Search Results - "Stillings, Michael R"

Indoline analogs of idazoxan: potent .alpha.2-antagonists and .alpha.1-agonists by Fagan, Gay P, Chapleo, Christopher B, Lane, Anthony C, Myers, Malcolm, Roach, Alan G, Smith, Colin F. C, Stillings, Michael R, Welbourn, Anthony P

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Substituted 1,3,4-thiadiazoles with anticonvulsant activity. 2. Aminoalkyl derivatives by Stillings, Michael R, Welbourn, Anthony P, Walter, Donald S

“…This paper describes the synthesis and pharmacological evaluation of a number evaluation of a number of substituted 1,3,4-thiadiazoles. The first member of the…”
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Substituted 1,3,4-thiadiazoles with anticonvulsant activity. 4. Amidines by Chapleo, Christopher B, Myers, Peter L, Smith, Alan C. B, Stillings, Michael R, Tulloch, Ian F, Walter, Donald S

“…Two different structural types of 2-aryl-1,3,4-thiadiazole amidines were synthesized and evaluated for anticonvulsant activity. Enhancement of the inherent…”
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Substituted 1,3,4-thiadiazoles with anticonvulsant activity. 1. Hydrazines by Chapleo, Christopher B, Myers, Malcolm, Myers, Peter L, Saville, John F, Smith, Alan C. B, Stillings, Michael R, Tulloch, Ian F, Walter, Donald S, Welbourn, Anthony P

“…The synthesis and anticonvulsant activity of a series of 2-aryl-5-hydrazino-1,3,4-thiadiazoles are described. The combination of preferred aromatic…”
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Effect of methoxy substitution on the adrenergic activity of three structurally related .alpha.2-adrenoreceptor antagonists by Stillings, Michael R, England, C. David, Welbourn, Anthony P, Smith, Colin F. C

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Heteroaromatic analogs of the .alpha.2-adrenoreceptor partial agonist clonidine by Chapleo, Christopher B, Butler, Richard C. M, England, David C, Myers, Peter L, Roach, Alan G, Smith, Colin F. C, Stillings, Michael R, Tulloch, Ian F

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Substituted 5H-dibenz[b,g]-1,4-oxazocines and related amino acids with antiinflammatory activity by Stillings, Michael R, Freeman, Stephen, Myers, Peter L, Readhead, Michael J, Welbourn, Anthony P, Rance, Michael J, Atkinson, David C

“…During an investigation of the antiinflammatory properties of a number of tetracyclic derivatives of 6,8-dichlorodibenz[b,f]oxepin-10(11H)-one, the…”
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alpha.-Adrenoreceptor reagents. 4. Resolution of some potent selective prejunctional .alpha.2-adrenoreceptor antagonists by Welbourn, Anthony P, Chapleo, Christopher B, Lane, Anthony C, Myers, Peter L, Roach, Alan G, Smith, Colin F. C, Stillings, Michael R, Tulloch, Ian F

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Substituted (2-phenoxyphenyl)acetic acids with antiinflammatory activity. 1 by Atkinson, David C, Godfrey, Keith E, Meek, Bernard, Saville, John F, Stillings, Michael R

“…The synthesis and antiinflammatory activity of a series of substituted (2-phenoxyphenyl)acetic acids are described. Initial screening in the adjuvant arthritis…”
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Substituted (2-phenoxyphenyl)acetic acids with antiinflammatory activity. 2 by Atkinson, David C, Godfrey, Keith E, Myers, Peter L, Phillips, Nigel C, Stillings, Michael R, Welbourn, Anthony P

“…A number of polychlorinated (phenoxyphenyl)acetic acids were prepared as close structural analogues of the antiinflammatory compound fenclofenac,…”
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alpha.-Adrenoreceptor reagents. 3. Synthesis of some 2-substituted 1,4-benzodioxans as selective presynaptic .alpha.2-adrenoreceptor antagonists by Stillings, Michael R, Chapleo, Christopher B, Butler, Richard C. M, Davis, J. Alfred, England, C. David, Myers, Malcolm, Myers, Peter L, Tweddle, Neil, Welbourn, Anthony P

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The alpha 2-adrenoceptor antagonist efaroxan modulates K+ATP channels in insulin-secreting cells by Chan, S L, Dunne, M J, Stillings, M R, Morgan, N G

“…The actions of efaroxan, a highly selective and potent alpha 2-adrenoceptor antagonist, on insulin secretion, cAMP levels, 86Rb+ efflux and ATP-regulated…”
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Antagonism of the stimulatory effects of efaroxan and glibenclamide in rat pancreatic islets by the imidazoline, RX801080 by Brown, Colin A., Chan, Susan L.F., Stillings, Michael R., Smith, Stephen A., Morgan, Noel G.

“…1 The imidazoline α2‐adrenoceptor antagonist, efaroxan, stimulates insulin secretion from rat isolated islets and antagonizes the ability of diazoxide to…”
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Mechanisms involved in stimulation of insulin secretion by the hypoglycaemic alpha-adrenergic antagonist, DG-5128 by Chan, S L, Stillings, M R, Morgan, N G

“…The selective alpha 2-antagonist DG-5128 provoked a dose-dependent stimulation of insulin release from isolated rat islets. DG-5128 was only weakly effective…”
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Indoline analogues of idazoxan: potent α2-antagonists and α1-agonists by FAGAN, G. P, CHAPLEO, C. B, LANE, A. C, MYERS, M, ROACH, A. G, SMITH, C. F. C, STILLINGS, M. R, WELBOURN, A. P

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Heteroaromatic analogues of the α2-adrenoreceptor partial agonist clonidine by CHAPLEO, C. B, BUTLER, R. C. M, ENGLAND, D. C, MYERS, P. L, ROACH, A. G, SMITH, C. F. C, STILLINGS, M. R, TULLOCH, I. F

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Alpha-adrenoreceptor reagents. 2. Effects of modification of the 1,4-benzodioxan ring system on alpha-adrenoreceptor activity by Chapleo, C B, Myers, P L, Butler, R C, Davis, J A, Doxey, J C, Higgins, S D, Myers, M, Roach, A G, Smith, C F, Stillings, M R

“…Modification of the 1,4-benzodioxan ring present in RX 781094 has not previously been considered. This paper describes a number of analogues of this ring…”
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An investigation of some base induced transformations of the 1,4-benzodioxan ring system by Chapleo, Christopher B., Davis, John A., Myers, Peter L., Readhead, Michael J., Stillings, Michael R., Welbourn, Anthony P., Hampson, Frank C., Sugden, Keith

“…The reaction between benzodioxan‐2‐carboxylic acid and ethylenediamine has been examined and related base induced transformations investigated…”
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