Search Results - "Steyn, F. J."

Development of a Methodology for and Assessment of Pulsatile Luteinizing Hormone Secretion in Juvenile and Adult Male Mice by Steyn, F. J, Wan, Y, Clarkson, J, Veldhuis, J. D, Herbison, A. E, Chen, C

“…Current methodology to monitor pulsatile LH release in mice is limited by inadequate assay sensitivity, resulting in the need for collection of large blood…”
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Development of a Method for the Determination of Pulsatile Growth Hormone Secretion in Mice by Steyn, F. J, Huang, L, Ngo, S. T, Leong, J. W, Tan, H. Y, Xie, T. Y, Parlow, A. F, Veldhuis, J. D, Waters, M. J, Chen, C

“…Measures of pulsatile GH secretion require frequent collection and analysis of blood samples at regular intervals. Due to blood volume constraints, repeat…”
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The interplay between metabolic homeostasis and neurodegeneration: insights into the neurometabolic nature of amyotrophic lateral sclerosis by Ngo, S. T., Steyn, F. J.

“…Amyotrophic lateral sclerosis (ALS) is a fatal, neurodegenerative disease that is characterized by the selective degeneration of upper motor neurons and lower…”
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Growth Hormone Secretion Is Correlated With Neuromuscular Innervation Rather Than Motor Neuron Number in Early-Symptomatic Male Amyotrophic Lateral Sclerosis Mice by Steyn, F. J, Lee, K, Fogarty, M. J, Veldhuis, J. D, McCombe, P. A, Bellingham, M. C, Ngo, S. T, Chen, C

“…GH deficiency is thought to be involved in the pathogenesis of amyotrophic lateral sclerosis (ALS). However, therapy with GH and/or IGF-I has not shown…”
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The Decline in Pulsatile GH Secretion throughout Early Adulthood in Mice Is Exacerbated by Dietary-Induced Weight Gain by Huang, L, Steyn, F. J, Tan, H. Y, Xie, T. Y, Veldhuis, J. D, Ngo, S. T, Chen, C

“…The transition between puberty and adulthood is accompanied by a slowing in linear growth. Although GH is a key factor that drives somatic development into…”
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Hypothalamic Distribution of Somatostatin mRNA Expressing Neurones Relative to Pubertal and Adult Changes in Pulsatile Growth Hormone Secretion in Mice by Tan, H. Y., Huang, L., Simmons, D., Veldhuis, J. D., Steyn, F. J., Chen, C.

“…The age‐associated decline in growth hormone (GH) secretion may be a consequence of the reduction in the number of GH‐releasing hormone (GHRH) positive…”
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GH Does Not Modulate the Early Fasting-Induced Release of Free Fatty Acids in Mice by Steyn, F. J, Leong, J. W, Huang, L, Tan, H. Y, Xie, T. Y, Nelson, C, Waters, M. J, Veldhuis, J. D, Epelbaum, J, Chen, C

“…Fasting results in the mobilization of adipose stores and the elevation of levels of free fatty acids (FFA). In humans, this process is driven by a release in…”
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Gender differences in autoimmune disease by Ngo, S.T, Steyn, F.J, McCombe, P.A

“…Highlights • Gender differences that exist in autoimmunity follow a female bias. • Differences in immune response may underlie gender bias in autoimmune…”
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Impairments to the GH-IGF-I Axis in hSOD1G93A Mice Give Insight into Possible Mechanisms of GH Dysregulation in Patients with Amyotrophic Lateral Sclerosis by Steyn, F. J, Ngo, S. T, Lee, J. D, Leong, J. W, Buckley, A. J, Veldhuis, J. D, McCombe, P. A, Chen, C, Bellingham, M. C

“…GH deficiency has been found in subjects with amyotrophic lateral sclerosis (ALS). Disrupted endocrine function could contribute to the progressive muscle loss…”
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Supramolecular Self-Associating Amphiphiles Inhibit Biofilm Formation by the Critical Pathogens, Pseudomonas aeruginosa and Candida albicans by Steyn, Hendrik J. F., White, Lisa J., Hilton, Kira L. F., Hiscock, Jennifer R., Pohl, Carolina H.

“…In 2019, 4.95 million deaths were directly attributed to antimicrobial-resistant bacterial infections globally. In addition, the mortality associated with…”
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The role of lipids in the central nervous system and their pathological implications in amyotrophic lateral sclerosis by Tracey, T.J., Kirk, S.E., Steyn, F.J., Ngo, S.T.

“…Lipids play an important role in the central nervous system (CNS). They contribute to the structural integrity and physical characteristics of cell and…”
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Nutrient Sensing Overrides Somatostatin and Growth Hormone-Releasing Hormone to Control Pulsatile Growth Hormone Release by Steyn, F. J.

“…Pharmacological studies reveal that interactions between hypothalamic inhibitory somatostatin and stimulatory growth hormone‐releasing hormone (GHRH) govern…”
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Adiponectin Regulate Growth Hormone Secretion Via Adiponectin Receptor Mediated Ca2+ Signalling in Rat Somatotrophs In Vitro by Steyn, F. J., Boehme, F., Vargas, E., Wang, K., Parkington, H. C., Rao, J. R., Chen, C.

“…Obesity is associated with reduced levels of growth hormone (GH) and the disruption of pulsatile GH secretion. This results in relative GH deficiency. It is…”
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Expression of Ovarian Steroid Hormone Receptors in Tuberoinfundibular Dopaminergic Neurones During Pregnancy and Lactation by Steyn, F. J., Anderson, G. M., Grattan, D. R.

“…During late‐pregnancy, tuberoinfundibular dopaminergic (TIDA) neurones, a critical component of the negative‐feedback loop regulating prolactin secretion,…”
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Restraint stress increases prolactin‐mediated phosphorylation of signal transducer and activator of transcription 5 in the hypothalamus and adrenal cortex in the male mouse by Kirk, S. E., Xie, T. Y., Steyn, F. J., Grattan, D. R., Bunn, S. J.

“…Prolactin is a pleiotropic peptide hormone produced by the lactotrophs in the anterior pituitary. Its rate of secretion is primarily regulated by a…”
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Body mass index and dietary intervention: Implications for prognosis of amyotrophic lateral sclerosis by Ngo, S.T, Steyn, F.J, McCombe, P.A

“…Abstract Amyotrophic lateral sclerosis (ALS) is an adult onset, neurodegenerative disease that is characterized by the loss of upper (corticospinal) and lower…”
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Altered expression of metabolic proteins and adipokines in patients with amyotrophic lateral sclerosis by Ngo, S.T, Steyn, F.J, Huang, L, Mantovani, S, Pfluger, C.M.M, Woodruff, T.M, O'Sullivan, J.D, Henderson, R.D, McCombe, P.A

“…Abstract Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by the loss of upper cortical and lower motor neurons…”
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Hyperphagia in male melanocortin 4 receptor deficient mice promotes growth independently of growth hormone by Tan, H. Y., Steyn, F. J., Huang, L., Cowley, M., Veldhuis, J. D., Chen, C.

“…Key points Loss of function of the melanocortin 4 receptor (MC4R) results in hyperphagia, obesity and increased growth. Despite knowing that MC4Rs control food…”
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Differential Effects of Centrally-Administered Oestrogen Antagonist ICI-182,780 on Oestrogen-Sensitive Functions in the Hypothalamus by Steyn, F. J., Anderson, G. M., Grattan, D. R.

“…Oestrogen actions within the hypothalamus are essential for a range of reproductive functions. In this study, we sought to develop a method for suppressing…”
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Monocyte CD14 and HLA-DR expression increases with disease duration and severity in amyotrophic lateral sclerosis by Mcgill, R.B., Steyn, F.J., Ngo, S.T., Thorpe, K.A., Heggie, S., Henderson, R.D., Mccombe, P.A., Woodruff, T.M.

“…Objective: To investigate changes in immune markers and frequencies throughout disease progression in patients with amyotrophic lateral sclerosis (ALS)…”
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