Search Results - "Sticht, Carsten"

miRWalk: An online resource for prediction of microRNA binding sites by Sticht, Carsten, De La Torre, Carolina, Parveen, Alisha, Gretz, Norbert

“…miRWalk is an open-source platform providing an intuitive interface that generates predicted and validated miRNA-binding sites of known genes of human, mouse,…”
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miRWalk – Database: Prediction of possible miRNA binding sites by “walking” the genes of three genomes by Dweep, Harsh, Sticht, Carsten, Pandey, Priyanka, Gretz, Norbert

“…miRWalk (http://mirwalk.uni-hd.de/), a comprehensive database that provides predicted as well as validated miRNA binding site information on miRNAs for human,…”
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Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling by Winkler, Manuel, Staniczek, Theresa, Kürschner, Sina Wietje, Schmid, Christian David, Schönhaber, Hiltrud, Cordero, Julio, Kessler, Linda, Mathes, Arthur, Sticht, Carsten, Neßling, Michelle, Uvarovskii, Alexey, Anders, Simon, Zhang, Xue-jun, von Figura, Guido, Hartmann, Daniel, Mogler, Carolin, Dobreva, Gergana, Schledzewski, Kai, Géraud, Cyrill, Koch, Philipp-Sebastian, Goerdt, Sergij

“…Angiocrine signaling by liver sinusoidal endothelial cells (LSECs) regulates hepatic functions such as growth, metabolic maturation, and regeneration…”
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System analysis of metabolism and the transcriptome in Arabidopsis thaliana roots reveals differential co‐regulation upon iron, sulfur and potassium deficiency by Forieri, Ilaria, Sticht, Carsten, Reichelt, Michael, Gretz, Norbert, Hawkesford, Malcolm J., Malagoli, Mario, Wirtz, Markus, Hell, Ruediger

“…Deprivation of mineral nutrients causes significant retardation of plant growth. This retardation is associated with nutrient‐specific and general…”
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IER2-induced senescence drives melanoma invasion through osteopontin by Kyjacova, Lenka, Saup, Rafael, Rönsch, Kerstin, Wallbaum, Sabine, Dukowic-Schulze, Stefanie, Foss, Amelia, Scherer, Sandra D., Rothley, Melanie, Neeb, Antje, Grau, Nicole, Thiele, Wilko, Thaler, Sonja, Cremers, Natascha, Sticht, Carsten, Gretz, Norbert, Garvalov, Boyan K., Utikal, Jochen, Sleeman, Jonathan P.

“…Expression of the immediate-early response gene IER2 has been associated with the progression of several types of cancer, but its functional role is poorly…”
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YAP-dependent induction of UHMK1 supports nuclear enrichment of the oncogene MYBL2 and proliferation in liver cancer cells by Wei, Teng, Weiler, Sofia Maria Elisabeth, Tóth, Marcell, Sticht, Carsten, Lutz, Teresa, Thomann, Stefan, De La Torre, Carolina, Straub, Beate, Merker, Sabine, Ruppert, Thomas, Marquardt, Jens, Singer, Stephan, Gretz, Norbert, Schirmacher, Peter, Breuhahn, Kai

“…The oncogene yes-associated protein (YAP) is a key modifier of liver homeostasis and regulates mitosis in hepatocytes as well as in malignantly transformed…”
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Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma by Tschaharganeh, Darjus Felix, Chen, Xin, Latzko, Philipp, Malz, Mona, Gaida, Matthias Martin, Felix, Klaus, Ladu, Sara, Singer, Stephan, Pinna, Federico, Gretz, Norbert, Sticht, Carsten, Tomasi, Maria Lauda, Delogu, Salvatore, Evert, Matthias, Fan, Biao, Ribback, Silvia, Jiang, Lijie, Brozzetti, Stefania, Bergmann, Frank, Dombrowski, Frank, Schirmacher, Peter, Calvisi, Diego Francesco, Breuhahn, Kai

“…Background & Aims Cancer cells often lose contact inhibition to undergo anchorage-independent proliferation and become resistant to apoptosis by inactivating…”
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High-content analysis of microRNAs involved in the phenotype regulation of vascular smooth muscle cells by Zhang, Jian, Starkuviene, Vytaute, Erfle, Holger, Wang, Zhaohui, Gunkel, Manuel, Zeng, Ziwei, Sticht, Carsten, Kan, Kejia, Rahbari, Nuh, Keese, Michael

“…In response to vascular injury vascular smooth muscle cells (VSMCs) alternate between a differentiated (contractile) and a dedifferentiated (synthetic) state…”
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Induction of Chromosome Instability by Activation of Yes-Associated Protein and Forkhead Box M1 in Liver Cancer by Weiler, Sofia M.E, Pinna, Federico, Wolf, Thomas, Lutz, Teresa, Geldiyev, Aman, Sticht, Carsten, Knaub, Maria, Thomann, Stefan, Bissinger, Michaela, Wan, Shan, Rössler, Stephanie, Becker, Diana, Gretz, Norbert, Lang, Hauke, Bergmann, Frank, Ustiyan, Vladimir, Kalin, Tatiana V, Singer, Stephan, Lee, Ju-Seog, Marquardt, Jens U, Schirmacher, Peter, Kalinichenko, Vladimir V, Breuhahn, Kai

“…Background & Aims Many different types of cancer cells have chromosome instability. The hippo pathway leads to phosphorylation of the transcriptional activator…”
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receptor-like protein mediates the response to pectin modification by activating brassinosteroid signaling by Wolf, Sebastian, van der Does, Dieuwertje, Ladwig, Friederike, Sticht, Carsten, Kolbeck, Andreas, Schürholz, Ann-Kathrin, Augustin, Sebastian, Keinath, Nana, Rausch, Thomas, Greiner, Steffen, Schumacher, Karin, Harter, Klaus, Zipfel, Cyril, Höfte, Herman

“…The brassinosteroid (BR) signaling module is a central regulator of plant morphogenesis, as indicated by the large number of BR-responsive cell wall-related…”
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Hepatocyte caveolin-1 modulates metabolic gene profiles and functions in non-alcoholic fatty liver disease by Han, Mei, Piorońska, Weronika, Wang, Sai, Nwosu, Zeribe Chike, Sticht, Carsten, Wang, Shanshan, Gao, Yan, Ebert, Matthias Philip, Dooley, Steven, Meyer, Christoph

“…Caveolin-1 (CAV1) is a crucial regulator of lipid accumulation and metabolism. Previous studies have shown that global Cav1 deficiency affects lipid metabolism…”
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A new path in defining light parameters for hair growth: Discovery and modulation of photoreceptors in human hair follicle by Buscone, Serena, Mardaryev, Andrei N., Raafs, Bianca, Bikker, Jan W., Sticht, Carsten, Gretz, Norbert, Farjo, Nilofer, Uzunbajakava, Natallia E., Botchkareva, Natalia V.

“…Background and Objective Though devices for hair growth based on low levels of light have shown encouraging results, further improvements of their efficacy is…”
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Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in Arabidopsis by Linster, Eric, Stephan, Iwona, Bienvenut, Willy V., Maple-Grødem, Jodi, Myklebust, Line M., Huber, Monika, Reichelt, Michael, Sticht, Carsten, Geir Møller, Simon, Meinnel, Thierry, Arnesen, Thomas, Giglione, Carmela, Hell, Rüdiger, Wirtz, Markus

“…N-terminal acetylation (NTA) catalysed by N-terminal acetyltransferases (Nats) is among the most common protein modifications in eukaryotes, but its…”
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NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis by Luiken, Sarah, Fraas, Angelika, Bieg, Matthias, Sugiyanto, Raisatun, Goeppert, Benjamin, Singer, Stephan, Ploeger, Carolin, Warsow, Gregor, Marquardt, Jens U., Sticht, Carsten, De La Torre, Carolina, Pusch, Stefan, Mehrabi, Arianeb, Gretz, Norbert, Schlesner, Matthias, Eils, Roland, Schirmacher, Peter, Longerich, Thomas, Roessler, Stephanie

“…NOTCH receptor signaling plays a pivotal role in liver homeostasis and hepatocarcinogenesis. However, the role of NOTCH pathway mutations and the NOTCH target…”
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Parallel analysis of mRNA and microRNA microarray profiles to explore functional regulatory patterns in polycystic kidney disease: using PKD/Mhm rat model by Dweep, Harsh, Sticht, Carsten, Kharkar, Asawari, Pandey, Priyanka, Gretz, Norbert

“…Autosomal polycystic kidney disease (ADPKD) is a frequent monogenic renal disease, characterised by fluid-filled cysts that are thought to result from multiple…”
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Sulforaphane Promotes Dendritic Cell Stimulatory Capacity Through Modulation of Regulatory Molecules, JAK/STAT3- and MicroRNA-Signaling by Wang, Yangyi, Petrikova, Emilia, Gross, Wolfgang, Sticht, Carsten, Gretz, Norbert, Herr, Ingrid, Karakhanova, Svetlana

“…The broccoli isothiocyanate sulforaphane was shown to inhibit inflammation and tumor progression, also in pancreatic cancer, while its effect on tumor immunity…”
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Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival by Horn, Sebastian, Hughes, Michelle A., Schilling, Ramon, Sticht, Carsten, Tenev, Tencho, Ploesser, Michaela, Meier, Pascal, Sprick, Martin R., MacFarlane, Marion, Leverkus, Martin

“…Formation of the death-inducing signaling complex (DISC) initiates extrinsic apoptosis. Caspase-8 and its regulator cFLIP control death signaling by binding to…”
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Hyperglycaemic memory affects the neurovascular unit of the retina in a diabetic mouse model by Friedrichs, Patrick, Schlotterer, Andrea, Sticht, Carsten, Kolibabka, Matthias, Wohlfart, Paulus, Dietrich, Axel, Linn, Thomas, Molema, Grietje, Hammes, Hans-Peter

“…Aims/hypothesis The aim of this study was to evaluate damage to the neurovascular unit in a mouse model of hyperglycaemic memory. Methods A…”
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IL-6 regulates CCR5 expression and immunosuppressive capacity of MDSC in murine melanoma by Weber, Rebekka, Riester, Zeno, Hüser, Laura, Sticht, Carsten, Siebenmorgen, Alina, Groth, Christopher, Hu, Xiaoying, Altevogt, Peter, Utikal, Jochen S, Umansky, Viktor

“…BackgroundMyeloid-derived suppressor cells (MDSC) play a major role in the immunosuppressive melanoma microenvironment. They are generated under chronic…”
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Hepatic Endothelial Notch Activation Protects against Liver Metastasis by Regulating Endothelial-Tumor Cell Adhesion Independent of Angiocrine Signaling by Wohlfeil, Sebastian A, Häfele, Verena, Dietsch, Bianca, Schledzewski, Kai, Winkler, Manuel, Zierow, Johanna, Leibing, Thomas, Mohammadi, Mona Malek, Heineke, Joerg, Sticht, Carsten, Olsavszky, Victor, Koch, Philipp-Sebastian, Géraud, Cyrill, Goerdt, Sergij

“…: The interaction of tumor cells with organ-specific endothelial cells (EC) is an important step during metastatic progression. Notch signaling in…”
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