Search Results - "Stith, Carrie M."

Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes by Netz, Daili J A, Stith, Carrie M, Stümpfig, Martin, Köpf, Gabriele, Vogel, Daniel, Genau, Heide M, Stodola, Joseph L, Lill, Roland, Burgers, Peter M J, Pierik, Antonio J

“…DNA polymerases contain two cysteine-rich metal binding motifs (CysA and CysB), which have been assigned as zinc-ion binding sites by structural studies. A…”
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Division of Labor at the Eukaryotic Replication Fork by Nick McElhinny, Stephanie A., Gordenin, Dmitry A., Stith, Carrie M., Burgers, Peter M.J., Kunkel, Thomas A.

“…DNA polymerase δ (Pol δ) and DNA polymerase ɛ (Pol ɛ) are both required for efficient replication of the nuclear genome, yet the division of labor between…”
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Flexibility of Eukaryotic Okazaki Fragment Maturation through Regulated Strand Displacement Synthesis by Stith, Carrie M., Sterling, Joan, Resnick, Michael A., Gordenin, Dmitry A., Burgers, Peter M.

“…Okazaki fragment maturation to produce continuous lagging strands in eukaryotic cells requires precise coordination of strand displacement synthesis by DNA…”
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Yeast Exonuclease 5 Is Essential for Mitochondrial Genome Maintenance by Burgers, Peter M., Stith, Carrie M., Yoder, Bonita L., Sparks, Justin L.

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The Multiple Biological Roles of the 3′→5′ Exonuclease of Saccharomyces cerevisiae DNA Polymerase δ Require Switching between the Polymerase and Exonuclease Domains by Jin, Yong Hwan, Garg, Parie, Stith, Carrie M. W., Al-Refai, Hanan, Sterling, Joan F., Murray, Laura J. W., Kunkel, Thomas A., Resnick, Michael A., Burgers, Peter M., Gordenin, Dmitry A.

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PCNA Is Required for Initiation of Recombination-Associated DNA Synthesis by DNA Polymerase δ by Li, Xuan, Stith, Carrie M., Burgers, Peter M., Heyer, Wolf-Dietrich

“…Genetic recombination ensures proper chromosome segregation during meiosis and is essential for genome stability and tumor suppression. DNA synthesis after…”
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DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures by Northam, Matthew R, Moore, Elizabeth A, Mertz, Tony M, Binz, Sara K, Stith, Carrie M, Stepchenkova, Elena I, Wendt, Kathern L, Burgers, Peter M J, Shcherbakova, Polina V

“…DNA polymerase ζ (Pol ζ) and Rev1 are key players in translesion DNA synthesis. The error-prone Pol ζ can also participate in replication of undamaged DNA when…”
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Proficient Replication of the Yeast Genome by a Viral DNA Polymerase by Stodola, Joseph L., Stith, Carrie M., Burgers, Peter M.

“…DNA replication in eukaryotic cells requires minimally three B-family DNA polymerases: Pol α, Pol δ, and Pol ɛ. Pol δ replicates and matures Okazaki fragments…”
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The roles of fission yeast exonuclease 5 in nuclear and mitochondrial genome stability by Sparks, Justin L., Gerik, Kimberly J., Stith, Carrie M., Yoder, Bonita L., Burgers, Peter M.

“…•Exo5 is an understudied 5′-exonuclease that is downregulated in several cancers.•Fission yeast Exo5 is a good model system for the human enzyme.•Fission yeast…”
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Idling by DNA polymerase delta maintains a ligatable nick during lagging-strand DNA replication by Garg, Parie, Stith, Carrie M, Sabouri, Nasim, Johansson, Erik, Burgers, Peter M

“…During each yeast cell cycle, approximately 100,000 nicks are generated during lagging-strand DNA replication. Efficient nick processing during Okazaki…”
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eukaryotic leading and lagging strand DNA polymerases are loaded onto primer-ends via separate mechanisms but have comparable processivity in the presence of PCNA by Chilkova, Olga, Stenlund, Peter, Isoz, Isabelle, Stith, Carrie M, Grabowski, Pawel, Lundström, Else-Britt, Burgers, Peter M, Johansson, Erik

“…Saccharomyces cerevisiae DNA polymerase δ (Pol δ) and DNA polymerase ε (Pol ε) are replicative DNA polymerases at the replication fork. Both enzymes are…”
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fidelity of DNA synthesis by yeast DNA polymerase zeta alone and with accessory proteins by Zhong, Xuejun, Garg, Parie, Stith, Carrie M, McElhinny, Stephanie A. Nick, Kissling, Grace E, Burgers, Peter M.J, Kunkel, Thomas A

“…DNA polymerase zeta (pol ζ) participates in several DNA transactions in eukaryotic cells that increase spontaneous and damage-induced mutagenesis. To better…”
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Inefficient Proofreading and Biased Error Rates during Inaccurate DNA Synthesis by a Mutant Derivative of Saccharomyces cerevisiae DNA Polymerase δ by McElhinny, Stephanie A. Nick, Stith, Carrie M., Burgers, Peter M.J., Kunkel, Thomas A.

“…DNA polymerase δ (pol δ) is a high fidelity eukaryotic enzyme that participates in DNA repair and is essential for DNA replication. Toward the goal of…”
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Proliferating Cell Nuclear Antigen Promotes Translesion Synthesis by DNA Polymerase ζ by Garg, Parie, Stith, Carrie M., Majka, Jerzy, Burgers, Peter M.J.

“…DNA polymerase ζ (Pol ζ), a heterodimer of Rev3 and Rev7, is essential for DNA damage provoked mutagenesis in eukaryotes. DNA polymerases that function in a…”
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Uracil recognition by replicative DNA polymerases is limited to the archaea, not occurring with bacteria and eukarya by Wardle, Josephine, Burgers, Peter M.J, Cann, Isaac K.O, Darley, Kate, Heslop, Pauline, Johansson, Erik, Lin, Li-Jung, McGlynn, Peter, Sanvoisin, Jonathan, Stith, Carrie M, Connolly, Bernard A

“…Family B DNA polymerases from archaea such as Pyrococcus furiosus, which live at temperatures ~100°C, specifically recognize uracil in DNA templates and stall…”
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RPA and PCNA suppress formation of large deletion errors by yeast DNA polymerase δ by Fortune, John M, Stith, Carrie M, Kissling, Grace E, Burgers, Peter M.J, Kunkel, Thomas A

“…In fulfilling its biosynthetic roles in nuclear replication and in several types of repair, DNA polymerase δ (pol δ) is assisted by replication protein A…”
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Low-fidelity DNA synthesis by the L979F mutator derivative of Saccharomyces cerevisiae DNA polymerase ζ by Stone, Jana E, Kissling, Grace E, Lujan, Scott A, Rogozin, Igor B, Stith, Carrie M, Burgers, Peter M.J, Kunkel, Thomas A

“…To probe Pol ζ functions in vivo via its error signature, here we report the properties of Saccharomyces cerevisiae Pol ζ in which phenyalanine was substituted…”
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Low-fidelity DNA synthesis by the L979F mutator derivative of Saccharomyces cerevisiae DNA polymerase [zeta] by Stone, Jana E, Kissling, Grace E, Lujan, Scott A, Rogozin, Igor B, Stith, Carrie M, Burgers, Peter M J, Kunkel, Thomas A

“…To probe Pol ζ functions in vivo via its error signature, here we report the properties of Saccharomyces cerevisiae Pol ζ in which phenyalanine was substituted…”
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Partial reconstitution of DNA large loop repair with purified proteins from Saccharomyces cerevisiae by Sommer, Debbie, Stith, Carrie M., Burgers, Peter M. J., Lahue, Robert S.

“…Small looped mispairs are corrected by DNA mismatch repair. In addition, a distinct process called large loop repair (LLR) corrects heteroduplexes up to…”
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Flexibility of Eukaryotic Okazaki Fragment Maturation through Regulated Strand Displacement SynthesisS by Stith, Carrie M., Sterling, Joan, Resnick, Michael A., Gordenin, Dmitry A., Burgers, Peter M.

“…Okazaki fragment maturation to produce continuous lagging strands in eukaryotic cells requires precise coordination of strand displacement synthesis by DNA…”
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