Search Results - "Stick, Robert V"

An Efficient, Inexpensive, and Shelf-Stable Diazotransfer Reagent:  Imidazole-1-sulfonyl Azide Hydrochloride by Goddard-Borger, Ethan D, Stick, Robert V

“…The design and synthesis of a new diazotransfer reagent, imidazole-1-sulfonyl azide hydrochloride, are reported. This reagent has proven to equal triflyl azide…”
Get full text

Carbohydrates: the essential molecules of life by Stick, Robert V, Williams, Spencer

“…This book provides the "nuts and bolts" background for a successful study of carbohydrates - the essential molecules that not only give you energy, but are an…”
Get full text

Glycosidase Inhibition:  An Assessment of the Binding of 18 Putative Transition-State Mimics by Gloster, Tracey M, Meloncelli, Peter, Stick, Robert V, Zechel, David, Vasella, Andrea, Davies, Gideon J

“…The inhibition of glycoside hydrolases, through transition-state mimicry, is important both as a probe of enzyme mechanism and in the continuing quest for new…”
Get full text

Structure−Activity Relationship of Karrikin Germination Stimulants by Flematti, Gavin R, Scaffidi, Adrian, Goddard-Borger, Ethan D, Heath, Charles H, Nelson, David C, Commander, Lucy E, Stick, Robert V, Dixon, Kingsley W, Smith, Steven M, Ghisalberti, Emilio L

“…Karrikins (2H-furo[2,3-c]pyran-2-ones) are potent smoke-derived germination promoters for a diverse range of plant species but, to date, their mode of action…”
Get full text

The Structural Basis of Glycosidase Inhibition by Five-Membered Iminocyclitols: The Clan A Glycoside Hydrolase Endoglycoceramidase as a Model System by Caines, Matthew E. C., Hancock, Susan M., Tarling, Chris A., Wrodnigg, Tanja M., Stick, Robert V., Stütz, Arnold E., Vasella, Andrea, Withers, Stephen G., Strynadka, Natalie C. J.

“…Fitting five into six: The crystal structure of a glycosidase‐bound, five‐membered iminocyclitol inhibitor was determined (see picture), and its binding…”
Get full text

Mycobacterium tuberculosis Strains Possess Functional Cellulases by Varrot, Annabelle, Leydier, Sabine, Pell, Gavin, Macdonald, James M., Stick, Robert V., Henrissat, Bernard, Gilbert, Harry J., Davies, Gideon J.

“…The genomes of various Mycobacterium tuberculosis strains encode proteins that do not appear to play a role in the growth or survival of the bacterium in its…”
Get full text

Direct Observation of the Protonation State of an Imino Sugar Glycosidase Inhibitor upon Binding by Varrot, Annabelle, Tarling, Chris A, Macdonald, James M, Stick, Robert V, Zechel, David L, Withers, Stephen G, Davies, Gideon J

“…Glycosidases are some of the most ubiquitous enzyme in nature. Their biological significance, coupled to their enormous catalytic prowess derived from tight…”
Get full text

An Efficient, Inexpensive, and Shelf-Stable Diazotransfer Reagent: Imidazole-1-sulfonyl Azide Hydrochloride by Goddard-Borger, Ethan D, Stick, Robert V

Get full text

Synthesis and Use of Mechanism-Based Protein-Profiling Probes for Retaining β-d-Glucosaminidases Facilitate Identification of Pseudomonas aeruginosa NagZ by Stubbs, Keith A, Scaffidi, Adrian, Debowski, Aleksandra W, Mark, Brian L, Stick, Robert V, Vocadlo, David J

“…The NagZ class of retaining exo-glucosaminidases play a critical role in peptidoglycan recycling in Gram-negative bacteria and the induction of resistance to…”
Get full text

Structural and biochemical evidence for a boat-like transition state in β-mannosidases by Gilbert, Harry J, Davies, Gideon J, Tailford, Louise E, Offen, Wendy A, Smith, Nicola L, Dumon, Claire, Morland, Carl, Gratien, Julie, Heck, Marie-Pierre, Stick, Robert V, Blériot, Yves, Vasella, Andrea

“…Enzyme inhibition through mimicry of the transition state is a major area for the design of new therapeutic agents. Emerging evidence suggests that many…”
Get full text

Iminosugar Glycosidase Inhibitors:  Structural and Thermodynamic Dissection of the Binding of Isofagomine and 1-Deoxynojirimycin to β-Glucosidases by Zechel, David L, Boraston, Alisdair B, Gloster, Tracey, Boraston, Catherine M, Macdonald, James M, Tilbrook, D. Matthew G, Stick, Robert V, Davies, Gideon J

“…The design and synthesis of transition-state mimics reflects the growing need both to understand enzymatic catalysis and to influence strategies for…”
Get full text

α-L-Arabinofuranosylated pyrrolidines as arabinanase inhibitors by Goddard-Borger, Ethan D, Carapito, Raphael, Jeltsch, Jean-Marc, Phalip, Vincent, Stick, Robert V, Varrot, Annabelle

“…As part of continued efforts to understand the mechanisms of 1,5-α-l-arabinanases better, some arabinan-like iminosugar oligosaccharides were synthesized. An…”
Get more information

Substrate Distortion by a Lichenase Highlights the Different Conformational Itineraries Harnessed by Related Glycoside Hydrolases by Money, Victoria A., Smith, Nicola L., Scaffidi, Adrian, Stick, Robert V., Gilbert, Harry J., Davies, Gideon J.

“…Pick‐a‐path: A series of enzymatic snapshots along the reaction coordinate of a lichenase (specific for gluco‐configured substrates) demonstrates that this…”
Get full text

How family 26 glycoside hydrolases orchestrate catalysis on different polysaccharides: structure and activity of a Clostridium thermocellum lichenase, CtLic26A by Taylor, Edward J, Goyal, Arun, Guerreiro, Catarina I P D, Prates, José A M, Money, Victoria A, Ferry, Natalie, Morland, Carl, Planas, Antoni, Macdonald, James A, Stick, Robert V, Gilbert, Harry J, Fontes, Carlos M G A, Davies, Gideon J

“…One of the most intriguing features of the 90 glycoside hydrolase families (GHs) is the range of specificities displayed by different members of the same…”
Get full text

A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of beta-N-acetylglucosaminidases by Scaffidi, Adrian, Stubbs, Keith A, Dennis, Rebecca J, Taylor, Edward J, Davies, Gideon J, Vocadlo, David J, Stick, Robert V

“…The synthesis of an analogue of 6-epi-valienamine bearing an acetamido group and its characterisation as an inhibitor of beta-N-acetylglucosaminidases are…”
Get more information

The synthesis and biological evaluation of some carbocyclic analogues of PUGNAc by Scaffidi, Adrian, Stubbs, Keith A., Vocadlo, David J., Stick, Robert V.

“…The synthesis of some analogues of O-(2-acetamido-2-deoxy- d-glucopyranosylidene)amino N-phenylcarbamate, PUGNAc, an inhibitor of β- N-acetylglucosaminidases,…”
Get full text

From glycoside hydrolases to thioglycoligases: the synthesis of thioglycosides by Stick, Robert V., Stubbs, Keith A.

“…[Display omitted] The treatment of various glycosyl acceptors, each containing a reactive thiol group, with the appropriate glycosyl donor and a glycoside…”
Get full text

Carbohydrate-Bearing 3-Hydroxy-4-pyridinonato Complexes of Gallium(III) and Indium(III) by Green, David E, Ferreira, Cara L, Stick, Robert V, Patrick, Brian O, Adam, Michael J, Orvig, Chris

“…Gallium and indium complexes with pendant carbohydrates have been prepared and examined for their potential as radiopharmaceuticals. Carbohydrate-bearing…”
Get full text

Structural, thermodynamic, and kinetic analyses of tetrahydrooxazine-derived inhibitors bound to beta-glucosidases by Gloster, Tracey M, Macdonald, James M, Tarling, Chris A, Stick, Robert V, Withers, Stephen G, Davies, Gideon J

“…The understanding of transition state mimicry in glycoside hydrolysis is increasingly important both in the quest for novel specific therapeutic agents and for…”
Get full text

The synthesis of 2-, 3-, 4- and 6-O-α-d-glucopyranosyl-d-galactopyranose, and their evaluation as nutritional supplements for pre-term infants by Meloncelli, Peter J., Williams, Tracey M., Hartmann, Peter E., Stick, Robert V.

“…Four methods have been screened for the synthesis of various structural isomers of O-α-d-glucopyranosyl-d-galactopyranose. One of these isomers, namely…”
Get full text