Search Results - "Stitt, Trevor"

The IGF-1/PI3K/Akt Pathway Prevents Expression of Muscle Atrophy-Induced Ubiquitin Ligases by Inhibiting FOXO Transcription Factors by Stitt, Trevor N., Drujan, Doreen, Clarke, Brian A., Panaro, Frank, Timofeyva, Yekatarina, Kline, William O., Gonzalez, Michael, Yancopoulos, George D., Glass, David J.

“…Skeletal muscle size depends upon a dynamic balance between anabolic (or hypertrophic) and catabolic (or atrophic) processes. Previously, no link between the…”
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Activin A more prominently regulates muscle mass in primates than does GDF8 by Latres, Esther, Mastaitis, Jason, Fury, Wen, Miloscio, Lawrence, Trejos, Jesus, Pangilinan, Jeffrey, Okamoto, Haruka, Cavino, Katie, Na, Erqian, Papatheodorou, Angelos, Willer, Tobias, Bai, Yu, Hae Kim, Jee, Rafique, Ashique, Jaspers, Stephen, Stitt, Trevor, Murphy, Andrew J., Yancopoulos, George D., Gromada, Jesper

“…Growth and differentiation factor 8 (GDF8) is a TGF-β superfamily member, and negative regulator of skeletal muscle mass. GDF8 inhibition results in prominent…”
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The E3 Ligase MuRF1 Degrades Myosin Heavy Chain Protein in Dexamethasone-Treated Skeletal Muscle by Clarke, Brian A., Drujan, Doreen, Willis, Monte S., Murphy, Leon O., Corpina, Richard A., Burova, Elena, Rakhilin, Sergey V., Stitt, Trevor N., Patterson, Cam, Latres, Esther, Glass, David J.

“…Skeletal muscle atrophy occurs as a side effect of treatment with synthetic glucocorticoids such as dexamethasone (DEX) and is a hallmark of cachectic…”
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Conditional Activation of Akt in Adult Skeletal Muscle Induces Rapid Hypertrophy by Lai, Ka-Man V., Gonzalez, Michael, Poueymirou, William T., Kline, William O., Na, Erqian, Zlotchenko, Elizabeth, Stitt, Trevor N., Economides, Aris N., Yancopoulos, George D., Glass, David J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo by Bodine, Sue C, Yancopoulos, George D, Stitt, Trevor N, Gonzalez, Michael, Kline, William O, Stover, Gretchen L, Bauerlein, Roy, Zlotchenko, Elizabeth, Scrimgeour, Angus, Lawrence, John C, Glass, David J

“…Skeletal muscles adapt to changes in their workload by regulating fibre size by unknown mechanisms. The roles of two signalling pathways implicated in muscle…”
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Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways by Glass, David J, Rommel, Christian, Bodine, Sue C, Clarke, Brian A, Rossman, Roni, Nunez, Lorna, Stitt, Trevor N, Yancopoulos, George D

“…Skeletal muscle is composed of multinucleated fibres, formed after the differentiation and fusion of myoblast precursors. Skeletal muscle atrophy and…”
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Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy by Bodine, Sue C., Latres, Esther, Baumhueter, Susanne, Venus K.-M. Lai, Nunez, Lorna, Clarke, Brian A., Poueymirou, William T., Panaro, Frank J., Na, Erqian, Dharmarajan, Kumar, Pan, Zhen-Qiang, Valenzuela, David M., DeChiara, Thomas M., Stitt, Trevor N., Yancopoulos, George D., Glass, David J.

“…Skeletal muscle adapts to decreases in activity and load by undergoing atrophy. To identify candidate molecular mediators of muscle atrophy, we performed…”
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Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity by Glass, David J, Sleeman, Mark W, Wortley, Katherine E, Lai, Ka-Man V, Gowen, Lori C, Kintner, Jennifer, Kline, William O, Garcia, Karen, Stitt, Trevor N, Yancopoulos, George D, Wiegand, Stanley J

“…Genetic ablation of Inppl1, which encodes SHIP2 (SH2-domain containing inositol 5-phosphatase 2), was previously reported to induce severe insulin sensitivity,…”
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Genetic Deletion of Trb3, the Mammalian Drosophila tribbles Homolog, Displays Normal Hepatic Insulin Signaling and Glucose Homeostasis by Okamoto, Haruka, Latres, Esther, Liu, Rong, Thabet, Karen, Murphy, Andrew, Valenzeula, David, Yancopoulos, George D, Stitt, Trevor N, Glass, David J, Sleeman, Mark W

“…Genetic Deletion of Trb3, the Mammalian Drosophila tribbles Homolog, Displays Normal Hepatic Insulin Signaling and Glucose Homeostasis Haruka Okamoto , Esther…”
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Agrin Acts via a MuSK Receptor Complex by Glass, David J, Bowen, David C, Stitt, Trevor N, Radziejewski, Czeslaw, Bruno, JoAnne, Ryan, Terence E, Gies, David R, Shah, Sonal, Mattsson, Karen, Burden, Steven J, DiStefano, Peter S, Valenzuela, David M, DeChiara, Thomas M, Yancopoulos, George D

“…Formation of the neuromuscular junction depends upon reciprocal inductive interactions between the developing nerve and muscle, resulting in the precise…”
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The Growth Arrest-Specific Gene Product Gas6 Promotes the Survival of Human Oligodendrocytes via a Phosphatidylinositol 3-Kinase-Dependent Pathway by Shankar, Sai Latha, O'Guin, Kathleen, Cammer, Michael, McMorris, F. Arthur, Stitt, Trevor N, Basch, Ross S, Varnum, Brian, Shafit-Zagardo, Bridget

“…Microarray analysis revealed that transcripts for the Axl and Mer receptor tyrosine kinases are expressed at high levels in O4+-immunopanned oligodendrocytes…”
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The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases by Stitt, Trevor N, Conn, Greg, Goret, Martin, Lai, Cary, Bruno, Joanne, Radzlejewski, Czeslaw, Mattsson, Karen, Fisher, John, Gies, David R, Jones, Pamela F, Masiakowski, Piotr, Ryan, Terence E, Tobkes, Nancy J, Chen, D.H, DiStefano, Peter S, Long, George L, Basilico, Claudio, Goldfarb, Mitchell P, Lemke, Greg, Glass, David J, Yancopoulos, George D

“…We report the identification of ligands for Tyro 3 (alternatively called Sky, rse, brt, or tif) and Axl (alternatively, Ark or UFO), members of a previously…”
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Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells by Ip, Nancy Y, Stitt, Trevor N, Tapley, Peter, Klein, Rudiger, Glass, David J, Fandl, James, Greene, Lloyd A, Barbacid, Mariano, Yancopoulos, George D

“…We have exploited a battery of approaches to address several controversies that have accompanied the expansion of the nerve growth factor (NGF) family of…”
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trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor by Squinto, Stephen P, Stitt, Trevor N, Aldrich, Thomas H, Davis, Samuel, Blanco, Stella M, RadzieJewski, Czeslaw, Glass, David J, Masiakowski, Piotr, Furth, Mark E, Valenzuela, David M, Distefano, Peter S, Yancopoulos, George D

“…A variety of findings seem to functionally link brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), while distinguishing both of these factors…”
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Alternative forms of rat TrkC with different functional capabilities by Valenzuela, David M, Maisonpierre, Peter C, Glass, David J, Rojas, Eduardo, Nuñez, Lorna, Kong, Yuan, Gies, David R, Stitt, Trevor N, Ip, Nancy Y, Yancopoulos, George D

“…We have identified transcripts encoding several different forms of rat TrkC, a member of the Trk family of receptor tyrosine kinases that serves as a receptor…”
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Receptor tyrosine kinase specific for the skeletal muscle lineage: Expression in embryonic muscle, at the neuromuscular junction, and after injury by Valenzuela, David M., Stitt, Trevor N., DiStefano, Peter S., Rojas, Eduardo, Mattsson, Karen, Compton, Debra L., Nunez, Lorna, Park, John S., Stark, Jennifer L., Gies, David R., Thomas, Susan, Le Beau, Michelle M., Fernald, Anthony A., Copeland, Neal G., Jenkins, Nancy A., Burden, Steven J., Glass, David J., Yancopoulos, George D.

“…While a number of growth factors have been described that are highly specific for particular cell lineages, neither a factor nor a receptor uniquely specific…”
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Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice by Latres, Esther, Pangilinan, Jeffrey, Miloscio, Lawrence, Bauerlein, Roy, Na, Erqian, Potocky, Terra B, Huang, Ying, Eckersdorff, Mark, Rafique, Ashique, Mastaitis, Jason, Lin, Calvin, Murphy, Andrew J, Yancopoulos, George D, Gromada, Jesper, Stitt, Trevor

“…Loss of skeletal muscle mass and function in humans is associated with significant morbidity and mortality. The role of myostatin as a key negative regulator…”
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Kinase Domain of the Muscle-Specific Receptor Tyrosine Kinase (MuSK) is Sufficient for Phosphorylation but not Clustering of Acetylcholine Receptors: Required Role for the MuSK Ectodomain? by Glass, David J., Apel, Elizabeth D., Shah, Sonal, Bowen, David C., DeChiara, Thomas M., Stitt, Trevor N., Sanes, Joshua R., Yancopoulos, George D.

“…Formation of the neuromuscular junction (NMJ) depends upon a nerve-derived protein, agrin, acting by means of a muscle-specific receptor tyrosine kinase, MuSK,…”
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Localization and Regulation of MuSK at the Neuromuscular Junction by Bowen, David C., Park, John S., Bodine, Sue, Stark, Jennifer L., Valenzuela, David M., Stitt, Trevor N., Yancopoulos, George D., Lindsay, Ronald M., Glass, David J., DiStefano, Peter S.

“…The receptor tyrosine kinase, MuSK, is required for the formation of the neuromuscular junction (NMJ) where MuSK becomes phosphorylated when exposed to…”
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Loss of SFRP4 Alters Body Size, Food Intake, and Energy Expenditure in Diet-Induced Obese Male Mice by Mastaitis, Jason, Eckersdorff, Mark, Min, Soo, Xin, Yurong, Cavino, Katie, Aglione, Johnpaul, Okamoto, Haruka, Na, Erqian, Stitt, Trevor, Dominguez, Melissa G, Schmahl, Jennifer P, Lin, Calvin, Gale, Nicholas W, Valenzuela, David M, Murphy, Andrew J, Yancopoulos, George D, Gromada, Jesper

“…Secreted frizzled-related protein 4 (SFRP4) is an extracellular regulator of the wingless-type mouse mammary tumor virus integration site family (WNT) pathway…”
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