Search Results - "Stichel, Damian"

Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience by Capper, David, Stichel, Damian, Sahm, Felix, Jones, David T. W., Schrimpf, Daniel, Sill, Martin, Schmid, Simone, Hovestadt, Volker, Reuss, David E., Koelsche, Christian, Reinhardt, Annekathrin, Wefers, Annika K., Huang, Kristin, Sievers, Philipp, Ebrahimi, Azadeh, Schöler, Anne, Teichmann, Daniel, Koch, Arend, Hänggi, Daniel, Unterberg, Andreas, Platten, Michael, Wick, Wolfgang, Witt, Olaf, Milde, Till, Korshunov, Andrey, Pfister, Stefan M., von Deimling, Andreas

“…Recently, we described a machine learning approach for classification of central nervous system tumors based on the analysis of genome-wide DNA methylation…”
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CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas by Sievers, Philipp, Hielscher, Thomas, Schrimpf, Daniel, Stichel, Damian, Reuss, David E., Berghoff, Anna S., Neidert, Marian C., Wirsching, Hans-Georg, Mawrin, Christian, Ketter, Ralf, Paulus, Werner, Reifenberger, Guido, Lamszus, Katrin, Westphal, Manfred, Etminan, Nima, Ratliff, Miriam, Herold-Mende, Christel, Pfister, Stefan M., Jones, David T. W., Weller, Michael, Harter, Patrick N., Wick, Wolfgang, Preusser, Matthias, von Deimling, Andreas, Sahm, Felix

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Evolutionary Trajectories of IDHWT Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis by Körber, Verena, Yang, Jing, Barah, Pankaj, Wu, Yonghe, Stichel, Damian, Gu, Zuguang, Fletcher, Michael Nai Chung, Jones, David, Hentschel, Bettina, Lamszus, Katrin, Tonn, Jörg Christian, Schackert, Gabriele, Sabel, Michael, Felsberg, Jörg, Zacher, Angela, Kaulich, Kerstin, Hübschmann, Daniel, Herold-Mende, Christel, von Deimling, Andreas, Weller, Michael, Radlwimmer, Bernhard, Schlesner, Matthias, Reifenberger, Guido, Höfer, Thomas, Lichter, Peter

“…We studied how intratumoral genetic heterogeneity shapes tumor growth and therapy response for isocitrate dehydrogenase (IDH)-wild-type glioblastoma, a rapidly…”
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DNA methylation profiling reliably distinguishes pulmonary enteric adenocarcinoma from metastatic colorectal cancer by Jurmeister, Philipp, Schöler, Anne, Arnold, Alexander, Klauschen, Frederick, Lenze, Dido, Hummel, Michael, Schweizer, Leonille, Bläker, Hendrik, Pfitzner, Berit Maria, Mamlouk, Soulafa, Sers, Christine, Denkert, Carsten, Stichel, Damian, Frost, Nikolaj, Horst, David, von Laffert, Maximilian, Capper, David

“…Pulmonary enteric adenocarcinoma is a rare non-small cell lung cancer subtype. It is poorly characterized and cannot be distinguished from metastatic…”
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Integrative analysis reveals early and distinct genetic and epigenetic changes in intraductal papillary and tubulopapillary cholangiocarcinogenesis by Goeppert, Benjamin, Stichel, Damian, Toth, Reka, Fritzsche, Sarah, Loeffler, Moritz Anton, Schlitter, Anna Melissa, Neumann, Olaf, Assenov, Yassen, Vogel, Monika Nadja, Mehrabi, Arianeb, Hoffmann, Katrin, Köhler, Bruno, Springfeld, Christoph, Weichenhan, Dieter, Plass, Christoph, Esposito, Irene, Schirmacher, Peter, von Deimling, Andreas, Roessler, Stephanie

“…A detailed understanding of the molecular alterations in different forms of cholangiocarcinogenesis is crucial for a better understanding of cholangiocarcinoma…”
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Clinicopathologic and molecular analysis of embryonal rhabdomyosarcoma of the genitourinary tract: evidence for a distinct DICER1-associated subgroup by Kommoss, Felix K.F., Stichel, Damian, Mora, Jaume, Esteller, Manel, Jones, David T.W., Pfister, Stefan M., Brack, Eva, Wachtel, Marco, Bode, Peter Karl, Sinn, Hans-Peter, Schmidt, Dietmar, Mentzel, Thomas, Kommoss, Friedrich, Sahm, Felix, von Deimling, Andreas, Koelsche, Christian

“…Embryonal rhabdomyosarcoma (ERMS) of the uterus has recently been shown to frequently harbor DICER1 mutations. Interestingly, only rare cases of extrauterine…”
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Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations by Pfaff, Elke, Aichmüller, Christian, Sill, Martin, Stichel, Damian, Snuderl, Matija, Karajannis, Matthias A., Schuhmann, Martin U., Schittenhelm, Jens, Hasselblatt, Martin, Thomas, Christian, Korshunov, Andrey, Rhizova, Marina, Wittmann, Andrea, Kaufhold, Anna, Iskar, Murat, Ketteler, Petra, Lohmann, Dietmar, Orr, Brent A., Ellison, David W., von Hoff, Katja, Mynarek, Martin, Rutkowski, Stefan, Sahm, Felix, von Deimling, Andreas, Lichter, Peter, Kool, Marcel, Zapatka, Marc, Pfister, Stefan M., Jones, David T. W.

“…Tumors of the pineal region comprise several different entities with distinct clinical and histopathological features. Whereas some entities predominantly…”
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Rapid-CNS2: rapid comprehensive adaptive nanopore-sequencing of CNS tumors, a proof-of-concept study by Patel, Areeba, Dogan, Helin, Payne, Alexander, Krause, Elena, Sievers, Philipp, Schoebe, Natalie, Schrimpf, Daniel, Blume, Christina, Stichel, Damian, Holmes, Nadine, Euskirchen, Philipp, Hench, Jürgen, Frank, Stephan, Rosenstiel-Goidts, Violaine, Ratliff, Miriam, Etminan, Nima, Unterberg, Andreas, Dieterich, Christoph, Herold-Mende, Christel, Pfister, Stefan M., Wick, Wolfgang, Loose, Matthew, von Deimling, Andreas, Sill, Martin, Jones, David T. W., Schlesner, Matthias, Sahm, Felix

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Mosaic trisomy of chromosome 1q in human brain tissue associates with unilateral polymicrogyria, very early-onset focal epilepsy, and severe developmental delay by Kobow, Katja, Jabari, Samir, Pieper, Tom, Kudernatsch, Manfred, Polster, Tilman, Woermann, Friedrich G., Kalbhenn, Thilo, Hamer, Hajo, Rössler, Karl, Mühlebner, Angelika, Spliet, Wim G. M., Feucht, Martha, Hou, Yanghao, Stichel, Damian, Korshunov, Andrey, Sahm, Felix, Coras, Roland, Blümcke, Ingmar, von Deimling, Andreas

“…Polymicrogyria (PMG) is a developmental cortical malformation characterized by an excess of small and frustrane gyration and abnormal cortical lamination. PMG…”
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Oligosarcomas, IDH-mutant are distinct and aggressive by Suwala, Abigail K., Felix, Marius, Friedel, Dennis, Stichel, Damian, Schrimpf, Daniel, Hinz, Felix, Hewer, Ekkehard, Schweizer, Leonille, Dohmen, Hildegard, Pohl, Ute, Staszewski, Ori, Korshunov, Andrey, Stein, Marco, Wongsurawat, Thidathip, Cheunsuacchon, Pornsuk, Sathornsumetee, Sith, Koelsche, Christian, Turner, Clinton, Le Rhun, Emilie, Mühlebner, Angelika, Schucht, Philippe, Özduman, Koray, Ono, Takahiro, Shimizu, Hiroaki, Prinz, Marco, Acker, Till, Herold-Mende, Christel, Kessler, Tobias, Wick, Wolfgang, Capper, David, Wesseling, Pieter, Sahm, Felix, von Deimling, Andreas, Hartmann, Christian, Reuss, David E.

“…Oligodendrogliomas are defined at the molecular level by the presence of an IDH mutation and codeletion of chromosomal arms 1p and 19q. In the past, case…”
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Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas by Kirches, Elmar, Sahm, Felix, Korshunov, Andrey, Bluecher, Christina, Waldt, Natalie, Kropf, Siegfried, Schrimpf, Daniel, Sievers, Philipp, Stichel, Damian, Schüller, Ulrich, Schittenhelm, Jens, Riemenschneider, Markus J., Karajannis, Matthias A., Perry, Arie, Pietsch, Torsten, Boekhoff, Svenja, Capper, David, Beck, Katja, Paramasivam, Nagarajan, Schlesner, Matthias, Brastianos, Priscilla K., Müller, Hermann L., Pfister, Stefan M., Mawrin, Christian

“…In contrast to adults, meningiomas are uncommon tumors in childhood and adolescence. Whether adult and pediatric meningiomas differ on a molecular level is…”
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Routine RNA sequencing of formalin-fixed paraffin-embedded specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions by Stichel, Damian, Schrimpf, Daniel, Casalini, Belén, Meyer, Jochen, Wefers, Annika K., Sievers, Philipp, Korshunov, Andrey, Koelsche, Christian, Reuss, David E., Reinhardt, Annekathrin, Ebrahimi, Azadeh, Fernández-Klett, Francisco, Kessler, Tobias, Sturm, Dominik, Ecker, Jonas, Milde, Till, Herold-Mende, Christel, Witt, Olaf, Pfister, Stefan M., Wick, Wolfgang, Jones, David T. W., von Deimling, Andreas, Sahm, Felix

“…Molecular markers have become pivotal in brain tumor diagnostics. Mutational analyses by targeted next-generation sequencing of DNA and array-based DNA…”
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Intimal sarcomas and undifferentiated cardiac sarcomas carry mutually exclusive MDM2, MDM4, and CDK6 amplifications and share a common DNA methylation signature by Koelsche, Christian, Benhamida, Jamal K., Kommoss, Felix K. F., Stichel, Damian, Jones, David T. W., Pfister, Stefan M., Heilig, Christoph E., Fröhling, Stefan, Stenzinger, Albrecht, Buslei, Rolf, Mentzel, Thomas, Baumhoer, Daniel, Ladanyi, Marc, Antonescu, Cristina R., Flucke, Uta, Gorp, Joost van, Bode-Lesniewska, Beata, Deimling, Andreas von, Mechtersheimer, Gunhild

“…Undifferentiated mesenchymal tumors arising from the inner lining (intima) of large arteries are classified as intimal sarcomas (ISA) with MDM2 amplification…”
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Molecular differences in IDH wildtype glioblastoma according to MGMT promoter methylation by Kessler, Tobias, Sahm, Felix, Sadik, Ahmed, Stichel, Damian, Hertenstein, Anne, Reifenberger, Guido, Zacher, Angela, Sabel, Michael, Tabatabai, Ghazaleh, Steinbach, Joachim, Sure, Ulrich, Krex, Dietmar, Grosu, Anca-L, Bewerunge-Hudler, Melanie, Jones, David, Pfister, Stefan M, Weller, Michael, Opitz, Christiane, Bendszus, Martin, von Deimling, Andreas, Platten, Michael, Wick, Wolfgang

“…O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status is a predictive biomarker in glioblastoma. We investigated whether this marker…”
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Epigenetically Regulated Chromosome 14q32 miRNA Cluster Induces Metastasis and Predicts Poor Prognosis in Lung Adenocarcinoma Patients by González-Vallinas, Margarita, Rodríguez-Paredes, Manuel, Albrecht, Marco, Sticht, Carsten, Stichel, Damian, Gutekunst, Julian, Pitea, Adriana, Sass, Steffen, Sánchez-Rivera, Francisco J, Lorenzo-Bermejo, Justo, Schmitt, Jennifer, De La Torre, Carolina, Warth, Arne, Theis, Fabian J, Müller, Nikola S, Gretz, Norbert, Muley, Thomas, Meister, Michael, Tschaharganeh, Darjus F, Schirmacher, Peter, Matthäus, Franziska, Breuhahn, Kai

“…Most lung cancer deaths are related to metastases, which indicates the necessity of detecting and inhibiting tumor cell dissemination. Here, we aimed to…”
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Molecular characterization of CNS paragangliomas identifies cauda equina paragangliomas as a distinct tumor entity by Schweizer, Leonille, Thierfelder, Felix, Thomas, Christian, Soschinski, Patrick, Suwala, Abigail, Stichel, Damian, Wefers, Annika K., Wessels, Lars, Misch, Martin, Kim, Hee-yeong, Jödicke, Ruben, Teichmann, Daniel, Kaul, David, Kahn, Johannes, Bockmayr, Michael, Hasselblatt, Martin, Younsi, Alexander, Unterberg, Andreas, Knie, Bettina, Walter, Jan, Al Safatli, Diaa, May, Sven-Axel, Jödicke, Andreas, Ntoulias, Georgios, Moskopp, Dag, Vajkoczy, Peter, Heppner, Frank L., Capper, David, Hartmann, Wolfgang, Hartmann, Christian, von Deimling, Andreas, Reuss, David E., Schöler, Anne, Koch, Arend

“…Paragangliomas/pheochromocytomas are rare neuroendocrine tumors that arise from the adrenal gland or ganglia at various sites throughout the body. They display…”
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Posterior fossa pilocytic astrocytomas with oligodendroglial features show frequent FGFR1 activation via fusion or mutation by Sievers, Philipp, Schrimpf, Daniel, Stichel, Damian, Reuss, David E., Hasselblatt, Martin, Hagel, Christian, Staszewski, Ori, Hench, Jürgen, Frank, Stephan, Brandner, Sebastian, Korshunov, Andrey, Wick, Wolfgang, Pfister, Stefan M., Reifenberger, Guido, von Deimling, Andreas, Sahm, Felix, Jones, David T. W.

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Genetic and epigenetic characterization of posterior pituitary tumors by Schmid, Simone, Solomon, David A., Perez, Eilis, Thieme, Anne, Kleinschmidt-DeMasters, Bette K., Giannini, Caterina, Reinhardt, Annekathrin, Asa, Sylvia L., Mete, Ozgur, Stichel, Damian, Siewert, Christin, Dittmayer, Carsten, Hasselblatt, Martin, Paulus, Werner, Nagel, Christoph, Harter, Patrick N., Schittenhelm, Jens, Honegger, Jürgen, Rushing, Elisabeth, Coras, Roland, Pfister, Stefan M., Buslei, Rolf, Koch, Arend, Perry, Arie, Jones, David T. W., von Deimling, Andreas, Capper, David, Lopes, M. Beatriz

“…Pituicytoma (PITUI), granular cell tumor (GCT), and spindle cell oncocytoma (SCO) are rare tumors of the posterior pituitary. Histologically, they may be…”
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An optimized workflow to improve reliability of detection of KIAA1549:BRAF fusions from RNA sequencing data by Sommerkamp, Alexander C., Uhrig, Sebastian, Stichel, Damian, St-Onge, Pascal, Sun, Pengbo, Jäger, Natalie, von Deimling, Andreas, Sahm, Felix, Pfister, Stefan M., Korshunov, Andrey, Sinnett, Daniel, Jabado, Nada, Wefers, Annika K., Jones, David T. W.

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Transcriptional profiling of medulloblastoma with extensive nodularity (MBEN) reveals two clinically relevant tumor subsets with VSNL1 as potent prognostic marker by Korshunov, Andrey, Okonechnikov, Konstantin, Sahm, Felix, Ryzhova, Marina, Stichel, Damian, Schrimpf, Daniel, Ghasemi, David R., Pajtler, Kristian W., Antonelli, Manila, Donofrio, Vittoria, Mastronuzzi, Angela, Rossi, Sabrina, Camassei, Francesca Diomedi, Buccoliero, Anna Maria, Haberler, Christine, Slavc, Irene, Dahiya, Sonika, Casalini, Belen, Sievers, Philipp, Meyer, Jochen, Kumirova, Ella, Zheludkova, Olga, Golanov, Andrey, Jones, David T. W., Pfister, Stefan M., Kool, Marcel, von Deimling, Andreas

“…Medulloblastoma with extensive nodularity (MBEN) is one of the few central nervous system (CNS) tumor entities occurring in infants which is traditionally…”
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