Search Results - "Stewart, Gregory"

Targeting Adenosine Receptor Signaling in Cancer Immunotherapy by Sek, Kevin, Mølck, Christina, Stewart, Gregory D, Kats, Lev, Darcy, Phillip K, Beavis, Paul A

“…The immune system plays a major role in the surveillance and control of malignant cells, with the presence of tumor infiltrating lymphocytes (TILs) correlating…”
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Prevalence and incidence of drug-resistant mesial temporal lobe epilepsy in the United States by Asadi-Pooya, Ali A., M.D, Stewart, Gregory R., Ph.D, Abrams, Daniel J., M.D, Sharan, Ashwini, M.D

“…Abstract Objective We reviewed data on the epidemiology of epilepsy in the United States and estimated the prevalence and incidence of drug-resistant temporal…”
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Molecular and structural insights into the 5‐HT2C receptor as a therapeutic target for substance use disorders by Ubhayarathna, Maleesha, Langmead, Christopher J., Diepenhorst, Natalie A., Stewart, Gregory D.

“…Substance use disorder (SUD) is a chronic condition, with maintained abuse of a substance leading to physiological and psychological alterations and often…”
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CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy by Giuffrida, Lauren, Sek, Kevin, Henderson, Melissa A., Lai, Junyun, Chen, Amanda X. Y., Meyran, Deborah, Todd, Kirsten L., Petley, Emma V., Mardiana, Sherly, Mølck, Christina, Stewart, Gregory D., Solomon, Benjamin J., Parish, Ian A., Neeson, Paul J., Harrison, Simon J., Kats, Lev M., House, Imran G., Darcy, Phillip K., Beavis, Paul A.

“…Adenosine is an immunosuppressive factor that limits anti-tumor immunity through the suppression of multiple immune subsets including T cells via activation of…”
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Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists by Zhang, Xin, Belousoff, Matthew J., Zhao, Peishen, Kooistra, Albert J., Truong, Tin T., Ang, Sheng Yu, Underwood, Christina Rye, Egebjerg, Thomas, Šenel, Petr, Stewart, Gregory D., Liang, Yi-Lynn, Glukhova, Alisa, Venugopal, Hari, Christopoulos, Arthur, Furness, Sebastian G.B., Miller, Laurence J., Reedtz-Runge, Steffen, Langmead, Christopher J., Gloriam, David E., Danev, Radostin, Sexton, Patrick M., Wootten, Denise

“…Peptide drugs targeting class B1 G-protein-coupled receptors (GPCRs) can treat multiple diseases; however, there remains substantial interest in the…”
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Molecular insights into orphan G protein‐coupled receptors relevant to schizophrenia by Lu, Yao, Hatzipantelis, Cassandra J., Langmead, Christopher J., Stewart, Gregory D.

“…Schizophrenia remains a sizable socio‐economic burden that continues to be treated with therapeutics based on 70‐year old science. All currently approved…”
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Molecular and structural insights into the 5-HT 2C receptor as a therapeutic target for substance use disorders by Ubhayarathna, Maleesha, Langmead, Christopher J, Diepenhorst, Natalie A, Stewart, Gregory D

“…Substance use disorder (SUD) is a chronic condition, with maintained abuse of a substance leading to physiological and psychological alterations and often…”
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Beyond antipsychotics: a twenty-first century update for preclinical development of schizophrenia therapeutics by Spark, Daisy L., Fornito, Alex, Langmead, Christopher J., Stewart, Gregory D.

“…Despite 50+ years of drug discovery, current antipsychotics have limited efficacy against negative and cognitive symptoms of schizophrenia, and are…”
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THE EFFECT OF CAREER PLAYING POSITION AND DETRAINING TIME ON THE PREVALENCE AND PERSISTANCE OF LEFT VENTRICULAR HYPERTROPHY IN A POPULATION OF FORMER PROFESSIONAL FOOTBALL PLAYERS by Smith, Genevieve, Cassidy, Mark, Stewart, Gregory W.

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Proximal threats promote enhanced acquisition and persistence of reactive fear-learning circuits by Faul, Leonard, Stjepanoviać, Daniel, Stivers, Joshua M., Stewart, Gregory W., Graner, John L., Morey, Rajendra A., LaBar, Kevin S.

“…Physical proximity to a traumatic event increases the severity of accompanying stress symptoms, an effect that is reminiscent of evolutionarily configured fear…”
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A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain by Ramírez-García, Paulina D., Retamal, Jeffri S., Shenoy, Priyank, Imlach, Wendy, Sykes, Matthew, Truong, Nghia, Constandil, Luis, Pelissier, Teresa, Nowell, Cameron J., Khor, Song Y., Layani, Louis M., Lumb, Chris, Poole, Daniel P., Lieu, TinaMarie, Stewart, Gregory D., Mai, Quynh N., Jensen, Dane D., Latorre, Rocco, Scheff, Nicole N., Schmidt, Brian L., Quinn, John F., Whittaker, Michael R., Veldhuis, Nicholas A., Davis, Thomas P., Bunnett, Nigel W.

“…Nanoparticle-mediated drug delivery is especially useful for targets within endosomes because of the endosomal transport mechanisms of many nanomedicines…”
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Murine GPRC6A Mediates Cellular Responses to L-Amino Acids, but Not Osteocalcin Variants by Rueda, Patricia, Harley, Elizabeth, Lu, Yao, Stewart, Gregory D, Fabb, Stewart, Diepenhorst, Natalie, Cremers, Béatrice, Rouillon, Marie-Hélène, Wehrle, Isabelle, Geant, Anne, Lamarche, Gwladys, Leach, Katie, Charman, William N, Christopoulos, Arthur, Summers, Roger J, Sexton, Patrick M, Langmead, Christopher J

“…Phenotyping of Gprc6a KO mice has shown that this promiscuous class C G protein coupled receptor is variously involved in regulation of metabolism,…”
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Intrathecal catheter implantation decreases cerebrospinal fluid dynamics in cynomolgus monkeys by Khani, Mohammadreza, Fu, Audrey Q, Pluid, Joshua, Gibbs, Christina P, Oshinski, John N, Xing, Tao, Stewart, Gregory R, Zeller, Jillynne R, Martin, Bryn A

“…A detailed understanding of the CSF dynamics is needed for design and optimization of intrathecal drug delivery devices, drugs, and protocols. Preclinical…”
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What if? Neural activity underlying semantic and episodic counterfactual thinking by Parikh, Natasha, Ruzic, Luka, Stewart, Gregory W., Spreng, R. Nathan, De Brigard, Felipe

“…Counterfactual thinking (CFT) is the process of mentally simulating alternative versions of known facts. In the past decade, cognitive neuroscientists have…”
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Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery by Sengmany, Kathy, Singh, Junaid, Stewart, Gregory D., Conn, P. Jeffrey, Christopoulos, Arthur, Gregory, Karen J.

“…Allosteric modulators, that exhibit no intrinsic agonist activity, offer the advantage of spatial and temporal fine-tuning of endogenous agonist activity,…”
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Chemical Modification of ProRoot MTA to Improve Handling Characteristics and Decrease Setting Time by Ber, Benjamin S., DDS, MS, Hatton, John F., DMD, Stewart, Gregory P., PhD

“…Abstract Mineral trioxide aggregate (MTA) fulfills many of the ideal properties of a root-end filling material. However, the composition of this material often…”
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Psychosocial determinants of anxiety about the COVID-19 pandemic by Wright, Rachael N., Faul, Leonard, Graner, John L., Stewart, Gregory W., LaBar, Kevin S.

“…Pandemic health threats can cause considerable anxiety, but not all individuals react similarly. To understand the sources of this variability, we applied a…”
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Addressing the carbon footprint of health organisations: eight lessons for implementation by Charlesworth, Kate E, Stewart, Gregory J, Sainsbury, Peter

“…The scientific evidence for global warming is overwhelming. Health organisations, as large carbon polluters, are at significant 'carbon risk' and must act to…”
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THE ASSOCIATION OF OBSTRUCTIVE SLEEP APNEA WITH LEFT VENTRICULAR HYPERTROPHY AND AORTIC ROOT DILATION IN A POPULATION OF FORMER PROFESSIONAL FOOTBALL PLAYERS by Smith, Genevieve, Simpson, Kaitlin C., Cassidy, Mark, Stewart, Gregory W.

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Targeting appetite and satiety in diabetes and obesity, via G protein-coupled receptors by Piper, Noah B.C., Whitfield, Emily A., Stewart, Gregory D., Xu, Xiaomeng, Furness, Sebastian G.B.

“…[Display omitted] Type 2 diabetes and obesity have reached pandemic proportions throughout the world, so much so that the World Health Organisation coined the…”
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