Search Results - "Stiles, Charles"

Glioma Stem Cells: A Midterm Exam by Stiles, Charles D., Rowitch, David H.

“…Several years ago, the discovery of a highly tumorigenic subpopulation of stem-like cells embedded within fresh surgical isolates of malignant gliomas lent…”
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Phosphorylation State of Olig2 Regulates Proliferation of Neural Progenitors by Sun, Yu, Meijer, Dimphna H., Alberta, John A., Mehta, Shwetal, Kane, Michael F., Tien, An-Chi, Fu, Hui, Petryniak, Magdalena A., Potter, Gregory B., Liu, Zijing, Powers, James F., Runquist, I. Sophie, Rowitch, David H., Stiles, Charles D.

“…The bHLH transcription factors that regulate early development of the central nervous system can generally be classified as either antineural or proneural…”
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Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2 by Meijer, Dimphna H., Kane, Michael F., Mehta, Shwetal, Liu, Hongye, Harrington, Emily, Taylor, Christopher M., Stiles, Charles D., Rowitch, David H.

“…Despite their structural similarities and seemingly coordinated expression patterns, oligodendrocyte transcription factor 1 (OLIG1) and OLIG2 have largely…”
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The Central Nervous System-Restricted Transcription Factor Olig2 Opposes p53 Responses to Genotoxic Damage in Neural Progenitors and Malignant Glioma by Mehta, Shwetal, Huillard, Emmanuelle, Kesari, Santosh, Maire, Cecile L., Golebiowski, Diane, Harrington, Emily P., Alberta, John A., Kane, Michael F., Theisen, Matthew, Ligon, Keith L., Rowitch, David H., Stiles, Charles D.

“…High-grade gliomas are notoriously insensitive to radiation and genotoxic drugs. Paradoxically, the p53 gene is structurally intact in the majority of these…”
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MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism by Bandopadhayay, Pratiti, Ramkissoon, Lori A, Jain, Payal, Bergthold, Guillaume, Wala, Jeremiah, Zeid, Rhamy, Schumacher, Steven E, Urbanski, Laura, O'Rourke, Ryan, Gibson, William J, Pelton, Kristine, Ramkissoon, Shakti H, Han, Harry J, Zhu, Yuankun, Choudhari, Namrata, Silva, Amanda, Boucher, Katie, Henn, Rosemary E, Kang, Yun Jee, Knoff, David, Paolella, Brenton R, Gladden-Young, Adrianne, Varlet, Pascale, Pages, Melanie, Horowitz, Peleg M, Federation, Alexander, Malkin, Hayley, Tracy, Adam A, Seepo, Sara, Ducar, Matthew, Van Hummelen, Paul, Santi, Mariarita, Buccoliero, Anna Maria, Scagnet, Mirko, Bowers, Daniel C, Giannini, Caterina, Puget, Stephanie, Hawkins, Cynthia, Tabori, Uri, Klekner, Almos, Bognar, Laszlo, Burger, Peter C, Eberhart, Charles, Rodriguez, Fausto J, Hill, D Ashley, Mueller, Sabine, Haas-Kogan, Daphne A, Phillips, Joanna J, Santagata, Sandro, Stiles, Charles D, Bradner, James E, Jabado, Nada, Goren, Alon, Grill, Jacques, Ligon, Azra H, Goumnerova, Liliana, Waanders, Angela J, Storm, Phillip B, Kieran, Mark W, Ligon, Keith L, Beroukhim, Rameen, Resnick, Adam C

“…Keith Ligon, Adam Resnick, Rameen Beroukhim and colleagues identify MYB - QKI fusions in angiocentric gliomas and show that these rearrangements promote…”
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Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells by Reitman, Zachary J., Paolella, Brenton R., Bergthold, Guillaume, Pelton, Kristine, Becker, Sarah, Jones, Robert, Sinai, Claire E., Malkin, Hayley, Huang, Ying, Grimmet, Leslie, Herbert, Zachary T., Sun, Yu, Weatherbee, Jessica L., Alberta, John A., Daley, John F., Rozenblatt-Rosen, Orit, Condurat, Alexandra L., Qian, Kenin, Khadka, Prasidda, Segal, Rosalind A., Haas-Kogan, Daphne, Filbin, Mariella G., Suva, Mario L., Regev, Aviv, Stiles, Charles D., Kieran, Mark W., Goumnerova, Liliana, Ligon, Keith L., Shalek, Alex K., Bandopadhayay, Pratiti, Beroukhim, Rameen

“…Pilocytic astrocytoma (PA), the most common childhood brain tumor, is a low-grade glioma with a single driver BRAF rearrangement. Here, we perform scRNAseq in…”
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Population Control: Cortical Interneurons Modulate Oligodendrogenesis by Bandopadhayay, Pratiti, Stiles, Charles D.

“…During central nervous system development, oligodendrocytes must be formed in proportion to the number of neurons requiring their services. In this issue of…”
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Olig2-Regulated Lineage-Restricted Pathway Controls Replication Competence in Neural Stem Cells and Malignant Glioma by Ligon, Keith L., Huillard, Emmanuelle, Mehta, Shwetal, Kesari, Santosh, Liu, Hongye, Alberta, John A., Bachoo, Robert M., Kane, Michael, Louis, David N., DePinho, Ronald A., Anderson, David J., Stiles, Charles D., Rowitch, David H.

“…Recent studies have identified stem cells in brain cancer. However, their relationship to normal CNS progenitors, including dependence on common…”
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Of Brains and Blood: Developmental Origins of Glioma Diversity? by Filbin, Mariella G., Stiles, Charles D.

“…The multiple cell types of brain and blood arise from pluripotent stem cells via progressively more committed downstream progenitors. In this issue of Cancer…”
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Germline mutations in TMEM127 confer susceptibility to pheochromocytoma by King, Elizabeth E, Yao, Li, Lechleiter, James D, Aronin, Neil, Opocher, Giuseppe, Boaretto, Francesca, Chocron, E Sandra, Lenci, Romina E, Stiles, Charles, Buddavarapu, Kalyan, Toledo, Sergio P A, Dahia, Patricia L M, Schiavi, Francesca, Qin, Yuejuan, Sass, Meghan, Aguiar, Ricardo C T, Toledo, Rodrigo A

“…Pheochromocytomas, which are catecholamine-secreting tumors of neural crest origin, are frequently hereditary. However, the molecular basis of the majority of…”
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A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas by Sun, Yu, Alberta, John A, Pilarz, Catherine, Calligaris, David, Chadwick, Emily J, Ramkissoon, Shakti H, Ramkissoon, Lori A, Garcia, Veronica Matia, Mazzola, Emanuele, Goumnerova, Liliana, Kane, Michael, Yao, Zhan, Kieran, Mark W, Ligon, Keith L, Hahn, William C, Garraway, Levi A, Rosen, Neal, Gray, Nathanael S, Agar, Nathalie Y, Buhrlage, Sara J, Segal, Rosalind A, Stiles, Charles D

“…Activating mutations or structural rearrangements in BRAF are identified in roughly 75% of all pediatric low-grade astrocytomas (PLGAs). However,…”
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Basic Helix-Loop-Helix Factors in Cortical Development by Ross, Sarah E, Greenberg, Michael E, Stiles, Charles D

“…Transcription factors with bHLH motifs modulate critical events in the development of the mammalian neocortex. Multipotent cortical progenitors are maintained…”
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Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain by Silbereis, John C, Nobuta, Hiroko, Tsai, Hui-Hsin, Heine, Vivi M, McKinsey, Gabriel L, Meijer, Dimphna H, Howard, Mackenzie A, Petryniak, Magda A, Potter, Gregory B, Alberta, John A, Baraban, Scott C, Stiles, Charles D, Rubenstein, John L R, Rowitch, David H

“…Abnormal GABAergic interneuron density, and imbalance of excitatory versus inhibitory tone, is thought to result in epilepsy, neurodevelopmental disorders, and…”
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Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging by Liu, Xiaohui, Ide, Jennifer L., Norton, Isaiah, Marchionni, Mark A., Ebling, Maritza C., Wang, Lan Y., Davis, Erin, Sauvageot, Claire M., Kesari, Santosh, Kellersberger, Katherine A., Easterling, Michael L., Santagata, Sandro, Stuart, Darrin D., Alberta, John, Agar, Jeffrey N., Stiles, Charles D., Agar, Nathalie Y. R.

“…Drug transit through the blood-brain barrier (BBB) is essential for therapeutic responses in malignant glioma. Conventional methods for assessment of BBB…”
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Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors by Ramkissoon, Shakti H, Bandopadhayay, Pratiti, Hwang, Jaeho, Ramkissoon, Lori A, Greenwald, Noah F, Schumacher, Steven E, O'Rourke, Ryan, Pinches, Nathan, Ho, Patricia, Malkin, Hayley, Sinai, Claire, Filbin, Mariella, Plant, Ashley, Bi, Wenya Linda, Chang, Michael S, Yang, Edward, Wright, Karen D, Manley, Peter E, Ducar, Matthew, Alexandrescu, Sanda, Lidov, Hart, Delalle, Ivana, Goumnerova, Liliana C, Church, Alanna J, Janeway, Katherine A, Harris, Marian H, MacConaill, Laura E, Folkerth, Rebecca D, Lindeman, Neal I, Stiles, Charles D, Kieran, Mark W, Ligon, Azra H, Santagata, Sandro, Dubuc, Adrian M, Chi, Susan N, Beroukhim, Rameen, Ligon, Keith L

“…Clinical genomics platforms are needed to identify targetable alterations, but implementation of these technologies and best practices in routine clinical…”
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BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma by Panditharatna, Eshini, Marques, Joana G, Wang, Tingjian, Trissal, Maria C, Liu, Ilon, Jiang, Li, Beck, Alexander, Groves, Andrew, Dharia, Neekesh V, Li, Deyao, Hoffman, Samantha E, Kugener, Guillaume, Shaw, McKenzie L, Mire, Hafsa M, Hack, Olivia A, Dempster, Joshua M, Lareau, Caleb, Dai, Lingling, Sigua, Logan H, Quezada, Michael A, Stanton, Ann-Catherine J, Wyatt, Meghan, Kalani, Zohra, Goodale, Amy, Vazquez, Francisca, Piccioni, Federica, Doench, John G, Root, David E, Anastas, Jamie N, Jones, Kristen L, Conway, Amy Saur, Stopka, Sylwia, Regan, Michael S, Liang, Yu, Seo, Hyuk-Soo, Song, Kijun, Bashyal, Puspalata, Jerome, William P, Mathewson, Nathan D, Dhe-Paganon, Sirano, Suvà, Mario L, Carcaboso, Angel M, Lavarino, Cinzia, Mora, Jaume, Nguyen, Quang-De, Ligon, Keith L, Shi, Yang, Agnihotri, Sameer, Agar, Nathalie Y R, Stegmaier, Kimberly, Stiles, Charles D, Monje, Michelle, Golub, Todd R, Qi, Jun, Filbin, Mariella G

“…Diffuse midline gliomas are uniformly fatal pediatric central nervous system cancers that are refractory to standard-of-care therapeutic modalities. The…”
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Gliomas “Dope Up” for Growth by Paolella, Brenton R., Stiles, Charles D.

“…An emerging body of data highlights trophic functions of neurotransmitters on proliferation and differentiation of normal neural progenitors. In this issue of…”
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A Genome-Wide Screen for Spatially Restricted Expression Patterns Identifies Transcription Factors That Regulate Glial Development by Fu, Hui, Cai, Jun, Clevers, Hans, Fast, Eva, Gray, Susan, Greenberg, Rachel, Jain, Mukesh K, Ma, Qiufu, Qiu, Mengsheng, Rowitch, David H, Taylor, Christopher M, Stiles, Charles D

“…Forward genetic screens in genetically accessible invertebrate organisms such as Drosophila melanogaster have shed light on transcription factors that specify…”
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Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability by Paolella, Brenton R, Gibson, William J, Urbanski, Laura M, Alberta, John A, Zack, Travis I, Bandopadhayay, Pratiti, Nichols, Caitlin A, Agarwalla, Pankaj K, Brown, Meredith S, Lamothe, Rebecca, Yu, Yong, Choi, Peter S, Obeng, Esther A, Heckl, Dirk, Wei, Guo, Wang, Belinda, Tsherniak, Aviad, Vazquez, Francisca, Weir, Barbara A, Root, David E, Cowley, Glenn S, Buhrlage, Sara J, Stiles, Charles D, Ebert, Benjamin L, Hahn, William C, Reed, Robin, Beroukhim, Rameen

“…Genomic instability is a hallmark of human cancer, and results in widespread somatic copy number alterations. We used a genome-scale shRNA viability screen in…”
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Development of NG2 Neural Progenitor Cells Requires Olig Gene Function by Ligon, Keith L., Kesari, Santosh, Kitada, Masaaki, Sun, Tao, Arnett, Heather A., Alberta, John A., Anderson, David J., Stiles, Charles D., Rowitch, David H.

“…n the adult central nervous system, two distinct populations of glial cells expressing the chondroitin sulfate proteoglycan NG2 have been described: bipolar…”
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