Search Results - "Stinson, Sherman F."

Antitumor Benzothiazoles. 8. Synthesis, Metabolic Formation, and Biological Properties of the C- and N-Oxidation Products of Antitumor 2-(4-Aminophenyl)benzothiazoles by Kashiyama, Eiji, Hutchinson, Ian, Chua, Mei-Sze, Stinson, Sherman F, Phillips, Lawrence R, Kaur, Gurmeet, Sausville, Edward A, Bradshaw, Tracey D, Westwell, Andrew D, Stevens, Malcolm F. G

“…2-(4-Aminophenyl)benzothiazoles 1 and their N-acetylated forms have been converted to C- and N-hydroxylated derivatives to investigate the role of metabolic…”
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FLUORINATED 2-(4-AMINO-3-METHYLPHENYL)BENZOTHIAZOLES INDUCE CYP1A1 EXPRESSION, BECOME METABOLIZED, AND BIND TO MACROMOLECULES IN SENSITIVE HUMAN CANCER CELLS by BRANTLEY, Eileen, TRAPANI, Valentina, ALLEY, Michael C, HOSE, Curtis D, BRADSHAW, Tracey D, STEVENS, Malcolm F. G, SAUSVILLE, Edward A, STINSON, Sherman F

“…Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles possess potent antiproliferative activity against certain cancer cells, similar to the unfluorinated…”
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17-(Allylamino)-17-demethoxygeldanamycin activity in human melanoma models by Burger, Angelika M, Fiebig, Heinz-Herbert, Stinson, Sherman F, Sausville, Edward A

“…17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) is a semisynthetic antitumor agent, which has entered phase I/II clinical trials. Melanoma cell lines in the…”
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Optimization of Naphthalimide-imidazoacridone with Potent Antitumor Activity Leading to Clinical Candidate (HKH40A, RTA 502) by Hariprakasha, Humcha K, Kosakowska-Cholody, Teresa, Meyer, Colin, Cholody, Wieslaw M, Stinson, Sherman F, Tarasova, Nadya I, Michejda, Christopher. J

“…Unsymmetrical bifunctional antitumor agent WMC79 was further optimized to generate compound 7b that not only inhibited the growth of many tumor cell lines, but…”
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Anti-tumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces single-strand breaks and DNA-protein cross-links in sensitive MCF-7 breast cancer cells by BRANTLEY, Eileen, ANTONY, Smitha, KOHLHAGEN, Glenda, LINGHUA MENG, AGAMA, Keli, STINSON, Sherman F, SAUSVILLE, Edward A, POMMIER, Yves

“…The fluorinated benzothiazole analogue 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) exhibits selective and potent anticancer activity,…”
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Preclinical evaluation of amino acid prodrugs of novel antitumor 2-(4-amino-3-methylphenyl)benzothiazoles by Bradshaw, Tracey D, Bibby, Michael C, Double, John A, Fichtner, Iduna, Cooper, Patricia A, Alley, Michael C, Donohue, Susan, Stinson, Sherman F, Tomaszewjski, Joseph E, Sausville, Edward A, Stevens, Malcolm F G

“…Novel 2-(4-aminophenyl)benzothiazoles (e.g., compounds 1 and 2) possess highly selective, potent antitumor properties in vitro and in vivo. Elucidation of the…”
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The antitumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces NF-κB activity in drug-sensitive MCF-7 cells by Brantley, Eileen, Patel, Vyomesh, Stinson, Sherman F, Trapani, Valentina, Hose, Curtis D, Ciolino, Henry P, Yeh, Grace C, Gutkind, J Silvio, Sausville, Edward A, Loaiza-Pérez, Andrea I

“…2-(4-Amino-3-methylphenyl)-5-fluoro-benzothiazole (5F 203) potently inhibits MCF-7 breast cancer cell growth in part by activating the aryl hydrocarbon…”
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Synthesis, structure-activity relationship, and p210(bcr-abl) protein tyrosine kinase activity of novel AG 957 analogs by Kaur, Gurmeet, Narayanan, Ven L, Risbood, Prabhakar A, Hollingshead, Melinda G, Stinson, Sherman F, Varma, Ravi K, Sausville, Edward A

“…A series of novel, sterically hindered lipophilic analogs of AG 957 was designed and synthesized as potential protein tyrosine kinase (PTK) inhibitors. The in…”
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Clinical Pharmacology of Flavopiridol Following a 72-Hour Continuous Infusion by Rudek, Michelle A, Bauer, Kenneth S, Jr, Lush, Richard M, III, Stinson, Sherman F, Senderowicz, Adrian M, Headlee, Donna J, Arbuck, Susan G, Cox, Michael C, Murgo, Anthony J, Sausville, Edward A, Figg, William D

“…Background Flavopiridol, a novel flavone derivative, inhibits cyclin-dependent kinase-1. We initiated a Phase I trial in patients with refractory solid tumors…”
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Poly(ethylene glycol) Prodrugs of the CDK Inhibitor, Alsterpaullone (NSC 705701):  Synthesis and Pharmacokinetic Studies by Greenwald, Richard B, Zhao, Hong, Xia, Jing, Wu, Dechun, Nervi, Stephen, Stinson, Sherman F, Majerova, Eva, Bramhall, Chris, Zaharevitz, Daniel W

“…Two methods were devised to conjugate PEG to alsterpaullone (NSC 705701) via the N of the indole ring portion of the molecule. In the first approach,…”
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Identification of cytosolic aldehyde dehydrogenase 1 from non-small cell lung carcinomas as a flavopiridol-binding protein by Schnier, Joachim B., Kaur, Gurmet, Kaiser, Astrid, Stinson, Sherman F., Sausville, Edward A., Gardner, John, Nishi, Kayoko, Bradbury, E.Morton, Senderowicz, Adrian M.

“…The synthetic flavone flavopiridol can be cytostatic or cytotoxic to mammalian cells, depending on the concentration of the drug and the duration of exposure…”
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Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell lines: Differential accumulation and metabolism by Rivera, Maria I, Stinson, Sherman F, Vistica, David T, Jorden, Jean L, Kenney, Susan, Sausville, Edward A

“…The tricyclic compound 2,5-bis(5-hydroxymethyl-2-thienyl)furan (NSC 652287) has shown a highly selective pattern of differential cytotoxic activity in the…”
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Multidrug-resistant phenotype of disease-oriented panels of human tumor cell lines used for anticancer drug screening by LIN WU, SMYTHE, A. M, SHOEMAKER, R. H, STINSON, S. F, MULLENDORE, L. A, MONKS, A, SCUDIERO, D. A, PAULL, K. D, KOUTSOUKOS, A. D, RUBINSTEIN, L. V, BOYD, M. R

“…Disease-oriented panels of human tumor cell lines used by the National Cancer Institute for large-scale in vitro anticancer drug screening were evaluated for…”
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Identification of the major metabolite of 2,5-bis(5-hydroxymethyl-2-thienyl)furan (NSC 652287), an antitumor agent, in the S9 subcellular fraction of dog liver cells by Phillips, Lawrence R, Jorden, Jean L, Rivera, Maria I, Upadhyay, Kaye, Wolfe, Tracy L, Stinson, Sherman F

“…α-Terthienyl ( 1) is a trithiophene found widely distributed in plants. Other naturally occurring trithiophenes are less widely distributed, but nonetheless…”
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Preclinical evaluation of 9-chloro-2-methylellipticinium acetate alone and in combination with conventional anticancer drugs for the treatment of human brain tumor xenografts by ARGUELLO, F, ALEXANDER, M. A, GREENE, J. F, STINSON, S. F, JORDEN, J. L, SMITH, E. M, KALAVAR, N. T, ALVORD, W. G, KLABANSKY, R. L, SAUSVILLE, E. A

“…Some ellipticine derivative salts, including 9-chloro-2-methylellipticinium (CME), have been found to have a marked selectivity against all eight brain tumor…”
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Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms by Senderowicz, A M, Headlee, D, Stinson, S F, Lush, R M, Kalil, N, Villalba, L, Hill, K, Steinberg, S M, Figg, W D, Tompkins, A, Arbuck, S G, Sausville, E A

“…We conducted a phase I trial of the cyclin-dependent kinase inhibitor, flavopiridol (National Service Center [NSC] 649890), to determine the maximum-tolerated…”
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Multifactorial hamster respiratory carcinogenesis with interdependent effects of cannula-induced mucosal wounding, saline, ferric oxide, benzo[a]pyrene and N-methyl-N-nitrosourea by KEENAN, K. P, SAFFIOTTI, U, STINSON, S. F, RIGGS, C. W, MCDOWELL, E. M

“…The carcinogenic response induced in the respiratory tract of Syrian golden hamsters by repeated intratracheal instillations of benzo[a]pyrene (BP) adsorbed to…”
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Morphological and cytokinetic responses of hamster airways to intralaryngeal or intratracheal cannulation with instillation of saline or ferric oxide particles in saline by KEENAN, K. P, SAFFIOTTI, U, STINSON, S. F, RIGGS, C. W, MCDOWELL, E. M

“…The morphological and proliferative effects of intratracheal cannulation (ITC) or intralaryngeal cannulation (ILC), with or without the instillation of saline…”
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Role of CYP1A1 in modulation of antitumor properties of the novel agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cells by CHUA, Mei-Sze, KASHIYAMA, Eiji, BRADSHAW, Tracey D, STINSON, Sherman F, BRANTLEY, Eileen, SAUSVILLE, Edward A, STEVENS, Malcolm F. G

“…2-(4-Amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) is a candidate antitumor agent with potent and selective activity against human-derived tumor cell…”
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Flavopiridol Induces Apoptosis of Normal Lymphoid Cells, Causes Immunosuppression, and Has Potent Antitumor Activity In Vivo Against Human Leukemia and Lymphoma Xenografts by Arguello, Francisco, Alexander, Mark, Sterry, Judith A., Tudor, Gabriela, Smith, Erik M., Kalavar, Naina T., Greene, John F., Koss, William, Morgan, C. David, Stinson, Sherman F., Siford, Timothy J., Alvord, W. Gregory, Klabansky, Richard L., Sausville, Edward A.

“…Flavopiridol is a novel semisynthetic flavone derivative of the alkaloid rohitukine. Flavopiridol is known to inhibit potently the activity of multiple…”
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