss, Laetitia, Sheremeti, Etnik, Bartoszek, Ewelina, Stivala, Simona, Hartmann, Karin

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Targeting compensatory MEK/ERK activation increases JAK inhibitor efficacy in myeloproliferative neoplasms by Stivala, Simona, Codilupi, Tamara, Brkic, Sime, Baerenwaldt, Anne, Ghosh, Nilabh, Hao-Shen, Hui, Dirnhofer, Stephan, Dettmer, Matthias S, Simillion, Cedric, Kaufmann, Beat A, Chiu, Sophia, Keller, Matthew, Kleppe, Maria, Hilpert, Morgane, Buser, Andreas S, Passweg, Jakob R, Radimerski, Thomas, Skoda, Radek C, Levine, Ross L, Meyer, Sara C

“…Constitutive JAK2 signaling is central to myeloproliferative neoplasm (MPN) pathogenesis and results in activation of STAT, PI3K/AKT, and MEK/ERK signaling…”
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Recent Advances in Molecular Diagnostics and Targeted Therapy of Myeloproliferative Neoplasms by Stivala, Simona, Meyer, Sara C.

“…Somatic mutations in JAK2, calreticulin, and MPL genes drive myeloproliferative neoplasms (MPN), and recent technological advances have revealed a…”
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Rapid and Body Weight–Independent Improvement of Endothelial and High-Density Lipoprotein Function After Roux-en-Y Gastric Bypass: Role of Glucagon-Like Peptide-1 by Osto, Elena, Doytcheva, Petia, Corteville, Caroline, Bueter, Marco, Dörig, Claudia, Stivala, Simona, Buhmann, Helena, Colin, Sophie, Rohrer, Lucia, Hasballa, Reda, Tailleux, Anne, Wolfrum, Christian, Tona, Francesco, Manz, Jasmin, Vetter, Diana, Spliethoff, Kerstin, Vanhoutte, Paul M, Landmesser, Ulf, Pattou, Francois, Staels, Bart, Matter, Christian M, Lutz, Thomas A, Lüscher, Thomas F

“…BACKGROUND—Roux-en-Y gastric bypass (RYGB) reduces body weight and cardiovascular mortality in morbidly obese patients. Glucagon-like peptide-1 (GLP-1) seems…”
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Dietary alpha‐linolenic acid reduces platelet activation and collagen‐mediated cell adhesion in sickle cell disease mice by Stivala, Simona, Gobbato, Sara, Bonetti, Nicole, Camici, Giovanni G., Lüscher, Thomas F., Beer, Jürg H.

“…Background Sickle cell disease (SCD) is a genetic hemoglobinopathy associated with high morbidity and mortality. The primary cause of hospitalization in SCD is…”
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Escape from Type II JAK2 Inhibition in MPN Depends on AXL/MAPK Activation and Is Targetable by Codilupi, Tamara, Szybinski, Jakub, Brkic, Sime, Stivala, Simona, Yang, Julie, Ghosh, Nilabh, Buczak, Katarzyna, Passweg, Jakob, Angelillo-Scherrer, Anne, Dirnhofer, Stefan, Levine, Ross L., Koche, Richard, Meyer, Sara C.

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Development of Resistance to Type II JAK2 Inhibitors in MPN Depends on AXL Kinase and Is Targetable by Codilupi, Tamara, Szybinski, Jakub, Arunasalam, Stefanie, Jungius, Sarah, Dunbar, Andrew C, Stivala, Simona, Brkic, Sime, Albrecht, Camille, Vokalova, Lenka, Yang, Julie L, Buczak, Katarzyna, Ghosh, Nilabh, Passweg, Jakob R, Rovo, Alicia, Angelillo-Scherrer, Anne, Pankov, Dmitry, Dirnhofer, Stefan, Levine, Ross L, Koche, Richard, Meyer, Sara C

“…Myeloproliferative neoplasms (MPN) dysregulate JAK2 signaling. Because clinical JAK2 inhibitors have limited disease-modifying effects, type II JAK2 inhibitors…”
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The NO-donor MPC-1011 stimulates angiogenesis and arteriogenesis and improves hindlimb ischemia via a cGMP-dependent pathway involving VEGF and SDF-1α by Gomes de Almeida Schirmer, Brigida, Crucet, Margot, Stivala, Simona, Vucicevic, Goran, da Silva Barcelos, Luciola, Vanhoutte, Paul M., Pellegrini, Giovanni, Camici, Giovanni G., Seebeck, Petra, Pfundstein, Svende, Stein, Sokrates, Paneni, Francesco, Lüscher, Thomas F., Simic, Branko

“…Peripheral arterial disease (PAD) is an important cause of morbidity and mortality with little effective medical treatment currently available. Nitric oxide…”
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Whole blood omega-3 fatty acid concentrations are inversely associated with blood pressure in young, healthy adults by Filipovic, Mark G, Aeschbacher, Stefanie, Reiner, Martin F, Stivala, Simona, Gobbato, Sara, Bonetti, Nicole, Risch, Martin, Risch, Lorenz, Camici, Giovanni G, Luescher, Thomas F, von Schacky, Clemens, Conen, David, Beer, Juerg H

“…BACKGROUND:Omega-3 fatty acids (n − 3 FA) may have blood pressure (BP)-lowering effects in untreated hypertensive and elderly patients. The effect of n − 3 FA…”
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