Search Results - "Stirzaker, Roslynn A."

Hyperglycemia Promotes Myelopoiesis and Impairs the Resolution of Atherosclerosis by Nagareddy, Prabhakara R., Murphy, Andrew J., Stirzaker, Roslynn A., Hu, Yunying, Yu, Shiquing, Miller, Rachel G., Ramkhelawon, Bhama, Distel, Emilie, Westerterp, Marit, Huang, Li-Shin, Schmidt, Ann Marie, Orchard, Trevor J., Fisher, Edward A., Tall, Alan R., Goldberg, Ira J.

“…Diabetes is a major risk factor for atherosclerosis. Although atherosclerosis is initiated by deposition of cholesterol-rich lipoproteins in the artery wall,…”
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Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity by Nagareddy, Prabhakara R., Kraakman, Michael, Masters, Seth L., Stirzaker, Roslynn A., Gorman, Darren J., Grant, Ryan W., Dragoljevic, Dragana, Hong, Eun Shil, Abdel-Latif, Ahmed, Smyth, Susan S., Choi, Sung Hee, Korner, Judith, Bornfeldt, Karin E., Fisher, Edward A., Dixit, Vishwa Deep, Tall, Alan R., Goldberg, Ira J., Murphy, Andrew J.

“…Obesity is associated with infiltration of macrophages into adipose tissue (AT), contributing to insulin resistance and diabetes. However, relatively little is…”
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Neutrophil Activation Is Attenuated by High-Density Lipoprotein and Apolipoprotein A-I in In Vitro and In Vivo Models of Inflammation by Murphy, Andrew J, Woollard, Kevin J, Suhartoyo, Andreas, Stirzaker, Roslynn A, Shaw, James, Sviridov, Dmitri, Chin-Dusting, Jaye P.F

“…OBJECTIVE—Neutrophils play a key role in the immune response but can undesirably exacerbate inflammation. High-density lipoproteins (HDL) are antiinflammatory…”
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High-Density Lipoprotein Reduces the Human Monocyte Inflammatory Response by Murphy, Andrew J, Woollard, Kevin J, Hoang, Anh, Mukhamedova, Nigora, Stirzaker, Roslynn A, McCormick, Sally P.A, Remaley, Alan T, Sviridov, Dmitri, Chin-Dusting, Jaye

“…OBJECTIVE—Whereas the anti–inflammatory effects of high-density lipoprotein (HDL) on endothelial cells are well described, such effects on monocytes are less…”
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Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice by Biswas, Partha S, Gupta, Sanjay, Chang, Emily, Song, Li, Stirzaker, Roslynn A, Liao, James K, Bhagat, Govind, Pernis, Alessandra B

“…Deregulated production of IL-17 and IL-21 plays a key pathogenic role in many autoimmune disorders. A delineation of the mechanisms that underlie the…”
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Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia by Kile, Benjamin T., Panopoulos, Athanasia D., Stirzaker, Roslynn A., Hacking, Douglas F., Tahtamouni, Lubna H., Willson, Tracy A., Mielke, Lisa A., Henley, Katya J., Zhang, Jian-Guo, Wicks, Ian P., Stevenson, William S., Nurden, Paquita, Watowich, Stephanie S., Justice, Monica J.

“…A pivotal mediator of actin dynamics is the protein cofilin, which promotes filament severing and depolymerization, facilitating the breakdown of existing…”
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Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β by Kim, Man Lyang, Chae, Jae Jin, Park, Yong Hwan, De Nardo, Dominic, Stirzaker, Roslynn A, Ko, Hyun-Ja, Tye, Hazel, Cengia, Louise, DiRago, Ladina, Metcalf, Donald, Roberts, Andrew W, Kastner, Daniel L, Lew, Andrew M, Lyras, Dena, Kile, Benjamin T, Croker, Ben A, Masters, Seth L

“…Gain-of-function mutations that activate the innate immune system can cause systemic autoinflammatory diseases associated with increased IL-1β production. This…”
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Dual regulation of IRF4 function in T and B cells is required for the coordination of T-B cell interactions and the prevention of autoimmunity by Biswas, Partha S, Gupta, Sanjay, Stirzaker, Roslynn A, Kumar, Varsha, Jessberger, Rolf, Lu, Theresa T, Bhagat, Govind, Pernis, Alessandra B

“…Effective humoral responses to protein antigens require the precise execution of carefully timed differentiation programs in both T and B cell compartments…”
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Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β by Kim, Man Lyang, Chae, Jae Jin, Park, Yong Hwan, De Nardo, Dominic, Stirzaker, Roslynn A., Ko, Hyun-Ja, Tye, Hazel, Cengia, Louise, DiRago, Ladina, Metcalf, Donald, Roberts, Andrew W., Kastner, Daniel L., Lew, Andrew M., Lyras, Dena, Kile, Benjamin T., Croker, Ben A., Masters, Seth L.

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