Search Results - "Stierum, Rob H."

A dictionary to identify small molecules and drugs in free text by Hettne, Kristina M., Stierum, Rob H., Schuemie, Martijn J., Hendriksen, Peter J. M., Schijvenaars, Bob J. A., Mulligen, Erik M. van, Kleinjans, Jos, Kors, Jan A.

“…Motivation: From the scientific community, a lot of effort has been spent on the correct identification of gene and protein names in text, while less effort…”
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Toxicogenomics of bromobenzene hepatotoxicity: a combined transcriptomics and proteomics approach by Heijne, Wilbert H.M, Stierum, Rob H, Slijper, Monique, van Bladeren, Peter J, van Ommen, Ben

“…Toxicogenomics is a novel approach integrating the expression analysis of thousands of genes (transcriptomics) or proteins (proteomics) with classical methods…”
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Parallelogram Approach Using Rat-Human In Vitro and Rat In Vivo Toxicogenomics Predicts Acetaminophen-induced Hepatotoxicity in Humans by Kienhuis, Anne S., van de Poll, Marcel C. G., Wortelboer, Heleen, van Herwijnen, Marcel, Gottschalk, Ralph, Dejong, Cornelis H. C., Boorsma, André, Paules, Richard S., Kleinjans, Jos C. S., Stierum, Rob H., van Delft, Joost H. M.

“…The frequent use of rodent hepatic in vitro systems in pharmacological and toxicological investigations challenges extrapolation of in vitro results to the…”
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Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data by Hettne, Kristina M, Boorsma, André, van Dartel, Dorien A M, Goeman, Jelle J, de Jong, Esther, Piersma, Aldert H, Stierum, Rob H, Kleinjans, Jos C, Kors, Jan A

“…Availability of chemical response-specific lists of genes (gene sets) for pharmacological and/or toxic effect prediction for compounds is limited. We…”
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Comparison of Coumarin-Induced Toxicity between Sandwich-Cultured Primary Rat Hepatocytes and Rats in Vivo: A Toxicogenomics Approach by KIENHUIS, Anne S, WORTELBOER, Heleen M, HOFLACK, Jean-Christophe, MOONEN, Edwin J, KLEINJANS, Jos C. S, VAN OMMEN, Ben, VAN DELFT, Joost H. M, STIERUM, Rob H

“…Sandwich-cultured primary rat hepatocytes are often used as an in vitro model in toxicology and pharmacology. However, loss of liver-specific functions, in…”
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Delay and impairment in brain development and function in rat offspring after maternal exposure to methylmercury by Radonjic, Marijana, Cappaert, Natalie L M, de Vries, Erik F J, de Esch, Celine E F, Kuper, Frieke C, van Waarde, Aren, Dierckx, Rudi A J O, Wadman, Wytse J, Wolterbeek, André P M, Stierum, Rob H, de Groot, Didima M G

“…Maternal exposure to the neurotoxin methylmercury (MeHg) has been shown to have adverse effects on neural development of the offspring in man. Little is known…”
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Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans by Jetten, Marlon J.A., Gaj, Stan, Ruiz-Aracama, Ainhoa, de Kok, Theo M., van Delft, Joost H.M., Lommen, Arjen, van Someren, Eugene P., Jennen, Danyel G.J., Claessen, Sandra M., Peijnenburg, Ad A.C.M., Stierum, Rob H., Kleinjans, Jos C.S.

“…Acetaminophen is the primary cause of acute liver toxicity in Europe/USA, which led the FDA to reconsider recommendations concerning safe acetaminophen…”
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Quercetin, but not its glycosidated conjugate rutin, inhibits azoxymethane-induced colorectal carcinogenesis in F344 rats by Dihal, Ashwin A, de Boer, Vincent C J, van der Woude, Hester, Tilburgs, Chantal, Bruijntjes, Joost P, Alink, Gerrit M, Rietjens, Ivonne M C M, Woutersen, Ruud A, Stierum, Rob H

“…The effect of the flavonoid quercetin and its conjugate rutin was investigated on (biomarkers of) colorectal cancer (CRC). Male F344 rats (n = 42/group) were…”
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Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology by Heijne, Wilbert H M, Kienhuis, Anne S, van Ommen, Ben, Stierum, Rob H, Groten, John P

“…Toxicogenomics can facilitate the identification and characterization of toxicity, as illustrated in this review. Toxicogenomics, the application of the…”
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Transcriptome and proteome profiling of colon mucosa from quercetin fed F344 rats point to tumor preventive mechanisms, increased mitochondrial fatty acid degradation and decreased glycolysis by Dihal, Ashwin A, van der Woude, Hester, Hendriksen, Peter J.M, Charif, Halima, Dekker, Lennard J, IJsselstijn, Linda, de Boer, Vincent C.J, Alink, Gerrit M, Burgers, Peter C, Rietjens, Ivonne M.C.M, Woutersen, Ruud A, Stierum, Rob H

“…Quercetin has been shown to act as an anticarcinogen in experimental colorectal cancer (CRC). The aim of the present study was to characterize transcriptome…”
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Modulatory effects of quercetin on proliferation and differentiation of the human colorectal cell line Caco-2 by Dihal, Ashwin A., Woutersen, Ruud A., Ommen, Ben van, Rietjens, Ivonne M.C.M., Stierum, Rob H.

“…The effect of the dietary flavonoid quercetin was investigated on proliferation and differentiation of the human colon cancer cell line Caco-2. Confluent…”
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Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro by Erk, M.J. van, Roepman, P, Lende, T.R. van der, Stierum, R.H, Aarts, J.M.M.J.G, Bladeren, P.J. van, Ommen, B. van

“…Many different mechanisms are involved in nutrient-related prevention of colon cancer. In this study, a comprehensive assessment of the spectrum of possible…”
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Unraveling toxicological mechanisms and predicting toxicity classes with gene dysregulation networks by Pronk, Tessa E., van Someren, Eugene P., Stierum, Rob H., Ezendam, Janine, Pennings, Jeroen L.A.

“…ABSTRACT The use of genes for distinguishing classes of toxicity has become well established. In this paper we combine the reconstruction of a gene…”
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A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo by Kienhuis, Anne S., van de Poll, Marcel C.G., Dejong, Cornelis H.C., Gottschalk, Ralph, van Herwijnen, Marcel, Boorsma, André, Kleinjans, Jos C.S., Stierum, Rob H., van Delft, Joost H.M.

“…A compound for which marked species differences have been reported in laboratory animals and humans is coumarin. In rats, metabolites of coumarin are highly…”
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Bromobenzene-Induced Hepatotoxicity at the Transcriptome Level by Heijne, Wilbert H. M., Slitt, Angela L., van Bladeren, Peter J., Groten, John P., Klaassen, Curtis D., Stierum, Rob H., van Ommen, Ben

“…Rats were exposed to three levels of bromobenzene, sampled at 6, 24, and 48 h, and liver gene expression profiles were determined to identify dose and…”
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The contact allergen dinitrochlorobenzene (DNCB) and respiratory allergy in the Th2-prone Brown Norway rat by Kuper, C. Frieke, Stierum, Rob H, Boorsma, Andre, Schijf, Marcel A, Prinsen, Menk, Bruijntjes, Joost P, Bloksma, Nanne, Arts, Josje H.E

“…Abstract All LMW respiratory allergens known to date can also induce skin allergy in test animals. The question here was if in turn skin allergens can induce…”
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Toxicogenomic analysis of gene expression changes in rat liver after a 28-day oral benzene exposure by Heijne, Wilbert H M, Jonker, Diana, Stierum, Rob H, van Ommen, Ben, Groten, John P

“…Benzene is an industrial chemical, component of automobile exhaust and cigarette smoke. After hepatic bioactivation benzene induces bone marrow, blood and…”
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Transcriptomics analysis of interactive effects of benzene, trichloroethylene and methyl mercury within binary and ternary mixtures on the liver and kidney following subchronic exposure in the rat by Hendriksen, Peter J.M., Freidig, Andreas P., Jonker, Diana, Thissen, Uwe, Bogaards, Jan J.P., Mumtaz, Moiz M., Groten, John P., Stierum, Rob H.

“…The present research aimed to study the interaction of three chemicals, methyl mercury, benzene and trichloroethylene, on mRNA expression alterations in rat…”
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Pathway and single gene analyses of inhibited Caco-2 differentiation by ascorbate-stabilized quercetin suggest enhancement of cellular processes associated with development of colon cancer by Dihal, Ashwin A., Tilburgs, Chantal, van Erk, Marjan J., Rietjens, Ivonne M. C. M., Woutersen, Ruud A., Stierum, Rob H.

“…The aim was to investigate mechanisms contributing to quercetin's previously described effects on cell‐proliferation and ‐differentiation, which contradicted…”
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Single-nucleotide patch base excision repair of uracil in DNA by mitochondrial protein extracts by Stierum, Rob H., Dianov, Grigory L., Bohr, Vilhelm A.

“…Mammalian mitochondria contain several 16.5 kb circular DNAs (mtDNA) encoding electron transport chain proteins. Reactive oxygen species formed as byproducts…”
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