Search Results - "Stirling, Wanda"
-
1
Ubiquitin-proteasome system stress sensitizes ovarian cancer to proteasome inhibitor-induced apoptosis
Published in Cancer research (Chicago, Ill.) (01-04-2006)“…The ubiquitin-proteasome system (UPS) mediates targeted protein degradation. Notably, the UPS determines levels of key checkpoint proteins controlling…”
Get full text
Journal Article -
2
Human α-Synuclein-Harboring Familial Parkinson's Disease-Linked Ala-53 → Thr Mutation Causes Neurodegenerative Disease with α-Synuclein Aggregation in Transgenic Mice
Published in Proceedings of the National Academy of Sciences - PNAS (25-06-2002)“…Mutations in α-synuclein (α-Syn) cause Parkinson's disease (PD) in a small number of pedigrees with familial PD. Moreover, α-Syn accumulates as a major…”
Get full text
Journal Article -
3
Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation
Published in PloS one (31-01-2011)“…Genetic and biochemical abnormalities of α-synuclein are associated with the pathogenesis of Parkinson's disease. In the present study we investigated the in…”
Get full text
Journal Article -
4
-
5
Amyloid Pathology Is Associated with Progressive Monoaminergic Neurodegeneration in a Transgenic Mouse Model of Alzheimer's Disease
Published in The Journal of neuroscience (17-12-2008)“…beta-Amyloid (Abeta) pathology is an essential pathogenic component in Alzheimer's disease (AD). However, the significance of Abeta pathology, including Abeta…”
Get full text
Journal Article -
6
Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy
Published in The Journal of neuroscience (05-04-2006)“…Mutations in the genes coding for alpha-synuclein and parkin cause autosomal-dominant and autosomal-recessive forms of Parkinson's disease (PD), respectively…”
Get full text
Journal Article -
7
Resistance to MPTP-Neurotoxicity in [alpha]-Synuclein Knockout Mice Is Complemented by Human [alpha]-Synuclein and Associated with Increased [beta]-Synuclein and Akt Activation
Published in PloS one (31-01-2011)“…Genetic and biochemical abnormalities of [alpha]-synuclein are associated with the pathogenesis of Parkinson's disease. In the present study we investigated…”
Get full text
Journal Article -
8
Axonal transport of human α‐synuclein slows with aging but is not affected by familial Parkinson's disease‐linked mutations
Published in Journal of neurochemistry (01-01-2004)“…Biochemical and genetic abnormalities of α‐synuclein (α‐Syn) are implicated in the pathogenesis of Parkinson's disease (PD) and other α‐synucleinopathies. The…”
Get full text
Journal Article -
9
Inclusion Body Formation and Neurodegeneration Are Parkin Independent in a Mouse Model of {alpha}-Synucleinopathy
Published in The Journal of neuroscience (05-04-2006)Get full text
Journal Article