Search Results - "Stitelman, David"

In utero nanoparticle delivery for site-specific genome editing by Ricciardi, Adele S., Bahal, Raman, Farrelly, James S., Quijano, Elias, Bianchi, Anthony H., Luks, Valerie L., Putman, Rachael, López-Giráldez, Francesc, Coşkun, Süleyman, Song, Eric, Liu, Yanfeng, Hsieh, Wei-Che, Ly, Danith H., Stitelman, David H., Glazer, Peter M., Saltzman, W. Mark

“…Genetic diseases can be diagnosed early during pregnancy, but many monogenic disorders continue to cause considerable neonatal and pediatric morbidity and…”
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Prenatal Therapy for Congenital Diaphragmatic Hernia and Myelomeningocele: Advances in Particle-Based Delivery by Rivero, Rachel, Stitelman, David H.

“…Purpose of Review Prenatal intervention for congenital diseases could potentially halt or reverse devastating co-morbidities. Particle-based therapy has…”
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Surface conjugation of antibodies improves nanoparticle uptake in bronchial epithelial cells by Luks, Valerie L, Mandl, Hanna, DiRito, Jenna, Barone, Christina, Freedman-Weiss, Mollie R, Ricciardi, Adele S, Tietjen, Gregory G, Egan, Marie E, Saltzman, W Mark, Stitelman, David H

“…Advances in Molecular Therapy have made gene editing through systemic or topical administration of reagents a feasible strategy to treat genetic diseases in a…”
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Complications in Pediatric Enteral and Vascular Access by Stitelman, David H., M.D

“…Abstract Obtaining reliable enteral and vascular access constitutes a significant fraction of a pediatric surgeon′s job. Multiple approaches are available…”
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Institutional Variation in Gastrostomy Tube Placement After Duodenal Atresia Repair in Children With Trisomy 21 by Maassel, Nathan L., Guerra, Mary Elizabeth, Solomon, Daniel G., Stitelman, David H.

“…ABSTRACT Objectives: To compare institutional practice patterns for gastrostomy tube placement in neonates with duodenal atresia (DA) and trisomy 21. Methods:…”
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Evaluating Operative Exposure for Medical Students in the Era of Virtual Learning: A Single-Institution Experience by Rivero, Rachel, Brown, Leanne, Flom, Emily, Morton, Claire, Esdaille, C. Jayson, Jernigan, Ebony, Lui, Felix, Stitelman, David H.

“…•Surgery clerkship students have variable operative exposure to General Surgery cases.•About 40% of students are not experiencing most core General Surgery…”
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Diffusion weighted imaging as a biomarker of retinoic acid induced myelomeningocele by Maassel, Nathan, Farrelly, James, Coman, Daniel, Freedman-Weiss, Mollie, Ahle, Samantha, Ullrich, Sarah, Yung, Nicholas, Hyder, Fahmeed, Stitelman, David

“…Neural tube defects are a common congenital anomaly involving incomplete closure of the spinal cord. Myelomeningocele (MMC) is a severe form in which there is…”
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Surgical tray optimization as a simple means to decrease perioperative costs by Farrelly, James S., Clemons, Crystal, Witkins, Sherri, Hall, Walter, Christison-Lagay, Emily R., Ozgediz, Doruk E., Cowles, Robert A., Stitelman, David H., Caty, Michael G.

“…Health care spending in the US remains excessively high. Aside from complicated, large-scale efforts at health care cost reduction, there are still relatively…”
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Utility of Fetal Cardiac Axis and Cardiac Position Assessment in Predicting Neonatal Respiratory Morbidity in Fetal Congenital Lung Lesions by Tuzovic, Lea, Copel, Joshua A., Stitelman, David H., Levit, Orly, Bahtiyar, Mert Ozan

“…Objectives To assess the diagnostic performance of the fetal cardiac axis (CA) and/or cardiac position (CP) versus the congenital pulmonary malformation volume…”
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An Evidence-Based Guideline Supporting Restricted Opioid Prescription after Pediatric Appendectomy by Freedman-Weiss, Mollie R., Chiu, Alexander S., Worhunsky, David, Manchisi, Alefteria, Torres-Maldonado, Isabel, Sagnella, Lisa, Caty, Michael G., Cowles, Robert A., Ozgediz, Doruk E, Christison-Lagay, Emily R., Solomon, Daniel G., Stitelman, David H.

“…Surgeon overprescription of opioids is a modifiable contributor to the opioid epidemic. No clear guidelines exist for prescribing opioids to younger patients…”
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Nanoparticles for delivery of agents to fetal lungs by Ullrich, Sarah J., Freedman-Weiss, Mollie, Ahle, Samantha, Mandl, Hanna K., Piotrowski-Daspit, Alexandra S., Roberts, Katherine, Yung, Nicholas, Maassel, Nathan, Bauer-Pisani, Tory, Ricciardi, Adele S., Egan, Marie E., Glazer, Peter M., Saltzman, W. Mark, Stitelman, David H.

“…Fetal treatment of congenital lung disease, such as cystic fibrosis, surfactant protein syndromes, and congenital diaphragmatic hernia, has been made possible…”
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Intra-amniotic Injection of Poly(lactic-co-glycolic Acid) Microparticles Loaded with Growth Factor: Effect on Tissue Coverage and Cellular Apoptosis in the Rat Model of Myelomeningocele by Maassel, Nathan L, Wu, Douglas H, Yung, Nicholas K, Bauer-Pisani, Tory, Elizabeth Guerra, Mary, Ullrich, Sarah J, Mark Saltzman, W, Stitelman, David H

“…Myelomeningocele (MMC) is a devastating congenital neurologic disorder that can lead to lifelong morbidity and has limited treatment options. This study…”
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Prenatal Somatic Cell Gene Therapies: Charting a Path Toward Clinical Applications (Proceedings of the CERSI‐FDA Meeting) by Herzeg, Akos, Almeida‐Porada, Graça, Charo, R. Alta, David, Anna L., Gonzalez‐Velez, Juan, Gupta, Nalin, Lapteva, Larissa, Lianoglou, Billie, Peranteau, William, Porada, Christopher, Sanders, Stephan J., Sparks, Teresa N., Stitelman, David H., Struble, Evi, Sumner, Charlotte J., MacKenzie, Tippi C.

“…We are living in a golden age of medicine in which the availability of prenatal diagnosis, fetal therapy, and gene therapy/editing make it theoretically…”
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Engineering alginate microparticles for optimized accumulation in fetal rat myelomeningocele by Freedman-Weiss, Mollie R., Wu, Douglas, Maassel, Nathan, Ullrich, Sarah J., Ahle, Samantha L., Roberts, Katherine, Farrelly, James S., Buzzelli, Gina, Saltzman, W. Mark, Stitelman, David H.

“…Intraamniotic microparticle injection is a novel technique for the treatment of myelomeningocele (MMC) in which microparticles are delivered in-utero in a…”
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In utero delivery of miRNA induces epigenetic alterations and corrects pulmonary pathology in congenital diaphragmatic hernia by Ullrich, Sarah J., Yung, Nicholas K., Bauer-Pisani, Tory J., Maassel, Nathan L., Guerra, Mary Elizabeth, Freedman-Weiss, Mollie, Ahle, Samantha L., Ricciardi, Adele S., Sauler, Maor, Saltzman, W. Mark, Piotrowski-Daspit, Alexandra S., Stitelman, David H.

“…Structural fetal diseases, such as congenital diaphragmatic hernia (CDH) can be diagnosed prenatally. Neonates with CDH are healthy in utero as gas exchange is…”
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The Technical and Ethical Framework of Fetal Therapy: Past and Current Advances by Lynn, Anna Y., Glazer, Peter M., Saltzman, W. Mark, Stitelman, David H.

“…Purpose of Review Fetal therapy, a burgeoning field that encompasses prenatal surgical and medical interventions for congenital diseases, enables minimally…”
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Alginate microparticles loaded with basic fibroblast growth factor induce tissue coverage in a rat model of myelomeningocele by Farrelly, James S, Bianchi, Anthony H, Ricciardi, Adele S, Buzzelli, Gina L, Ahle, Samantha L, Freedman-Weiss, Mollie R, Luks, Valerie L, Saltzman, W Mark, Stitelman, David H

“…We sought to develop a minimally invasive intra-amniotic therapy for prenatal treatment of myelomeningocele (MMC) in an established rat model. Time-dated…”
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Opioid Prescribing Habits of General Versus Pediatric Surgeons After Uncomplicated Laparoscopic Appendectomy by Freedman-Weiss, Mollie R., Chiu, Alexander S., Solomon, Daniel G., Christison-Lagay, Emily R., Ozgediz, Doruk E., Cowles, Robert A., Caty, Michael G., Stitelman, David H.

“…Adolescents who use prescription opioids have an increased risk for future drug abuse and overdose, making them a high-risk population. Appendectomy is one of…”
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Outcomes following adoption of a standardized protocol for abscess drain management in pediatric appendicitis by Eysenbach, Lindsay M., Caty, Michael G., Christison-Lagay, Emily R., Cowles, Robert A., Dillon, Brian, Goodman, Thomas Robin, Ozgediz, Doruk E., Stitelman, David H., Solomon, Daniel G.

“…Though evidence-based clinical pathways for the diagnosis and treatment of pediatric appendicitis have been established, protocols guiding management of…”
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Routine postnatal chest x-ray and intensive care admission are unnecessary for a majority of infants with congenital lung malformations by Greig, Chasen J., Keiser, Amaris M., Cleary, Muriel A., Stitelman, David H., Christison-Lagay, Emily R., Ozgediz, Doruk E., Solomon, Daniel G., Caty, Michael G., Cowles, Robert A.

“…Postnatal evaluation of prenatally identified congenital lung malformations (CLMs) often includes a chest x-ray (CXR) and neonatal intensive care unit (NICU)…”
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