Search Results - "Stewart, Jason A."

Human CST Has Independent Functions during Telomere Duplex Replication and C-Strand Fill-In by Wang, Feng, Stewart, Jason A., Kasbek, Christopher, Zhao, Yong, Wright, Woodring E., Price, Carolyn M.

“…Human CST (CTC1-STN1-TEN1) is an RPA-like complex that is needed for efficient replication through the telomere duplex and genome-wide replication restart…”
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Cis- and trans-resveratrol have opposite effects on histone serine-ADP-ribosylation and tyrosine induced neurodegeneration by Jhanji, Megha, Rao, Chintada Nageswara, Massey, Jacob C., Hope, Marion C., Zhou, Xueyan, Keene, C. Dirk, Ma, Tao, Wyatt, Michael D., Stewart, Jason A., Sajish, Mathew

“…Serum tyrosine levels increase during aging, neurocognitive, metabolic, and cardiovascular disorders. However, calorie restriction (CR) and sleep lower serum…”
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Evolution of CST function in telomere maintenance by Price, Carolyn, Boltz, Kara A., Chaiken, Mary F., Stewart, Jason A., Beilstein, Mark A., Shippen, Dorothy E.

“…Telomeres consist of an elaborate, higher-order DNA architecture, and a suite of proteins that provide protection for the chromosome terminus by blocking…”
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To Join or Not to Join: Decision Points Along the Pathway to Double-Strand Break Repair vs. Chromosome End Protection by Ackerson, Stephanie M., Romney, Carlan, Schuck, P. Logan, Stewart, Jason A.

“…The regulation of DNA double-strand breaks (DSBs) and telomeres are diametrically opposed in the cell. DSBs are considered one of the most deleterious forms of…”
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Human CST suppresses origin licensing and promotes AND-1/Ctf4 chromatin association by Wang, Yilin, Brady, Kathryn S, Caiello, Benjamin P, Ackerson, Stephanie M, Stewart, Jason A

“…Human CTC1-STN1-TEN1 (CST) is an RPA-like single-stranded DNA-binding protein that interacts with DNA polymerase α-primase (pol α) and functions in telomere…”
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Human CST promotes telomere duplex replication and general replication restart after fork stalling by Stewart, Jason A, Wang, Feng, Chaiken, Mary F, Kasbek, Christopher, Chastain II, Paul D, Wright, Woodring E, Price, Carolyn M

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Dynamic Removal of Replication Protein A by Dna2 Facilitates Primer Cleavage during Okazaki Fragment Processing in Saccharomyces cerevisiae by Stewart, Jason A., Miller, Adam S., Campbell, Judith L., Bambara, Robert A.

“…Eukaryotic Okazaki fragments are initiated by a RNA/DNA primer, which is removed before the fragments are joined. Polymerase δ displaces the primer into a flap…”
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Significance of the Dissociation of Dna2 by Flap Endonuclease 1 to Okazaki Fragment Processing in Saccharomyces cerevisiae by Stewart, Jason A., Campbell, Judith L., Bambara, Robert A.

“…Okazaki fragments are initiated by short RNA/DNA primers, which are displaced into flap intermediates for processing. Flap endonuclease 1 (FEN1) and Dna2 are…”
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Emerging roles of CST in maintaining genome stability and human disease by Stewart, Jason A, Wang, Yilin, Ackerson, Stephanie M, Schuck, Percy Logan

“…The human CTC1-STN1-TEN1 (CST) complex is a single-stranded DNA binding protein that shares homology with RPA and interacts with DNA polymerase alpha/primase…”
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Flap Endonuclease Disengages Dna2 Helicase/Nuclease from Okazaki Fragment Flaps by Stewart, Jason A., Campbell, Judith L., Bambara, Robert A.

“…Okazaki fragments contain an initiator RNA/DNA primer that must be removed before the fragments are joined. In eukaryotes, the primer region is raised into a…”
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The DNA-binding protein CST associates with the cohesin complex and promotes chromosome cohesion by Schuck, P. Logan, Ball, Lauren E., Stewart, Jason A.

“…Sister chromatid cohesion (SCC), the pairing of sister chromatids after DNA replication until mitosis, is established by loading of the cohesin complex on…”
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Human CST Stimulates Base Excision Repair to Prevent the Accumulation of Oxidative DNA Damage by Wysong, Brandon C., Schuck, P. Logan, Sridharan, Madhumita, Carrison, Sophie, Murakami, Yuichihiro, Balakrishnan, Lata, Stewart, Jason A.

“…[Display omitted] •CST deficiency is linked to increased oxidative damage but it is unknown if CST promotes repair.•CST interacts with and stimulates multiple…”
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Human CTC1 promotes TopBP1 stability and CHK1 phosphorylation in response to telomere dysfunction and global replication stress by Ackerson, Stephanie M., Gable, Caroline I., Stewart, Jason A.

“…CST (CTC1-STN1-TEN1) is a heterotrimeric, RPA-like complex that binds to single-stranded DNA (ssDNA) and functions in the replication of telomeric and…”
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Human CST promotes telomere duplex replication and general replication restart after fork stalling by Stewart, Jason A, Wang, Feng, Chaiken, Mary F, Kasbek, Christopher, Chastain, Paul D, Wright, Woodring E, Price, Carolyn M

“…Mammalian CST (CTC1‐STN1‐TEN1) associates with telomeres and depletion of CTC1 or STN1 causes telomere defects. However, the function of mammalian CST remains…”
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FISHing for Damage on Metaphase Chromosomes by Schuck, P Logan, Stewart, Jason A

“…Fluorescence in situ hybridization (FISH) is used to examine chromosomal abnormalities and DNA damage. Developed in the early 1980s, this technique remains an…”
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Cooperative interaction of CST and RECQ4 resolves G‐quadruplexes and maintains telomere stability by Li, Tingfang, Zhang, Miaomiao, Li, Yanjing, Han, Xinyu, Tang, Lu, Ma, Tengfei, Zhao, Xiaotong, Zhao, Rui, Wang, Yuwen, Bai, Xue, Zhang, Kai, Geng, Xin, Sui, Lei, Feng, Xuyang, Zhang, Qiang, Zhao, Yang, Liu, Yang, Stewart, Jason A, Wang, Feng

“…Human CST (CTC1‐STN1‐TEN1) is a ssDNA‐binding complex that interacts with the replisome to aid in stalled fork rescue. We previously found that CST promotes…”
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Maintaining the end: roles of telomere proteins in end-protection, telomere replication and length regulation by Stewart, Jason A, Chaiken, Mary F, Wang, Feng, Price, Carolyn M

“…Chromosome end protection is essential to protect genome integrity. Telomeres, tracts of repetitive DNA sequence and associated proteins located at the…”
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Dna2 is a structure-specific nuclease, with affinity for 5'-flap intermediates by Stewart, Jason A, Campbell, Judith L, Bambara, Robert A

“…Dna2 is a nuclease/helicase with proposed roles in DNA replication, double-strand break repair and telomere maintenance. For each role Dna2 is proposed to…”
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Can the DCoHα isozyme compensate in patients with 4a-hydroxy-tetrahydrobiopterin dehydratase/DCoH deficiency? by Hevel, Joan M., Stewart, Jason A., Gross, Katherine L., Ayling, June E.

“…4a-Hydroxy-tetrahydrobiopterin dehydratase/DCoH is a bifunctional protein. In the cytoplasm it is an enzyme required for the regeneration of…”
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A Novel Role of the Human CST Complex in Regulating the DNA Damage Response by Stewart, Jason A., Ackerson, Stephanie M.

“…CST (CTC1‐STN1‐TEN1) is an RPA‐like, ssDNA binding protein that functions in telomere replication and genome‐wide DNA replication rescue. Previous studies have…”
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