Search Results - "Stieglitz, Kimberly A"

Structural Insights for Drugs Developed for Phospholipase D Enzymes by Stieglitz, Kimberly A

“…In recent years human phospholipase D enzymes (PLD1 and PLD2 isozymes) have emerged as drug targets for various diseases such as cardiovascular disease,…”
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Characterization of recombinant fructose-1,6-bisphosphatase gene mutations: evidence of inhibition/activation of FBPase protein by gene mutation by Topaz, Gemma, Epiter-Smith, Victor, Robalo, Cristina, Emad, Megan, Ford, Vanessa, Daley, Jadine, Byron, Jennifer, Stieglitz, Kimberly A

“…Specific residues of the highly regulated fructose-1,6-bisphosphatase (FBPase) enzyme serve as important contributors to the catalytic activity of the enzyme…”
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Development, Risk, and Resilience of Transgender Youth by Stieglitz, Kimberly A.

“…Transgender youth face unique and complex issues as they confront cultural expectations of gender expression and how these fit with what is natural for them…”
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The Structure of the R184A Mutant of the Inositol Monophosphatase Encoded by suhB and Implications for Its Functional Interactions in Escherichia coli by Wang, Yanling, Stieglitz, Kimberly A., Bubunenko, Mikhail, Court, Donald L., Stec, Boguslaw, Roberts, Mary F.

“…The Escherichia coli product of the suhB gene, SuhB, is an inositol monophosphatase (IMPase) that is best known as a suppressor of temperature-sensitive growth…”
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Structural Basis for Ordered Substrate Binding and Cooperativity in Aspartate Transcarbamoylase by Wang, Jie, Stieglitz, Kimberly A., Cardia, James P., Kantrowitz, Evan R., Lipscomb, William N.

“…X-ray structures of aspartate transcarbamoylase in the absence and presence of the first substrate carbamoyl phosphate are reported. These two structures in…”
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240s Loop Interactions Stabilize the T State of Escherichia coli Aspartate Transcarbamoylase by Alam, Neelima, Stieglitz, Kimberly A., Caban, Michael D., Gourinath, Samudrala, Tsuruta, Hiro, Kantrowitz, Evan R.

“…Here the functional and structural importance of interactions involving the 240s loop of the catalytic chain for the stabilization of the T state of aspartate…”
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The first high pH structure of Escherichia coli aspartate transcarbamoylase by Stieglitz, Kimberly A., Xia, Jiarong, Kantrowitz, Evan R.

“…The activity and cooperativity of Escherichia coli aspartate transcarbamoylase (ATCase) vary as a function of pH, with a maximum of both parameters at…”
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Crystal structure of the tetrameric inositol 1‐phosphate phosphatase (TM1415) from the hyperthermophile, Thermotoga maritima by Stieglitz, Kimberly A., Roberts, Mary F., Li, Weizhong, Stec, Boguslaw

“…The structure of the first tetrameric inositol monophosphatase (IMPase) has been solved. This enzyme, from the eubacterium Thermotoga maritima, similarly to…”
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Metal Specificity Is Correlated with Two Crucial Active Site Residues in Escherichia coli Alkaline Phosphatase by Wang, Jie, Stieglitz, Kimberly A, Kantrowitz, Evan R

“…Escherichia coli alkaline phosphatase exhibits maximal activity when Zn2+ fills the M1 and M2 metal sites and Mg2+ fills the M3 metal site. When other metals…”
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Mobile loop mutations in an archaeal inositol monophosphatase: Modulating three‐metal ion assisted catalysis and lithium inhibition by Li, Zheng, Stieglitz, Kimberly A., Shrout, Anthony L., Wei, Yang, Weis, Robert M., Stec, Boguslaw, Roberts, Mary F.

“…The inositol monophosphatase (IMPase) enzyme from the hyperthermophilic archaeon Methanocaldococcus jannaschii requires Mg2+ for activity and binds three to…”
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Reaching for Mechanistic Consensus Across Life Kingdoms:  Structure and Insights into Catalysis of the myo-Inositol-1-phosphate Synthase (mIPS) from Archaeoglobus fulgidus by Stieglitz, Kimberly A, Yang, Hongying, Roberts, Mary F, Stec, Boguslaw

“…myo-Inositol-1-phosphate synthase (mIPS) catalyzes the first step in the synthesis of l-myo-inositol-1-phosphate. We have solved and refined the structure of…”
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T-state Inhibitors of E. coli Aspartate Transcarbamoylase that Prevent the Allosteric Transition by Heng, Sabrina, Stieglitz, Kimberly A, Eldo, Joby, Xia, Jiarong, Cardia, James P, Kantrowitz, Evan R

“…Escherichia coli aspartate transcarbamoylase (ATCase) catalyzes the committed step in pyrimidine nucleotide biosynthesis, the reaction between carbamoyl…”
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Not so clear on oxygen. Comment on Structural basis for cofactor-independent dioxygenation in vancomycin biosynthesis by Widboom et al. (2007), Nature (London), 447, 342-345 by Stec, Boguslaw, Stieglitz, Kimberly A.

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Crystal structure of a dual activity IMPase/FBPase (AF2372) from Archaeoglobus fulgidus. The story of a mobile loop by Stieglitz, Kimberly A, Johnson, Kenneth A, Yang, Hongying, Roberts, Mary F, Seaton, Barbara A, Head, James F, Stec, Boguslaw

“…Several hyperthermophilic organisms contain an unusual phosphatase that has dual activity toward inositol monophosphates and fructose 1,6-bisphosphate. The…”
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A Single Amino Acid Substitution in the Active Site of Escherichia coli Aspartate Transcarbamoylase Prevents the Allosteric Transition by Stieglitz, Kimberly A., Pastra-Landis, Styliani C., Xia, Jiarong, Tsuruta, Hiro, Kantrowitz, Evan R.

“…Modeling of the tetrahedral intermediate within the active site of Escherichia coli aspartate transcarbamoylase revealed a specific interaction with the…”
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Structure of the E.coli aspartate transcarbamoylase trapped in the middle of the catalytic cycle by Stieglitz, Kimberly A, Dusinberre, Kelly J, Cardia, James P, Tsuruta, Hiro, Kantrowitz, Evan R

“…Snapshots of the catalytic cycle of the allosteric enzyme aspartate transcarbamoylase have been obtained via X-ray crystallography. The enzyme in the…”
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Binding of Proteolytically Processed Phospholipase D from Streptomyces chromofuscus to Phosphatidylcholine Membranes Facilitates Vesicle Aggregation and Fusion by Stieglitz, Kimberly A, Seaton, Barbara A, Roberts, Mary F

“…Ca2+-dependent phospholipase D is secreted from Streptomyces chromofuscus as an intact enzyme of 57 kDa (PLD57). Under certain growth conditions, PLD is…”
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Comparison of two T-state structures of regulatory-chain mutants of Escherichia coli aspartate transcarbamoylase suggests that His20 and Asp19 modulate the response to heterotropic effectors by Stec, Boguslaw, Williams, Mark K., Stieglitz, Kimberly A., Kantrowitz, Evan R.

“…Asp19 and His20 of Escherichia coli aspartate transcarbamoylase (EC 2.1.3.2) function in the binding of the triphosphate and ribose moieties of ATP and CTP and…”
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Unexpected similarity in regulation between an archaeal inositol monophosphatase/fructose bisphosphatase and chloroplast fructose bisphosphatase by Stieglitz, Kimberly A., Seaton, Barbara A., Head, James F., Stec, Boguslaw, Roberts, Mary F.

“…Hyperthermophilic archaea have an unusual phosphatase that exhibits activity toward both inositol‐1‐phosphate and fructose‐1,6‐bisphosphate, activities carried…”
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Crystal Structure of a Dual Activity IMPase/FBPase (AF2372) from Archaeoglobus fulgidus by Stieglitz, Kimberly A., Johnson, Kenneth A., Yang, Hongying, Roberts, Mary F., Seaton, Barbara A., Head, James F., Stec, Boguslaw

“…Several hyperthermophilic organisms contain an unusual phosphatase that has dual activity toward inositol monophosphates and fructose 1,6-bisphosphate. The…”
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