Search Results - "Stiff, Patrick J"

Regulation of Ovarian Cancer Prognosis by Immune Cells in the Tumor Microenvironment by Drakes, Maureen L, Stiff, Patrick J

“…It is estimated that in the United States in 2018 there will be 22,240 new cases of ovarian cancer and 14,070 deaths due to this malignancy. The most common…”
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Phase III Prospective Randomized Double-Blind Placebo-Controlled Trial of Plerixafor Plus Granulocyte Colony-Stimulating Factor Compared With Placebo Plus Granulocyte Colony-Stimulating Factor for Autologous Stem-Cell Mobilization and Transplantation for Patients With Non-Hodgkin's Lymphoma by DiPersio, John F, Micallef, Ivana N, Stiff, Patrick J, Bolwell, Brian J, Maziarz, Richard T, Jacobsen, Eric, Nademanee, Auayporn, McCarty, John, Bridger, Gary, Calandra, Gary

“…This study evaluates the safety and efficacy of plerixafor (AMD3100), a CXCR4 antagonist, in mobilizing hematopoietic stem cells for autologous stem-cell…”
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Omidubicel vs standard myeloablative umbilical cord blood transplantation: results of a phase 3 randomized study by Horwitz, Mitchell E., Stiff, Patrick J., Cutler, Corey, Brunstein, Claudio, Hanna, Rabi, Maziarz, Richard T., Rezvani, Andrew R., Karris, Nicole A., McGuirk, Joseph, Valcarcel, David, Schiller, Gary J., Lindemans, Caroline A., Hwang, William Y.K., Koh, Liang Piu, Keating, Amy, Khaled, Yasser, Hamerschlak, Nelson, Frankfurt, Olga, Peled, Tony, Segalovich, Irit, Blackwell, Beth, Wease, Stephen, Freedman, Laurence S., Galamidi-Cohen, Einat, Sanz, Guillermo

“…Omidubicel is an ex vivo expanded hematopoietic progenitor cell and nonexpanded myeloid and lymphoid cell product derived from a single umbilical cord blood…”
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Randomized Phase III Trial of ABVD Versus Stanford V With or Without Radiation Therapy in Locally Extensive and Advanced-Stage Hodgkin Lymphoma: An Intergroup Study Coordinated by the Eastern Cooperative Oncology Group (E2496) by GORDON, Leo I, FANGXIN HONG, ADVANI, Ranjana, KAHL, Brad S, FRIEDBERG, Jonathan W, BLUM, Kristie A, HABERMANN, Thomas M, TUSCANO, Joseph M, HOPPE, Richard T, HORNING, Sandra J, FISHER, Richard I, BARTLETT, Nancy L, CONNORS, Joseph M, GASCOYNE, Randy D, WAGNER, Henry, STIFF, Patrick J, CHESON, Bruce D, GOSPODAROWICZ, Mary

“…Although ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) has been established as the standard of care in patients with advanced Hodgkin lymphoma,…”
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The efficacy and tolerability of adriamycin, bleomycin, vinblastine, dacarbazine and Stanford V in older Hodgkin lymphoma patients: a comprehensive analysis from the North American intergroup trial E2496 by Evens, Andrew M., Hong, Fangxin, Gordon, Leo I., Fisher, Richard I., Bartlett, Nancy L., Connors, Joseph M., Gascoyne, Randy D., Wagner, Henry, Gospodarowicz, Mary, Cheson, Bruce D., Stiff, Patrick J., Advani, Ranjana, Miller, Thomas P., Hoppe, Richard T., Kahl, Brad S., Horning, Sandra J.

“…Summary There is a lack of contemporary prospective data examining the adriamycin, bleomycin, vinblastine, dacarbazine (ABVD) and Stanford V (SV; doxorubicin,…”
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Stratification of ovarian tumor pathology by expression of programmed cell death-1 (PD-1) and PD-ligand- 1 (PD-L1) in ovarian cancer by Drakes, Maureen L, Mehrotra, Swati, Aldulescu, Monica, Potkul, Ronald K, Liu, Yueying, Grisoli, Anne, Joyce, Cara, O'Brien, Timothy E, Stack, M Sharon, Stiff, Patrick J

“…Ovarian cancer is the major cause of death among gynecologic cancers with 75% of patients diagnosed with advanced disease, and only 20% of these patients…”
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Palifermin Reduces Patient-Reported Mouth and Throat Soreness and Improves Patient Functioning in the Hematopoietic Stem-Cell Transplantation Setting by STIFF, Patrick J, EMMANOUILIDES, Christos, BENSINGER, William I, GENTILE, Teresa, BLAZAR, Bruce, SHEA, Thomas C, LU, John, ISITT, John, CESANO, Alessandra, SPIELBERGER, Ricardo

“…To describe patient-reported outcomes of mouth and throat soreness (MTS) and related sequelae on daily activities from a phase III study of palifermin in the…”
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c-Myc–mediated control of cell fate in megakaryocyte-erythrocyte progenitors by Guo, Yinshi, Niu, Chao, Breslin, Peter, Tang, Minghui, Zhang, Shubin, Wei, Wei, Kini, Ameet R., Paner, Gladell P., Alkan, Serhan, Morris, Stephan W., Diaz, Manuel, Stiff, Patrick J., Zhang, Jiwang

“…It has been found that c-Myc protein plays a critical role in controlling self-renewal versus differentiation in hematopoietic stem cells. We report that c-Myc…”
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Phase II Studies of Gemcitabine and Cisplatin in Heavily and Minimally Pretreated Metastatic Breast Cancer by CHEW, Helen K, DOROSHOW, James H, SPICER, Darcy, SYNOLD, Tim, BAYER, Robert, HANTEL, Alexander, STIFF, Patrick J, TETEF, Merry L, GANDARA, David R, ALBAIN, Kathy S, FRANKEL, Paul, MARGOLIN, Kim A, SOMLO, George, LENZ, Heinz-Josef, GORDON, Michael, WU ZHANG, DONGYUN YANG, RUSSELL, Christy

“…Cisplatin and gemcitabine have single-agent activity in metastatic breast cancer, and preclinical data support synergy of the combination. Two parallel, phase…”
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Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma by Neelapu, Sattva S, Locke, Frederick L, Bartlett, Nancy L, Lekakis, Lazaros J, Miklos, David B, Jacobson, Caron A, Braunschweig, Ira, Oluwole, Olalekan O, Siddiqi, Tanya, Lin, Yi, Timmerman, John M, Stiff, Patrick J, Friedberg, Jonathan W, Flinn, Ian W, Goy, Andre, Hill, Brian T, Smith, Mitchell R, Deol, Abhinav, Farooq, Umar, McSweeney, Peter, Munoz, Javier, Avivi, Irit, Castro, Januario E, Westin, Jason R, Chavez, Julio C, Ghobadi, Armin, Komanduri, Krishna V, Levy, Ronald, Jacobsen, Eric D, Witzig, Thomas E, Reagan, Patrick, Bot, Adrian, Rossi, John, Navale, Lynn, Jiang, Yizhou, Aycock, Jeff, Elias, Meg, Chang, David, Wiezorek, Jeff, Go, William Y

“…In 101 patients with refractory large B-cell lymphoma, anti-CD19 chimeric antigen receptor (CAR) T-cell therapy (axicabtagene ciloleucel) resulted in an…”
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Inverse relationship between dendritic cell CCR9 expression and maturation state by Drakes, Maureen L., Stiff, Patrick J., Blanchard, Thomas G.

“…Summary CCR9 has been identified on T cells as a chemokine receptor that directs these cells to migrate to the intestine. CCR9 has also been reported on…”
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A human thymic epithelial cell culture system for the promotion of lymphopoiesis from hematopoietic stem cells by Beaudette-Zlatanova, Britte C, Knight, Katherine L, Zhang, Shubin, Stiff, Patrick J, Zúñiga-Pflücker, Juan Carlos, Le, Phong T

“…Objective A human thymic epithelial cell (TEC) line expressing human leukocyte antigen−ABC and human leukocyte antigen−DR was engineered to overexpress murine…”
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Expanding the Toolbox of Adoptive Cell Immunotherapy by Hossain, Nasheed M, Stiff, Patrick J

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Prospective, Randomized, Double-Blind, Phase III Clinical Trial of Anti-T-Lymphocyte Globulin to Assess Impact on Chronic Graft-Versus-Host Disease-Free Survival in Patients Undergoing HLA-Matched Unrelated Myeloablative Hematopoietic Cell Transplantation by Soiffer, Robert J, Kim, Haesook T, McGuirk, Joseph, Horwitz, Mitchell E, Johnston, Laura, Patnaik, Mrinal M, Rybka, Witold, Artz, Andrew, Porter, David L, Shea, Thomas C, Boyer, Michael W, Maziarz, Richard T, Shaughnessy, Paul J, Gergis, Usama, Safah, Hana, Reshef, Ran, DiPersio, John F, Stiff, Patrick J, Vusirikala, Madhuri, Szer, Jeff, Holter, Jennifer, Levine, James D, Martin, Paul J, Pidala, Joseph A, Lewis, Ian D, Ho, Vincent T, Alyea, Edwin P, Ritz, Jerome, Glavin, Frank, Westervelt, Peter, Jagasia, Madan H, Chen, Yi-Bin

“…Purpose Several open-label randomized studies have suggested that in vivo T-cell depletion with anti-T-lymphocyte globulin (ATLG; formerly antithymocyte…”
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A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia by Petersdorf, Stephen H., Kopecky, Kenneth J., Slovak, Marilyn, Willman, Cheryl, Nevill, Thomas, Brandwein, Joseph, Larson, Richard A., Erba, Harry P., Stiff, Patrick J., Stuart, Robert K., Walter, Roland B., Tallman, Martin S., Stenke, Leif, Appelbaum, Frederick R.

“…This randomized phase 3 clinical trial evaluated the potential benefit of the addition of gemtuzumab ozogamicin (GO) to standard induction and…”
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Phase I/II Study of Stem-Cell Transplantation Using a Single Cord Blood Unit Expanded Ex Vivo With Nicotinamide by Horwitz, Mitchell E, Wease, Stephen, Blackwell, Beth, Valcarcel, David, Frassoni, Francesco, Boelens, Jaap Jan, Nierkens, Stefan, Jagasia, Madan, Wagner, John E, Kuball, Jurgen, Koh, Liang Piu, Majhail, Navneet S, Stiff, Patrick J, Hanna, Rabi, Hwang, William Y K, Kurtzberg, Joanne, Cilloni, Daniela, Freedman, Laurence S, Montesinos, Pau, Sanz, Guillermo

“…Increasing the number of hematopoietic stem and progenitor cells within an umbilical cord blood (UCB) graft shortens the time to hematopoietic recovery after…”
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Plerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma by DiPersio, John F., Stadtmauer, Edward A., Nademanee, Auayporn, Micallef, Ivana N.M., Stiff, Patrick J., Kaufman, Jonathan L., Maziarz, Richard T., Hosing, Chitra, Früehauf, Stefan, Horwitz, Mitchell, Cooper, Dennis, Bridger, Gary, Calandra, Gary

“…This phase 3, multicenter, randomized (1:1), double-blind, placebo-controlled study evaluated the safety and efficacy of plerixafor with granulocyte…”
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Autologous Transplantation as Consolidation for Aggressive Non-Hodgkin's Lymphoma by Stiff, Patrick J, Unger, Joseph M, Cook, James R, Constine, Louis S, Couban, Stephen, Stewart, Douglas A, Shea, Thomas C, Porcu, Pierluigi, Winter, Jane N, Kahl, Brad S, Miller, Thomas P, Tubbs, Raymond R, Marcellus, Deborah, Friedberg, Jonathan W, Barton, Kevin P, Mills, Glenn M, LeBlanc, Michael, Rimsza, Lisa M, Forman, Stephen J, Fisher, Richard I

“…This randomized study showed that including autologous transplantation as part of primary treatment improved progression-free survival but not overall survival…”
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Immune Checkpoint Blockade in Gynecologic Cancers: State of Affairs by Drakes, Maureen L., Czerlanis, Cheryl M., Stiff, Patrick J.

“…This review provides an update on the current use of immune checkpoint inhibitors (ICI) in female gynecologic cancers, and it addresses the potential of these…”
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A Phase 2, Randomized, Double-blind, Placebo-Controlled Trial of Presatovir for the Treatment of Respiratory Syncytial Virus Upper Respiratory Tract Infection in Hematopoietic-Cell Transplant Recipients by Chemaly, Roy F, Dadwal, Sanjeet S, Bergeron, Anne, Ljungman, Per, Kim, Yae-Jean, Cheng, Guang-Shing, Pipavath, Sudhakar N, Limaye, Ajit P, Blanchard, Elodie, Winston, Drew J, Stiff, Patrick J, Zuckerman, Tsila, Lachance, Silvy, Rahav, Galia, Small, Catherine B, Mullane, Kathleen M, Patron, Roberto L, Lee, Dong-Gun, Hirsch, Hans H, Waghmare, Alpana, McKevitt, Matt, Jordan, Robert, Guo, Ying, German, Polina, Porter, Danielle P, Gossage, David L, Watkins, Timothy R, Marty, Francisco M, Chien, Jason W, Boeckh, Michael

“…Abstract Background Hematopoietic-cell transplant (HCT) recipients are at risk for severe respiratory syncytial virus (RSV) infection. We evaluated the RSV…”
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