Search Results - "Steyger, Peter S"

An integrated view of cisplatin-induced nephrotoxicity and ototoxicity by Karasawa, Takatoshi, Steyger, Peter S.

“…•Differing mechanisms of platinum-induced cytotoxicity are introduced.•Known pathways of cisplatin-induced nephrotoxicity are discussed.•Known mechanisms and…”
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Aminoglycoside-Induced Cochleotoxicity: A Review by Jiang, Meiyan, Karasawa, Takatoshi, Steyger, Peter S

“…Aminoglycoside antibiotics are used as prophylaxis, or urgent treatment, for many life-threatening bacterial infections, including tuberculosis, sepsis,…”
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Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier by Nyberg, Sophie, Abbott, N Joan, Shi, Xiaorui, Steyger, Peter S, Dabdoub, Alain

“…Permanent hearing loss affects more than 5% of the world's population, yet there are no nondevice therapies that can protect or restore hearing. Delivery of…”
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Aminoglycoside- and Cisplatin-Induced Ototoxicity: Mechanisms and Otoprotective Strategies by Kros, Corné J, Steyger, Peter S

“…Ototoxicity refers to damage of inner ear structures (i.e., the cochlea and vestibule) and their function (hearing and balance) following exposure to specific…”
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Functional hair cell mechanotransducer channels are required for aminoglycoside ototoxicity by Alharazneh, Abdelrahman, Luk, Lauren, Huth, Markus, Monfared, Ashkan, Steyger, Peter S, Cheng, Alan G, Ricci, Anthony J

“…Aminoglycosides (AG) are commonly prescribed antibiotics with potent bactericidal activities. One main side effect is permanent sensorineural hearing loss,…”
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Platinum-Induced Ototoxicity in Children: A Consensus Review on Mechanisms, Predisposition, and Protection, Including a New International Society of Pediatric Oncology Boston Ototoxicity Scale by BROCK, Penelope R, KNIGHT, Kristin R, SULLIVAN, Michael, NEUWELT, Edward A, FREYER, David R, CAMPBELL, Kathleen C. M, STEYGER, Peter S, BLAKLEY, Brian W, RASSEKH, Shahrad R, CHANG, Kay W, FLIGOR, Brian J, RAJPUT, Kaukab

“…The platinum chemotherapy agents cisplatin and carboplatin are widely used in the treatment of adult and pediatric cancers. Cisplatin causes hearing loss in at…”
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Preferential Cochleotoxicity of Cisplatin by Prayuenyong, Pattarawadee, Baguley, David M, Kros, Corné J, Steyger, Peter S

“…Cisplatin-induced ototoxicity in humans is more predominant in the cochlea than in the vestibule. Neither definite nor substantial vestibular dysfunction after…”
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Local Delivery of Therapeutics to the Cochlea Using Nanoparticles and Other Biomaterials by Dash, Shreshtha, Zuo, Jian, Steyger, Peter S

“…Hearing loss negatively impacts the well-being of millions of people worldwide. Systemic delivery of ototherapeutics has limited efficacy due to severe…”
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Identification of cisplatin-binding proteins using agarose conjugates of platinum compounds by Karasawa, Takatoshi, Sibrian-Vazquez, Martha, Strongin, Robert M, Steyger, Peter S

“…Cisplatin is widely used as an antineoplastic drug, but its ototoxic and nephrotoxic side-effects, as well as the inherent or acquired resistance of some…”
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Potential Mechanisms Underlying Inflammation-Enhanced Aminoglycoside-Induced Cochleotoxicity by Jiang, Meiyan, Taghizadeh, Farshid, Steyger, Peter S

“…Aminoglycoside antibiotics remain widely used for urgent clinical treatment of life-threatening infections, despite the well-recognized risk of permanent…”
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A novel long intergenic non-coding RNA, Nostrill, regulates iNOS gene transcription and neurotoxicity in microglia by Mathy, Nicholas W, Burleigh, Olivia, Kochvar, Andrew, Whiteford, Erin R, Behrens, Matthew, Marta, Patrick, Tian, Cong, Gong, Ai-Yu, Drescher, Kristen M, Steyger, Peter S, Chen, Xian-Ming, Shibata, Annemarie

“…Microglia are resident immunocompetent and phagocytic cells in the CNS. Pro-inflammatory microglia, stimulated by microbial signals such as bacterial…”
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Detecting Novel Ototoxins and Potentiation of Ototoxicity by Disease Settings by Coffin, Allison B, Boney, Robert, Hill, Jordan, Tian, Cong, Steyger, Peter S

“…Over 100 drugs and chemicals are associated with permanent hearing loss, tinnitus, and vestibular deficits, collectively known as ototoxicity. The ototoxic…”
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Uptake of fluorescent gentamicin by peripheral vestibular cells after systemic administration by Liu, Jianping, Kachelmeier, Allan, Dai, Chunfu, Li, Hongzhe, Steyger, Peter S

“…In addition to cochleotoxicity, systemic aminoglycoside pharmacotherapy causes vestibulotoxicity resulting in imbalance and visual dysfunction. The underlying…”
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Simplified, automated methods for assessing pixel intensities of fluorescently-tagged drugs in cells by Kachelmeier, Allan, Shola, Tsering, Meier, William B, Johnson, Anastasiya, Jiang, Meiyan, Steyger, Peter S

“…Assessing the cytoplasmic uptake of fluorescently-tagged drugs in heterogeneous cell types currently involves time-consuming manual segmentation of confocal…”
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Acoustic trauma increases cochlear and hair cell uptake of gentamicin by Li, Hongzhe, Wang, Qi, Steyger, Peter S

“…Exposure to intense sound or high doses of aminoglycoside antibiotics can increase hearing thresholds, induce cochlear dysfunction, disrupt hair cell…”
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Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss by Jiang, Meiyan, Li, Hongzhe, Johnson, Anastasiya, Karasawa, Takatoshi, Zhang, Yuan, Meier, William B, Taghizadeh, Farshid, Kachelmeier, Allan, Steyger, Peter S

“…Aminoglycoside antibiotics are essential for treating life-threatening bacterial infections, despite the risk of lifelong hearing loss. Infections induce…”
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TRPV4 enhances the cellular uptake of aminoglycoside antibiotics by Karasawa, Takatoshi, Wang, Qi, Fu, Yi, Cohen, David M, Steyger, Peter S

“…The cochlea and kidney are susceptible to aminoglycoside-induced toxicity. The non-selective cation channel TRPV4 is expressed in kidney distal tubule cells,…”
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A systemic gentamicin pathway across the stria vascularis by Dai, Chun Fu, Steyger, Peter S.

“…The mechanism(s) by which systemically-administered aminoglycosides enter the cochlea remain poorly understood. To elucidate which mechanisms may be involved,…”
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Editorial: Cellular Mechanisms of Ototoxicity by Steyger, Peter S, Cunningham, Lisa L, Esquivel, Carlos R, Watts, Kelly L, Zuo, Jian

“…On an evolutionary level, hearing loss reduces the perception of environmental auditory cues associated with beneficial or detrimental outcomes (e.g.,…”
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Mechanisms of Ototoxicity and Otoprotection by Steyger, Peter S.

“…Ototoxicity refers to damage to the inner ear that leads to functional hearing loss or vestibular disorders by selected pharmacotherapeutics as well as a…”
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