Search Results - "Stihle, M."

Structural differences between glycosylated, disulfide-linked heterodimeric Knob-into-Hole Fc fragment and its homodimeric Knob-Knob and Hole-Hole side products by Kuglstatter, A, Stihle, M, Neumann, C, Müller, C, Schaefer, W, Klein, C, Benz, J

“…Abstract An increasing number of bispecific therapeutic antibodies are progressing through clinical development. The Knob-into-Hole (KiH) technology uses…”
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A novel approach to crystallising proteins under oil by D'Arcy, A., Elmore, C., Stihle, M., Johnston, J.E.

“…The microbatch technique for crystallising proteins has become a useful alternative to the standard vapour diffusion method. One factor that may have a great…”
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Molecular Switch in the Glucocorticoid Receptor: Active and Passive Antagonist Conformations by Schoch, Guillaume A., D'Arcy, Brigitte, Stihle, Martine, Burger, Dominique, Bär, Dominik, Benz, Jörg, Thoma, Ralf, Ruf, Armin

“…Mifepristone is known to induce mixed passive antagonist, active antagonist, and agonist effects via the glucocorticoid receptor (GR) pathway. Part of the…”
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Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase by Ruf, Armin, Thoma, Ralf, Schulz-Gasch, Tanja, D'Arcy, Brigitte, Benz, Jörg, Aebi, Johannes, Dehmlow, Henrietta, Hennig, Michael, Stihle, Martine

“…In higher organisms the formation of the steroid scaffold is catalysed exclusively by the membrane-bound oxidosqualene cyclase (OSC; lanosterol synthase). In a…”
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Structural Basis of Proline-Specific Exopeptidase Activity as Observed in Human Dipeptidyl Peptidase-IV by Thoma, Ralf, Löffler, Bernd, Stihle, Martine, Huber, Walter, Ruf, Armin, Hennig, Michael

“…Inhibition of dipeptidyl peptidase IV (DPP-IV), the main glucagon-like peptide 1 (GLP1)-degrading enzyme, has been proposed for the treatment of type II…”
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A Novel Partial Agonist of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) Recruits PPARγ-Coactivator-1α, Prevents Triglyceride Accumulation, and Potentiates Insulin Signaling in Vitro by Burgermeister, Elke, Schnoebelen, Astride, Flament, Angele, Benz, Jörg, Stihle, Martine, Gsell, Bernard, Rufer, Arne, Ruf, Armin, Kuhn, Bernd, Märki, Hans Peter, Mizrahi, Jacques, Sebokova, Elena, Niesor, Eric, Meyer, Markus

“…Partial agonists of peroxisome proliferator-activated receptor-γ (PPARγ), also termed selective PPARγ modulators, are expected to uncouple insulin…”
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Quantification of Cation-π Interactions in Protein-Ligand Complexes: Crystal-Structure Analysis of Factor Xa Bound to a Quaternary Ammonium Ion Ligand by Schärer, Kaspar, Morgenthaler, Martin, Paulini, Ralph, Obst-Sander, Ulrike, Banner, David W., Schlatter, Daniel, Benz, Jörg, Stihle, Martine, Diederich, François

“…The aromatic box formed by the side chains Phe 174, Tyr 99, and Trp 215 in the S4‐pocket of Factor Xa is a very effective onium binding site (see picture; red…”
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The Crystal Structure of Carnitine Palmitoyltransferase 2 and Implications for Diabetes Treatment by Rufer, Arne C., Thoma, Ralf, Benz, Jörg, Stihle, Martine, Gsell, Bernard, De Roo, Elodie, Banner, David W., Mueller, Francis, Chomienne, Odile, Hennig, Michael

“…Carnitine palmitoyltransferases 1 and 2 (CPTs) facilitate the import of long-chain fatty acids into mitochondria. Modulation of the catalytic activity of the…”
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The monotopic membrane protein human oxidosqualene cyclase is active as monomer by Ruf, Armin, Müller, Francis, D’Arcy, Brigitte, Stihle, Martine, Kusznir, Eric, Handschin, Corinne, Morand, Olivier H, Thoma, Ralf

“…The monotopic integral membrane protein 2,3-oxidosqualene cyclase (OSC) catalyzes the formation of lanosterol the first sterol precursor of cholesterol in…”
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The advantages of using a modified microbatch method for rapid screening of protein crystallization conditions by D'Arcy, Allan, Mac Sweeney, Aengus, Stihle, Martine, Haber, Alexander

“…In this study, characterization and optimization of a modified microbatch crystallization technique has been attempted in order to provide a rapid screening…”
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Fyn, Fab, Xap: evaluation of different protein binders as crystallization aids by Ruf, A., Banner, D. W., Benz, J., Bertschinger, J., Burger, D., Crisci, M., Cuppuleri, S., Debulpaep, M., Grabulovski, D., Gsell, B., Huber, W., Kusznir, E., Laeremans, T., Matile, H., Pecoraro, V., Rufer, A., Schlatter, D., Steyeart, J., Stihle, M., Thoma, R., Weber, M., Wiget, A.

“…Abstract only…”
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Crystal engineering: a case study using the 24 kDa fragment of the DNA gyrase B subunit from Escherichia coli by D'Arcy, Allan, Stihle, Martine, Kostrewa, Dirk, Dale, Glenn

“…Site‐directed mutagenesis was used to determine the efficacy of changing surface residues to improve crystal quality. Nine mutants of the 24 kDa fragment of…”
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Crystal structure of oxido squalene cyclase by Ruf, A., Thoma, R., D'Arcy, B., Müller, F., Kusznir, E., Stihle, M., Morand, O.

“…Abstract only…”
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Crystal structure of oxido squalene cyclase by Thoma, R., D'Arcy, B., Müller, F., Kusznir, E., Stihle, M., Morand, O., Ruf, A.

“…Abstract only…”
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Crystal engineering yields crystals of cyclophilin D diffracting to 1.5 Å resolution: a sound basis for the support of drug discovery by Hennig, M., Schlatter, D., Stihle, M., Thoma, R.

“…Abstract only…”
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Crystal engineering yields crystals of cyclophilin D diffracting to 1.5 Å resolution by Thoma, R., Schlatter, D., Stihle, M., Kueng, E., Mueller, F., Boroni, E., Hennig, M.

“…Abstract only…”
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