Search Results - "Stirling, David P"

IP3R-mediated intra-axonal Ca2+ release contributes to secondary axonal degeneration following contusive spinal cord injury by Orem, Ben C., Rajaee, Arezoo, Stirling, David P.

“…Secondary axonal loss contributes to the persistent functional disability following trauma. Consequently, preserving axons following spinal cord injury (SCI)…”
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Mechanisms of axonal injury: internodal nanocomplexes and calcium deregulation by Stirling, David P, Stys, Peter K

“…Axonal degeneration causes morbidity in many neurological conditions including stroke, neurotrauma and multiple sclerosis. The limited ability of central…”
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NKCC1 inhibition reduces periaxonal swelling, increases white matter sparing, and improves neurological recovery after contusive SCI by Ames, Spencer, Brooks, Jesse, Jones, Emma, Morehouse, Johnny, Cortez-Thomas, Francisco, Desta, Dereje, Stirling, David P.

“…Ultrastructural studies of contusive spinal cord injury (SCI) in mammals have shown that the most prominent acute changes in white matter are periaxonal…”
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Depletion of Ly6G/Gr-1 Leukocytes after Spinal Cord Injury in Mice Alters Wound Healing and Worsens Neurological Outcome by Stirling, David P, Liu, Shuhong, Kubes, Paul, Yong, V. Wee

“…Spinal cord injury (SCI) induces a robust inflammatory response and the extravasation of leukocytes into the injured tissue. To further knowledge of the…”
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Toll-like receptor 2-mediated alternative activation of microglia is protective after spinal cord injury by STIRLING, David P, CUMMINS, Karen, MISHRA, Manoj, WULIN TEO, WEE YONG, V, STYS, Peter

“…Improving neurological outcome after spinal cord injury is a major clinical challenge because axons, once severed, do not regenerate but 'dieback' from the…”
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Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination by Lau, Lorraine W., Keough, Michael B., Haylock-Jacobs, Sarah, Cua, Rowena, Döring, Axinia, Sloka, Scott, Stirling, David P., Rivest, Serge, Yong, V. Wee

“…Objective: Failure of remyelination is a critical impediment to recovery in multiple sclerosis (MS). Chondroitin sulfate proteoglycans (CSPGs) have been…”
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Potential physiological and pathological roles for axonal ryanodine receptors by Stirling, David

“…Clinical disability following trauma or disease to the spinal cord often involves the loss of vital white matter elements including axons and glia. Although…”
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Dynamics of the inflammatory response after murine spinal cord injury revealed by flow cytometry by Stirling, David P., Yong, V. Wee

“…Spinal cord injury (SCI) triggers a robust inflammatory response that contributes in part to the secondary degeneration of spared tissue. Here, we use flow…”
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Inhibiting store-operated calcium entry attenuates white matter secondary degeneration following SCI by Orem, Ben C., Partain, Steven B., Stirling, David P.

“…Axonal degeneration plays a key role in the pathogenesis of numerous neurological disorders including spinal cord injury. After the irreversible destruction of…”
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Immune modulatory therapies for spinal cord injury – Past, present and future by Plemel, Jason R., Wee Yong, V., Stirling, David P.

“…Historically, the immune response after spinal cord injury was considered largely detrimental owing to the release of neurotoxic factors. While there is…”
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Axoplasmic reticulum Ca2+ release causes secondary degeneration of spinal axons by Stirling, David P., Cummins, Karen, Wayne Chen, S. R., Stys, Peter

“…Objective Transected axons of the central nervous system fail to regenerate and instead die back away from the lesion site, resulting in permanent disability…”
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Intracellular calcium release through IP3R or RyR contributes to secondary axonal degeneration by Orem, Ben C., Pelisch, Nicolas, Williams, Joshua, Nally, Jacqueline M., Stirling, David P.

“…Severed CNS axons often retract or dieback away from the injury site and fail to regenerate. The precise mechanisms underlying acute axonal dieback and…”
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Ca2+-induced myelin pathology precedes axonal spheroid formation and is mediated in part by store-operated Ca2+ entry after spinal cord injury by Ames, Spencer, Adams, Kia, Geisen, Mariah, Stirling, David

“…[INLINE:1] The formation of axonal spheroid is a common feature following spinal cord injury. To further understand the source of Ca2+ that mediates axonal…”
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Minocycline Treatment Reduces Delayed Oligodendrocyte Death, Attenuates Axonal Dieback, and Improves Functional Outcome after Spinal Cord Injury by Stirling, David P, Khodarahmi, Kourosh, Liu, Jie, McPhail, Lowell T, McBride, Christopher B, Steeves, John D, Ramer, Matt S, Tetzlaff, Wolfram

“…Minocycline has been demonstrated to be neuroprotective after spinal cord injury (SCI). However, the cellular consequences of minocycline treatment on the…”
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Minocycline as a Neuroprotective Agent by Stirling, David P., Koochesfahani, Kaveh M., Steeves, John D., Tetzlaff, Wolfram

“…Several studies have shown that minocycline, a semisynthetic, second-generation tetracycline derivative, is neuroprotective in animal models of central nervous…”
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Direct Ryanodine Receptor-2 Knockout in Primary Afferent Fibers Modestly Affects Neurological Recovery after Contusive Spinal Cord Injury by Orem, Ben C., Morehouse, Johnny R., Ames, Spencer, Burke, Darlene A., Magnuson, David S.K., Stirling, David P.

“…Neuronal ryanodine receptors (RyR) release calcium from internal stores and play a key role in synaptic plasticity, learning, and memory. Dysregulation of RyR…”
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Inhibiting Calcium Release from Ryanodine Receptors Protects Axons after Spinal Cord Injury by Orem, Ben C, Rajaee, Arezoo, Stirling, David P

“…Ryanodine receptors (RyRs) mediate calcium release from calcium stores and have been implicated in axonal degeneration. Here, we use an intravital imaging…”
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Axoplasmic reticulum Ca(2+) release causes secondary degeneration of spinal axons by Stirling, David P, Cummins, Karen, Wayne Chen, S R, Stys, Peter

“…Transected axons of the central nervous system fail to regenerate and instead die back away from the lesion site, resulting in permanent disability. Although…”
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Repeat intravital imaging of the murine spinal cord reveals degenerative and reparative responses of spinal axons in real-time following a contusive SCI by Rajaee, Arezoo, Geisen, Mariah E., Sellers, Alexandra K., Stirling, David P.

“…Spinal cord injury (SCI) induces a secondary degenerative response that causes the loss of spared axons and worsens neurological outcome. The complex molecular…”
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The toll-like receptor 2 agonist Pam3CSK4 is neuroprotective after spinal cord injury by Stivers, Nicole S., Pelisch, Nicolas, Orem, Ben C., Williams, Joshua, Nally, Jacqueline M., Stirling, David P.

“…Microglia/macrophage activation and recruitment following spinal cord injury (SCI) is associated with both detrimental and reparative functions. Stimulation of…”
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