Search Results - "Stitt, Alan"

Neurodegeneration in diabetic retinopathy: does it really matter? by Simó, Rafael, Stitt, Alan W., Gardner, Thomas W.

“…The concept of diabetic retinopathy as a microvascular disease has evolved, in that it is now considered a more complex diabetic complication in which…”
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Current understanding of the molecular and cellular pathology of diabetic retinopathy by Antonetti, David A., Silva, Paolo S., Stitt, Alan W.

“…Diabetes mellitus has profound effects on multiple organ systems; however, the loss of vision caused by diabetic retinopathy might be one of the most impactful…”
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The pathology associated with diabetic retinopathy by Lechner, Judith, O'Leary, Olivia E., Stitt, Alan W.

“…This review summarizes the pathological features of diabetic retinopathy. The lesions occurring in the diabetic retina have been described over many decades…”
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AGEs and diabetic retinopathy by Stitt, Alan W

“…The pathogenesis of diabetic retinopathy is multifactorial, and a range of hyperglycemia-linked pathways have been implicated in the initiation and progression…”
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Diabetic retinopathy: current understanding, mechanisms, and treatment strategies by Duh, Elia J, Sun, Jennifer K, Stitt, Alan W

“…Diabetic retinopathy (DR) causes significant visual loss on a global scale. Treatments for the vision-threatening complications of diabetic macular edema (DME)…”
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Molecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities by Medina, Reinhold J, O'Neill, Christina L, Sweeney, Mark, Guduric-Fuchs, Jasenka, Gardiner, Tom A, Simpson, David A, Stitt, Alan W

“…The term endothelial progenitor cells (EPCs) is currently used to refer to cell populations which are quite dissimilar in terms of biological properties. This…”
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AGEs, RAGE, and Diabetic Retinopathy by Zong, Hongliang, Ward, Micheal, Stitt, Alan W.

“…Diabetic retinopathy is a major diabetic complication with a highly complex etiology. Although there are many pathways involved, it has become established that…”
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Advances in our understanding of diabetic retinopathy by Stitt, Alan W, Lois, Noemi, Medina, Reinhold J, Adamson, Peter, Curtis, Timothy M

“…Diabetic retinopathy remains the most common complication of diabetes mellitus and is a leading cause of visual loss in industrialized nations. The…”
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Claudin-5 Redistribution Induced by Inflammation Leads to Anti-VEGF-Resistant Diabetic Macular Edema by Arima, Mitsuru, Nakao, Shintaro, Yamaguchi, Muneo, Feng, Hao, Fujii, Yuya, Shibata, Kensuke, Wada, Iori, Kaizu, Yoshihiro, Ahmadieh, Hamid, Ishibashi, Tatsuro, Stitt, Alan W, Sonoda, Koh-Hei

“…Approximately 40% of patients with diabetic macular edema (DME) are resistant to anti-vascular endothelial growth factor (VEGF) therapy (rDME). Here, we…”
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The role of placental growth factor (PlGF) and its receptor system in retinal vascular diseases by Van Bergen, Tine, Etienne, Isabelle, Cunningham, Fiona, Moons, Lieve, Schlingemann, Reinier O., Feyen, Jean H.M., Stitt, Alan W.

“…Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family. Upon binding to VEGF- and neuropilin-receptor sub-types,…”
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Animal Models of Retinal Vein Occlusion by Khayat, Meiaad, Lois, Noemi, Williams, Michael, Stitt, Alan W

“…To provide a comprehensive and current review on the available experimental animal models of retinal vein occlusion (RVO) and to identify their strengths and…”
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Publisher Correction: Current understanding of the molecular and cellular pathology of diabetic retinopathy by Antonetti, David A, Silva, Paolo S, Stitt, Alan W

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Endothelial Progenitors: A Consensus Statement on Nomenclature by Medina, Reinhold J., Barber, Chad L., Sabatier, Florence, Dignat‐George, Francoise, Melero‐Martin, Juan M., Khosrotehrani, Kiarash, Ohneda, Osamu, Randi, Anna M., Chan, Jerry K.Y., Yamaguchi, Teruhide, Van Hinsbergh, Victor W.M., Yoder, Mervin C., Stitt, Alan W.

“…Summary Endothelial progenitor cell (EPC) nomenclature remains ambiguous and there is a general lack of concordance in the stem cell field with many distinct…”
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IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment by Augustine, Josy, Pavlou, Sofia, Ali, Imran, Harkin, Kevin, Ozaki, Ema, Campbell, Matthew, Stitt, Alan W, Xu, Heping, Chen, Mei

“…Interleukin-33 (IL-33) belongs to the IL-1 cytokine family and resides in the nuclei of various cell types. In the neural retina, IL-33 is predominately…”
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Targeting RGD-binding integrins as an integrative therapy for diabetic retinopathy and neovascular age-related macular degeneration by Van Hove, Inge, Hu, Tjing-Tjing, Beets, Karen, Van Bergen, Tine, Etienne, Isabelle, Stitt, Alan W., Vermassen, Elke, Feyen, Jean H.M.

“…Integrins are a class of transmembrane receptors that are involved in a wide range of biological functions. Dysregulation of integrins has been implicated in…”
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Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony–forming cells by Prasain, Nutan, Lee, Man Ryul, Vemula, Sasidhar, Meador, Jonathan Luke, Yoshimoto, Momoko, Ferkowicz, Michael J, Fett, Alexa, Gupta, Manav, Rapp, Brian M, Saadatzadeh, Mohammad Reza, Ginsberg, Michael, Elemento, Olivier, Lee, Younghee, Voytik-Harbin, Sherry L, Chung, Hyung Min, Hong, Ki Sung, Reid, Emma, O'Neill, Christina L, Medina, Reinhold J, Stitt, Alan W, Murphy, Michael P, Rafii, Shahin, Broxmeyer, Hal E, Yoder, Mervin C

“…Endothelial cells with properties of cord-blood endothelial colony-forming cells are generated from human pluripotent stem cells. The ability to differentiate…”
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The pathogenic role of Maillard reaction in the aging eye by Nagaraj, Ram H., Linetsky, Mikhail, Stitt, Alan W.

“…The proteins of the human eye are highly susceptible to the formation of advanced glycation end products (AGEs) from the reaction of sugars and carbonyl…”
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Angiogenic potential of vitreous from Proliferative Diabetic Retinopathy and Eales' Disease patients by Murugeswari, Ponnalagu, Shukla, Dhananjay, Kim, Ramasamy, Namperumalsamy, Perumalsamy, Stitt, Alan W, Muthukkaruppan, Veerappan

“…Proliferative Diabetic Retinopathy (PDR) and Eales' Disease (ED) have different aetiologies although they share certain common clinical symptoms including…”
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Targeting QKI-7 in vivo restores endothelial cell function in diabetes by Yang, Chunbo, Eleftheriadou, Magdalini, Kelaini, Sophia, Morrison, Thomas, González, Marta Vilà, Caines, Rachel, Edwards, Nicola, Yacoub, Andrew, Edgar, Kevin, Moez, Arya, Ivetic, Aleksandar, Zampetaki, Anna, Zeng, Lingfang, Wilkinson, Fiona L., Lois, Noemi, Stitt, Alan W., Grieve, David J., Margariti, Andriana

“…Vascular endothelial cell (EC) dysfunction plays a key role in diabetic complications. This study discovers significant upregulation of Quaking-7 (QKI-7) in…”
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Advances in cell therapies using stem cells/progenitors as a novel approach for neurovascular repair of the diabetic retina by Lechner, Judith, Medina, Reinhold J, Lois, Noemi, Stitt, Alan W

“…Diabetic retinopathy, a major complication of diabetes mellitus, is a leading cause of sigh-loss in working age adults. Progressive loss of integrity of the…”
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