Search Results - "Stickens, Dominique"

Altered endochondral bone development in matrix metalloproteinase 13-deficient mice by Stickens, Dominique, Behonick, Danielle J, Ortega, Nathalie, Heyer, Babette, Hartenstein, Bettina, Yu, Ying, Fosang, Amanda J, Schorpp-Kistner, Marina, Angel, Peter, Werb, Zena

“…The assembly and degradation of extracellular matrix (ECM) molecules are crucial processes during bone development. In this study, we show that ECM remodeling…”
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Mice deficient in Ext2 lack heparan sulfate and develop exostoses by Stickens, Dominique, Zak, Beverly M, Rougier, Nathalie, Esko, Jeffrey D, Werb, Zena

“…Hereditary multiple exostoses (HME) is a genetically heterogeneous human disease characterized by the development of bony outgrowths near the ends of long…”
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How Proteases Regulate Bone Morphogenesis by ORTEGA, NATHALIE, BEHONICK, DANIELLE, STICKENS, DOMINIQUE, WERB, ZENA

“…: Matrix metalloproteinases (MMPs) degrade most components of the extracellular matrix (ECM), as well as many non‐ECM molecules. MMPs participate in (1)…”
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EXT genes are differentially expressed in bone and cartilage during mouse embryogenesis by Stickens, Dominique, Brown, Doris, Evans, Glen A.

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PPARδ modulation rescues mitochondrial fatty acid oxidation defects in the mdx model of muscular dystrophy by Bell, Eric L, Shine, Robert W, Dwyer, Peter, Olson, Lyndsay, Truong, Jennifer, Fredenburg, Ross, Goddeeris, Matthew, Stickens, Dominique, Tozzo, Effie

“…Duchenne muscular dystrophy (DMD) is a recessive, fatal X-linked disease that is characterized by progressive skeletal muscle wasting due to the absence of…”
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Discovery of N‑[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1–3 (HIF PHD1–3) for the Treatment of Anemia by Debenham, John S, Madsen-Duggan, Christina, Clements, Matthew J, Walsh, Thomas F, Kuethe, Jeffrey T, Reibarkh, Mikhail, Salowe, Scott P, Sonatore, Lisa M, Hajdu, Richard, Milligan, James A, Visco, Denise M, Zhou, Dan, Lingham, Russell B, Stickens, Dominique, DeMartino, Julie A, Tong, Xinchun, Wolff, Michael, Pang, Jianmei, Miller, Randy R, Sherer, Edward C, Hale, Jeffrey J

“…The discovery of novel 4-hydroxy-2-(heterocyclic)­pyrimidine-5-carboxamide inhibitors of hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD) is described…”
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Discovery of Orally Bioavailable and Liver-Targeted Hypoxia-Inducible Factor Prolyl Hydroxylase (HIF-PHD) Inhibitors for the Treatment of Anemia by Liu, Ping, Wang, Liping, DuBois, Byron G, Colandrea, Vincent J, Liu, Rongqiang, Cai, Jiaqiang, Du, Xiaoxing, Quan, Weiguo, Morris, William, Bai, Jianwu, Bishwokarma, Bimjhana, Cheng, Mangeng, Piesvaux, Jennifer, Ray, Kallol, Alpert, Carla, Chiu, Chi-Sung, Zielstorff, Mark, Metzger, Joseph M, Yang, Liming, Leung, Dennis, Alleyne, Candice, Vincent, Stella H, Pucci, Vincenzo, Li, Xiaofang, Crespo, Alejandro, Stickens, Dominique, Hale, Jeffrey J, Ujjainwalla, Feroze, Sinz, Christopher J

“…We report herein the design and synthesis of a series of orally active, liver-targeted hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitors for the…”
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Epidermal Development and Wound Healing in Matrix Metalloproteinase 13-Deficient Mice by Hartenstein, Bettina, Dittrich, Bernd Thilo, Stickens, Dominique, Heyer, Babette, Vu, Thiennu H., Teurich, Sibylle, Schorpp-Kistner, Marina, Werb, Zena, Angel, Peter

“…Degradation of the extracellular matrix, which is an indispensable step in tissue remodelling processes such as embryonic development and wound healing of the…”
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A single dose of EGLN1 siRNA yields increased erythropoiesis in nonhuman primates by Abrams, Marc T, Koser, Martin, Burchard, Julja, Strapps, Walter, Mehmet, Huseyin, Gindy, Marian, Zaller, Dennis, Sepp-Lorenzino, Laura, Stickens, Dominique

“…Decreased production of erythropoietin (EPO) causes anemia in patients with chronic kidney disease, and recombinant human EPO is used to treat renal failure…”
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Metalloproteases and Adipogenesis: A Weighty Subject by Lilla, Jennifer, Stickens, Dominique, Werb, Zena

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The EXT2 multiple exostoses gene defines a family of putative tumour suppressor genes by Thomas, Sylvia, Evans, Glen A, Hecht, Jacqueline T, Clines, Gregory, Lovett, Michael, Burbee, David, Ramos, Purita, Stickens, Dominique, Hogue, Deborah

“…Hereditary multiple exostoses (EXT) is an autosomal dominant condition characterized by short stature and the development of bony protuberances at the ends of…”
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Commentary: Metalloproteases and adipogenesis: A weighty subject by Lilla, Jennifer, Stickens, Dominique, Werb, Zena

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EXT genes are differentially expressed in bone and cartilage during mouse embryogenesis by Stickens, Dominique, Brown, Doris, Evans, Glen A.

“…Hereditary multiple exostoses (HME) is a genetically heterogeneous disease characterized by the development of bony protuberances at the ends of all long…”
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A sugar fix for bone tumours? by Evans, Glen A, Stickens, Dominique

“…The success of modern molecular biology has been radically enhanced by the ability to identify disease-related genes through positional cloning, helped by…”
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Isolation and Characterization of the Murine Homolog of the Human EXT2 Multiple Exostoses Gene by Stickens, Dominique, Evans, Glen A.

“…Multiple exostoses is a polygenic disease of bone formation and development characterized by the presence of cartilage-capped osseous projections emanating…”
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Gene for multiple exostoses (EXT2) maps to 11(p11.2p12) and is deleted in patients with a contiguous gene syndrome by Ligon, Azra H., Potocki, Lorraine, Shaffer, Lisa G., Stickens, Dominique, Evans, Glen A.

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