Search Results - "Stewart, Isobel"

Plasma metabolites to profile pathways in noncommunicable disease multimorbidity by Pietzner, Maik, Stewart, Isobel D., Raffler, Johannes, Khaw, Kay-Tee, Michelotti, Gregory A., Kastenmüller, Gabi, Wareham, Nicholas J., Langenberg, Claudia

“…Multimorbidity, the simultaneous presence of multiple chronic conditions, is an increasing global health problem and research into its determinants is of high…”
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Mapping the proteo-genomic convergence of human diseases by Pietzner, Maik, Wheeler, Eleanor, Carrasco-Zanini, Julia, Cortes, Adrian, Koprulu, Mine, Wörheide, Maria A, Oerton, Erin, Cook, James, Stewart, Isobel D, Kerrison, Nicola D, Luan, Jian'an, Raffler, Johannes, Arnold, Matthias, Arlt, Wiebke, O'Rahilly, Stephen, Kastenmüller, Gabi, Gamazon, Eric R, Hingorani, Aroon D, Scott, Robert A, Wareham, Nicholas J, Langenberg, Claudia

“…Characterization of the genetic regulation of proteins is essential for understanding disease etiology and developing therapies. We identified 10,674 genetic…”
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Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases by Chen, Yiheng, Lu, Tianyuan, Pettersson-Kymmer, Ulrika, Stewart, Isobel D., Butler-Laporte, Guillaume, Nakanishi, Tomoko, Cerani, Agustin, Liang, Kevin Y. H., Yoshiji, Satoshi, Willett, Julian Daniel Sunday, Su, Chen-Yang, Raina, Parminder, Greenwood, Celia M. T., Farjoun, Yossi, Forgetta, Vincenzo, Langenberg, Claudia, Zhou, Sirui, Ohlsson, Claes, Richards, J. Brent

“…Metabolic processes can influence disease risk and provide therapeutic targets. By conducting genome-wide association studies of 1,091 blood metabolites and…”
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Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity by Lotta, Luca A., Mokrosiński, Jacek, Mendes de Oliveira, Edson, Li, Chen, Sharp, Stephen J., Luan, Jian’an, Brouwers, Bas, Ayinampudi, Vikram, Bowker, Nicholas, Kerrison, Nicola, Kaimakis, Vasileios, Hoult, Diana, Stewart, Isobel D., Wheeler, Eleanor, Day, Felix R., Perry, John R.B., Langenberg, Claudia, Wareham, Nicholas J., Farooqi, I. Sadaf

“…The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor whose disruption causes obesity. We functionally characterized 61 MC4R variants identified…”
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Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis by Lotta, Luca A, Scott, Robert A, Sharp, Stephen J, Burgess, Stephen, Luan, Jian'an, Tillin, Therese, Schmidt, Amand F, Imamura, Fumiaki, Stewart, Isobel D, Perry, John R B, Marney, Luke, Koulman, Albert, Karoly, Edward D, Forouhi, Nita G, Sjögren, Rasmus J O, Näslund, Erik, Zierath, Juleen R, Krook, Anna, Savage, David B, Griffin, Julian L, Chaturvedi, Nishi, Hingorani, Aroon D, Khaw, Kay-Tee, Barroso, Inês, McCarthy, Mark I, O'Rahilly, Stephen, Wareham, Nicholas J, Langenberg, Claudia

“…Higher circulating levels of the branched-chain amino acids (BCAAs; i.e., isoleucine, leucine, and valine) are strongly associated with higher type 2 diabetes…”
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Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies by Do, Kieu Trinh, Wahl, Simone, Raffler, Johannes, Molnos, Sophie, Laimighofer, Michael, Adamski, Jerzy, Suhre, Karsten, Strauch, Konstantin, Peters, Annette, Gieger, Christian, Langenberg, Claudia, Stewart, Isobel D., Theis, Fabian J., Grallert, Harald, Kastenmüller, Gabi, Krumsiek, Jan

“…Background Untargeted mass spectrometry (MS)-based metabolomics data often contain missing values that reduce statistical power and can introduce bias in…”
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Integrated Analyses of Microbiome and Longitudinal Metabolome Data Reveal Microbial-Host Interactions on Sulfur Metabolism in Parkinson’s Disease by Hertel, Johannes, Harms, Amy C., Heinken, Almut, Baldini, Federico, Thinnes, Cyrille C., Glaab, Enrico, Vasco, Daniel A., Pietzner, Maik, Stewart, Isobel D., Wareham, Nicholas J., Langenberg, Claudia, Trenkwalder, Claudia, Krüger, Rejko, Hankemeier, Thomas, Fleming, Ronan M.T., Mollenhauer, Brit, Thiele, Ines

“…Parkinson’s disease (PD) exhibits systemic effects on the human metabolism, with emerging roles for the gut microbiome. Here, we integrate longitudinal…”
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Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors by Lotta, Luca A, Wittemans, Laura B. L, Zuber, Verena, Stewart, Isobel D, Sharp, Stephen J, Luan, Jian’an, Day, Felix R, Li, Chen, Bowker, Nicholas, Cai, Lina, De Lucia Rolfe, Emanuella, Khaw, Kay-Tee, Perry, John R. B, O’Rahilly, Stephen, Scott, Robert A, Savage, David B, Burgess, Stephen, Wareham, Nicholas J, Langenberg, Claudia

“…IMPORTANCE: Body fat distribution, usually measured using waist-to-hip ratio (WHR), is an important contributor to cardiometabolic disease independent of body…”
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Association Between Low-Density Lipoprotein Cholesterol–Lowering Genetic Variants and Risk of Type 2 Diabetes: A Meta-analysis by Lotta, Luca A, Sharp, Stephen J, Burgess, Stephen, Perry, John R. B, Stewart, Isobel D, Willems, Sara M, Luan, Jian’an, Ardanaz, Eva, Arriola, Larraitz, Balkau, Beverley, Boeing, Heiner, Deloukas, Panos, Forouhi, Nita G, Franks, Paul W, Grioni, Sara, Kaaks, Rudolf, Key, Timothy J, Navarro, Carmen, Nilsson, Peter M, Overvad, Kim, Palli, Domenico, Panico, Salvatore, Quirós, Jose-Ramón, Riboli, Elio, Rolandsson, Olov, Sacerdote, Carlotta, Salamanca-Fernandez, Elena, Slimani, Nadia, Spijkerman, Annemieke M. W, Tjonneland, Anne, Tumino, Rosario, van der A, Daphne L, van der Schouw, Yvonne T, McCarthy, Mark I, Barroso, Inês, O’Rahilly, Stephen, Savage, David B, Sattar, Naveed, Langenberg, Claudia, Scott, Robert A, Wareham, Nicholas J

“…IMPORTANCE: Low-density lipoprotein cholesterol (LDL-C)–lowering alleles in or near NPC1L1 or HMGCR, encoding the respective molecular targets of ezetimibe and…”
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Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance by Lotta, Luca A, Gulati, Pawan, Day, Felix R, Payne, Felicity, Ongen, Halit, van de Bunt, Martijn, Gaulton, Kyle J, Eicher, John D, Sharp, Stephen J, Luan, Jian'an, De Lucia Rolfe, Emanuella, Stewart, Isobel D, Wheeler, Eleanor, Willems, Sara M, Adams, Claire, Yaghootkar, Hanieh, Forouhi, Nita G, Khaw, Kay-Tee, Johnson, Andrew D, Semple, Robert K, Frayling, Timothy, Perry, John R B, Dermitzakis, Emmanouil, McCarthy, Mark I, Barroso, Inês, Wareham, Nicholas J, Savage, David B, Langenberg, Claudia, O'Rahilly, Stephen, Scott, Robert A

“…Luca Lotta, Robert Scott, Stephen O’Rahilly, Claudia Langenberg, David Savage, Nicholas Wareham, Inês Barroso and colleagues identify 53 genomic regions…”
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A cross-platform approach identifies genetic regulators of human metabolism and health by Lotta, Luca A., Pietzner, Maik, Stewart, Isobel D., Wittemans, Laura B. L., Li, Chen, Bonelli, Roberto, Raffler, Johannes, Biggs, Emma K., Oliver-Williams, Clare, Auyeung, Victoria P. W., Luan, Jian’an, Wheeler, Eleanor, Paige, Ellie, Surendran, Praveen, Michelotti, Gregory A., Scott, Robert A., Burgess, Stephen, Zuber, Verena, Sanderson, Eleanor, Koulman, Albert, Imamura, Fumiaki, Forouhi, Nita G., Khaw, Kay-Tee, Griffin, Julian L., Wood, Angela M., Kastenmüller, Gabi, Danesh, John, Butterworth, Adam S., Gribble, Fiona M., Reimann, Frank, Bahlo, Melanie, Fauman, Eric, Wareham, Nicholas J., Langenberg, Claudia

“…In cross-platform analyses of 174 metabolites, we identify 499 associations ( P  < 4.9 × 10 −10 ) characterized by pleiotropy, allelic heterogeneity, large and…”
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Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations by Zheng, Ju-Sheng, Luan, Jian'an, Sofianopoulou, Eleni, Imamura, Fumiaki, Stewart, Isobel D, Day, Felix R, Pietzner, Maik, Wheeler, Eleanor, Lotta, Luca A, Gundersen, Thomas E, Amiano, Pilar, Ardanaz, Eva, Chirlaque, María-Dolores, Fagherazzi, Guy, Franks, Paul W, Kaaks, Rudolf, Laouali, Nasser, Mancini, Francesca Romana, Nilsson, Peter M, Onland-Moret, N Charlotte, Olsen, Anja, Overvad, Kim, Panico, Salvatore, Palli, Domenico, Ricceri, Fulvio, Rolandsson, Olov, Spijkerman, Annemieke M W, Sánchez, María-José, Schulze, Matthias B, Sala, Núria, Sieri, Sabina, Tjønneland, Anne, Tumino, Rosario, van der Schouw, Yvonne T, Weiderpass, Elisabete, Riboli, Elio, Danesh, John, Butterworth, Adam S, Sharp, Stephen J, Langenberg, Claudia, Forouhi, Nita G, Wareham, Nicholas J

“…Higher plasma vitamin C levels are associated with lower type 2 diabetes risk, but whether this association is causal is uncertain. To investigate this, we…”
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Development and validation of a metabolite score for red meat intake: an observational cohort study and randomized controlled dietary intervention by Li, Chunxiao, Imamura, Fumiaki, Wedekind, Roland, Stewart, Isobel D, Pietzner, Maik, Wheeler, Eleanor, Forouhi, Nita G, Langenberg, Claudia, Scalbert, Augustin, Wareham, Nicholas J

“…Self-reported meat consumption is associated with disease risk but objective assessment of different dimensions of this heterogeneous dietary exposure in…”
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Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population: EPIC-Norfolk Study by Cardona, Alexia, Day, Felix R, Perry, John R B, Loh, Marie, Chu, Audrey Y, Lehne, Benjamin, Paul, Dirk S, Lotta, Luca A, Stewart, Isobel D, Kerrison, Nicola D, Scott, Robert A, Khaw, Kay-Tee, Forouhi, Nita G, Langenberg, Claudia, Liu, Chunyu, Mendelson, Michael M, Levy, Daniel, Beck, Stephan, Leslie, R David, Dupuis, Josée, Meigs, James B, Kooner, Jaspal S, Pihlajamäki, Jussi, Vaag, Allan, Perfilyev, Alexander, Ling, Charlotte, Hivert, Marie-France, Chambers, John C, Wareham, Nicholas J, Ong, Ken K

“…Epigenetic changes may contribute substantially to risks of diseases of aging. Previous studies reported seven methylation variable positions (MVPs) robustly…”
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Meta-analysis investigating the role of interleukin-6 mediated inflammation in type 2 diabetes by Bowker, Nicholas, Shah, Rupal L., Sharp, Stephen J., Luan, Jian'an, Stewart, Isobel D., Wheeler, Eleanor, Ferreira, Manuel A.R., Baras, Aris, Wareham, Nicholas J., Langenberg, Claudia, Lotta, Luca A.

“…Evidence from animal models and observational epidemiology points to a role for chronic inflammation, in which interleukin 6 (IL-6) is a key player, in the…”
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Assessing the causal association of glycine with risk of cardio-metabolic diseases by Wittemans, Laura B. L., Lotta, Luca A., Oliver-Williams, Clare, Stewart, Isobel D., Surendran, Praveen, Karthikeyan, Savita, Day, Felix R., Koulman, Albert, Imamura, Fumiaki, Zeng, Lingyao, Erdmann, Jeanette, Schunkert, Heribert, Khaw, Kay-Tee, Griffin, Julian L., Forouhi, Nita G., Scott, Robert A., Wood, Angela M., Burgess, Stephen, Howson, Joanna M. M., Danesh, John, Wareham, Nicholas J., Butterworth, Adam S., Langenberg, Claudia

“…Circulating levels of glycine have previously been associated with lower incidence of coronary heart disease (CHD) and type 2 diabetes (T2D) but it remains…”
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Whole-exome sequencing identifies rare genetic variants associated with human plasma metabolites by Bomba, Lorenzo, Walter, Klaudia, Guo, Qi, Surendran, Praveen, Kundu, Kousik, Nongmaithem, Suraj, Karim, Mohd Anisul, Stewart, Isobel D., Langenberg, Claudia, Danesh, John, Di Angelantonio, Emanuele, Roberts, David J., Ouwehand, Willem H., Dunham, Ian, Butterworth, Adam S., Soranzo, Nicole

“…Metabolite levels measured in the human population are endophenotypes for biological processes. We combined sequencing data for 3,924 (whole-exome sequencing,…”
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Rare and common genetic determinants of metabolic individuality and their effects on human health by Surendran, Praveen, Stewart, Isobel D., Au Yeung, Victoria P. W., Pietzner, Maik, Raffler, Johannes, Wörheide, Maria A., Li, Chen, Smith, Rebecca F., Wittemans, Laura B. L., Bomba, Lorenzo, Menni, Cristina, Zierer, Jonas, Rossi, Niccolò, Sheridan, Patricia A., Watkins, Nicholas A., Mangino, Massimo, Hysi, Pirro G., Di Angelantonio, Emanuele, Falchi, Mario, Spector, Tim D., Soranzo, Nicole, Michelotti, Gregory A., Arlt, Wiebke, Lotta, Luca A., Denaxas, Spiros, Hemingway, Harry, Gamazon, Eric R., Howson, Joanna M. M., Wood, Angela M., Danesh, John, Wareham, Nicholas J., Kastenmüller, Gabi, Fauman, Eric B., Suhre, Karsten, Butterworth, Adam S., Langenberg, Claudia

“…Garrod’s concept of ‘chemical individuality’ has contributed to comprehension of the molecular origins of human diseases. Untargeted high-throughput…”
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Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma by Kachroo, Priyadarshini, Stewart, Isobel D., Kelly, Rachel S., Stav, Meryl, Mendez, Kevin, Dahlin, Amber, Soeteman, Djøra I., Chu, Su H., Huang, Mengna, Cote, Margaret, Knihtilä, Hanna M., Lee-Sarwar, Kathleen, McGeachie, Michael, Wang, Alberta, Wu, Ann Chen, Virkud, Yamini, Zhang, Pei, Wareham, Nicholas J., Karlson, Elizabeth W., Wheelock, Craig E., Clish, Clary, Weiss, Scott T., Langenberg, Claudia, Lasky-Su, Jessica A.

“…The application of large-scale metabolomic profiling provides new opportunities for realizing the potential of omics-based precision medicine for asthma. By…”
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The association between circulating 25-hydroxyvitamin D metabolites and type 2 diabetes in European populations: A meta-analysis and Mendelian randomisation analysis by Zheng, Ju-Sheng, Luan, Jian'an, Sofianopoulou, Eleni, Sharp, Stephen J, Day, Felix R, Imamura, Fumiaki, Gundersen, Thomas E, Lotta, Luca A, Sluijs, Ivonne, Stewart, Isobel D, Shah, Rupal L, van der Schouw, Yvonne T, Wheeler, Eleanor, Ardanaz, Eva, Boeing, Heiner, Dorronsoro, Miren, Dahm, Christina C, Dimou, Niki, El-Fatouhi, Douae, Franks, Paul W, Fagherazzi, Guy, Grioni, Sara, Huerta, José María, Heath, Alicia K, Hansen, Louise, Jenab, Mazda, Jakszyn, Paula, Kaaks, Rudolf, Kühn, Tilman, Khaw, Kay-Tee, Laouali, Nasser, Masala, Giovanna, Nilsson, Peter M, Overvad, Kim, Olsen, Anja, Panico, Salvatore, Quirós, J Ramón, Rolandsson, Olov, Rodríguez-Barranco, Miguel, Sacerdote, Carlotta, Spijkerman, Annemieke M W, Tong, Tammy Y N, Tumino, Rosario, Tsilidis, Konstantinos K, Danesh, John, Riboli, Elio, Butterworth, Adam S, Langenberg, Claudia, Forouhi, Nita G, Wareham, Nicholas J

“…Prior research suggested a differential association of 25-hydroxyvitamin D (25(OH)D) metabolites with type 2 diabetes (T2D), with total 25(OH)D and 25(OH)D3…”
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