Search Results - "Stirling, Peter"

Dynamics of DNA damage-induced nuclear inclusions are regulated by SUMOylation of Btn2 by Kumar, Arun, Mathew, Veena, Stirling, Peter C.

“…Spatial compartmentalization is a key facet of protein quality control that serves to store disassembled or non-native proteins until triage to the refolding…”
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Nuclear protein quality control in yeast: The latest INQuiries by Kumar, Arun, Mathew, Veena, Stirling, Peter C.

“…The nucleus is a highly organized organelle with an intricate substructure of chromatin, RNAs, and proteins. This environment represents a challenge for…”
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ARID1A regulates R-loop associated DNA replication stress by Tsai, Shuhe, Fournier, Louis-Alexandre, Chang, Emily Yun-Chia, Wells, James P, Minaker, Sean W, Zhu, Yi Dan, Wang, Alan Ying-Hsu, Wang, Yemin, Huntsman, David G, Stirling, Peter C

“…ARID1A is a core DNA-binding subunit of the BAF chromatin remodeling complex, and is lost in up to 7% of all cancers. The frequency of ARID1A loss increases in…”
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Go along to get along: Integrator at active replication forks defuses co-directional transcription-replication conflicts by Dinatto, Leticia, Stirling, Peter C.

“…There has been growing appreciation that transcription is an endogenous source of replication stress and must be coordinated with replication. In this issue,…”
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Turning up the heat on essential E. coli genes by Kumar, Arun, Stirling, Peter C

“…Temperature‐sensitive (TS) alleles create tunable thermoswitches to deplete essential cellular activities and are used to dissect gene function. In their…”
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Canonical DNA Repair Pathways Influence R-Loop-Driven Genome Instability by Stirling, Peter C., Hieter, Philip

“…DNA repair defects create cancer predisposition in humans by fostering a higher rate of mutations. While DNA repair is quite well characterized, recent studies…”
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Genome-wide profiling of yeast DNA:RNA hybrid prone sites with DRIP-chip by Chan, Yujia A, Aristizabal, Maria J, Lu, Phoebe Y T, Luo, Zongli, Hamza, Akil, Kobor, Michael S, Stirling, Peter C, Hieter, Philip

“…DNA:RNA hybrid formation is emerging as a significant cause of genome instability in biological systems ranging from bacteria to mammals. Here we describe the…”
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RAD18 opposes transcription-associated genome instability through FANCD2 recruitment by Wells, James P, Chang, Emily Yun-Chia, Dinatto, Leticia, White, Justin, Ryall, Stephanie, Stirling, Peter C

“…DNA replication is a vulnerable time for genome stability maintenance. Intrinsic stressors, as well as oncogenic stress, can challenge replication by fostering…”
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The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components by Stirling, Peter C, Bloom, Michelle S, Solanki-Patil, Tejomayee, Smith, Stephanie, Sipahimalani, Payal, Li, Zhijian, Kofoed, Megan, Ben-Aroya, Shay, Myung, Kyungjae, Hieter, Philip

“…Chromosome instability (CIN) is observed in most solid tumors and is linked to somatic mutations in genome integrity maintenance genes. The spectrum of…”
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CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours by Xu, Hong, Di Antonio, Marco, McKinney, Steven, Mathew, Veena, Ho, Brandon, O’Neil, Nigel J., Santos, Nancy Dos, Silvester, Jennifer, Wei, Vivien, Garcia, Jessica, Kabeer, Farhia, Lai, Daniel, Soriano, Priscilla, Banáth, Judit, Chiu, Derek S., Yap, Damian, Le, Daniel D., Ye, Frank B., Zhang, Anni, Thu, Kelsie, Soong, John, Lin, Shu-chuan, Tsai, Angela Hsin Chin, Osako, Tomo, Algara, Teresa, Saunders, Darren N., Wong, Jason, Xian, Jian, Bally, Marcel B., Brenton, James D., Brown, Grant W., Shah, Sohrab P., Cescon, David, Mak, Tak W., Caldas, Carlos, Stirling, Peter C., Hieter, Phil, Balasubramanian, Shankar, Aparicio, Samuel

“…G-quadruplex DNAs form four-stranded helical structures and are proposed to play key roles in different cellular processes. Targeting G-quadruplex DNAs for…”
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Mechanisms of genome instability induced by RNA-processing defects by Chan, Yujia A, Hieter, Philip, Stirling, Peter C

“…Highlights • Genome instability is an established consequence of perturbations in RNA processing. • Genome instability in RNA-processing mutants occurs via…”
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R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants by Stirling, Peter C, Chan, Yujia A, Minaker, Sean W, Aristizabal, Maria J, Barrett, Irene, Sipahimalani, Payal, Kobor, Michael S, Hieter, Philip

“…Genome instability via RNA:DNA hybrid-mediated R loops has been observed in mutants involved in various aspects of transcription and RNA processing. The…”
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RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability by Chang, Emily Yun-Chia, Novoa, Carolina A, Aristizabal, Maria J, Coulombe, Yan, Segovia, Romulo, Chaturvedi, Richa, Shen, Yaoqing, Keong, Christelle, Tam, Annie S, Jones, Steven J M, Masson, Jean-Yves, Kobor, Michael S, Stirling, Peter C

“…Sgs1, the orthologue of human Bloom's syndrome helicase BLM, is a yeast DNA helicase functioning in DNA replication and repair. We show that loss increases…”
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MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts by Chang, Emily Yun-Chia, Tsai, Shuhe, Aristizabal, Maria J., Wells, James P., Coulombe, Yan, Busatto, Franciele F., Chan, Yujia A., Kumar, Arun, Dan Zhu, Yi, Wang, Alan Ying-Hsu, Fournier, Louis-Alexandre, Hieter, Philip, Kobor, Michael S., Masson, Jean-Yves, Stirling, Peter C.

“…Ectopic R-loop accumulation causes DNA replication stress and genome instability. To avoid these outcomes, cells possess a range of anti-R-loop mechanisms,…”
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A nuclear proteome localization screen reveals the exquisite specificity of Gpn2 in RNA polymerase biogenesis by Minaker, Sean W., Kofoed, Megan C., Hieter, Philip, Stirling, Peter C.

“…The GPN proteins are a conserved family of GTP-binding proteins that are involved in the assembly and subsequent import of RNA polymerase II and III. In this…”
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Integrative analysis and prediction of human R-loop binding proteins by Kumar, Arun, Fournier, Louis-Alexandre, Stirling, Peter C

“…In the past decade there has been a growing appreciation for R-loop structures as important regulators of the epigenome, telomere maintenance, DNA repair and…”
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Beyond Kinases: Targeting Replication Stress Proteins in Cancer Therapy by Baillie, Katherine E, Stirling, Peter C

“…DNA replication stress describes a state of impaired replication fork progress that triggers a cellular stress response to maintain genome stability and…”
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What makes a histone variant a variant: Changing H2A to become H2A.Z by Brewis, Hilary T, Wang, Alice Y, Gaub, Aline, Lau, Justine J, Stirling, Peter C, Kobor, Michael S

“…Chromatin structure and underlying DNA accessibility is modulated by the incorporation of histone variants. H2A.Z, a variant of the H2A core histone family,…”
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Cdc48 regulates intranuclear quality control sequestration of the Hsh155 splicing factor in budding yeast by Mathew, Veena, Kumar, Arun, Jiang, Yangyang K, West, Kyra, Tam, Annie S, Stirling, Peter C

“…Cdc48 (known as VCP in mammals) is a highly conserved ATPase chaperone that plays an essential role in the assembly and disassembly of protein-DNA complexes…”
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Splicing, genome stability and disease: splice like your genome depends on it by Tam, Annie S., Stirling, Peter C.

“…The spliceosome has been implicated in genome maintenance for decades. Recently, a surge in discoveries in cancer has suggested that the oncogenic mechanism of…”
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