Search Results - "Stewart, Paul M"

Adrenal Incidentaloma by Sherlock, Mark, Scarsbrook, Andrew, Abbas, Afroze, Fraser, Sheila, Limumpornpetch, Padiporn, Dineen, Rosemary, Stewart, Paul M

“…Abstract An adrenal incidentaloma is now established as a common endocrine diagnosis that requires a multidisciplinary approach for effective management. The…”
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11β-Hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action by Draper, Nicole, Stewart, Paul M

“…Two isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD1 and 11β-HSD2) catalyse the interconversion of hormonally active cortisol and inactive cortisone. The…”
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The Diagnosis of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline by Nieman, Lynnette K., Biller, Beverly M. K., Findling, James W., Newell-Price, John, Savage, Martin O., Stewart, Paul M., Montori, Victor M.

“…Objective: The objective of the study was to develop clinical practice guidelines for the diagnosis of Cushing's syndrome. Participants: The Task Force…”
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11β-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess by Morgan, Stuart A, McCabe, Emma L, Gathercole, Laura L, Hassan-Smith, Zaki K, Larner, Dean P, Bujalska, Iwona J, Stewart, Paul M, Tomlinson, Jeremy W, Lavery, Gareth G

“…The adverse metabolic effects of prescribed and endogenous glucocorticoid (GC) excess, Cushing syndrome, create a significant health burden. We found that…”
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Corticosteroid Insufficiency in Acutely Ill Patients by Cooper, Mark S, Stewart, Paul M

“…Recent studies report benefits from corticosteroid treatment in patients with septic shock. This review summarizes the physiology of the corticosteroid…”
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Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS) by Krone, Nils, Hughes, Beverly A., Lavery, Gareth G., Stewart, Paul M., Arlt, Wiebke, Shackleton, Cedric H.L.

“…Liquid chromatography tandem mass spectrometry (LC/MS/MS) is replacing classical methods for steroid hormone analysis. It requires small sample volumes and has…”
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Urine Steroid Metabolomics as a Biomarker Tool for Detecting Malignancy in Adrenal Tumors by Arlt, Wiebke, Biehl, Michael, Taylor, Angela E, Hahner, Stefanie, Libé, Rossella, Hughes, Beverly A, Schneider, Petra, Smith, David J, Stiekema, Han, Krone, Nils, Porfiri, Emilio, Opocher, Giuseppe, Bertherat, Jerôme, Mantero, Franco, Allolio, Bruno, Terzolo, Massimo, Nightingale, Peter, Shackleton, Cedric H. L, Bertagna, Xavier, Fassnacht, Martin, Stewart, Paul M

“…Context: Adrenal tumors have a prevalence of around 2% in the general population. Adrenocortical carcinoma (ACC) is rare but accounts for 2–11% of incidentally…”
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Regulation of lipogenesis by glucocorticoids and insulin in human adipose tissue by Gathercole, Laura L, Morgan, Stuart A, Bujalska, Iwona J, Hauton, David, Stewart, Paul M, Tomlinson, Jeremy W

“…Patients with glucocorticoid (GC) excess, Cushing's syndrome, develop a classic phenotype characterized by central obesity and insulin resistance. GCs are…”
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Mortality in patients with Cushing's disease more than 10 years after remission: a multicentre, multinational, retrospective cohort study by Clayton, Richard N, Prof, Jones, Peter W, Prof, Reulen, Raoul C, Prof, Stewart, Paul M, Prof, Hassan-Smith, Zaki K, PhD, Ntali, Georgia, MD, Karavitaki, Niki, PhD, Dekkers, Olaf M, Prof, Pereira, Alberto M, Prof, Bolland, Mark, PhD, Holdaway, Ian, Prof, Lindholm, Jorgen, Prof

“…Summary Background No agreement has been reached on the long-term survival prospects for patients with Cushing's disease. We studied life expectancy in…”
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High throughput LC–MS/MS method for the simultaneous analysis of multiple vitamin D analytes in serum by Jenkinson, Carl, Taylor, Angela E., Hassan-Smith, Zaki K., Adams, John S., Stewart, Paul M., Hewison, Martin, Keevil, Brian G.

“…•High throughput LC–MS/MS method to measure multiple vitamin D metabolites in serum.•SLE is an effective sample preparation method for multiple vitamin D…”
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11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial by Othonos, Nantia, Pofi, Riccardo, Arvaniti, Anastasia, White, Sarah, Bonaventura, Ilaria, Nikolaou, Nikolaos, Moolla, Ahmad, Marjot, Thomas, Stimson, Roland H., van Beek, André P., van Faassen, Martijn, Isidori, Andrea M., Bateman, Elizabeth, Sadler, Ross, Karpe, Fredrik, Stewart, Paul M., Webster, Craig, Duffy, Joanne, Eastell, Richard, Gossiel, Fatma, Cornfield, Thomas, Hodson, Leanne, Jane Escott, K., Whittaker, Andrew, Kirik, Ufuk, Coleman, Ruth L., Scott, Charles A. B., Milton, Joanne E., Agbaje, Olorunsola, Holman, Rury R., Tomlinson, Jeremy W.

“…Glucocorticoids prescribed to limit inflammation, have significant adverse effects. As 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) regenerates active…”
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A switch in hepatic cortisol metabolism across the spectrum of non alcoholic fatty liver disease by Ahmed, Adeeba, Rabbitt, Elizabeth, Brady, Theresa, Brown, Claire, Guest, Peter, Bujalska, Iwona J, Doig, Craig, Newsome, Philip N, Hubscher, Stefan, Elias, Elwyn, Adams, David H, Tomlinson, Jeremy W, Stewart, Paul M

“…Non alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. NAFLD represents a spectrum of liver disease ranging from…”
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MicroRNA-24 Is a Novel Regulator of Aldosterone and Cortisol Production in the Human Adrenal Cortex by Robertson, Stacy, MacKenzie, Scott M., Alvarez-Madrazo, Samantha, Diver, Louise A., Lin, Junjun, Stewart, Paul M., Fraser, Robert, Connell, John M., Davies, Eleanor

“…Dysregulation of aldosterone or cortisol production can predispose to hypertension, as seen in aldosterone-producing adenoma, a form of primary aldosteronism…”
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Hypertension and the Cortisol-Cortisone Shuttle by Quinkler, Marcus, Stewart, Paul M.

“…11β-Hydroxysteroid dehydrogenase type 2 (11β-HSD2) plays a crucial role in converting hormonally active cortisol to inactive cortisone, thereby conferring…”
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11β-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice by Doig, Craig L., Fletcher, Rachel S., Morgan, Stuart A., McCabe, Emma L., Larner, Dean P., Tomlinson, Jeremy W., Stewart, Paul M., Philp, Andrew, Lavery, Gareth G.

“…Glucocorticoids (GCs) are potent regulators of energy metabolism. Chronic GC exposure suppresses brown adipose tissue (BAT) thermogenic capacity in mice, with…”
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Premature adrenarche: novel lessons from early onset androgen excess by Idkowiak, Jan, Lavery, Gareth G, Dhir, Vivek, Barrett, Timothy G, Stewart, Paul M, Krone, Nils, Arlt, Wiebke

“…Adrenarche reflects the maturation of the adrenal zona reticularis resulting in increased secretion of the adrenal androgen precursor DHEA and its sulphate…”
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Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS by Mahida, Rahul Y, Lax, Siân, Bassford, Christopher R, Scott, Aaron, Parekh, Dhruv, Hardy, Rowan S, Naidu, Babu, Matthay, Michael A, Stewart, Paul M, Cooper, Mark C, Perkins, Gavin D, Thickett, David R

“…Acute Respiratory Distress Syndrome (ARDS) is a devastating pulmonary inflammatory disorder, commonly precipitated by sepsis. Glucocorticoids are…”
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11β-Hydroxysteroid Dehydrogenase Type 1 Regulates Glucocorticoid-Induced Insulin Resistance in Skeletal Muscle by MORGAN, Stuart A, SHERLOCK, Mark, HEGYI, Krisztina, SETHI, Jaswinder K, STEWART, Paul M, SMITH, David M, TOMLINSON, Jeremy W, GATHERCOLE, Laura L, LAVERY, Gareth G, LENAGHAN, Carol, BUJALSKA, Iwona J, LABER, David, YU, Alice, CONVEY, Gemma, MAYERS, Rachel

“…11β-Hydroxysteroid Dehydrogenase Type 1 Regulates Glucocorticoid-Induced Insulin Resistance in Skeletal Muscle Stuart A. Morgan 1 , Mark Sherlock 1 , Laura L…”
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Maternal iodine status, intrauterine growth, birth outcomes and congenital anomalies in a UK birth cohort by Snart, Charles Jonathan Peter, Threapleton, Diane Erin, Keeble, Claire, Taylor, Elizabeth, Waiblinger, Dagmar, Reid, Stephen, Alwan, Nisreen A, Mason, Dan, Azad, Rafaq, Cade, Janet Elizabeth, Simpson, Nigel A B, Meadows, Sarah, McKillion, Amanda, Santorelli, Gillian, Waterman, Amanda H, Zimmermann, Michael, Stewart, Paul M, Wright, John, Mon-Williams, Mark, Greenwood, Darren Charles, Hardie, Laura J

“…Severe iodine insufficiency in pregnancy has significant consequences, but there is inadequate evidence to indicate what constitutes mild or moderate…”
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Clinical Practice and Nomenclature of Pituitary Neoplasms: Common Sense Must Prevail by Stewart, Paul M

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