Search Results - "Stewart, Graeme J."

MicroRNAs miR-17 and miR-20a inhibit T cell activation genes and are under-expressed in MS whole blood by Cox, Mathew B, Cairns, Murray J, Gandhi, Kaushal S, Carroll, Adam P, Moscovis, Sophia, Stewart, Graeme J, Broadley, Simon, Scott, Rodney J, Booth, David R, Lechner-Scott, Jeannette

“…It is well established that Multiple Sclerosis (MS) is an immune mediated disease. Little is known about what drives the differential control of the immune…”
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IL28B, HLA-C, and KIR variants additively predict response to therapy in chronic hepatitis C virus infection in a European Cohort: a cross-sectional study by Suppiah, Vijayaprakash, Gaudieri, Silvana, Armstrong, Nicola J, O'Connor, Kate S, Berg, Thomas, Weltman, Martin, Abate, Maria Lorena, Spengler, Ulrich, Bassendine, Margaret, Dore, Gregory J, Irving, William L, Powell, Elizabeth, Hellard, Margaret, Riordan, Stephen, Matthews, Gail, Sheridan, David, Nattermann, Jacob, Smedile, Antonina, Müller, Tobias, Hammond, Emma, Dunn, David, Negro, Francesco, Bochud, Pierre-Yves, Mallal, Simon, Ahlenstiel, Golo, Stewart, Graeme J, George, Jacob, Booth, David R

“…To date, drug response genes have not proved as useful in clinical practice as was anticipated at the start of the genomic era. An exception is in the…”
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Evidence from genome wide association studies implicates reduced control of Epstein-Barr virus infection in multiple sclerosis susceptibility by Afrasiabi, Ali, Parnell, Grant P, Fewings, Nicole, Schibeci, Stephen D, Basuki, Monica A, Chandramohan, Ramya, Zhou, Yuan, Taylor, Bruce, Brown, David A, Swaminathan, Sanjay, McKay, Fiona C, Stewart, Graeme J, Booth, David R

“…Genome wide association studies have identified > 200 susceptibility loci accounting for much of the heritability of multiple sclerosis (MS). Epstein-Barr…”
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Combined effects of different interleukin-28B gene variants on the outcome of dual combination therapy in chronic hepatitis C virus type 1 infection by Fischer, Janett, Böhm, Stephan, Scholz, Markus, Müller, Tobias, Witt, Heiko, George, Jacob, Sarrazin, Christoph, Susser, Simone, Schott, Eckart, Suppiah, Vijayaprakash, Booth, David R., Stewart, Graeme J., van Bömmel, Florian, Brodzinski, Annika, Fülöp, Balazs, Migaud, Pascal, Berg, Thomas

“…In patients with chronic hepatitis C virus (HCV) infection, several variants of the interleukin‐28B (IL28B) gene have been shown to correlate significantly…”
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role of the CD58 locus in multiple sclerosis by De Jager, Philip L, Baecher-Allan, Clare, Maier, Lisa M, Arthur, Ariel T, Ottoboni, Linda, Barcellos, Lisa, McCauley, Jacob L, Sawcer, Stephen, Goris, An, Saarela, Janna, Yelensky, Roman, Price, Alkes, Leppa, Virpi, Patterson, Nick, de Bakker, Paul I.W, Tran, Dong, Aubin, Cristin, Pobywajlo, Susan, Rossin, Elizabeth, Hu, Xinli, Ashley, Charles W, Choy, Edwin, Rioux, John D, Pericak-Vance, Margaret A, Ivinson, Adrian, Booth, David R, Stewart, Graeme J, Palotie, Aarno, Peltonen, Leena, Dubois, Bénédicte, Haines, Jonathan L, Weiner, Howard L, Compston, Alastair, Hauser, Stephen L, Daly, Mark J, Reich, David, Oksenberg, Jorge R, Hafler, David A

“…Multiple sclerosis (MS) is an inflammatory disease of the central nervous system associated with demyelination and axonal loss. A whole genome association scan…”
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A transcription factor map as revealed by a genome-wide gene expression analysis of whole-blood mRNA transcriptome in multiple sclerosis by Riveros, Carlos, Mellor, Drew, Gandhi, Kaushal S, McKay, Fiona C, Cox, Mathew B, Berretta, Regina, Vaezpour, S Yahya, Inostroza-Ponta, Mario, Broadley, Simon A, Heard, Robert N, Vucic, Stephen, Stewart, Graeme J, Williams, David W, Scott, Rodney J, Lechner-Scott, Jeanette, Booth, David R, Moscato, Pablo

“…Several lines of evidence suggest that transcription factors are involved in the pathogenesis of Multiple Sclerosis (MS) but complete mapping of the whole…”
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The autoimmune disease-associated transcription factors EOMES and TBX21 are dysregulated in multiple sclerosis and define a molecular subtype of disease by Parnell, Grant P, Gatt, Prudence N, Krupa, Malgorzata, Nickles, Dorothee, McKay, Fiona C, Schibeci, Stephen D, Batten, Marcel, Baranzini, Sergio, Henderson, Andrew, Barnett, Michael, Slee, Mark, Vucic, Steve, Stewart, Graeme J, Booth, David R

“…Abstract We have identified a marked over-representation of transcription factors controlling differentiation of T, B, myeloid and NK cells among the 110 MS…”
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IL7Rα expression and upregulation by IFNβ in dendritic cell subsets is haplotype-dependent by McKay, Fiona C, Hoe, Edwin, Parnell, Grant, Gatt, Prudence, Schibeci, Stephen D, Stewart, Graeme J, Booth, David R

“…The IL7Rα gene is unequivocally associated with susceptibility to multiple sclerosis (MS). Haplotype 2 (Hap 2) confers protection from MS, and T cells and…”
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A polymorphism in the HLA-DPB1 gene is associated with susceptibility to multiple sclerosis by Field, Judith, Browning, Sharon R, Johnson, Laura J, Danoy, Patrick, Varney, Michael D, Tait, Brian D, Gandhi, Kaushal S, Charlesworth, Jac C, Heard, Robert N, Stewart, Graeme J, Kilpatrick, Trevor J, Foote, Simon J, Bahlo, Melanie, Butzkueven, Helmut, Wiley, James, Booth, David R, Taylor, Bruce V, Brown, Matthew A, Rubio, Justin P, Stankovich, Jim

“…We conducted an association study across the human leukocyte antigen (HLA) complex to identify loci associated with multiple sclerosis (MS). Comparing 1927…”
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Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort by Smith, Katherine R, Suppiah, Vijayaprakash, O'Connor, Kate, Berg, Thomas, Weltman, Martin, Abate, Maria Lorena, Spengler, Ulrich, Bassendine, Margaret, Matthews, Gail, Irving, William L, Powell, Elizabeth, Riordan, Stephen, Ahlenstiel, Golo, Stewart, Graeme J, Bahlo, Melanie, George, Jacob, Booth, David R

“…The hepatitis C virus (HCV) infects nearly 3% of the World's population, causing severe liver disease in many. Standard of care therapy is currently pegylated…”
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IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy by Suppiah, Vijayaprakash, Moldovan, Max, Ahlenstiel, Golo, Berg, Thomas, Weltman, Martin, Abate, Maria Lorena, Bassendine, Margaret, Spengler, Ulrich, Dore, Gregory J, Powell, Elizabeth, Riordan, Stephen, Sheridan, David, Smedile, Antonina, Fragomeli, Vincenzo, Müller, Tobias, Bahlo, Melanie, Stewart, Graeme J, Booth, David R, George, Jacob

“…Hepatitis C virus (HCV) infects 3% of the world's population. Treatment of chronic HCV consists of a combination of PEGylated interferon-α (PEG-IFN-α) and…”
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Genes implicated in multiple sclerosis pathogenesis from consilience of genotyping and expression profiles in relapse and remission by Arthur, Ariel T, Armati, Patricia J, Bye, Chris, Heard, Robert N S, Stewart, Graeme J, Pollard, John D, Booth, David R

“…Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Although the pathogenesis of MS remains unknown, it is…”
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Implementation of the Garling recommendations can offer real hope for rescuing the New South Wales public hospital system by Stewart, Graeme J, Dwyer, John M

“…Public hospital clinicians across Australia will relate to the problems described in the Garling report and endorse most of the recommendations to bring the…”
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Functional characterization of the atopy-associated gene PHF11 by Clarke, Emily, BSc, Rahman, Nusrat, BMedSci, Page, Natalie, PhD, Rolph, Michael S., PhD, Stewart, Graeme J., MD, PhD, Jones, Graham J., PhD

“…Background Polymorphisms in the plant homeodomain finger protein 11 gene (PHF11) are associated with increased total serum IgE levels, asthma, and severe…”
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The interaction of Multiple Sclerosis risk loci with Epstein-Barr virus phenotypes implicates the virus in pathogenesis by Afrasiabi, Ali, Parnell, Grant P., Swaminathan, Sanjay, Stewart, Graeme J., Booth, David R.

“…Translating the findings of genome wide association studies (GWAS) to new therapies requires identification of the relevant immunological contexts to…”
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Novel approaches to detect serum biomarkers for clinical response to interferon-beta treatment in multiple sclerosis by Gandhi, Kaushal S, McKay, Fiona C, Diefenbach, Eve, Crossett, Ben, Schibeci, Stephen D, Heard, Robert N, Stewart, Graeme J, Booth, David R, Arthur, Jonathan W

“…Interferon beta (IFNbeta) is the most common immunomodulatory treatment for relapsing-remitting multiple sclerosis (RRMS). However, some patients fail to…”
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Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci by Patsopoulos, Nikolaos A., de Bakker, Paul I. W.

“…Objective: To perform a 1‐stage meta‐analysis of genome‐wide association studies (GWAS) of multiple sclerosis (MS) susceptibility and to explore functional…”
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Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20 by Bahlo, Melanie, Booth, David R, Broadley, Simon A, Brown, Matthew A, Foote, Simon J, Griffiths, Lyn R, Kilpatrick, Trevor J, Lechner-Scott, Jeanette, Moscato, Pablo, Perreau, Victoria M, Rubio, Justin P, Scott, Rodney J, Stankovich, Jim, Stewart, Graeme J, Taylor, Bruce V, Wiley, James, Clarke, Glynnis, Cox, Mathew B, Csurhes, Peter A, Danoy, Patrick, Drysdale, Karen, Field, Judith, Greer, Judith M, Guru, Preethi, Hadler, Johanna, McMorran, Brendan J, Jensen, Cathy J, Johnson, Laura J, McCallum, Ruth, Merriman, Marilyn, Merriman, Tony, Pryce, Karen, Tajouri, Lotfi, Wilkins, Ella J, Browning, Brian L, Browning, Sharon R, Perera, Devindri, Broadley, Simon, Butzkueven, Helmut, Carroll, William M, Chapman, Caron, Kermode, Allan G, Marriott, Mark, Mason, Deborah, Heard, Robert N, Pender, Michael P, Slee, Mark, Tubridy, Niall, Willoughby, Ernest

“…To identify multiple sclerosis (MS) susceptibility loci, we conducted a genome-wide association study (GWAS) in 1,618 cases and used shared data for 3,413…”
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Amyloid Cardiomyopathy by Bart, Nicole K., Thomas, Liza, Korczyk, Dariusz, Atherton, John J., Stewart, Graeme J., Fatkin, Diane

“…Amyloid cardiomyopathy is emerging as an important and under-recognised cause of heart failure and cardiac arrhythmias, especially in older adults. This…”
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Current approaches to the diagnosis and management of amyloidosis by Taylor, Mark S., Sidiqi, Hasib, Hare, James, Kwok, Fiona, Choi, Bo, Lee, Darren, Baumwol, Jay, Carroll, Antonia S., Vucic, Steve, Neely, Pat, Korczyk, Dariusz, Thomas, Liza, Mollee, Peter, Stewart, Graeme J., Gibbs, Simon D. J.

“…Amyloidosis is a collection of diseases caused by the misfolding of proteins that aggregate into insoluble amyloid fibrils and deposit in tissues. While these…”
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