Search Results - "Stiles, Gary L."

Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke by Feuerstein, Giora Z, Zaleska, Margaret M, Krams, Michael, Wang, Xinkang, Day, Mark, Rutkowski, Julia L, Finklestein, Seth P, Pangalos, Menelas N, Poole, Michael, Stiles, Gary L, Ruffolo, Robert R, Walsh, Frank L

“…The continued failure in approving new drugs for treatment of acute stroke has been recently set back by the failure of the NXY-059 (Stroke-Acute Ischemic NXY…”
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The role of receptor structure in determining adenosine receptor activity by Olah, Mark E, Stiles, Gary L

“…Adenosine produces a wide variety of physiological effects through the activation of cell surface adenosine receptors (ARs). ARs are members of the…”
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Development and impact of prescription opioid abuse deterrent formulation technologies by Alexander, Louis, Mannion, Richard O, Weingarten, Brianne, Fanelli, Richard J, Stiles, Gary L

“…Abstract Background Millions of patients are treated with opioid analgesics (OpAs) to relieve pain. Unfortunately, these medications are subject to abuse…”
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Synthesis and Biological Activities of Flavonoid Derivatives as A3 Adenosine Receptor Antagonists by Karton, Yishai, Jiang, Ji-long, Ji, Xiao-duo, Melman, Neli, Olah, Mark E, Stiles, Gary L, Jacobson, Kenneth A

“…A broad screening of phytochemicals has demonstrated that certain flavone and flavonol derivatives have a relatively high affinity at A3 adenosine receptors,…”
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Selective publication of antidepressant trials by Ninan, Philip T, Poole, R Michael, Stiles, Gary L

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Selective publication of antidepressant trials by Schoones, Jan W

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Identification of an A2a Adenosine Receptor Domain Specifically Responsible for Mediating Short-Term Desensitization by Palmer, Timothy M, Stiles, Gary L

“…In an attempt to delineate the structural requirements necessary for agonist-induced desensitization, we have stably expressed wild-type and mutant A2a…”
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Pharmacological characterization of novel A3 adenosine receptor-selective antagonists by JACOBSON, K. A, PARK, K.-S, JIANG, J.-L, KIM, Y.-C, OLAH, M. E, STILES, G. L, JI, X.-D

“…The effects of putative A3 adenosine receptor antagonists of three diverse chemical classes (the flavonoid MRS 1067, the 6-phenyl-1,4-dihydropyridines MRS 1097…”
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Outcomes Following Elective Percutaneous Coronary Intervention Without On-Site Surgical Backup in a Community Hospital by Paraschos, Alexander, Callwood, Dwayne, Wightman, Marilyn B., Tcheng, James E., Phillips, Harry R., Stiles, Gary L., Daniel, John M., Sketch, Michael H.

“…Despite guidelines to the contrary, limited numbers of elective percutaneous coronary intervention (PCI) procedures without on-site surgical backup are being…”
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Interaction of 1,4-Dihydropyridine and Pyridine Derivatives with Adenosine Receptors:  Selectivity for A3 Receptors by van Rhee, A. Michiel, Jiang, Ji-long, Melman, Neli, Olah, Mark E, Stiles, Gary L, Jacobson, Kenneth A

“…1,4-Dihydropyridine and pyridine derivatives bound to three subtypes of adenosine receptors in the micromolar range. Affinity was determined in radioligand…”
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Wyeth Pharmaceutical's perspective on vaccine production by Stiles, Gary L

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Dexamethasone stimulates human A1 adenosine receptor (A1AR) gene expression through multiple regulatory sites in promoter B by Ren, H, Stiles, G L

“…The expression of the human A1 adenosine receptor gene is controlled by two promoters, promoters A and B, and they are located 600 base pairs apart. The…”
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Should an academic radiation oncologist be allowed to "opt out" of medicare? by Halperin, Edward C, Fulkerson, William J, Kaufman, Russel, Newman, Paul, Stiles, Gary L

“…Federal law permits physicians to "opt out" of Medicare. When a radiation oncologist chooses this option, he or she may neither bill nor collect from Medicare,…”
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Induction of multiple effects on adenylyl cyclase regulation by chronic activation of the human A3 adenosine receptor by Palmer, T M, Harris, C A, Coote, J, Stiles, G L

“…The A3 adenosine receptor (A3AR) contributes to several cardiovascular effects of adenosine, including antihypertensive and cardioprotective effects. Although…”
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A single-stranded DNA binding site in the human A1 adenosine receptor gene promoter by Ren, H, Stiles, G L

“…Human A1 adenosine receptor gene expression is controlled by two independent promoters. The upstream promoter, promoter A, is subject to tissue specific…”
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Selective A3 Adenosine Receptor Antagonists:  Water-Soluble 3,5-Diacyl-1,2,4-trialkylpyridinium Salts and Their Oxidative Generation from Dihydropyridine Precursors by Xie, Rongyuan, Li, An-Hu, Ji, Xiao-Duo, Melman, Neli, Olah, Mark E, Stiles, Gary L, Jacobson, Kenneth A

“…A3 adenosine receptor antagonists are sought for their potential antiinflammatory, antiasthmatic, and antiischemic properties. We have found that…”
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Structure-Activity Relationships of 9-Alkyladenine and Ribose-Modified Adenosine Derivatives at Rat A3 Adenosine Receptors by Jacobson, Kenneth A, Siddiqi, Suhaib M, Olah, Mark E, Ji, Xiao-duo, Melman, Neli, Bellamkonda, Kamala, Meshulam, Yacov, Stiles, Gary L, Kim, Hea O

“…9-Alkyladenine derivatives and ribose-modified N6-benzyladenosine derivatives were synthesized in an effort to identify selective ligands for the rat A3…”
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Structure-Activity Relationships of 1,3-Dialkylxanthine Derivatives at Rat A3 Adenosine Receptors by Kim, Hea Ok, Ji, Xiao-duo, Melman, Neli, Olah, Mark E, Stiles, Gary L, Jacobson, Kenneth A

“…1,3-Dialkylxanthine analogues containing carboxylic acid and other charged groups on 8-position substituents were synthesized. These derivatives were examined…”
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Mechanisms of membrane-receptor regulation. Biochemical, physiological, and clinical insights derived from studies of the adrenergic receptors by Lefkowitz, R J, Caron, M G, Stiles, G L

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Multifunctional G proteins. Searching for functions in the heart by Stiles, G L

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