Search Results - "Steyn, Dewald"

Buried Treasure (Sven Axelrad) by Steyn, Dewald

Get full text

The Role of Functional Excipients in Solid Oral Dosage Forms to Overcome Poor Drug Dissolution and Bioavailability by van der Merwe, Jannes, Steenekamp, Jan, Steyn, Dewald, Hamman, Josias

“…Many active pharmaceutical ingredients (APIs) exhibit poor solubility and low dissolution rates in aqueous environments such as the luminal fluids of the…”
Get full text

Task shifting of antiretroviral treatment from doctors to primary-care nurses in South Africa (STRETCH): a pragmatic, parallel, cluster-randomised trial by Fairall, Lara, PhD, Bachmann, Max O, Prof, Lombard, Carl, PhD, Timmerman, Venessa, MSc, Uebel, Kerry, MBChB, Zwarenstein, Merrick, PhD, Boulle, Andrew, PhD, Georgeu, Daniella, Dip Nursing, Colvin, Christopher J, PhD, Lewin, Simon, PhD, Faris, Gill, Dip General Nursing, Cornick, Ruth, MBChB, Draper, Beverly, MBChB, Tshabalala, Mvula, MBChB, Kotze, Eduan, PhD, van Vuuren, Cloete, MBChB, Steyn, Dewald, MBChB, Chapman, Ronald, MMed, Bateman, Eric, Prof

“…Summary Background Robust evidence of the effectiveness of task shifting of antiretroviral therapy (ART) from doctors to other health workers is scarce. We…”
Get full text

A Novel NCI-H69AR Drug-Resistant Small-Cell Lung Cancer Mini-Tumor Model for Anti-Cancer Treatment Screening by van Niekerk, Alandi, Wrzesinski, Krzysztof, Steyn, Dewald, Gouws, Chrisna

“…Small-cell lung cancer is a fast-growing carcinoma with a poor prognosis and a high level of relapse due to multi-drug resistance (MDR). Genetic mutations that…”
Get full text

Intranasal Insulin Delivery: Microparticle Formulations Consisting of Aloe vera Polysaccharides for Advanced Delivery across Excised Olfactory and Respiratory Nasal Epithelial Tissues by Kirby-Smith, Cassandra, Steenekamp, Jan, Steyn, Dewald, Haasbroek-Pheiffer, Anja, Hamman, Hannlie, Hamman, Josias

“…Aloe vera gel and whole leaf materials, as well as polysaccharides, precipitated from the gel, have previously been shown to enhance macromolecular drug…”
Get full text

Pharmacokinetic interactions: The effects of selected herbal extracts on permeation of P-glycoprotein substrate drugs across excised pig intestinal tissue by Peterson, Bianca, Jacobsz, Corneli, Hamman, Josias, Viljoen, Alvaro, Steyn, Dewald

“…Introduction: There is growing concern that co-administered herbal medicines may alter the pharmacokinetics and, therefore, the efficacy and toxicity of…”
Get full text

Absorption of the novel artemisinin derivatives artemisone and artemiside: Potential application of Pheroid™ technology by Steyn, J. Dewald, Wiesner, Lubbe, du Plessis, Lissinda H., Grobler, Anne F., Smith, Peter J., Chan, Wing-Chi, Haynes, Richard K., Kotzé, Awie F.

“…Artemisinins have low aqueous solubility that results in poor and erratic absorption upon oral administration. The poor solubility and erratic absorption…”
Get full text

Permeation enhancement effects of leaf materials from different aloe species on in vitro and ex vivo nasal epithelial models by Gerber, Werner, Steyn, Dewald, Kotzé, Awie, Svitina, Hanna, Weldon, Ché, Hamman, Josias

“…Introduction: The nasal route of drug administration offers an alternative way for oral drug delivery and has the benefit of avoiding first-pass metabolism…”
Get full text

Combination therapy of Western drugs and herbal medicines: recent advances in understanding interactions involving metabolism and efflux by Gouws, Chrisna, Steyn, Dewald, Du Plessis, Lissinda, Steenekamp, Jan, Hamman, Josias H

“…While complementary and alternative medicine markets prosper with an increasing number of consumers of herbal medicines, there is an associated likelihood for…”
Get more information

Progression to AIDS in South Africa is associated with both reverting and compensatory viral mutations by Huang, Kuan-Hsiang Gary, Goedhals, Dominique, Carlson, Jonathan M, Brockman, Mark A, Mishra, Swati, Brumme, Zabrina L, Hickling, Stephen, Tang, Christopher S W, Miura, Toshiyuki, Seebregts, Chris, Heckerman, David, Ndung'u, Thumbi, Walker, Bruce, Klenerman, Paul, Steyn, Dewald, Goulder, Philip, Phillips, Rodney, van Vuuren, Cloete, Frater, John

“…We lack the understanding of why HIV-infected individuals in South Africa progress to AIDS. We hypothesised that in end-stage disease there is a shifting…”
Get full text

HIV Control through a Single Nucleotide on the HLA-B Locus by Kløverpris, Henrik N, Harndahl, Mikkel, Leslie, Alasdair J, Carlson, Jonathan M, Ismail, Nasreen, van der Stok, Mary, Huang, Kuan-Hsiang Gary, Chen, Fabian, Riddell, Lynn, Steyn, Dewald, Goedhals, Dominique, van Vuuren, Cloete, Frater, John, Walker, Bruce D, Carrington, Mary, Ndung'u, Thumbi, Buus, Søren, Goulder, Philip

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Evaluation of Isolated Fractions of Aloe vera Gel Materials on Indinavir Pharmacokinetics: In vitro and in vivo Studies by Wallis, Lonette, Malan, Maides, Gouws, Chrisna, Steyn, Dewald, Ellis, Suria, Abay, Efrem, Wiesner, Lubbe, Otto, Daniel P, Hamman, Josias

“…Aloe vera is a plant with a long history of traditional medicinal use and is consumed in different products, sometimes in conjunction with prescribed…”
Get more information

Co-operative additive effects between HLA alleles in control of HIV-1 by Matthews, Philippa C, Listgarten, Jennifer, Carlson, Jonathan M, Payne, Rebecca, Huang, Kuan-Hsiang Gary, Frater, John, Goedhals, Dominique, Steyn, Dewald, van Vuuren, Cloete, Paioni, Paolo, Jooste, Pieter, Ogwu, Anthony, Shapiro, Roger, Mncube, Zenele, Ndung'u, Thumbi, Walker, Bruce D, Heckerman, David, Goulder, Philip J R

“…HLA class I genotype is a major determinant of the outcome of HIV infection, and the impact of certain alleles on HIV disease outcome is well studied. Recent…”
Get full text

Nasal delivery of recombinant human growth hormone: in vivo evaluation with Pheroid technology and N-trimethyl chitosan chloride by Steyn, Dewald, du Plessis, Lissinda, Kotzé, Awie

“…It was the aim of this study to investigate the possible enhancement of the absorption of recombinant human growth hormone (rhGH) in the nasal cavity, in the…”
Get full text

Buried Treasure (Sven Axelrad) by Dewald Steyn

Get full text

Streamlining tasks and roles to expand treatment and care for HIV: randomised controlled trial protocol by Fairall, Lara R, Bachmann, Max O, Zwarenstein, Merrick F, Lombard, Carl J, Uebel, Kerry, van Vuuren, Cloete, Steyn, Dewald, Boulle, Andrew, Bateman, Eric D

“…A major barrier to accessing free government-provided antiretroviral treatment (ART) in South Africa is the shortage of suitably skilled health professionals…”
Get full text

In vitro wound healing effects of combinations of Aloe vera gel with different extracts of Bulbine frutescens by Hattingh, Anri, Laux, Jean-Pierre, Willers, Clarissa, Hamman, Josias, Steyn, Dewald, Hamman, Hannlie

“…•vera gel, B. frutescens aqueous and gel extracts showed wound healing effects.•Combining A. vera gel and B. frutescens aqueous extract increased wound…”
Get full text

Capsaicin and Piperine as Functional Excipients for Improved Drug Delivery across Nasal Epithelial Models by Gerber, Werner, Steyn, Dewald, Kotzé, Awie, Svitina, Hanna, Weldon, Ché, Hamman, Josias

“…The fruit from various pepper plants has been employed for the seasoning of food, as perfuming agents, and also as traditional medicines. Phytochemicals…”
Get more information

Comparison of RPMI 2650 cell layers and excised sheep nasal epithelial tissues in terms of nasal drug delivery and immunocytochemistry properties by Gerber, Werner, Svitina, Hanna, Steyn, Dewald, Peterson, Bianca, Kotzé, Awie, Weldon, Ché, Hamman, Josias H.

“…Nasal drug administration has been identified as a potential alternative to oral drug administration, especially for systemic delivery of large molecular…”
Get full text

Intranasal Insulin Delivery: Microparticle Formulations Consisting of IAloe vera/I Polysaccharides for Advanced Delivery across Excised Olfactory and Respiratory Nasal Epithelial Tissues by Kirby-Smith, Cassandra, Steenekamp, Jan, Steyn, Dewald, Haasbroek-Pheiffer, Anja, Hamman, Hannlie, Hamman, Josias

“…Aloe vera gel and whole leaf materials, as well as polysaccharides, precipitated from the gel, have previously been shown to enhance macromolecular drug…”
Get full text